Results for 'Apoptosis'

4 found
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  1. In Defense of Methodological Mechanism: The Case of Apoptosis.Stavros Ioannidis & Stathis Psillos - 2017 - Axiomathes 27 (6):601-619.
    This paper advances the thesis of methodological mechanism, the claim that to be committed to mechanism is to adopt a certain methodological postulate, i.e. to look for causal pathways for the phenomena of interest. We argue that methodological mechanism incorporates a minimal account of understanding mechanisms, according to which a mechanism just is a causal pathway described in the language of theory. In order to argue for this position we discuss a central example of a biological mechanism, the mechanism of (...)
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  2.  36
    Zinc Deficiency Induces Apoptosis Via Mitochondrial P53- and Caspase-Dependent Pathways in Human Neuronal Precursor Cells. James - 2014 - Journal of Trace Elements in Medicine and Biology 59 (65).
    Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we have now identified the translocation of phosphorylated p53 to the mitochondria and p53-dependent increases in the pro-apoptotic mitochondrial protein BAX leading to a loss of mitochondrial membrane potential as demonstrated by a 25% decrease in JC-1 red:green fluorescence ratio. Disruption (...)
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    Mechanisms in Practice: A Methodological Approach.Stavros Ioannidis & Stathis Psillos - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1177-1183.
    In this paper we offer a minimal characterisation of the concept of mechanism in biomedicine, according to which a mechanism is a theoretically described causal pathway. We argue that this conceptionan be drawn from scientific practice, as illustrated by how a central biological and biomedical mechanism, the mechanism of apoptosis, was first identified and characterised. We will use the example of cytological and biochemical theoretical descriptions of the mechanism of apoptosis to draw lessons about the meaning of the (...)
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  4. Differential Activation of ER Stress Signal Pathway s Contributes to Palmitate-Induced Hepatocyte Lipoapoptosis.Xiaofang Zhao - 2016 - Cell Biology 4 (1):128.
    Saturated free fatty acids-induced hepatocyte lipoapoptosis plays a pivotal role in non-alcoholic steatohepatitis. Theactivation of endoplasmic reticulum (ER) stress isinvolved in hepatocyte lipoapoptosis induced by thesaturated free fatty acidpalmitate (PA). However, the underlying mechanismsof the role of ER stress in hepatocyte lipoapoptosis remain largely unclear.In this study, we showed that PA and tunicamycin (Tun), a classic ER stress inducer, resulted in differential activation of ERstress pathways. Our data revealed that PA inducedchronic and persistent ER stress response, but Tuninduced acute and (...)
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