Objective: The objective of this study was to evaluate the clinical efficacy and appropriateness of colistin therapy in patients with hematological malignancies. -/- Methods: Age, gender, type of hematologic malignancy, and potential carbapenem-resistant microorganism risk factors were all noted in this retrospective study. In empirical and agent-specific treatment groups, differences in demographic features, risk factors, treatment responses, and side effects were compared. -/- Results: Sixty-three patients were included, 54% were male, and the median age was 49. In the last three (...) months, the hospitalization rate history was 68%, and four patients had a hospitalization history in the ICU. Carbapenem-resistant K. pneumoniae colonization was present in 22 patients (35%). Gram-negative microorganisms were isolated in 34 patients (54%). The carbapenem, quinolone, and colistin resistance rates were 82%, 76%, and 4% respectively. Clinical and microbiological response rates were 60% and 69%. 7 and 28-day mortality rates were 17% and 35%. There was no significant difference in demographic data and comorbidities in empirical (n=48) and agent-specific (n=15) treatment groups. The rate of carbapenem and glycopeptide treatments before colistin was higher in the empirical treatment group (p = 0.004; p = 0.001). The rate of starting combined antibiotics was higher in the empirical treatment group (p = 0.016). Two of the patients developed renal failure in the first week after treatment. -/- Conclusion: The use of empirical colistin may be unavoidable given the risk considerations. Shortly, colistin-resistant strains may also be a factor affecting treatment success negatively. (shrink)

The structure is the backbone of a book. Beneath the surface, it holds everything together and imposes order on the flow. Without a coherent and logical structure, the novel’s key elements are unclear. Victorian Age is known for perfection of the novel from all corners. Though Charles Dickens and Emily Bronte have distinct places in the literary World, Yet their representation of their age has many things in common. The two novels in question “Great Expectations” and “Wuthering Heights” range from (...) Gothic tradition to migration and romance to villainy. Both of these stories can be set off and paralleled to the other. The setting, narration, plot, time era, and lover’s relationships are the elements of comparison as they form the overall structure of a novel. (shrink)

Chondrosarcoma is slow growing but locally aggressive malignancy with a propensity tor progressive spread and multiple recurrences that eventually leads to death it inadequately treated, and uncommonly seen in the head and neck. in this article, a review of literature regarding on the chondrosarcoma of the head and neck was pr"sented and treatment modalities and results o this alternatives were discussed.