This article examines an uncommon materialist argument preserved in late medieval Prague quodlibets by Matthias of Knín (1409) and Prokop of Kladruby (1417). The argument connects the Galenic claim that the human body has the noblest and best-balanced complexion possible with the Alexandrist claim that the human rational soul emerges from such well-balanced matter without any supernatural intervention. Of the various medieval renderings of these claims, John Wyclif’s De compositione hominis is singled out as the most probable source of (...) the argument. Far from attributing plain materialism to Wyclif, the article highlights a semimaterialist position, mentioned in two fifteenth-century De anima commentaries of Prague origin, grafting the immortal spirit postulate onto an Alexandrist-like doctrine of the intellect as educed from the harmoniously complexioned body. Finally, it is argued that this semimaterialist position may not only encapsulate how Bohemian masters read Wyclif, but also be close to Wyclif’s actual anthropological stance. (shrink)