In biomedical measurement, biomarkers are used to achieve reliable prediction of, and useful causal information about patient outcomes while minimizing complexity of measurement, resources, and invasiveness. A biomarker is an assayable metric that discloses the status of a biological process of interest, be it normative, pathophysiological, or in response to intervention. The greatest utility from biomarkers comes from their ability to help clinicians (and researchers) make and evaluate clinical decisions. In this paper we discuss a specific methodological use of clinical (...) biomarkers in pharmacological measurement: Some biomarkers, called ‘surrogate markers’, are used to substitute for a clinically meaningful endpoint corresponding to events and their penultimate risk factors. We confront the reliability of clinical biomarkers that are used to gather information about clinically meaningful endpoints. Our aim is to present a systematic methodology for assessing the reliability of multiple surrogate markers (and biomarkers in general). To do this we draw upon the robustness analysis literature in the philosophy of science and the empirical use of clinical biomarkers. -/- After introducing robustness analysis we present two problems with biomarkers in relation to reliability. Next, we propose an intervention-based robustness methodology for organizing the reliability of biomarkers in general. We propose three relevant conditions for a robust methodology for biomarkers: (R1) Intervention-based demonstration of partial independence of modes: In biomarkers partial independence can be demonstrated through exogenous interventions that modify a process some number of “steps” removed from each of the markers. (R2) Comparison of diverging and converging results across biomarkers: By systematically comparing partially-independent biomarkers we can track under what conditions markers fail to converge in results, and under which conditions they successfully converge. (R3) Information within the context of theory: Through a systematic cross-comparison of the markers we can make causal conclusions as well as eliminate competing theories. We apply our robust methodology to currently developing Alzheimer’s research to show its usefulness for making causal conclusions. (shrink)

The article offers an attempt to understand the present state of Kant’s legacy in Russia on the threshold of the Tercentenary. An explanans is found in the metaphors of “ tabula rasa ” and “unplowed virgin soil,” first used by Leibniz in relation to Russia in his letters and memoranda addressed to tsar Peter I and other members of the Russian elite, which became the country’s “absolute metaphors to live by” up to present time. Several known and unknown episodes from (...) the history of the reception of Kantian ideas, his followers in Russia, and the transformation of the urban environment of Kant’s life in Königsberg, as it was becoming Kaliningrad, are presented through the prism of this metaphor. Without hoping to make specific recommendations of any use from such metaphorical grounds, this study aims to emphasize the depth, interconnectedness, and basic, metaphysical tension of the relationship between Europe and Russia, which cannot be terminated at will by either side, or by a third party. In a situation where the sides are doomed to dialog, Kant, appropriated by Russia as its “subject,” occupies the unique position of mediator of philosophical understanding and peaceful action. (shrink)

On the eve of the tercentenary of Kant’s birth, just as it was a hundred years ago, Kantianism is simultaneously on the receiving end of the blows of history and attacks by rival philosophical parties, both progressivist and reactionary. The radical wings of both parties perceive modernity as a depressing, nauseating period which must be broken with by moving toward the past or toward the future. One of the most original and profound diagnoses of this attitude was offered by Hans (...) Jonas, who discerned in radical doctrines of a hundred years ago a similarity with the gnosticism of antiquity. Jonas’s diagnosis has not lost its relevance. That is why the central question addressed in this study is as follows: what prescription does the Kantian programme offer for modernity’s “gnostic dizziness?” I maintain that Kant’s critical turn is still an effective strategy by means of which to compensate for the sudden stresses and “gnostic impulses” provoked by the modern worldview revolution, bringing back an “orientation in thinking” which reorients the world process and individual activity. The imperative to always see and respect humanity in a particular individual warns against the “category mistake” committed by modern radicals who ascribe agency (subjectivity) to non-­human abstractions which cannot possess this property. In theory, Kant grounds the view that humanity should resign itself to the fact of its perspective being limited and local. Kantian practical philosophy provides the traveler with a map of regulative ideas and a “moral compass”, along with an explanation of disruptive factors, offering a working explanation of the situation and its possible outcomes. Kant’s “Copernican revolution” brings human beings back into focus and imagination to order, allowing for the hope that new challenges will be successfully met. (shrink)

Using the two cases of the Icelandic Health Sector Database and Russian initiatives in biobanking, the article criticizes the view of narratives and imaginaries as a sufficient and unproblematic means of shaping public understanding of genetics and justifying population-wide projects. Narrative representations of national biobanking engage particular imaginaries that are not bound by the universal normative framework of human rights, promote affective thinking, distract the public from recognizing and discussing tangible ethical and socioeconomic issues, and harm trust in science and (...) technology. In the Icelandic case, the presentation of the project in association with national imaginaries concealed its market identity and could lead to the commodification of biodata. In the Russian case, framing in terms of "genetic sovereignty" and "civilizational code" offers pretexts for state securitization. Adherence to normative framework of human rights and public discussion of genetics in an argumentative and factual mode can counter these trends. (shrink)

In experimental settings, scientists often “make” new things, in which case the aim is to intervene in order to produce experimental objects and processes—characterized as ‘effects’. In this discussion, I illuminate an important performative function in measurement and experimentation in general: intervention-based experimental production. I argue that even though the goal of IEP is the production of new effects, it can be informative for causal details in scientific representations. Specifically, IEP can be informative about causal relations in: regularities under study; (...) ‘intervention systems’, which are measurement/experimental systems; and new technological systems. (shrink)

A murder of an Afro-American detainee by a policeman at the end of May 2020 caused a public outrage in the United States, which led to a campaign against the monuments to historical figures whose reputation, according to the protesters, was marred by racism. Some German publicists, impressed by the campaign, initiated an analogous search for racists among the national thinkers and politicians of the past. Suddenly Kant emerged as a ‘scapegoat’. This statement is an attempt to assess such reactions (...) from the perspective of Russia’s experience. (shrink)

Publication of Taras Lyuty’s book on Nietzsche is a salient event in the philosophical life of Ukraine in 2016. Given the fact that the book covers a great number of different issues, the reviewer decides to focus on those of them which correspond to his own academic interests, related primarily to the history of psychoanalysis and biographical approach within the historiography of philosophy. As a review shows, Lyuty masterfully avoids such a trap as a biographical reductivism. He neither reduces his (...) hero’s teaching to his life, nor isolates the former from the latter. The reviewer pays a special attention to Lyuty’s delineation of intellectual links between the great philosopher and some of his predecessors (such as Ralf Waldo Emerson) and followers (some pioneers of depth psychology). In the end, the reviewer demonstrates that a very deep and systematic analysis of Nietzsche’s biography and philosophical heritage carried out by Lyuty leaves a room for further productive reflections and interpretations. (shrink)

The article aims at clarifying the historical status and cognitive potentials of such a genre of contemporary historiography of philosophy as biographical encyclopedia (dictionary). Based on extensive bibliographic material, the author demonstrates that in the late XX – early XXI centuries in the English-speaking countries there was a real outbreak of interest in encyclopedias and dictionaries, compiled from personalized articles about the life and works of philosophers of certain epochs, countries, trends, etc. According to the author, the increasing popularity of (...) this genre can be considered as a logical continuation of the historical and biographical turns that took place in the Anglo-American (analytic) philosophy in the 1980s and 1990s, respectively. The author specifically emphasizes that it caused the appearance of a significant number of encyclopedias and dictionaries, which contain the well-known facts as well as the significant elements of scholar novelty. The article also shows that similar tendencies have taken place in the contemporary Ukrainian historiography of philosophy. It is shown that Ukrainian experts also made their own significant contribution to the development of this genre. They have successfully developed a special approach, which presupposes the focus on life and works of the representatives of a particular academic institution. The intellectual value of this approach is demonstrated by the example of the recently published two-volume encyclopedia “Kyiv Theological Academy in Names: 1819-1924”. It contains a systematic and very informative presentation of the biographies of many representatives of the national philosophy, whose activities were associated with this institution. The author also shows that from the perspective of the historiography of philosophy, the general methodological foundations of this encyclopedic research is a matter of special interest. (shrink)

The current state of philosophy of science is characterized by stasis in the struggle between realism and antirealism. In recent years, a number of authors have come out with a program of scientific perspectivism that claims to sublate this great collision and gain the status of a new epistemological paradigm: “perspectivism, or, better, perspectival realism, is one of the newest attempts to find a middle ground between scientific realism and antirealism” [1. P. 2]. Important milestones of the perspective movement were (...) the works of Ronald Giere, Francois Recanati, Bas van Fraassen, Michela Massimi, and others. The thesis of the article is that perspectivism has not yet realized its claims to autonomy, although it has become an important new arena for discussions between realists and antirealists who try to appropriate perspectivist concepts and arguments. The “middle ground,” when thought out consistently and thoroughly, turns out to lie not “between,” but either in the territory of realism or in the territory of antirealism, depending on the presumptions of the author of a particular perspectivist conception. This is demonstrated by the analysis of the conceptions of Giere, Massimi, and Recanati. Giere’s perspectivism is based on the metaphor of color vision, and for him only some (secondary) qualities of real objects turn out to be perspectival, i.e., subject-dependent. Massimi’s perspectivism attempts, on the basis of a visual arts metaphor, to combine the phenomenon of the plurality of scientific theories (“perspectival disagreement” about what an object is) with the general realist attitude of science (agreement about that there is an object). Recanati’s perspectivism syncretizes realism about ordinary objects and relativism about other things. The first two versions of perspectivism rely on a perceptual metaphor: perspective is conditioned by the perceptual constitution of the observer, that is, it arises at the mental or cognitive level. Recanati’s version attempts to derive perspective from contextuality, that is, it is semantic. However, it does not show exactly how perceptual categories are superimposed on theories or how scientific concepts reveal their perspectival character. The isomorphism of perception and theoretical thinking, sensibility and understanding, remains undemonstrated. On the one hand, perspectivist efforts are motivated by an important concern to account for antirealist critique (lack of access to the “view from nowhere,” factual and semantic underdetermination, difficulties with the idea of approaching the truth, the historicity of knowledge, the activeness of the constructing subject, etc.) while preserving the scientific commitment to universality, validity, and truthfulness. On the other hand, the ontological question remains fundamental and unavoidable, and perspectivism (yet?) fails to circumvent it. As we see, all three versions of perspectivism considered in this article turn out to be varieties of realism: Giere and Massimi recognize this explicitly, while Recanati de facto assumes a quite respectable and conservative position of selective realism with respect to ordinary objects. (shrink)

The aim of this essay is to clarify the meaning and extent of Kant's liberalism by contrasting some of his key ideas to those of Burke, Hobbes, Machiavelli, Nozick, Rawls, and Schmitt. My claim is that Kant's political philosophy navigates the path between the extremes of liberalism and conservatism, just as his theoretical philosophy tries to navigate between dogmatism and skepticism, and that current liberal claim on Kant has important limitations in Kant's letter, as well as in spirit.

In recent decades, perspectivism has developed into an independent epistemological research program. Perspectivism is based on the idea of perspective as an attempt to elucidate an object from a multitude of factors. Perspectivists are concerned with reconstructing and explaining these factors, identifying the conditioning of epistemic acts, using concepts such as “position”/“point of view,” “gaze,” “angle of view,” “horizon,” “focus,” “picture,” “relativity,” and “context”. Although these concepts are part of the perspectivist's toolkit, their content and interrelationship have not yet been (...) critically and comprehensively analyzed. The purpose of this article is to clarify the conceptual basis of perspectivism as an epistemological program, which began in the works of F. Kaulbach (1990) and W. Stegmaier (2008). For this purpose, a systematic conceptual analysis will be carried out, a detailed presentation of the logical content of perspectivist notions and their reduction into a single coherent model, which can become the conceptual basis of perspectivism. Perspectivist concepts constitute a “population” or matrix of the concept “epistemic situation”. Being consistently expounded and correlated in a conceptual model, they can be used as a tool for a detailed analysis of epistemic situations and their results (theories, positions, views, etc.). The final part of the article will formulate a number of significant implications of the new programmatic understanding of perspectivism: the status of perspectivist concepts, the distinction of perspectivism from similar epistemological programs, and the challenges for its further development. (shrink)

In recent decades, perspectivism has developed into an epistemological research program claiming its independence. This autonomy stems from Perspectivism’s potential ability to resolve the contradictions between realist and constructivist programs. Perspectivism is based on the idea that the object depends on perspective, which constitutes any subjective attempt to cognize it. Perspectivists reconstruct and explain the factors involved in the formation of perspective, identifying the conditionality of epistemic acts, using concepts such as “position”, “point of view”, “view”, “angle”, “horizon”, “focus”, “picture”, (...) “context”, “aspect”, etc. Although these concepts are part of the perspectivist’s toolkit, their meanings and interrelation have so far been taken for granted and have not yet been critically and comprehensively analyzed. The purpose of this article is to take steps toward clarifying the conceptual basis for defending perspectivism as an epistemological program. Once consistently uncovered and correlated in a conceptual model, Perspectivist concepts can be used as a tool for a detailed analysis of theories, positions, and beliefs. The article begins with a preliminary description of the concept of perspectivism and its brief history as an epistemological program. In particular, the first modern attempts to outline perspectivist epistemology are described in the works of F. Kaulbach (1990), W. Stegmaier (2008), and M. Massimi (2017, 2020). The problem of identifying the special a priori status of perspectivist notions as a strategy for justifying the autonomy of Perspectivism is then posed. A method for demonstrating such a status, based on Kant’s transcendentalism and P. Strawson’s descriptive metaphysics, is then suggested. (shrink)

In this paper we motivate and develop the analytic theory of measurement, in which autonomously specified algebras of quantities (together with the resources of mathematical analysis) are used as a unified mathematical framework for modeling (a) the time-dependent behavior of natural systems, (b) interactions between natural systems and measuring instruments, (c) error and uncertainty in measurement, and (d) the formal propositional language for describing and reasoning about measurement results. We also discuss how a celebrated theorem in analysis, known as Gelfand (...) representation, guarantees that autonomously specified algebras of quantities can be interpreted as algebras of observables on a suitable state space. Such an interpretation is then used to support (i) a realist conception of quantities as objective characteristics of natural systems, and (ii) a realist conception of measurement results (evaluations of quantities) as determined by and descriptive of the states of a target natural system. As a way of motivating the analytic approach to measurement, we begin with a discussion of some serious philosophical and theoretical problems facing the well-known representational theory of measurement. We then explain why we consider the analytic approach, which avoids all these problems, to be far more attractive on both philosophical and theoretical grounds. (shrink)

In this publisher's preface to 'Beobachtungen über den Geist des Menschen und dessen Verhältniß zur Welt' - outstanding, but, despite its merits, so far almost totally unknown philosophical treatise of the late Enlightenment, published in 1790 under a pseudonym 'Andrei Peredumin Koliwanow', I show that the real author of this book was an educator Christlieb Feldstrauch (1734 - 1799).

The bi-polar confrontation between the Soviet Union and the USA involved many leading game theorists from both sides of the Iron Curtain: Oskar Morgenstern, John von Neumann, Michael Intriligator, John Nash, Thomas Schelling and Steven Brams from the United States and Nikolay Vorob’ev, Leon A. Petrosyan, Elena B. Yanovskaya and Olga N. Bondareva from the Soviet Union. The formalization of game theory (GT) took place prior to the Cold War but the geopolitical confrontation hastened and shaped its evolution. In our (...) article we outline four similarities and differences between Western GT and Soviet GT: 1) the Iron Curtain resulted in a lagged evolution of GT in the Soviet Union; 2) Soviet GT focused more on operations research and issues of centralized planning; 3) the contemporary Western view on Soviet GT was biased and Soviet contributions, including works on dynamic stability, non-emptiness of the core and many refinements, suggest that Soviet GT was able to catch up to the Western level relatively fast; 4) international conferences, including Vilnius, 1971, fostered interaction between Soviet game theorists and their Western colleagues. In general, we consider the Cold War to be a positive environment for GT in the West and in the Soviet Union. (shrink)

In this paper I try to explain a strange omission in Hume’s methodological descriptions in his first Enquiry. In the course of this explanation I reveal a kind of rationalistic tendency of the latter work. It seems to contrast with “experimental method” of his early Treatise of Human Nature, but, as I show that there is no discrepancy between the actual methods of both works, I make an attempt to explain the change in Hume’s characterization of his own methods. This (...) attempt leads to the question about his interpretation of the science of human nature. I argue that his view on this science was not a constant one and that initially he identified this science with his account of passions. As this presupposes the primacy of Book 2 of his Treatise I try to find new confirmations of the old hypothesis that this Book had been written before the Book 1, dealing with understanding. Finally, I show that this discussion of Hume’s methodology may be of some interest to proponents of conceptual analysis. -/- . (shrink)

This book is a compilation of the answers given by 100 of the top Kant-scholars around the world to three questions: (1) In your opinion, which of Kant’s ideas have universal and enduring value? (2) What, in your opinion, was Kant’s main mistake? and (3) Do we understand Kant better than 100 years ago? The original (mostly English or German) versions of the replies can be read on the web page called "International Kant Interview".