Simple regression (regression analysis with a single explanatory variable), and multiple regression (regression models with multiple explanatory variables), typically correspond to very different biological questions. The former use regression lines to describe univariate associations. The latter describe the partial, or direct, effects of multiple variables, conditioned on one another. We suspect that the superficial similarity of simple and multiple regression leads to confusion in their interpretation. A clear understanding of these methods is essential, as they underlie a large range of (...) procedures in common use in biology. Beyond simple and multiple regression in their most basic forms, understanding the key principles of these procedures is critical to understanding, and properly applying, many methods, such as mixed models, generalised models, and causal inference using graphs (including path analysis and its extensions). A simple, but careful, look at the distinction between these two analyses is valuable in its own right, and can also be used to clarify widely-held misconceptions about collinearity (correlations among explanatory variables). There is no general sense in which collinearity is a problem. We suspect that the perception of collinearity as a hindrance to analysis stems from misconceptions about interpretation of multiple regression models, and so we pursue discussions about these misconceptions in this light. In particular, collinearity causes multiple regression coefficients to be less precisely estimated than corresponding simple regression coefficients. This should not be interpreted as a problem, as it is perfectly natural that direct effects should be harder to characterise than univariate associations. Purported solutions to the perceived problems of collinearity are detrimental to most biological analyses. (shrink)

We address a long-standing debate over whether classical magnetic forces can do work, ultimately answering the question in the affirmative. In detail, we couple a classical particle with intrinsic spin and elementary dipole moments to the electromagnetic field, derive the appropriate generalization of the Lorentz force law, show that the particle's dipole moments must be collinear with its spin axis, and argue that the magnetic field does mechanical work on the particle's elementary magnetic dipole moment. As consistency checks, we calculate (...) the overall system's energy-momentum and angular momentum, and show that their local conservation equations lead to the same force law and therefore the same conclusions about magnetic forces and work. We also compute the system's Belinfante-Rosenfeld energy-momentum tensor. (shrink)

The segregation of image parts into foreground and background is an important aspect of the neural computation of 3D scene perception. To achieve such segregation, the brain needs information about border ownership; that is, the belongingness of a contour to a specific surface represented in the image. This article presents psychophysical data derived from 3D percepts of figure and ground that were generated by presenting 2D images composed of spatially disjoint shapes that pointed inward or outward relative to the continuous (...) boundaries that they induced along their collinear edges. The shapes in some images had the same contrast (black or white) with respect to the background gray. Other images included opposite contrasts along each induced continuous boundary. Psychophysical results demonstrate conditions under which figure-ground judgment probabilities in response to these ambiguous displays are determined by the orientation of contrasts only, not by their relative contrasts, despite the fact that many border ownership cells in cortical area V2 respond to a preferred relative contrast. Studies are also reviewed in which both polarity-specific and polarity-invariant properties obtain perceptual figure-ground grouping results. The FACADE and 3D LAMINART models are used to explain these data. Keywords: figure-ground separation, border ownership, perceptual grouping, surface filling-in, V2, V4, FACADE Theory. (shrink)

“Negative probability” in practice. Quantum Communication: Very small phase space regions turn out to be thermodynamically analogical to those of superconductors. Macro-bodies or signals might exist in coherent or entangled state. Such physical objects having unusual properties could be the basis of quantum communication channels or even normal physical ones … Questions and a few answers about negative probability: Why does it appear in quantum mechanics? It appears in phase-space formulated quantum mechanics; next, in quantum correlations … and for wave-particle (...) dualism. Its meaning:- mathematically: a ratio of two measures (of sets), which are not collinear; physically: the ratio of the measurements of two physical quantities, which are not simultaneously measurable. The main innovation is in the mapping between phase and Hilbert space, since both are sums. Phase space is a sum of cells, and Hilbert space is a sum of qubits. The mapping is reduced to the mapping of a cell into a qubit and vice versa. Negative probability helps quantum mechanics to be represented quasi-statistically by quasi-probabilistic distributions. Pure states of negative probability cannot exist, but they, where the conditions for their expression exists, decrease the sum probability of the integrally positive regions of the distributions. They reflect the immediate interaction (interference) of probabilities common in quantum mechanics. (shrink)

The thresholds of human observers detecting line targets improve significantly when the targets are presented in a spatial context of collinear inducing stimuli. This phenomenon is referred to as spatial facilitation, and may reflect the output of long-range interactions between cortical feature detectors. Spatial facilitation has thus far been observed with luminance-defined, achromatic stimuli on achromatic backgrounds. This study compares spatial facilitation with line targets and collinear, edge-like inducers defined by luminance contrast to spatial facilitation with targets and inducers defined (...) by color contrast. The results of a first experiment show that achromatic inducers facilitate the detection of achromatic targets on gray and colored backgrounds, but tend to suppress the detection of chromatic targets. Chromatic inducers facilitate the detection of chromatic targets on gray and colored backgrounds, but tend to suppress the detection of achromatic targets. Chromatic spatial facilitation appears to be strongest when inducers and background are isoluminant. The results of a second experiment show that spatial facilitation with chromatic targets and inducers requires a longer exposure duration of the inducers than spatial facilitation with achromatic targets and inducers, which is already fully effective at an inducer exposure of 30 ms only. The findings point towards two separate mechanisms for spatial facilitation with collinear form stimuli: one that operates in the domain of luminance, and one that operates in the domain of color contrast. These results are consistent with neural models of boundary and surface formation which suggest that achromatic and chromatic visual cues are represented on different cortical surface representations that are capable of selectively attracting attention. Multiple copies of these achromatic and chromatic surface representations exist corresponding to different ranges of perceived depth from an observer, and each can attract attention to itself. Color and contrast differences between inducing and test stimuli, and transient responses to inducing stimuli, can cause attention to shift across these surface representations in ways that sometimes enhance and sometimes interfere with target detection. (shrink)

This article introduces an experimental paradigm to selectively probe the multiple levels of visual processing that influence the formation of object contours, perceptual boundaries, and illusory contours. The experiments test the assumption that, to integrate contour information across space and contrast sign, a spatially short-range filtering process that is sensitive to contrast polarity inputs to a spatially long-range grouping process that pools signals from opposite contrast polarities. The stimuli consisted of thin subthreshold lines, flashed upon gaps between collinear inducers which (...) potentially enable the formation of illusory contours. The subthreshold lines were composed of one or more segments with opposite contrast polarities. The polarity nearest to the inducers was varied to differentially excite the short-range filtering process. The experimental results are consistent with neurophysiological evidence for cortical mechanisms of contour processing and with the Boundary Contour System model, which identifies the short-range filtering process with cortical simple cells, and the long-range grouping process with cortical bipole cells. (shrink)

A natural extension of Heron's 2000 year old formula for the area of a triangle to the volume of a tetrahedron is presented. This gives the fourth power of the volume as a polynomial in six simple rational functions of the areas of its four faces and three medial parallelograms, which will be referred to herein as "interior faces." Geometrically, these rational functions are the areas of the triangles into which the exterior faces are divided by the points at which (...) the tetrahedron's in-sphere touches those faces. Part I presents an overview of these results and some necessary but little-known background in areal geometry. Part II derives the promised extension, and ends with a conjecture as to how the formula extends to n-dimensional simplices for all n>3. Part III explains how, for n=3, the zeros of the polynomial constitute a five-dimensional semi-algebraic variety consisting almost entirely of collinear tetrahedra with vertices separated by infinite distances, but with generically well-defined distance ratios; it further proves that these unconventional Euclidean configurations can be identified with a quotient of the Klein quadric by an action of a group of reflections isomorphic to ℤ42, wherein four-point configurations in the affine plane constitute a distinguished three-dimensional subvariety. Part IV consists of five appendices which show, among other things, that the algebraic structure of the zeros in the affine plane naturally defines the associated four-element, rank 3 chirotope, aka affine oriented matroid. (shrink)