Textbook descriptions of the foundations of Genetics give the impression that besides Mendel’s no other research on heredity took place during the nineteenth century. However, the publication of the Origin of Species in 1859, and the criticism that it received, placed the study of heredity at the centre of biological thought. Consequently, Herbert Spencer, Charles Darwin himself, Francis Galton, William Keith Brooks, Carl von Nägeli, August Weismann, and Hugo de Vries attempted to develop theories of heredity under an evolutionary perspective, (...) and they were all influenced by each other in various ways. Nonetheless, only Nägeli became aware of Mendel’s experimental work; it has also been questioned whether Mendel even had the intention to develop a theory of heredity. In this article, a short presentation of these theories is made, based on the original writings. The major aim of this article is to suggest that Mendel was definitely not the only one studying heredity before 1900, if he even did this, as may be inferred by textbooks. Although his work had a major impact after 1900, it had no impact during the latter half of the nineteenth century when an active community of students of heredity emerged. Thus, textbooks should not only present the work of Mendel, but also provide a wider view of the actual history and a depiction of science as a social process. (shrink)

Diffusion theory explains in physical terms how materials move through a medium, e.g. water or a biological fluid. There are strong and widely acknowledged grounds for doubting the applicability of this theory in biology, although it continues to be accepted almost uncritically and taught as a basis of both biology and medicine. Our principal aim is to explore how this situation arose and has been allowed to continue seemingly unchallenged for more than 150 years. The main shortcomings of diffusion theory (...) will be briefly reviewed to show that the entrenchment of this theory in the corpus of biological knowledge needs to be explained, especially as there are equally valid historical grounds for presuming that bulk fluid movement powered by the energy of cell metabolism plays a prominent note in the transport of molecules in the living body. First, the theory's evolution, notably from its origins in connection with the mechanistic materialist philosophy of mid nineteenth century physiology, is discussed. Following this, the entrenchment of the theory in twentieth century biology is analyzed in relation to three situations: the mechanism of oxygen transport between air and mammalian tissues; the structure and function of cell membranes; and the nature of the intermediary metabolism, with its implicit presumptions about the intracellular organization and the movement of molecules within it. In our final section, we consider several historically based alternatives to diffusion theory, all of which have their precursors in nineteenth and twentieth century philosophy of science. (shrink)

The rise of applied biology was one of the most striking features of the biological sciences in the early 20th century. Strongly oriented toward agriculture, this was closely associated with the growth of a number of disciplines, notably, entomology and mycology. This period also saw a marked expansion of the English University system, and biology departments in the newly inaugurated civic universities took an early and leading role in the development of applied biology through their support of Economic Biology. This (...) sought explicitly to promote the application of biological knowledge to economically important problems and especially to agriculture. The impact of Economic Biology was felt most strongly within Zoology, where it became synonymous with entomology. The transience of Economic Biology belies its significance, for example, in providing a means for the expansion of biology at the civic universities. More broadly, it opened up new research and employment opportunities within the life sciences. In late Edwardian Britain, newly available state funds for agriculturally relevant biological disciplines transformed the life sciences. This paper examines the impact of these funds -- mobilized either under the 1909 Development Act, or under the auspices of colonial interests -- on Economic Biology and the institutionalization of applied biology. The rise and fall of Economic Biology casts new light on the way in which institutional and political alignments profoundly shaped the development of British biology. (shrink)

To some, a misguided Lamarckian and a fraud, to others a martyr in the fight against Darwinism, the Viennese zoologist Paul Kammerer (1880-1926) remains one of the most controversial scientists of the early 20th century. Here his work is reconsidered in light of turn-of-the-century problems in evolutionary theory and experimental methodology, as seen from Kammerer's perspective in Vienna. Kammerer emerges not as an opponent of Darwinism, but as one would-be modernizer of the 19th-century theory, which had included a role for (...) the inheritance of acquired characteristics. Kammerer attempted a synthesis of Darwinism with genetics and the chromosome theory, while retaining the modifying effects of the environment as the main source of favorable variation, and he developed his program of experimentation to support it. Kammerer never had a regular university position, but worked at a private experimental laboratory, with sidelines as a teacher and a popular writer and lecturer. On the lecture circuit he held forth on the significance of his science for understanding and furthering cultural evolution and he satisfied his passion for the arts and performance. In his dual career as researcher and popularizer, he did not always follow academic convention. In the contentious and rapidly changing fields of heredity and evolution, some of his stances and practices, as well as his outsider status and part-Jewish background, aroused suspicion and set the stage for the scandal that ended his career and prompted his suicide. (shrink)

August Weismann is famous for having argued against the inheritance of acquired characters. However, an analysis of his work indicates that Weismann always held that changes in external conditions, acting during development, were the necessary causes of variation in the hereditary material. For much of his career he held that acquired germ-plasm variation was inherited. An irony, which is in tension with much of the standard twentieth-century history of biology, thus exists – Weismann was not a Weismannian. I distinguish three (...) claims regarding the germ-plasm: (1) its continuity, (2) its morphological sequestration, and (3) its variational sequestration. With respect to changes in Weismann’s views on the cause of variation, I divide his career into four stages. For each stage I analyze his beliefs on the relative importance of changes in external conditions and sexual reproduction as causes of variation in the hereditary material. Weismann believed, and Weismannism denies, that variation, heredity, and development were deeply intertwined processes. This article is part of a larger project comparing commitments regarding variation during the latter half of the nineteenth century. (shrink)

Continental philosophies of science tend to exemplify holistic themes connecting order and contingency, questions and answers, writers and readers, speakers and hearers. Such philosophies of science also tend to feature a fundamental emphasis on the historical and cultural situatedness of discourse as significant; relevance of mutual attunement of speaker and hearer; necessity of pre-linguistic cognition based in human engagement with a common socio-cultural historical world; role of narrative and metaphor as explanatory; sustained emphasis on understanding questioning; truth seen as horizonal, (...) aletheic, or perspectival; and a tolerance for paradoxical and complex forms of expression. Continental philosophy of science is thus more comprehensive than philosophy of science in the analytic tradition, including (and as analytic philosophy of science does not tend to include) perspectives on the history of science as well as the social and practical dimensions of scientific discovery. Where analytic philosophy is about reducing or, indeed, eliminating the perennial problems of philosophy, Continental philosophy is all about thinking and that will mean, as both Heidegger and Nietzsche emphasize, making such problems more not less problematic. (shrink)

In 1889 Hugo de Vries published " Intracellular Pangenesis " in which he formulated his ideas on heredity. The high expectations of the impression these ideas would make did not come true and publication was negated or reviewed critically. From the reactions of his Dutch colleagues and the discussion with the famous German zoologist August Weismann we conclude that the assertion that each cell contains all hereditary material was controversial and even more the claim that characters are inherited independently of (...) each other. De Vries felt that he had to convince his colleagues of the validity of his theory by providing experimental evidence. He established an important research program which resulted in the rediscovery of Mendel's laws and the publication of "The Mutation Theory." This article also illustrates some phenomena that go beyond an interesting episode in the development of theories of heredity. It shows that criticism from colleagues can move a researcher so deeply that he feels compelled to set up an extensive research program. Moreover it illustrates that it is not unusual that a creative scientist is only partially willing to take criticism on his theories into account. Last but not least it demonstrates that common opinion on the validity of specific arguments may change in the course of time. (shrink)

The marriage of Sally Peris Hughes (1895–1984) and Franz Schrader (1891–1962) in November 1920 launched a highly successful scientific collaboration that lasted over four decades. The Schraders were avid naturalists, adroit experimentalists, and keen theoreticians, and both had long, productive, and fruitful careers in zoology. They offer an extraordinarily rich case study that provides an insightful view of the work carried out in several areas of the life sciences from the 1920s to the 1960s—fieldwork, cytology, cytogenetics, and entomology—as well as (...) critical aspects of the social world of contemporary science. By focusing on the fieldwork the couple carried out in Mexico and Central America in the late 1920s and early 1930s, this paper seeks to illuminate how this collaborative scientific marriage embodies a collective, complex, and integrated personal and social arrangement that served to enhance both knowledge production and disciplinary development in several areas of science. It also reveals ways in which marriage could serve as a means to help both parties navigate and negotiate restrictive sociocultural norms and institutional arrangements in science involving gender, power, and authority in the early twentieth century. (shrink)

The Greenough stereomicroscope, or “Stemi” as it is colloquially known among microscopists, is a stereoscopic binocular instrument yielding three-dimensional depth perception when working with larger microscopic specimens. It has become ubiquitous in laboratory practice since its introduction by the unknown scientist Horatio Saltonstall Greenough in 1892. However, because it enabled new experimental practices rather than new knowledge, it has largely eluded historical and epistemological investigation, even though its design, production, and reception in the scientific community was inextricably connected to the (...) new epistemological ideals of the life sciences caught between natural history and modern science. The development of the microscope will be contextualized within the scientific and technological landscape, showing how Greenough navigated his way through this terrain, and what led him to sow the seeds for the stereoscopic microscope. The historical controversy over the optical mechanism, through which the instrument would generate the desired depth perception, and how this quality was embedded into laboratory practice, will be examined. Subsequently, it will become evident that the specific image of nature produced by the stereoscopic microscope corresponded to the new ideals of the life sciences and their representation. (shrink)

This Ph.D. thesis provides a pilosophical account of the structure of the evolutionary synthesis of the 1930s and 40s. The first, more historical part analyses how classical genetics came to be integrated into evolutionary thinking, highlighting in particular the importance of chromosomal mapping of Drosophila strains collected in the wild by Dobzansky, but also the work of Goldschmidt, Sumners, Timofeeff-Ressovsky and others. The second, more philosophical part attempts to answer the question wherein the unity of the synthesis consisted. I argue (...) that it exemplifies a weak of form of explanatory unification. (shrink)

In 1929 the newly-reorganized Rockefeller Foundation funded the work of a cross-disciplinary group at Harvard University called the Committee on Industrial Physiology. The committee’s research and pedagogical work was oriented towards different things for different members of the alliance. The CIP program included a research component in the Harvard Fatigue Laboratory and Elton May’s interpretation of the Hawthorne Studies; a pedagogical aspect as part of Wallace Donham’s curriculum for Harvard Business School; and Lawrence Henderson’s work with the Harvard Pareto Circle, (...) his course Sociology 23, and the Harvard Society of Fellows. The key actors within the CIP alliance shared a concern with training men for elite careers in government service, business leadership, and academic prominence. But the first communications between the CIP and the Rockefeller Foundation did not emphasize training in human biology. Instead, the CIP presented itself as a coordinating body that would be able to organize all the varied work going on at Harvard that did not fit easily into one department, and it was on this basis that the CIP became legible to the President of Harvard, A. Lawrence Lowell, and to Rockefeller’s Division of Social Sciences. The members of the CIP alliance used the term human biology for this project of research, training and institutional coordination. (shrink)

This paper is based on my M.Sc. dissertation: ‘The Origins of Numerical Taxonomy’ 1985, submitted to the University of Leicester during the tenure of a D.E.S. State Studentship. For this work I drew extensively on interviews with Professors A. J. Cain, G. A. Harrison, R. R. Sokal and P. H. A. Sneath. I am very grateful to them for their time, interest and encouragement. Without the indefatigable assistance of Jon Harwood, this paper would never have been finished.

During its centennial celebrations in 2008, the Museum of Vertebrate Zoology (MVZ) at the University of California, Berkeley paid homage to its founding director, Joseph Grinnell. Recognized as a leading scientific institution, the MVZ managed to grow throughout the twentieth century, a period often characterized by the decline of natural history. To understand how and why research flourished at the MVZ, this paper looks closely at Grinnell's undergraduate course, the Natural History of the Vertebrates (NHV). Taught by MVZ affiliates since (...) 1914, the NHV offers an important window on Grinnell's approach and legacy. This paper argues that the NHV contributed to the MVZ's long-term success by acting as, first, a gateway to natural history; second, a vector for the MVZ's research programme; and third, a shared faculty responsibility. Grinnell's significance in the history of science is understated, in part because his writing style de-emphasized the importance of his theoretical contributions, including his development of the niche concept, his emphasis on population thinking and geographic isolation in studies of evolution, and his effort to integrate speciation questions and genetics. Studying the NHV highlights these contributions because Grinnell freely communicated his ideas to his students. An analysis of Grinnell's course material shows that his theoretical and methodological approach pre-dated the evolutionary synthesis and inspired natural-history research throughout the past century. (shrink)

The purpose of this article is twofold: on the one hand, we present the outlines of a history of university collections in Germany. On the other hand, we discuss this history as a case study of the changing attitudes of the sciences towards their material heritage. Based on data from 1094 German university collections, we distinguish three periods that are by no means homogeneous but offer a helpful starting point for a discussion of the entangled institutional and epistemic factors in (...) the history of university collections. In the 19th century, university collections were institutionalized and widely recognized as indispensable in research and teaching. During the 20th century, university collection became increasingly marginalized both on an institutional and theoretical level. Towards the end of the 20th century, the situation of university collections improved partly because of their reconsideration as material heritage. (shrink)

This paper discusses how growth and aging became interrelated phenomena with the creation of gerontology in the United States. I first show that the relation of growth to senescence, which had hardly attracted scientific attention before the twentieth century, started to be investigated by several experimental scientists around the 1900s. Subsequently, research on the connection between the two phenomena entered a new domain through the birth of gerontology as a scientific field comprised of various disciplines, many of which addressed growth. (...) Due to gerontologists’ efforts, the association between aging and growth became stronger and more multifaceted within the discursive and organizational matrix constituting the new science, leading to a broader definition of senescence with an ambiguous connection to chronological age. Furthermore, as gerontologists borrowed the cultural agendas as well as research methods from studies of growth, aging began to be defined as a phenomenon that could be actively controlled and managed in both social arenas and laboratory environments. (shrink)

Bionomics was a research approach invented by British biological scientists in the late nineteenth century and adopted by the American entomologist and evolutionist Vernon Lyman Kellogg in the early twentieth century. Kellogg hoped to use bionomics, which was the controlled observation and experimentation of organisms within settings that approximated their natural environments, to overcome the percieved weaknesses in the Darwinian natural selection theory. To this end, he established a bionomics laboratory at Stanford University, widely published results from his bionomic investigations, (...) and encouraged other biological researchers to adopt bionomics. (shrink)

One possible interpretation of the species concept is that specifies are natural kinds. Another species concept is that species are individuals whose parts are organisms. Philip Kitcher takes seriously both these ideas; he sees a role for the genealogical/historical conception and also for the one that is “purely qualitative”. I criticize his ideas here. I see the genealogical conception at work in biological discussion of species and it is presupposed by an active and inventive research program, but the natural kind (...) concept is not. I also criticize Kitcher’s criticisms against Hull’s position that species are individuals, including Kitcher’s idea that species are sets of organisms, his explanations of why “all swans are white” isn’t law-like, his discussion of the example of multiple origination. Finally, I argue that given the current evolutionary developments, pluralism is the "null hypothesis" that we should attempt to refute. (shrink)

At the beginning of the twentieth century Haeckel’s biogenetic law was widely questioned. On the one hand, there were those who wanted to dismiss it altogether: ontogeny and phylogeny did not have any systematic or interesting relation. On the other hand, there were those who sought to revise it. They argued that while Haeckel’s recapitulationism might have been erroneous, this should not deter the research over the relation between evolution and development. The British embryologist Walter Garstang was one of the (...) main figures on the “revisionists” side. In this paper, I first situate Garstang’s contribution to embryology and evolution within the extraordinarily creative period of the first three decades of the twentieth century. Then, I review some of Garstang’s specific ideas in detail, especially his most well-known 1922 paper “The Theory of Recapitulation.” Finally, I look at how the demise of the biogenetic law in light of Garstang’s views—as well as from the perspective of contemporary developmental evolution—should be understood. My main concern is not about the dismissal of Haeckel’s law or the sidelining of embryology in the twentieth-century evolutionary biology. I am rather interested in exploring why Garstang’s revised version of biogenetic law—which was entirely consistent with the neo-Darwinian perspective underpinning the Modern synthesis—did not spur a major new agenda in evolutionary biology after the 1930s. (shrink)

In this paper, I investigate the variety and richness of the taxonomical practices between the end of the nineteenth and the early twentieth centuries. During these decades, zoologists and paleontologists came up with different quantitative practices in order to classify their data in line with the new biological principles introduced by Charles Darwin. Specifically, I will investigate Florentino Ameghino’s mathematization of mammalian dentition and the quantitative practices and visualizations of several German-speaking paleontologists at the beginning of the twentieth century. In (...) so doing, this paper will call attention to the visual and quantitative language of early twentieth-century systematics. My analysis will therefore contribute to a prehistory of the statistical frame of mind in biology, a study which has yet to be written in full. Second, my work highlights the productive intertwinement between biological practices and philosophical frameworks at the turn of the nineteenth century. Deeply rooted in Kantian bio-philosophy, several biologists sought to find rules in order to apply ordering principles to chaotic taxonomic information. This implies the necessity to investigate the neglected role of Kantian and Romantic bio-philosophy in the unfolding of twentieth-century biology. (shrink)

Computer simulation of an epistemic landscape model, modified to include explicit representation of a centralized funding body, show the method of funding allocation has significant effects on communal trade-off between exploration and exploitation, with consequences for the community’s ability to generate significant truths. The results show this effect is contextual, and depends on the size of the landscape being explored, with funding that includes explicit random allocation performing significantly better than peer review on large landscapes. The article proposes a way (...) of incorporating external institutional factors in formal social epistemology, and offers a way of bringing such investigations to bear on current research policy questions. 1Introduction2Theoretical Background3Model Description4Simulation Details 4.1Simulating the epistemic landscape4.2Simulating agents4.3Simulating communal knowledge4.4Simulating funding strategies4.5Simulating merit dynamics5Results and Discussion 5.1Experiment 1: The winner-takes-it-all mechanism only5.2Experiment 2: All dynamic mechanisms5.3Experiment 3: Adding a new funding mechanism 5.4Experiment 4: Varying the degree of myopia5.5Experiment 5: Variability of individual epistemic gain5.6Experiment 6: Likelihood of renewal6Discussion7Conclusion. (shrink)

The pursuit of mechanistic explanations in biology has produced a great deal of knowledge about the parts, operations, and organization of mechanisms taken to be responsible for biological phenomena. Holist critics have often raised important criticisms of proposed mechanistic explanations, but until recently holists have not had alternative research strategies through which to advance explanations. This paper argues both that the results of mechanistic strategies has forced mechanists to confront ways in which whole systems affect their components and that new (...) representational and modeling strategies are providing tools for understanding these effects of whole systems upon components. Drawing from research on the mechanism responsible for circadian rhythms in mammals, I develop two examples in which mechanistic analysis is being integrated into a more holist perspective: research revealing intercellular integration of circadian mechanisms with those involved in cell metabolism and research revealing that stable␣rhythms are dependent on how individual cells in the suprachiasmatic nucleus synchronize with each other to generate regular rhythms. Tools such as network diagramming and computational modeling are providing means to integrate mechanistic models into accounts of whole systems. (shrink)

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration. In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors. This essay probes into the history of regeneration (...) studies by looking in depth at Regeneration and evaluating Morgan’s contribution. Although famous for his work with fruit fly genetics, studying Regeneration illuminates Morgan’s earlier scientific approach which emphasized the importance of studying a diversity of organisms. Surveying a broad range of regenerative phenomena allowed Morgan to institute a standard scientific terminology that continues to inform regeneration studies today. Most importantly, Morgan argued that regeneration was a fundamental aspect of the growth process and therefore should be accounted for within developmental theory. Establishing important similarities between regeneration and development allowed Morgan to make the case that regeneration could act as a model of development. The nature of the relationship between embryogenesis and regeneration remains an active area of research. (shrink)

The production of big pictures is arguably the most significant sign of the intellectual maturity of a field. It suggests both that the field's broad contours, refined over several generations of scholarship, enjoy the approval of practitioners, and that audiences exist with an interest in or need for overviews. The situation is somewhat more complicated in the history of science, since the existence of big historical pictures precedes that of a well-defined scholarly field by about two centuries. Broadly conceived histories (...) of science and medicine were being written in the eighteenth century, when such an all-encompassing vision was central to the claims about the progress of knowledge upon which Enlightenment ideologues set such store. The Plato to Nato style histories, characteristic of the earlier twentieth century, were written largely by isolated pioneers, and while these were used in teaching as the field was becoming professionalized, recent scholars have preferred to concentrate on a monographic style of research. Despite the existence of the series started by Wiley, and now published by Cambridge University Press, it is only in the last ten years or so that more conscious attempts have been made to generate a big-picture literature informed by new scholarship. It is noteworthy that most of this is addressed to students and general readers, although there is no logical reason why it should not tackle major theoretical issues of concern to scholars. My point about maturity still holds, then, since as a designated discipline the history of science is rather new; it is still feeling out its relationship with cognate disciplines. Big-picture histories have an important role to play in these explorations since they make findings and ideas widely available and thereby offer material through which ambitious interpretations can be debated, modified and transformed. (shrink)

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration (1901). In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors. This essay probes into the history of (...) regeneration studies by looking in depth at Regeneration and evaluating Morgan's contribution. Although famous for his work with fruit fly genetics, studying Regeneration illuminates Morgan's earlier scientific approach which emphasized the importance of studying a diversity of organisms. Surveying a broad range of regenerative phenomena allowed Morgan to institute a standard scientific terminology that continues to inform regeneration studies today. Most importantly, Morgan argued that regeneration was a fundamental aspect of the growth process and therefore should be accounted for within developmental theory. Establishing important similarities between regeneration and development allowed Morgan to make the case that regeneration could act as a model of development. The nature of the relationship between embryogenesis and regeneration remains an active area of research. (shrink)

This paper seeks to reinterpret the life and work of J. B. S. Haldane by focusing on an illuminating but largely ignored essay he published in 1927, "The Last Judgment" -- the sequel to his better known work, "Daedalus" (1924). This astonishing essay expresses a vision of the human future over the next 40,000,000 years, one that revises and updates Wellsian futurism with the long range implications of the "new biology" for human destiny. That vision served as a kind of (...) lifelong credo, one that infused and informed his diverse scientific work, political activities, and popular writing, and that gave unity and coherence to his remarkable career. (shrink)

The Plymouth Laboratory of the Marine Biological Association of the United Kingdom (1884) was founded in 1888. In addition to conducting morphological and other biological research, the founders of the laboratory aimed at promoting research in experimental zoology which will be used in this paper as a synonym for e. g. experimental embryology, comparative physiology or general physiology. This dream was not fully realized until 1920. The Great War and its immediate aftermath had a positive impact on the development of (...) the Plymouth Laboratory. The war greatly upset the operation of the Zoological Station in Naples and the ensuing crisis in its operations was closely related to the establishment of the physiological department in Plymouth in 1920. Two other key factors in the Plymouth story were the establishment of the Development Fund in 1909, which began contributing funds to the Plymouth Laboratory in 1912, and the patronage of the Cambridge zoologist George P. Bidder (1863-1954). This paper will focus on the combined influence of the Development Fund and Bidder on the development of the Plymouth Laboratory from around 1902 through the early 1920s, and the important role the laboratory played in promoting experimental zoology in Britain in the 1920s. (shrink)

This essay analyzes one of Germany's former premier research institutions for biomedical research, the Kaiser Wilhelm Institute for Anthropology, Human Heredity and Eugenics (KWIA) as a test case for the way in which politics and human heredity served as resources for each other during the Third Reich. Examining the KWIA from this perspective brings us a step closer to answering the questions at the heart of most recent scholarship concerning the biomedical community under the swastika: (1) How do we explain (...) why the vast majority of German human geneticists and eugenicists were willing to work for the National Socialist state and, at the very least, legitimized its exterminationist racial policy; and (2) what accounts for at least some of Germany's most renowned medically trained professionals' involvement in forms of morally compromised science that wholly transcend the bounds of normal scientific practice? Although a complete answer to this question must await an examination of other German biological research centers, the present study suggests that during the Nazi period the symbiotic relationship between human genetics and politics served to radicalize both. The dynamic between the science of human heredity and Nazi politics changed the research practice of some of the biomedical sciences housed at the KWIA. It also simultaneously made it easier for the Nazi state to carry out its barbaric racial program leading, finally, to the extermination of millions of so-called racial undesirables. (shrink)

Tim Crane's ‘Cosmic Hermeneutics vs. Emergence: The Challenge of the Explanatory Gap’ claims that non‐reductive physicalism must either close the explanatory gap, addressing the challenge famously posed by Levine's argument, or become identical to emergentism. Since no way to close the gap is available, the result is that there can be no interesting philosophical position intermediate between physicalism and emergentism. This chapter argues that if we look at the relation between physicalism and emergentism from the vantage point of reduction, Crane's (...) analysis is rather persuasive. However, if we switch from reduction to causality, its conclusions appear more disputable. In particular, if we shift from ‘novelty and explanation’ to ‘novelty and causality’ as key features of emergent properties, we may introduce a distinction between two kinds of emergentism (moderate and radical) based on their attitude towards the causal inheritance principle. If the causal inheritance principle is accepted (some versions of) moderate emergentism may be considered as non‐trivial forms of non‐reductive physicalism. (shrink)

This paper explores the work of Nicolas Rashevsky, a Russian émigré theoretical physicist who developed a program in "mathematical biophysics" at the University of Chicago during the 1930s. Stressing the complexity of many biological phenomena, Rashevsky argued that the methods of theoretical physics -- namely mathematics -- were needed to "simplify" complex biological processes such as cell division and nerve conduction. A maverick of sorts, Rashevsky was a conspicuous figure in the biological community during the 1930s and early 1940s: he (...) participated in several Cold Spring Harbor symposia and received several years of funding from the Rockefeller Foundation. However, in contrast to many other physicists who moved into biology, Rashevsky's work was almost entirely theoretical, and he eventually faced resistance to his mathematical methods. Through an examination of the conceptual, institutional, and scientific context of Rashevsky's work, this paper seeks to understand some of the reasons behind this resistance. (shrink)

Recently a growing number of biologists have begun to consider the causal role that processes of embryonic development may play in evolution. This constitutes a reunion of these phenomena which had been linked in the nineteenth century through Haeckel's biogenetic law. This reunion may result in a new subdiscipline of biology, if there is a set of unique concepts and methods which tie the various research approaches together. Such concepts as bauplan, canalization, and developmental constraint, may serve in such a (...) capacity. The methods employed must combine comparative and experimental analyses, with special attention paid to the range of variation in developmental events within each taxon. These concepts and methods are also applicable to the problem of how development evolved, thus the evolution of development may also be considered part of the reunion. The reunion is discussed in terms of the potential participation of various schools of thought found in the current literature. (shrink)

The Dutch biologist C J. van der Klaauw (1893–1972) structuralized the epistemology of oecology using concepts which exceeded the limits of a strictly teleological interpretation of nature. This article relates to his theory of holistic oecology which van der Klaauw formulated departing from a critical confrontation with Kant's teleological view on nature. He substituted this extra-scientifically heuristic maxim by the holistic notion of network-like associations between organisms within a community. The analogous similarities between the organization of individual organisms and communities (...) drawn up by van der Klaauw, merely remained propaedeutics for a genuine holistic oecology, which would only employ epistemological principles specifically referring to the organization of supra-individual communities of organisms. This article discusses the process of structuralizing the theory of holistic oecology by van der Klaauw in his dialogue with Kantian philosophy. (shrink)

Though better recognized for its immediate endeavors in human embryo research, the Carnegie Department of Embryology also employed a breeding colony of rhesus macaques for the purposes of studying human reproduction. This essay follows the course of the first enterprise in maintaining a primate colony for laboratory research and the overlapping scientific, social, and political circumstances that tolerated and cultivated the colony's continued operation from 1925 until 1971. Despite a new-found priority for reproductive sciences in the United States, by the (...) early 1920s an unfertilized human ovum had not yet been seen and even the timing of ovulation remained unresolved. Progress would require an organized research approach that could extend beyond the limitations of working with scant and inherently restrictive human subjects or with common lab mammals like mice. In response, the Department of Embryology, under the Carnegie Institution of Washington (CIW), instituted a novel methodology using a particular primate species as a surrogate in studying normal human reproductive physiology. Over more than 40 years the monkey colony followed an unpremeditated trajectory that would contribute fundamentally to discoveries in human reproduction, early embryo development, reliable birth control methods, and to the establishment of the rhesus macaque as a common model organism. (shrink)

Though better recognized for its immediate endeavors in human embryo research, the Carnegie Department of Embryology also employed a breeding colony of rhesus macaques for the purposes of studying human reproduction. This essay follows the course of the first enterprise in maintaining a primate colony for laboratory research and the overlapping scientific, social, and political circumstances that tolerated and cultivated the colony’s continued operation from 1925 until 1971. Despite a new-found priority for reproductive sciences in the United States, by the (...) early 1920s an unfertilized human ovum had not yet been seen and even the timing of ovulation remained unresolved. Progress would require an organized research approach that could extend beyond the limitations of working with scant and inherently restrictive human subjects or with common lab mammals like mice. In response, the Department of Embryology, under the Carnegie Institution of Washington, instituted a novel methodology using a particular primate species as a surrogate in studying normal human reproductive physiology. Over more than 40 years the monkey colony followed an unpremeditated trajectory that would contribute fundamentally to discoveries in human reproduction, early embryo development, reliable birth control methods, and to the establishment of the rhesus macaque as a common model organism. (shrink)

Biological field stations proliferated in the Rocky Mountains region of the western United States during the early decades of the twentieth century. This essay examines these Rocky Mountain field stations as hybrid lab-field sites from the perspective of the field side of the dichotomy: as field sites with raised walls rather than as laboratories whose walls with the natural world have been lowered. Not only were these field stations transformed to be more like laboratories, but they were also embedded within (...) the particular regional environmental and institutional context of the Rocky Mountains. Using the University of Colorado’s Mountain Laboratory at Tolland and other contemporaneous sites as examples, this essay analyzes key features of these sites, including their location within transportation networks, buildings, equipment, personnel, scheduling, recreational and social activities, and other material and social practices on the ground. Considering both the distinctive and shared characteristics of the Rocky Mountain field stations in comparison to other types of field stations provides a more complete picture of the diversity and range of lab-field hybrid sites in the biological sciences in the early twentieth-century United States. (shrink)

Science in the twentieth century has relied on enormous financial investment for its survival. Once departed from an amateur pursuit, industry, charity and government have ploughed huge resources into it, supplying the professional occupation of science with a complex of institutional facilities – full-time posts, research laboratories, students and journals. Financial support, however, has always been a limited resource and has gone most generously to those areas of research which appear particularly novel, innovative or promising, that is to the ‘leading (...) edges’. To secure the funds necessary to maintain their life-style, then, scientists have had to make their activities scientifically and economically attractive to the funding bodies. Historians and sociologists of twentieth-century science have tended to follow these priorities and have concentrated on the leading edges. We have studied at length the acquisition of new knowledge through research, the creation of the institutional complex and the furtherance of science through innovation, specialty and discipline formation, part and parcel of which is the gathering of the necessary funds. The competition for funds has been investigated in analyses of controversy between competing groups within a research area, which has provided important models for the social and conceptual development of science. This emphasis, however, may have missed a great deal of what happens in science. (shrink)

Notwithstanding the general rise of experimental disciplines in biology in the first decades of our century, in Germany and in the Netherlands the interest in the idealistic morphological tradition flourished, and compensated for a reductionistic causal approach to natural phenomena. This article analyses the influence of the German idealistic morphologists W. Lubosch and A. Meyer on the development of C.J. van der Klaauw's epistemology. It discusses the gradual incorporation of non-causal principles into van der Klaauw's concept of biology. Van der (...) Klaauw's epistemological concept of holistic biology was shaped in a critical confrontation with German idealistic morphology, and his early considerations can be interpreted as a direct impulse towards the development of his theory of functional components. Van der Klaauw's theories, being an alternative to the reductionistic experimental sciences, were among the causes of the fact that in the first half of our century biology in the Netherlands took a course deviating from the development of biology in the Anglo-American countries. (shrink)

In this paper, I investigate the variety and richness of the taxonomical practices between the end of the nineteenth and the early twentieth centuries. During these decades, zoologists and paleontologists came up with different quantitative practices in order to classify their data in line with the new biological principles introduced by Charles Darwin. Specifically, I will investigate Florentino Ameghino’s mathematization of mammalian dentition and the quantitative practices and visualizations of several German-speaking paleontologists at the beginning of the twentieth century. In (...) so doing, this paper will call attention to the visual and quantitative language of early twentieth-century systematics. My analysis will therefore contribute to a prehistory of the statistical frame of mind in biology, a study which has yet to be written in full. Second, my work highlights the productive intertwinement between biological practices and philosophical frameworks at the turn of the nineteenth century. Deeply rooted in Kantian bio-philosophy, several biologists sought to find rules in order to apply ordering principles to chaotic taxonomic information. This implies the necessity to investigate the neglected role of Kantian and Romantic bio-philosophy in the unfolding of twentieth-century biology. (shrink)

In this paper, I argue that the German morphological tradition made a major contribution to twentieth-century study of form. Several scientists paved the way for this research: paleontologist Adolf Seilacher, entomologist Hermann Weber, and biologist Johann-Gerhard Helmcke together with architect Frei Otto. All of them sought to examine morphogenetic processes to illustrate their inherent structural properties, thus challenging the neo-Darwinian framework of evolutionary theory. I point out that the German theoretical challenge to adaptationist thinking was possible through an exchange and (...) transfer of practices, data, technologies, and knowledge between biologically oriented students of form and architects, designers, and engineers. This exchange of practices and knowledge was facilitated by the establishment of two collaborative research centers at the beginning of the 1970s. Hence, by showing the richness of topics, methods, and technologies discussed in German-speaking morphology between 1950 and the 1970s, this paper paves the way to a much broader comprehension of the shifts that have shaped twentieth-century evolutionary biology. (shrink)

During the first forty years of this century, the concept of a living organism was discussed widely and publicly by biologists and philosophers. Two questions in particular excited discussion. In what ways should organisms be considered different from or the same as dead matter? And what can we learn about the nature of human society by regarding it as analogous to a living organism? Inevitably, these questions were closely related; the conclusions to be drawn about the social organism would depend (...) upon the particular properties attributed to the biological organism. In more recent years, discussion of these issues has largely been in abeyance, as biologists have with-drawn from debate over social policy into a more remote academia. A few biologists who still see their work as relevant to a wider social agenda have continued to treat the nature of life as a contentious issue. But the focus of interest has shifted away from the organismic analogy, which concerns the organization of society as a whole, to issues like sociobiology and evolutionary theory, which emphasize social differentiation and the treatment of out-groups and minorities. (shrink)

Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the rise of (...) molecular evolution in the 1960s, this paper shows that they grew out of research agendas from the previous decade, including the biochemical investigation of the relations between the structures and function of proteins and the theoretical attempt to decipher the genetic code. It also shows how computers became essential for the handling and analysis of sequence data. Finally, this paper reflects on the relationships between experimenting and collecting as two distinct "ways of knowing" that were essential for the transformation of the life sciences in the twentieth century. (shrink)

Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the rise of (...) molecular evolution in the 1960s, this paper shows that they grew out of research agendas from the previous decade, including the biochemical investigation of the relations between the structures and function of proteins and the theoretical attempt to decipher the genetic code. It also shows how computers became essential for the handling and analysis of sequence data. Finally, this paper reflects on the relationships between experimenting and collecting as two distinct “ways of knowing” that were essential for the transformation of the life sciences in the twentieth century. (shrink)