Contemporary science and technology research are now expected to become more responsible through collaboration with social scientists and scholars from the humanities. This paper suggests a frame explaining why such current calls for ‘integration’ are seen as appropriate across sectors even though there are no shared understanding of how proper integration is to take place. The call for integration is understood as a response to shifting roles of ethics within research structures following shifts in modes of knowledge production. Integration is (...) difficult, this paper suggests, because it challenges the modern normative division of labor affecting professional identities across sectors. Working out modes of integration is one important venue for working out alternative professional identities on the one hand and viable alternative understandings of research on the other hand. This paper discusses the matter with reference to three successive idioms for thinking about science, technology and society discussed in the literature; the representational, performative and co-production idiom. (shrink)

Traditionally, empiricism has relied on the specialness of human observation, yet science is rife with sophisticated instrumentation and techniques. The present article advances a conception of empirical evidence applicable to actual scientific practice. I argue that this conception elucidates how the results of scientific research can be repurposed across diverse epistemic contexts: it helps to make sense of how evidence accumulates across theory change, how different evidence can be amalgamated and used jointly, and how the same evidence can be used (...) to constrain competing theories in the service of breaking local underdetermination. (shrink)

The historical debate on representation in cognitive science and neuroscience construes representations as theoretical posits and discusses the degree to which we have reason to posit them. We reject the premise of that debate. We argue that experimental neuroscientists routinely observe and manipulate neural representations in their laboratory. Therefore, neural representations are as real as neurons, action potentials, or any other well-established entities in our ontology.

In this article, I explore the value of philosophy of science for history of science. I start by introducing a distinction between two ways of integrating history and philosophy of science: historical philosophy of science and philosophical history of science. I then offer a critical discussion of Imre Lakatos’s project to bring philosophy of science to bear on historical interpretation. I point out certain flaws in Lakatos’s project, which I consider indicative of what went wrong with PHS in the past. (...) Finally, I put forward my own attempt to bring out the historiographical potential of philosophy of science. Starting from Norwood Russell Hanson’s insight that historical studies of science involve metascientific concepts, I argue that philosophical reflection on those concepts can be historiographically fruitful. I focus on four issues and discuss their significance and utility for historiographical practice. (shrink)

Harry Collins' central argument about experimental practice revolves around the thesis that facts can only be generated by good instruments but good instruments can only be recognized as such if they produce facts. This is what Collins calls the experimenters' regress. For Collins, scientific controversies cannot be closed by the ‘facts’ themselves because there are no formal criteria independent of the outcome of the experiment that scientists can apply to decide whether an experimental apparatus works properly or not.No one seems (...) to have noticed that the debate is in fact a rehearsal of the ancient philosophical debate about skepticism. The present article suggests that the way out of radical skepticism offered by the so-called mitigated skeptics is a solution to the problem of consensus formation in science.Keywords: Argumentation; Skepticism; Sociology of science; Philosophy of science; Scientific controversies. (shrink)

Key words: rationality, communication, maxwellian revolution, Ampere-Weber research programme, synthesis, Kantian epistemology.. Why did Maxwell’s programme supersede the Ampere-Weber one? – To answer the question one has to consider the intertheoretic context of maxwellian electrodynamics genesis and development. It is demonstrated that maxwellian electrodynamics was created as a result of the old pre-maxwellian programmes reconciliation: the electrodynamics of Ampere-Weber, the wave theory of Young-Fresnel and Faraday’s programme. The programmes’ meeting led to construction of the hybrid theory at first with an (...) irregular set of theoretical schemes. However, step by step, on revealing and gradual eliminating the contradictions between the programmes involved, the hybrid set is “put into order”.A hierarchy of theoretical schemes starting from the crossbreeds and up to usual hybrids is set up. And after the displacement current construction the interpenetration of the pre-maxwellian programmes begins that markes the commencement of theoretical schemes of optics and electromagnetism real unification. Maxwell’s programme did supersede the Ampere-Weber one because it did assimilate the ideas of the Ampere-Weber programme, as well as the presuppositions of the programmes of Young-Fresnel and Faraday properly co-ordinating them with each other. But the opposite proposition is not true. Ampere-Weber programme did not assimilate the propositions of the Maxwellian programme. Maxwell’s victory became possible because the core of Maxwell’s unification strategy was formed by Kantian epistemology looked through the prism of William Whewell and such representatives of Scottish Enlightenment as Thomas Reid and William Hamilton. Maxwell did put forward as a basic synthetic principle the idea that radically differed from that of Ampere-Weber approach by its open, flexible and contra-ontological, strictly epistemological, Kantian character. For Maxwell, ether was not the last building block of physical reality, from which all the charges and fields should be constructed. “Action at a distance”, “incompressible fluid”, “molecular vortices” were contrived analogies for Maxwell, capable only to direct the researcher at the “right” mathematical relations. Namely the application of Kantian epistemology enabled Hermann von Helmholtz and his pupil Heinrich Hertz to arrive at such a version of Maxwell’s theory that served a heuristical basis for the radio waves discovery. (shrink)

Observation and experiment as categories for analysing scientific practice have a long pedigree in writings on science. There has, however, been little attempt to delineate observation and experiment with respect to analysing scientific practice; in particular, scientific experimentation, in a systematic manner. Someone who has presented a systematic account of observation and experiment as categories for analysing scientific experimentation is Ian Hacking. In this paper, I present a detailed analysis of Hacking’s observation versus experiment account. Using a range of cases (...) from various fields of scientific enquiry, I argue that the observation versus experiment account is not an adequate framework for delineating scientific experimentation in a systematic manner. (shrink)

On the relation between experiment and thought experiment in the natural sciences. To understand the reciprocal autonomy and complementarity of thought and real experiment, it is necessary to distinguish between a ‘positive’ (empirical or formal) and a transcendental perspective. Empirically and formally, real and thought experiments are indistinguishable. However, from a reflexive-transcendental viewpoint thought experiment is at the same time irreducible and complementary to real experiment. This is due to the fact that the hypothetical-anticipatory moment is in principle irreducible to (...) physical reality—even though it refers to physical reality and is bound with the empirical use of our understanding. The presence of counterfactuals is the condition of the possibility for thought experiments to become in principle real ones, by means of a series of technical realisations that gradually approximate the idealisations that they contain. (shrink)

This paper argues that even when simple analogue models picture parallel worlds, they generally still serve as isolating tools. But there are serious obstacles that often stop them isolating in just the right way. These are obstacles that face any model that functions as a thought-experiment but they are especially pressing for economic models because of the paucity of economic principles. Because of the paucity of basic principles, economic models are rich in structural assumptions. Without these no interesting conclusions can (...) be drawn. This, however, makes trouble when it comes to exporting conclusions from the model to the world. One uncontroversial constraint on induction from special cases is to beware of extending conclusions to situations that we know are different in relevant respects. In the case of economic models it is clear by inspection that the unrealistic structural assumptions of the model are intensely relevant to the conclusion. Any inductive leap to a real situation seems a bad bet. (shrink)

Science lies at the intersection of ideas and society, at the heart of the modern human experience. The study of past science should therefore be central to our humanistic attempt to know ourselves. Nevertheless, past science is not studied as an integral whole, but from two very different and divergent perspectives: the intellectual history of science, which focuses on the development of ideas and arguments, and the social history of science, which focuses on the development of science as a social (...) undertaking within its broader contexts. There is almost universal agreement that this bifurcation of the field is lamentable, and nearly universal disagreement about where, exactly, the problem lies. In order to identify the difficulty, this paper examines the institutional histories and disciplinary philosophies that have constituted the study of past science. I argue that science history, eventually allied itself with either History or Philosophy in order to find institutional support, thereby suffering the artificial imposition of the disciplinary prejudices of its allied fields, which lead science historians to adopt either the intellectual or the social perspective. Science history must reconcile its distinctions on its own terms, as an integrated unity with its own disciplinary bounds, and apart from History and Philosophy. As a catalyst for rapprochement, the historical and philosophical examination also yields a mapping of the field of science history that can be used to locate the problematic divisions in present scholarship and to draw new disciplinary bounds. (shrink)

PhD dissertation addressing what can be called conceptual-mathematical anomalies in quantum electrodynamics. This work can be seen as following the line of philosophy of physics studies of quantum field theory that started to emerge in a systematic way in the early eighties of last century. One example is Teller’s work on standard quantum electrodynamics.In this work, by following a historical approach, I will return to the standard version of quantum electrodynamics, which is the only one available when we want to (...) get numbers out to compare with experimental results. This work spins around two main vectors. One is the divergence of the S-matrix series expansion, the other is the spatio-temporal description of physical processes in the theory. (shrink)

Philosophical conceptual analysis is an experimental method. Focusing on this helps to justify it from the skepticism of experimental philosophers who follow Weinberg, Nichols & Stich. To explore the experimental aspect of philosophical conceptual analysis, I consider a simpler instance of the same activity: everyday linguistic interpretation. I argue that this, too, is experimental in nature. And in both conceptual analysis and linguistic interpretation, the intuitions considered problematic by experimental philosophers are necessary but epistemically irrelevant. They are like variables introduced (...) into mathematical proofs which drop out before the solution. Or better, they are like the hypotheses that drive science, which do not themselves need to be true. In other words, it does not matter whether or not intuitions are accurate as descriptions of the natural kinds that undergird philosophical concepts; the aims of conceptual analysis can still be met. (shrink)

In the methodology of scientific research programs (MSRP) there are important features on the problem of prediction, especially regarding novel facts. In his approach, Imre Lakatos proposed three different levels on prediction: aim, process, and assessment. Chapter 5 pays attention to the characterization of prediction in the methodology of research programs. Thus, it takes into account several features: (1) its pragmatic characterization, (2) the logical perspective as a proposition, (3) the epistemological component, (4) its role in the appraisal of research (...) programs, and (5) its place as a value for scientific research. -/- The notion of “novel facts” is highly relevant in his conception, where several aspects are involved: the directions of novel facts, the different kinds of novelty, and the transition from six possible options of “novel facts” to four choices. Thereafter, the prediction of novel facts as the criterion of appraisal is considered. On the one hand, this requires analyzing the theoretical, empirical, and heuristic possibilities of appraisal; and, on the other, whether there is an overemphasis on the role of prediction in methodology of scientific research programs. As a consequence, there is an analysis of Lakatos’ criterion of appraisal in MSRP and economics. (shrink)

Theory-ladenness is the view that observation cannot function in an unbiased way in the testing of theories because observational judgments are affected by the theoretical beliefs of the observer. Its more radical cousin, incommensurability, argues that because there is no theory-neutral language, paradigms, or worldviews, cannot be compared because in different paradigms the meaning of observational terms is different, even when the word used is the same. There are both philosophical and practical components to these problems. I argue, using a (...) procedurally-defined, theory-neutral experiment that paradigms are indeed commensurable. The practical problems of theory ladenness include experimental design, failure to interpret observations correctly, possible experimenter bias, and difficulties in data acquisition. I suggest that there are methods to deal with these problems, although sometimes they cannot be dealt with completely. I believe that the philosophical problems of theory-ladenness have been solved, although the practical problems remain. (shrink)

An early, very preliminary edition of this book was circulated in 1962 under the title Set-theoretical Structures in Science. There are many reasons for maintaining that such structures play a role in the philosophy of science. Perhaps the best is that they provide the right setting for investigating problems of representation and invariance in any systematic part of science, past or present. Examples are easy to cite. Sophisticated analysis of the nature of representation in perception is to be found already (...) in Plato and Aristotle. One of the great intellectual triumphs of the nineteenth century was the mechanical explanation of such familiar concepts as temperature and pressure by their representation in terms of the motion of particles. A more disturbing change of viewpoint was the realization at the beginning of the twentieth century that the separate invariant properties of space and time must be replaced by the space-time invariants of Einstein's special relativity. Another example, the focus of the longest chapter in this book, is controversy extending over several centuries on the proper representation of probability. The six major positions on this question are critically examined. Topics covered in other chapters include an unusually detailed treatment of theoretical and experimental work on visual space, the two senses of invariance represented by weak and strong reversibility of causal processes, and the representation of hidden variables in quantum mechanics. The final chapter concentrates on different kinds of representations of language, concluding with some empirical results on brain-wave representations of words and sentences. (shrink)

Many economists, it is said, “are inclined to deny that moral philosophy has anything to do with economics” . In this paper I challenge such inclinations bydrawing an analogy between economic interventions and humansubjects research. It is undeniable that investigators engaged in thelatter should adhere to specific ethical principles. I argue that analogousfeatures of economic interventions should lead us to recognise thatsimilar ethical concerns actually arise in both activities, and thusthat economic interventions should also be conducted in accordancewith ethical principles. (...) By exploring the analogy further I formulatesome ethical guidelines for economic practice, which in turn imply thatethical responsibilities will extend to all members of the economicsprofession. (shrink)

I argue for the Wittgensteinian thesis that mathematical statements are expressions of norms, rather than descriptions of the world. An expression of a norm is a statement like a promise or a New Year's resolution, which says that someone is committed or entitled to a certain line of action. A expression of a norm is not a mere description of a regularity of human behavior, nor is it merely a descriptive statement which happens to entail a norms. The view can (...) be thought of as a sort of logicism for the logical expressivist---a person who believes that the purpose of logical language is to make explicit commitments and entitlements that are implicit in ordinary practice. The thesis that mathematical statements are expression of norms is a kind of logicism, not because it says that mathematics can be reduced to logic, but because it says that mathematical statements play the same role as logical statements. ;I contrast my position with two sets of views, an empiricist view, which says that mathematical knowledge is acquired and justified through experience, and a cluster of nativist and apriorist views, which say that mathematical knowledge is either hardwired into the human brain, or justified a priori, or both. To develop the empiricist view, I look at the work of Kitcher and Mill, arguing that although their ideas can withstand the criticisms brought against empiricism by Frege and others, they cannot reply to a version of the critique brought by Wittgenstein in the Remarks on the Foundations of Mathematics. To develop the nativist and apriorist views, I look at the work of contemporary developmental psychologists, like Gelman and Gallistel and Karen Wynn, as well as the work of philosophers who advocate the existence of a mathematical intuition, such as Kant, Husserl, and Parsons. After clarifying the definitions of "innate" and "a priori," I argue that the mechanisms proposed by the nativists cannot bring knowledge, and the existence of the mechanisms proposed by the apriorists is not supported by the arguments they give. (shrink)

Scientific pluralism is an issue at the forefront of philosophy of science. This landmark work addresses the question, Can pluralism be advanced as a general, philosophical interpretation of science?

Recently, some philosophers of science (e.g., Gürol Irzik, Michael Friedman) have challenged the ‘received view’ on the relationship between Rudolf Carnap and Thomas Kuhn, suggesting that there is a close affinity (rather than opposition) between their philosophical views. In support of this argument, these authors cite Carnap and Kuhn’s similar views on incommensurability, theory-choice, and scientific revolutions. Against this revisionist view, I argue that the philosophical relationship between Carnap and Kuhn should be regarded as opposed rather than complementary. In particular, (...) I argue that a consideration of the fundamentally disparate nature of the broader philosophical projects of Carnap (logic of science) and Kuhn (providing a theory of scientific revolutions)renders the alleged similarities between their views superficial in comparison to their fundamental differences. In defense of the received view, I suggest that Carnap and Kuhn are model representatives of two contrasting styles of doing philosophy of science, viz., logical analysis and historical analysis respectively. This analysis clarifies the role played by Kuhn’s Structure of Scientific Revolutions in the demise of logical empiricism in the second half of the twentieth-century. (shrink)

This chapter presents the historical-investigative approach used in science teaching. Both history and philosophy of science have come to a sophisticated understanding of the role that experiments play in the generation and establishment of scientific knowledge. This recent development, called the “experimental turn,” is discussed first. Next, this chapter analyzes how practical work has been discussed among science educators in recent decades. Based on such a broad perspective, the historical-investigative approach is linked to recent advancements in history and philosophy of (...) science and in science education. Several modifications of the historical-investigative approach are outlined in order to illustrate their particular objectives, potential, and richness. (shrink)

In a widely received paper on theory choice, Kuhn made three central claims. First, as a matter of empirical fact, different theories tend to score differently with regard to what Kuhn considered to be the standard set of theoretical virtues, i.e., empirical accuracy, internal and external consistency, scope, simplicity, and fertility. Whereas some theories will for instance be more empirically accurate than others, other theories will have greater external coherence with our background theories. Second, hardly ever does a theory’s being (...) virtuous in one particular respect legitimize a choice for that theory—not even when that virtue is empirical accuracy. Third, following from the first two .. (shrink)

This inaugural handbook documents the distinctive research field that utilizes history and philosophy in investigation of theoretical, curricular and pedagogical issues in the teaching of science and mathematics. It is contributed to by 130 researchers from 30 countries; it provides a logically structured, fully referenced guide to the ways in which science and mathematics education is, informed by the history and philosophy of these disciplines, as well as by the philosophy of education more generally. The first handbook to cover the (...) field, it lays down a much-needed marker of progress to date and provides a platform for informed and coherent future analysis and research of the subject. -/- The publication comes at a time of heightened worldwide concern over the standard of science and mathematics education, attended by fierce debate over how best to reform curricula and enliven student engagement in the subjects There is a growing recognition among educators and policy makers that the learning of science must dovetail with learning about science; this handbook is uniquely positioned as a locus for the discussion. -/- The handbook features sections on pedagogical, theoretical, national, and biographical research, setting the literature of each tradition in its historical context. Each chapter engages in an assessment of the strengths and weakness of the research addressed, and suggests potentially fruitful avenues of future research. A key element of the handbook’s broader analytical framework is its identification and examination of unnoticed philosophical assumptions in science and mathematics research. It reminds readers at a crucial juncture that there has been a long and rich tradition of historical and philosophical engagements with science and mathematics teaching, and that lessons can be learnt from these engagements for the resolution of current theoretical, curricular and pedagogical questions that face teachers and administrators. (shrink)

This paper takes part in the methodological debate concerning the nature and the justification of hypotheses about computational systems in software engineering by providing an epistemological analysis of Software Testing, the practice of observing the programs’ executions to examine whether they fulfil software requirements. Property specifications articulating such requirements are shown to involve falsifiable hypotheses about software systems that are evaluated by means of tests which are likely to falsify those hypotheses. Software Reliability metrics, used to measure the growth of (...) probability that given failures will occur at specified times as new executions are observed, is shown to involve a Bayesian confirmation of falsifiable hypotheses on programs. Coverage criteria, used to select those input values with which the system under test is to be launched, are understood as theory-laden principles guiding software tests, here compared to scientific experiments. Redundant computations, fault seeding models and formal methods used in software engineering to evaluate test results are taken to be instantiations of some epistemological strategies used in scientific experiments to distinguish between valid and non-valid experimental outcomes. The final part of the paper explores the problem, advanced in the context of the philosophy of technology, of defining the epistemological status of software engineering by conceiving it as a scientifically attested technology. (shrink)

This chapter contains sections titled: Highlights of Past Literature Current Work Future Work.

I investigate a new understanding of realism in science, referred to as ‘interactive realism’, and I suggest the ‘evolutionary progressiveness’ of a theory as novel criterion for this kind of realism. My basic claim is that we cannot be realists about anything except the progress affected by myriad science-reality interactions that are constantly moving on a continuum of increased ‘fitness’ determined according to empirical constraints. Moreover to reflect this movement accurately, there is a corresponding continuum of verdicts about the status (...) of the knowledge conveyed by theories – ranging from stark instrumentalism to full-blown realism. This view may sound like a pessimistic inductivist's dream, but actually this is so only if one evaluates it from within a traditional context where the ‘truth’ of a single theory is the exclusive criterion for realism. I, on the other hand, want to redefine the terms of realist debate in such a way that the units of assessment of realism are sequences of theories evaluated according to their ‘evolutionary progressiveness’. I unpack ‘interactive realism’ by defining my notion of ‘evolutionary progressiveness’, the notion of ‘truth-as-historied reference’ underpinning it, and the continuum of interaction between theories and aspects of reality it affects. I conclude that, although interactive realism is a radically non-standard kind of realism, it is at least more realistic about science as a fractured complex multi-faceted enterprise than most other kinds of realism on the block, because it shows coherence amidst fragmentation. (shrink)

It is argued that the evolution of fundamental microphysics throughout the twentieth century is characterised by two interrelated developments. On the one hand, the experimental signatures which confirm theoretical statements are moving towards the fringes of the phenomenal world and, at the same time, leave increasingly wide spaces for entirely theoretical reasoning with little or no empirical interference. On the other hand, assessments of limitations to scientific underdetermination gain importance within the theoretical process.

The last forty years have produced a dramatic reversal in leading accounts of science. Once thought necessary to (explain) scientific progress, a rigid method of science is now widely considered impossible. Study of products yields to study of processes and practices, .unity gives way to diversity, generality to particularity, logic to luck, and final justification to heuristic scaffolding. I sketch the story, from Bacon and Descartes to the present, of the decline and fall of traditional scientific method, conceived as The (...) Central Planning Bureau for Science or as Rationality Czar. I defend a deflationary account of method and of rational judgment,. with emphasis on heuristic appraisal and cognitive economy. (shrink)

The early history of the attempts to unify quantum theory with the general theory of relativity is depicted through the work of the under--appreciated Italo-Brazilian physicist Gleb Wataghin, who is responsible for many of the ideas that the quantum gravity community is entertaining today.

The ideas of interdisciplinarity and transdisciplinarity have been widely applied to the relationship between sciences. This article is an attempt to discuss the reasons why scientific interdisciplinarity and transdisciplinarity pose specific problems. First of all, certain questions about terminology are taken into account in order to clarify the meaning of the word ?discipline? and its cognates. Secondly, we argue that the specificity of sciences does not lie in becoming disciplines. Then, we focus on the relationship between sciences, and between sciences (...) and technologies: we argue that multidisciplinarity and interdisciplinarity are a common practice among strict sciences and technologies. Finally, we discuss the different meanings of transdisciplinarity when it is applied to sciences. (shrink)

Attention to scientific practice offers a novel response to philosophical queries about how conceptual understanding is empirically accountable. The locus of the issue is thereby shifted, from perceptual experience to experimental and fieldwork interactions. More important, conceptual articulation is shown to be not merely ?spontaneous? and intralinguistic, but instead involves a establishing a systematic domain of experimental operations. The importance of experimental practice for conceptual understanding is especially clearly illustrated by cases in which entire domains of scientific investigation were first (...) made accessible to articulated conceptual understanding. We thereby see more clearly how experimental systems themselves, and not merely the theories and models they make possible, have an intentional directedness and ?representational? import. (shrink)

Stem cell biology is driven by experiment. Its major achievements are striking experimental productions: "immortal" human cell lines from spare embryos (Thomson et al. 1998); embryo-like cells from "reprogrammed" adult skin cells (Takahashi and Yamanaka 2006); muscle, blood and nerve tissue generated from stem cells in culture (Lanza et al. 2009, and references therein). Well-confirmed theories are not so prominent, though stem cell biologists do propose and test hypotheses at a profligate rate. 1 This paper aims to characterize the role (...) of experiment in stem cell biology, so as to answer the following question: how do experiments contribute to our knowledge of stem cells and related phenomena? The .. (shrink)

Part of the work for this paper was done during the tenure of a fellowship at the Center for Advanced Study in the Behavioral Sciences. I am grateful for financial support provided by the National Science Foundation, Grant #BNS-8011494, and for the assistance of the staff of the Center. I also want to thank David Bloor, Stephen Downes, David Hull and Andy Pickering for offering good advice and criticism, some of which I have heeded.

Laudan famously argued that neither truth nor approximate truth can be part of an explanation of a scientific theory's predictive success because in the history of science there were theories that enjoyed some limited success but now are considered outright false. The power of his argument lay in the many historic examples he listed . Realists have disputed that all theories on Laudan's list can be regarded as predictively successful but let's suppose momentarily that at least some exist that support (...) his point. In this case, there are historic false theories that made some true predictions. We are aiming for a general explanation of a theory's predictive success and hence these false theories necessarily are on board. Now, Laudan also argues that historic false theories – the downright false ones and the ones we nowadays judge as strictly false, but approximately true – do not in any principled sense differ from the ones we presently accept. These theories seem to present a good basis for inductively inferring that any presently accepted scientific theory is actually false. Many presently accepted theories certainly are predictively successful to a great extent and certainly their success should be covered by an acceptable explanation. Since there seems to be inductive support for the conclusion that …. (shrink)

It is customary to distinguish experimental from purely observational sciences. The former include physics and molecular biology, the latter astronomy and palaeontology. Experiments involve actively intervening in the course of nature, as opposed to observing events that would have happened anyway. When a molecular biologist inserts viral DNA into a bacterium in his laboratory, this is an experiment; but when an astronomer points his telescope at the heavens, this is an observation. Without the biologist’s handiwork the bacterium would never have (...) contained foreign DNA; but the planets would have continued orbiting the sun whether or not the astronomer had directed his telescope skyward. The observational/experimental distinction would probably be difficult to make precise 1, as the notion of an ‘intervention’ is not easily defined, but it is intuitively fairly clear, and is frequently invoked by scientists and historians of science. Experimentation, or ‘putting questions to nature’, is often cited as a hallmark of the modern scientific method, something that permitted the enormous advances of the last 350 years. And it is sometimes said that the social sciences lag behind the natural because controlled experiments cannot be done so readily in the former. Moreover in certain sciences, e.g. epidemiology, students are explicitly taught that experimental data is preferable to observational data, particularly for doing causal inference. So the distinction between observational and experimental science has quite wide currency, and is often regarded as methodologically significant. Surprisingly, mainstream philosophy of science has had rather little to say about the observational/experimental distinction. 2 For example, discussions of confirmation usually invoke a notion of ‘evidence’, to be contrasted with ‘theory’ or ‘hypothesis’; the aim is to understand how the evidence bears on the hypothesis. But whether this ‘evidence’ comes from observation or experiment generally plays no role in the discussion; this is true …. (shrink)

This article seeks to provide a historically well-informed analysis of an important post-Newtonian area of research in experimental physics between 1798 and 1898, namely the determination of the mean density of the earth and, by the end of the nineteenth century, the gravitational constant. Traditionally, research on these matters is seen as a case of “puzzle solving.” In this article, the author shows that such focus does not do justice to the evidential significance of eighteenth- and nineteenth-century experimental research on (...) the mean density of the earth and the gravitational constant. As Newton’s theory of universal gravitation was mainly based on astronomical observation, it remained to be shown that Newton’s law of universal gravitation did not break down at terrestrial distances. In this context, Cavendish’ experiment and related nineteenth-century experiments played a decisive role, for they provided converging and increasingly stronger evidence for the universality of Newton’s theory of gravitation. More precisely, the author shall argue that, as the accuracy and precision of the experimental apparatuses and the procedures to eliminate external disturbances involved increasingly improved, the empirical support for the universality of Newton’s theory of gravitation improved correspondingly. (shrink)

This is a defense of the doctrine of scientific realism. SR is defined through the following two claims: Most essential unobservables posited by the well-established current scientific theories exist independently of our minds. We know our well-established scientific theories to be approximately true. I first offer positive argumentation for SR. I begin with the so-called 'success arguments' for SR: 1) scientific theories most of the times entail successful predictions; 2) science is methodologically successful in generating empirically successful theories. SR explains (...) these facts via inference to the best explanation. I combine Hacking's experimental argument for entity realism with Salmon's common-cause principle. I take entity realism to be foundational to SR: one may believe in the existence of some theoretical entities without believing in any particular theory in which these are embedded. Its motivation comes from experimental practice, where the manipulation of these entities often relies on incompatible theoretical accounts. The underdetermination topic is thereafter discussed. Several attempts to distinguish between an observable and an unobservable realm are critically discussed, as well as the possibility that for any given theory, there are empirically equivalents generated by means of algorithms. I present extensive argumentation to the effect that such algorithmic rivals are not to be taken seriously. Social constructivism is being critically treated. I proceed by distinguishing between a metaphysical, a semantic, and an epistemic variant of SC. I conclude that only a moderate metaphysical constructivism can stand on its own feet. Its claim is merely that some facts about the world are socially constructed. I finish with a plea for a selective SR, able to do justice to the presence of both instrumentalism and modest constructivism in scientific practice. (shrink)

I examine the role of inference from experiment in theory building. What are the options open to the scientific community when faced with an experimental result that appears to be in conflict with accepted theory? I distinguish, in Laudan's (1977), Nickels's (1981), and Franklin's (1993) sense, between the context of pursuit and the context of justification of a scientific theory. Making this distinction allows for a productive middle position between epistemic realism and constructivism. The decision to pursue a new or (...) a revised theory in response to the new evidence may not be fully rationally determined. Nonetheless, it is possible to distinguish the question of whether there is reason to pursue a theory from the question of whether that theory, once it has been pursued over time, solves a problem of interest to science. I argue that, in this context, there is a solid way to distinguish between the contexts of pursuit and of justification, on the basis of a theory's evidential support and problem-solving ability. (shrink)

In this article, I introduce the notion of horizon for scientific practice (HSP), representing limits or boundaries within which scientists ply their trade, to facilitate analysis of scientific discovery and progress. The notion includes not only constraints that delimit scientific practice, e.g. of bringing experimentation to a temporary conclusion, but also possibilities that open up scientific practice to additional scientific discovery and to further scientific progress. Importantly, it represents scientific practice as a dynamic and developmental integration of activities to investigate (...) and analyze the natural world. I use the discovery of the clotting factor, thrombin, and the experiments conducted by the Johns Hopkins physiologist, William Howell, on the enzymatic nature of thrombin to illustrate the notion of HSP. In a concluding section, I compare the notion of HSP to other notions for scientific practice proposed in the history and philosophy of science literature. (shrink)

This paper aims to bring the epistemic dimensions of stem cell experiments out of the background, and show that they can be critically evaluated. After introducing some basic concepts of stem cell biology, I set out the current “gold standard” for experimental success in that field (§2). I then trace the origin of this standard to a 1988 controversy over blood stem cells (§3). Understanding the outcome of this controversy requires attention to the details of experimental techniques, the organization of (...) epistemic communities, and relations between the two (§4). With its resolution, a standard for experimental success was established for HSC research, which in turn serves as an exemplar for studies of other stem cells. This historical case study reveals a robust standard for experimental success in stem cell biology: to trace processes of development at the single-cell level, in the form of cell lineage hierarchies. Experiments conforming to this standard can be further critically assessed as means to the therapeutic end of stem cell research: use of stem cells to repair human organs and tissues. (shrink)