According to the methodological principle called ‘robustness’, empirical evidence is more reliable when it is generated using multiple, independent (experimental) routes that converge on the same result. As it happens, robustness as a methodological strategy is quite popular amongst philosophers. However, despite its popularity, my goal here is to criticize the value of this principle on historical grounds. My historical reasons take into consideration some recent history of astroparticle physics concerning the search for WIMPs (weakly interacting massive particles), one of (...) the main candidates for cosmic dark matter. On the basis of these reasons, I assert that robustness, at least in this historical case we are considering, has less value than usually assumed by philosophers. (shrink)

I develop the idea of what I call an interpretive praxis as a generalized procedure for analyzing how experimenters can formulate observable predictions, discern real effects from experimental artifacts, and compare predictions with data. An interpretive praxis requires theories – theories not only about instruments and the interpretation of phenomena, but also theories that connect the use of instruments and interpretation of phenomena to high‐level theory. I will call all such theories that enable experimentation to work intermediate theories. I offer (...) an account of theory‐networks that embrace these intermediate theories and explain their functions. (shrink)

In previous work we have described the nature of geologic reasoning and the relation between the geological observer and the outcrop which is the object of their study. We now turn to further consideration of the epistemological aspects of geology that have been largely neglected by twentieth century epistemology. Our basic claim is that the experiential facts of geological field work do not fit with a philosophy of science that has evolved out of considerations on the laboratory sciences. Shifting our (...) focus from the lab to the field offers a more embodied, historical, and fallibilistic understanding of geology. (shrink)

In this paper I consider the problem of interpreting quantum mechanics. I argue that this problem has evolved in part into the problem of selecting tenable interpretations from a set of available interpretations. We lack the means to make this selection. There is consensus that interpretations should be consistent and empirically adequate. But these conditions are not particularly discriminative. Other conditions may be discriminative but are not generally accepted. I propose two new conditions for selecting tenable interpretations, motivated by the (...) use of quantum mechanics in technology. The first requires that interpretations ascribe the physical properties to technical artefacts that are entailed by the ascription of technical functions to those artefacts. The second requires that they ascribe the physical properties represented by engineering sketches of those artefacts. I consider the example of quantum teleportation in some detail. Introduction The problem of interpreting quantum mechanics Technical functions Decoders in quantum teleportation Engineering sketches Conclusions Appendix: Quantum teleportation. (shrink)

In vitro experimental approaches are of central importance to contemporary molecular and cellular biology and toxicology. However, the scientific value or impact of in vitro results depends on their relevance in vivo. In vitro effect studies address inobservable in vivo phenomena through experiments on analogous in vitro phenomena. We present a theoretical basis developed to evaluate the in vivo relevance of in vitro effect studies. As a case study, the procedure for measuring specific gene transcription in isolated cell nuclei (nuclear (...) run-off method) is analyzed It is concluded that current evidence fails to justify in vivo interpretations of nuclear run-off experiments within the framework of theoretical models of transcription, implying that quantitative in vivo interpretations are unwarranted. Qualitative interpretations of nuclear run-off experiments may be justified by inferring the best explanation, especially when significant in vitro effects follow in vivo perturbations.Elements of a general theory are proposed. It is concluded that quantitative in vivo interpretations are warranted primarily in biochemical quantitation of biomolecules, while studies on biological function should be interpreted qualitatively in terms of causal explanations. Inferences to the best explanations are strengthened through additional evidence and the creation of experimental differences (effects). (shrink)

In this paper we use some ideas of Hertz and Duhem to propose a new concept of representation that overcomes the dichotomy between representation and intervention. It is based on the category-theoretical notion of adjoint situations and is used to explain the relation between empirical facts and theoretical laws in a new way.

In his book The Mangle of Practice and in other writings, Andrew Pickering purports to resolve the question of scientific realism by recasting the debate in terms of his own view “pragmatic” or “performative” realism. This view is informed by a constructivist view of scientific practice. Therefore it is characterised by Pickering as a species of anti‐realism that claims to take due account of the both the objective and pragmatic aspects of certain versions of scientific realism. This paper analyses Pickering's (...) claims to have resolved the debate and examines the merits and limitations of his proposed replacement.I show that insofar as Pickering conceives scientific practice as eschewing any position concerning the correspondence of theoretical concepts with nature, his position can be compared in several respects to Fine's much discussed alternative to realism, NOA. I contend that Pickering's proposed “performative realism” is no more successful at resolving the scientific realism question in than is NOA. (shrink)

It is argued that philosophical realism is well suited to serve as a perspective from which to understand nursing, and that it should be considered as an alternative to positivist, interpretivist, hermeneutical and phenomenological approaches. However, existing forms of realism, including theory and entity realism are shown to be faced with serious problems. In response, an alternative form ‘constraint realism’ is outlined, and shown to be apposite for illuminating the rule or convention governed behaviour characteristic of human beings. A brief (...) sketch is offered of its application to the social practice of nursing. (shrink)

According to classical molecular chemistry, molecules have a structure, that is, they are sets of atoms with a definite arrangements in space and held together by chemical bonds. The concept of molecular structure is central to modern chemical thought given its impressive predictive power. It is also a very useful concept in chemistry education, due to its role in the rationalization and visualization of microscopic phenomena. However, such a concept seems to find no place in the ontology described by quantum (...) mechanics, since it appeals to classical notions such as the position of the atomic nuclei or the individuality of electrons. Although this problem has attracted the attention of several authors, the discussion is far from settled. Some authors adopt an explicitly reductionist position and advocate to reconstruct the concept of molecular structure within the framework of the quantum theory. Others, although acknowledging the conceptual discontinuity between quantum mechanics and molecular chemistry, keep the hope of future reduction alive. From an explicitly non-reductionist position, on the contrary, others authors conceive molecular structure as an emergent phenomenon. The purpose of this article is to propose a different line of argumentation to address this problem. By contrast to reduction and emergence, the admission of a multiplicity of ontologies, not necessarily linked by hierarchical connections, cancels the need of finding a relation of dependence between the molecular level and the quantum level. This ontologically pluralist position can be applied to the issue of molecular structure, in order to argue that it is possible to admit the existence of structure in the ontology of molecular chemistry, in spite of the fact that it does not exist in the quantum world. (shrink)

Proven experience can be shared. Given this, we cannot assume that the character of proven experience is always manifest as a physical token in each individual sharing it. But the token might still exist somewhere. Perhaps that is a condition of the proven experience’s existence. Something similar could have been accepted as true of scientific knowledge, especially if those who argued that scientific claims were only shorthand for more complicated claims about observations had been right. But it seems that they (...) were not. Hence there might be an ontological difference explaining why there will always be a netto divergence between science and proven experience. (shrink)

There has been a great deal of skepticism towards the value of the realism/anti-realism debate. More specifically, many have argued that plausible formulations of realism and anti-realism do not differ substantially in any way. In this paper, I argue against this trend by demonstrating how a hypothetical resolution of the debate, through deeper engagement with the historical record, has important implications for our criterion of theory pursuit and science policy. I do this by revisiting Arthur Fine’s ‘small handful’ argument for (...) realism and show how the debate centers on whether continuity should be an indicator for the future fruitfulness of a theory. I then demonstrate how these debates work in practice by considering the case of the Human Brain Project. I close by considering some potential practical considerations of formulating meta-inductions. By doing this, I contribute three insights to the current debate: 1) demonstrate how the realism/anti-realism debate is a substantive debate, 2) connect debates about realism/anti-realism to debates about theory choice and pursuit, and 3) show the practical significance of meta-inductions. (shrink)

Agricultural experimentation is a world in constant evolution, spanning multiple scientific domains and affecting society at large. Even though the questions underpinning agricultural experiments remain largely the same, the instruments and practices for answering them have changed constantly during the twentieth century with the advent of new disciplines like molecular biology, genomics, statistics, and computing. Charting this evolving reality requires a mapping of the affinities and antinomies at work within the realm of agricultural research, and a consideration of the practices, (...) tools and social and political structures in which agricultural experiments are grounded. Three main questions will be addressed to provide an overview of the complex world of agricultural research investigated by the special issue: What is an agricultural experiment? Who is an experimenter in agriculture? Where do agricultural experiments take place? It will become apparent that agricultural experiments have a wide relevance for human development as they touch upon concerns related to human health and nutrition, contribute to policy discussions, and can affect the social and political structures in which farming is embedded. (shrink)

Large part of contemporary science is in fact technoscience, in the sense that it crucially depends on several technologies for the generation, collection, and analysis of data. This prompts a re-examination of the relations between science and technologies. In this essay, I advance the view that we’d better move beyond the ‘subordination view’ and the ‘instrumental’ view. The first aims to establish the primacy of science over technology, and the second uses technology instrumentally to support a realist position about theoretical (...) entities. I suggest that we should instead concentrate on how science and technology interact. This will reveal that technology has a poietic character, namely it actively partakes in the production of knowledge. But this poietic character can only be understood within the cognitive activity of scientific communities. Current research in molecular epidemiology, notably the projects funded within the ‘European exposome initiative’, serves as a motivation for such discussion and as an illustration of the claims made. (shrink)