Switch to: References

Add citations

You must login to add citations.
  1. Strategies of Explanatory Abstraction in Molecular Systems Biology.Nicholaos Jones - 2018 - Philosophy of Science 85 (5):955-968.
    I consider three explanatory strategies from recent systems biology that are driven by mathematics as much as mechanistic detail. Analysis of differential equations drives the first strategy; topological analysis of network motifs drives the second; mathematical theorems from control engineering drive the third. I also distinguish three abstraction types: aggregations, which simplify by condensing information; generalizations, which simplify by generalizing information; and structurations, which simplify by contextualizing information. Using a common explanandum as reference point—namely, the robust perfect adaptation of chemotaxis (...)
    Download  
     
    Export citation  
     
    Bookmark  
  • One Mechanism, Many Models: A Distributed Theory of Mechanistic Explanation.Eric Hochstein - 2016 - Synthese 193 (5):1387-1407.
    There have been recent disagreements in the philosophy of neuroscience regarding which sorts of scientific models provide mechanistic explanations, and which do not. These disagreements often hinge on two commonly adopted, but conflicting, ways of understanding mechanistic explanations: what I call the “representation-as” account, and the “representation-of” account. In this paper, I argue that neither account does justice to neuroscientific practice. In their place, I offer a new alternative that can defuse some of these disagreements. I argue that individual models (...)
    Download  
     
    Export citation  
     
    Bookmark   9 citations  
  • Equilibrium Explanation as Structural Non-Mechanistic Explanation: The Case Long-Term Bacterial Persistence in Human Hosts.Javier Suárez & Roger Deulofeu - 2019 - Teorema: International Journal of Philosophy 3 (38):95-120.
    Philippe Huneman has recently questioned the widespread application of mechanistic models of scientific explanation based on the existence of structural explanations, i.e. explanations that account for the phenomenon to be explained in virtue of the mathematical properties of the system where the phenomenon obtains, rather than in terms of the mechanisms that causally produce the phenomenon. Structural explanations are very diverse, including cases like explanations in terms of bowtie structures, in terms of the topological properties of the system, or in (...)
    Download  
     
    Export citation  
     
    Bookmark  
  • Getting Over Atomism: Functional Decomposition in Complex Neural Systems.Daniel C. Burnston - forthcoming - British Journal for the Philosophy of Science.
    Functional decomposition is an important goal in the life sciences, and is central to mechanistic explanation and explanatory reduction. A growing literature in philosophy of science, however, has challenged decomposition-based notions of explanation. ‘Holists’ posit that complex systems exhibit context-sensitivity, dynamic interaction, and network dependence, and that these properties undermine decomposition. They then infer from the failure of decomposition to the failure of mechanistic explanation and reduction. I argue that complexity, so construed, is only incompatible with one notion of decomposition, (...)
    Download  
     
    Export citation  
     
    Bookmark  
  • Quaderns de Filosofia VI, 1.Quad Fia - 2019 - Quaderns de Filosofia 6 (1).
    Download  
    Translate
     
     
    Export citation  
     
    Bookmark  
  • Network Analyses in Systems Biology: New Strategies for Dealing with Biological Complexity.Sara Green, Maria Şerban, Raphael Scholl, Nicholaos Jones, Ingo Brigandt & William Bechtel - 2018 - Synthese 195 (4):1751-1777.
    The increasing application of network models to interpret biological systems raises a number of important methodological and epistemological questions. What novel insights can network analysis provide in biology? Are network approaches an extension of or in conflict with mechanistic research strategies? When and how can network and mechanistic approaches interact in productive ways? In this paper we address these questions by focusing on how biological networks are represented and analyzed in a diverse class of case studies. Our examples span from (...)
    Download  
     
    Export citation  
     
    Bookmark   10 citations  
  • Systems Biology and Mechanistic Explanation.Ingo Brigandt, Sara Green & Maureen O'Malley - 2018 - In Stuart Glennan & Phyllis McKay Illari (eds.), The Routledge Handbook of Mechanisms and Mechanical Philosophy. New York: Routledge. pp. 362–374.
    We address the question of whether and to what extent explanatory and modelling strategies in systems biology are mechanistic. After showing how dynamic mathematical models are actually required for mechanistic explanations of complex systems, we caution readers against expecting all systems biology to be about mechanistic explanations. Instead, the aim may be to generate topological explanations that are not standardly mechanistic, or to arrive at design principles that explain system organization and behaviour in general, but not specific mechanisms. These abstraction (...)
    Download  
     
    Export citation  
     
    Bookmark   5 citations  
  • Revisiting Generality in the Life Sciences: Systems Biology and the Quest for General Principles.Sara Green - unknown
    Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes a different (...)
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • Mechanistic and Topological Explanations: An Introduction.Daniel Kostić - 2018 - Synthese 195 (1).
    In the last 20 years or so, since the publication of a seminal paper by Watts and Strogatz :440–442, 1998), an interest in topological explanations has spread like a wild fire over many areas of science, e.g. ecology, evolutionary biology, medicine, and cognitive neuroscience. The topological approach is still very young by all standards, and even within special sciences it still doesn’t have a single methodological programme that is applicable across all areas of science. That is why this special issue (...)
    Download  
     
    Export citation  
     
    Bookmark   7 citations  
  • Revisiting Generality in Biology: Systems Biology and the Quest for Design Principles.Sara Green - 2015 - Biology and Philosophy 30 (5):629-652.
    Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes a different (...)
    Download  
     
    Export citation  
     
    Bookmark   12 citations  
  • Indispensability and Effectiveness of Diagrams in Molecular Biology.Javier Anta - 2019 - Quaderns de Filosofia 6 (1):29-46.
    In this paper I aim to defend a twofold thesis. On one hand, I will sup-port, against Perini [7], the indispensability of diagrams when structurally complex biomolecules are concerned, since it is not possible to satisfactorily use linguistic-sentential representations at that domain. On the other hand, even when diagrams are dispensable I will defend than they will generally be more effective than other representations in encoding biomolecular knowledge, relying on Kulvicki-Shimojima’s diagrammatic effectiveness thesis. Finally, I will ground many epistemic virtues (...)
    Download  
     
    Export citation  
     
    Bookmark  
  • Leyes, mecanismos y modelos en biología: el caso de la genética mendeliana.Mario Casanueva - 2018 - Scientiae Studia 15 (2):343.
    Download  
    Translate
     
     
    Export citation  
     
    Bookmark   1 citation  
  • Network Representation and Complex Systems.Charles Rathkopf - 2018 - Synthese (1).
    In this article, network science is discussed from a methodological perspective, and two central theses are defended. The first is that network science exploits the very properties that make a system complex. Rather than using idealization techniques to strip those properties away, as is standard practice in other areas of science, network science brings them to the fore, and uses them to furnish new forms of explanation. The second thesis is that network representations are particularly helpful in explaining the properties (...)
    Download  
     
    Export citation  
     
    Bookmark   9 citations  
  • Explaining the Behaviour of Random Ecological Networks: The Stability of the Microbiome as a Case of Integrative Pluralism.Roger Deulofeu, Javier Suárez & Alberto Pérez-Cervera - forthcoming - Synthese:1-23.
    Explaining the behaviour of ecosystems is one of the key challenges for the biological sciences. Since 2000, new-mechanicism has been the main model to account for the nature of scientific explanation in biology. The universality of the new-mechanist view in biology has been however put into question due to the existence of explanations that account for some biological phenomena in terms of their mathematical properties (mathematical explanations). Supporters of mathematical explanation have argued that the explanation of the behaviour of ecosystems (...)
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • Constraint‐Based Reasoning for Search and Explanation: Strategies for Understanding Variation and Patterns in Biology.Sara Green & Nicholaos Jones - 2016 - Dialectica 70 (3):343-374.
    Life scientists increasingly rely upon abstraction-based modeling and reasoning strategies for understanding biological phenomena. We introduce the notion of constraint-based reasoning as a fruitful tool for conceptualizing some of these developments. One important role of mathematical abstractions is to impose formal constraints on a search space for possible hypotheses and thereby guide the search for plausible causal models. Formal constraints are, however, not only tools for biological explanations but can be explanatory by virtue of clarifying general dependency-relations and patterning between (...)
    Download  
     
    Export citation  
     
    Bookmark   6 citations  
  • The Topological Realization.Daniel Kostić - 2018 - Synthese (1).
    In this paper, I argue that the newly developed network approach in neuroscience and biology provides a basis for formulating a unique type of realization, which I call topological realization. Some of its features and its relation to one of the dominant paradigms of realization and explanation in sciences, i.e. the mechanistic one, are already being discussed in the literature. But the detailed features of topological realization, its explanatory power and its relation to another prominent view of realization, namely the (...)
    Download  
     
    Export citation  
     
    Bookmark   8 citations  
  • Diversifying the Picture of Explanations in Biological Sciences: Ways of Combining Topology with Mechanisms.Philippe Huneman - 2018 - Synthese 195 (1):115-146.
    Besides mechanistic explanations of phenomena, which have been seriously investigated in the last decade, biology and ecology also include explanations that pinpoint specific mathematical properties as explanatory of the explanandum under focus. Among these structural explanations, one finds topological explanations, and recent science pervasively relies on them. This reliance is especially due to the necessity to model large sets of data with no practical possibility to track the proper activities of all the numerous entities. The paper first defines topological explanations (...)
    Download  
     
    Export citation  
     
    Bookmark   12 citations