The recent discussion of fictional models has focused on imagination, implicitly considering fictions as something nonconcrete. We present two cases from synthetic biology that can be viewed as concrete fictions. Both minimal cells and alternative genetic systems are modal in nature: they, as well as their abstract cousins, can be used to study unactualized possibilia. We approach these synthetic constructs through Vaihinger’s notion of a semi-fiction and Goodman’s notion of semifactuality. Our study highlights the relative existence of such concrete fictions. (...) Before their realizations neither minimal cells nor alternative genetic systems were any well-defined objects, and the subsequent experimental work has given more content to these originally schematic imaginings. But it is as yet unclear whether individual members of these heterogeneous groups of somewhat functional synthetic constructs will eventually turn out to be fully realizable, remain only partially realizable, or prove outright impossible. (shrink)

This paper analyzes the notion of possibility in biology and demonstrates how synthetic biology can provide understanding on the modal dimension of biological systems. Among modal concepts, biological possibility has received surprisingly little explicit treatment in the philosophy of science. The aim of this paper is to argue for the importance of the notion of biological possibility by showing how it provides both a philosophically and biologically fruitful category as well as introducing a new practically grounded way for its assessment. (...) More precisely, we argue that synthetic biology can provide tools to scientifically anchor reasoning about biological possibilities. Two prominent strategies for this are identified and analyzed: the design of functionally new-to-nature systems and the redesign of naturally occurring systems and their parts. These approaches allow synthetic biologists to explore systems that are not normally evolutionarily accessible and draw modal inferences that extend in scope beyond their token realizations. Subsequently, these results in synthetic biology can also be relevant for discussions on evolutionary contingency, providing new methods and insight to the study of various sources of unactualized possibilities in biology. (shrink)

In this article, I deal with a conceptual issue concerning the framework of two special sciences: artificial intelligence and synthetic biology, i.e. the distinction between the natural and the artificial (a long-lasting topic of history of scientific though since the ancient philosophy). My claim is that the standard definition of the “artificial” is no longer useful to describe some present-day artificial sciences, as the boundary between the natural and the artificial is not so sharp and clear-cut as it was in (...) the past. Artificial intelligence and synthetic biology, two disciplines with new technologies, new experimental methods, and new theoretical frameworks, all need a new, more specific, and refined definition of (the) “artificial”, which is also related to the use of the synthetic method to build real world entities and in open-ended (real or virtual) environments. The necessity of a new definition of the artificial is due to the close relationship of AI and synthetic biology with biology itself. They both are engineering sciences that are moving closer and closer, at least apparently, towards (natural) biology, although from different and opposite directions. I show how the new concept of the artificial is, therefore, the result of a new view on biology from an engineering and synthetic point of view, where the boundary between the natural and the artificial is far more blurred. From this, I try to formulate a brand-new, more useful definition for future understanding, practical, and epistemological purposes of these two artificial sciences. (shrink)