Synthetic biology is described as a new field of biotechnology that models itself on engineering sciences. However, this view of synthetic biology as an engineering field has received criticism, and both biologists and philosophers have argued for a more nuanced and heterogeneous understanding of the field. This paper elaborates the heterogeneity of synthetic biology by clarifying the role of design and the variability of design methodologies in synthetic biology. I focus on two prominent design methodologies: rational design and directed evolution. (...) Rational design resembles the design methodology of traditional engineering sciences. However, it is often replaced and complemented by the more biologically-inspired method of directed evolution, which models itself on natural evolution. These two approaches take philosophically different stances to the design of biological systems. Rational design aims to make biological systems more machine-like, whereas directed evolution utilizes variation and emergent features of living systems. I provide an analysis of the methodological basis of these design approaches, and highlight important methodological differences between them. By analyzing the respective benefits and limitations of these approaches, I argue against the engineering-dominated conception of synthetic biology and its “methodological monism”, where the rational design approach is taken as the default design methodology. Alternative design methodologies, like directed evolution, should be considered as complementary, not competitive, to rational design. (shrink)

Synthetic biology offers a powerful method to design and construct biological devices for human purposes. Two prominent design methodologies are currently used. Rational design adapts the design methodology of traditional engineering sciences, such as mechanical engineering. Directed evolution, in contrast, models its design principles after natural evolution, as it attempts to design and improve systems by guiding them to evolve in a certain direction. Previous work has argued that the primary difference between these two is the way they treat variation: (...) rational design attempts to suppress it, whilst direct evolution utilizes variation. I argue that this contrast is too simplistic, as it fails to distinguish different types of variation and different phases of design in synthetic biology. I outline three types of variation and show how they influence the construction of synthetic biological systems during the design process. Viewing the two design approaches with these more fine-grained distinctions provides a better understanding of the methodological differences and respective benefits of rational design and directed evolution, and clarifies the constraints and choices that the different design approaches must deal with. (shrink)

In this article, I present a formal semantic framework that renders explicit how to reconcile the condition that a proposition about a contingent future event is true at a moment t0 with the idea that at t0, this proposition is ‘truth-maker indeterminate’: a state of affairs making it true will obtain later on, though no such state of affairs obtains at t0. The semantics I formulate employs ‘open temporal models’. They represent the passage of time by a specific component termed (...) time-resource, which acts on durations construed as model-external inputs. A model does not by itself specify which course of events gets actualized in a given duration depending on the latest moment that has already got actualized. A time-resource merely represents schematically the dependence between a moment t and a course of events that gets actualized in a time-span of a given length counted from t; until that much time has indeed passed, it is not fixed which course of events actually extends t. Further, I introduce evaluations as a fine-grained tool for studying truth-conditions of tensed formulas, and I use this tool to define the notion of truth-maker. I define what it means that a truth-maker will obtain but does not, and what it means for a truth-maker to be determinate. It is proven that my semantic analysis retains the desirable link between determinacy and historical necessity—namely, a truth-maker of a proposition being determinate entails that the proposition is historically necessary. (shrink)

We take up Jason Brennan’s critique of democracy as formulated in his monograph _Against Democracy_ (2016) and discuss the arguments that Åsa Wikforss presents against Brennan’s views in her book _Därför demokrati_ (2021). Both authors grant the importance of knowledge for political decision-making, but they differ in their respective understandings of what counts as knowledge and they draw very different conclusions from the relevant knowledge requirement. Our general aim is to detect problems in democracy as well as in attempts to (...) criticize democracy. We also briefly consider Brennan’s positive proposal to replace democracy by “epistocracy”, a form of government according to which only those citizens are entitled to vote who are “competent” in a sense to be discussed. Our aim is not to propagate any particular form of government. We merely wish to help the reader to recognize that democracy in particular involves a whole lot of assumptions that are in need of a better justification than what is normally provided. (shrink)

In 1992, Bengt Hägglund put forward a thesis according to which a codex in his possession is based on material Johannes Rudbeckius (1581–1646) authored in 1611, maintaining that the codex gives us information about Rudbeckius's lectures on _loci theologici_ in Uppsala during the years 1611–1613 and that it reveals to us characteristic features of Rudbeckius's thinking about dogmatics. Hägglund published the codex in 2001. I point out, first, weaknesses in Hägglund's argumentation. Second, I present indirect evidence against his thesis employing (...) the two series of Rudbeckius's published dissertations on dogmatics (1611–1613, 1620–1644) and his own comments about his lectures. Third, I indicate that three parts of the codex that are particularly important for Hägglund's argumentation stem from other authors: the introductory part on the nature of theo­logy, as well as the chapter on _locus de ecclesia_, have their origin in Jesper Brochmand's _Universae theologiae systema_ (1633), while the conclusion is taken from a dissertation that Balthasar Meisner published in 1614. The codex does not allow us to access a work Rudbeckius would have authored in 1611: it contains too many parts he cannot have authored then. In particular, the introduction and the conclusion of the codex do not tell us anything about Rudbeckius's characteristic thoughts on dogmatics. Hägglund's main reason for thinking that the codex is a transcript of Rudbeckius's work from 1611 is a date mentioned at the end of locus of the church. As it happens, this locus is borrowed from Brochmand, not from Rudbeckius. (shrink)

I argue that the semantics of sentences expressing future contingent propositions is best viewed as being based on a clear distinction between a time at which a proposition is true and a time at which a state of affairs that makes it true gets actualized. That a prediction is true here and now means that its truth-maker gets actualized later. This is not to say that if a contingent proposition p concerning the future is true at t, it acquires the (...) truth-value true at t only retrospectively, at a later moment. Nor must this be seen as suggesting that it is a settled, unpreventable fact at t that p is true at t. It just means that the reason for its present truth is something that happens later on: the future happens to evolve in such a way as to make a truth-maker of p obtain. In this case, then, it can be said that at t, p is truth-maker indeterminate, or that it has an indeterminate truth-maker. I develop a formal semantics based on this analysis in the follow-up article ‘A Formal Framework for Future Contingents’. Here, I lay down the conceptual framework and indicate Boethius and Abelard as precursors of the view I wish to defend. (shrink)

Kirja-arvio teoksesta Jordan B. Peterson, 12 elämänohjetta. Käsikirja kaaosta vastaan (12 Rules for Life. An Antidote to Chaos, 2018). Suom. Tero Valkonen. WSOY, Helsinki 2018.

THE EXISTENTIAL CONDITION OF THE IJAWS IN THE EMERGING SOCIO-ECONOMIC AND POLITICAL MILIEU OF NIGERIA. By Ebo Socrates, PhD. -/- Nigeria is a hybrid nation of over two hundred and fifty ethnic nationalities. The Ijaws as a people among the multitude of peoples that have come to constitute the geographic expression and sovereign entity known as Nigeria, find themselves enmeshed in the fluctuating socio-economic milieu of Nigeria. They as well as other ethnic nationalities that constitute Nigeria, found themselves bound to (...) the contingencies and exigencies of the nation-state called Nigeria not by act of will or treaty but by the Lugardian fiat which in itself was a full expression of the British imperialist will to power. By fiat and history, a country was made; the country is Nigeria, its people simply are; a fact of history. Their mode of being however, is a confluence of contraction and progress. So many models of nationhood explicates Nigeria. But Nigeria, is undeniably a “torn” nation. In the words of Samuel Huntington, a nation of conflicting civilizations: the Islamic civilization and the Judeo-Christian civilization. The Ijaws, an oil rich minority tribe found themselves entwined and involved in the destiny of this phenomenal nation called Nigeria. Has such an entwinement been a curse or blessing? Have the Ijaws significant power in the organogram of the Nigerian nationhood? Are they tossed about by the tide and flow of events or are they active movers in the making of the Nigerian history? This paper critically looks at these existential realities and elucidates the existential condition of the Ijaws in the contemporary Nigeria . (shrink)

Among critical concepts in Mulla Sadra's thought, which, of course, cannot be discussed separately between the parts. This is because the basic rules in philosophical discourse are universal traits that make it approached from various directions as a unified form of reality. One of Sadra's famous thoughts is the concept of the soul, which is related to the roots of his philosophical doctrine of being. The significance of the discussion of the soul by Mulla Sadra becomes increasingly crucial given the (...) discourse about the soul, especially in the debate of modern European philosophy in such a way that are absurd forms in Islamic religious doctrine. Therefore, seeing the relationship between the two models of approach to the soul is not only the only way to understand the universal message of the Islamic treatise about the soul but also creates a model of dialogue volume two of Ibn Rusyd-Ghazali becoming Mulla Sadra versus Modern Europe. (shrink)