In light of recent advances in machine learning for medical applications, the automation of medical diagnostics is imminent. That said, before machine learning algorithms find their way into clinical practice, various problems at the epistemic level need to be overcome. In this paper, we discuss different sources of uncertainty arising for clinicians trying to evaluate the trustworthiness of algorithmic evidence when making diagnostic judgments. Thereby, we examine many of the limitations of current machine learning algorithms (with deep learning in particular) (...) and highlight their relevance for medical diagnostics. Among the problems we inspect are the theoretical foundations of deep learning (which are not yet adequately understood), the opacity of algorithmic decisions, and the vulnerabilities of machine learning models, as well as concerns regarding the quality of medical data used to train the models. Building on this, we discuss different desiderata for an uncertainty amelioration strategy that ensures that the integration of machine learning into clinical settings proves to be medically beneficial in a meaningful way. (shrink)

How we can reliably draw inferences from data, evidence and/or experience has been and continues to be a pressing question in everyday life, the sciences, politics and a number of branches in philosophy (traditional epistemology, social epistemology, formal epistemology, logic and philosophy of the sciences). In a world in which we can now longer fully rely on our experiences, interlocutors, measurement instruments, data collection and storage systems and even news outlets to draw reliable inferences, the issue becomes even more pressing. (...) While we were working on this question using a formal epistemology approach Landes and Osimani (2020); De Pretis et al. (2019); Osimani and Landes (2020); Osimani (2020), we realised that the width of current active interests in the notion of reliability was much broader than we initially thought. Given the breadth of approaches and angles present in philosophy (even in this journal Schubert 2012; Avigad 2021; Claveau and Grenier 2019; Kummerfeld and Danks 2014; Landes 2021; Trpin et al. 2021; Schippers 2014; Schindler 2011; Kelly et al. 2016; Mayo-Wilson 2014; Olsson and Schubert 2007; Pittard 2017), we thought that it would be beneficial to provide a forum for an open exchange of ideas, in which philosophers working in different paradigms could come together. Our call for expression of interest received a great variety of promised manuscripts, the variety is reflected in the published papers. They range from fields far away from our own interests such as quantum probabilities de Ronde et al. (2021), evolvable software systems Primiero et al. (2021), to topics closer to our own research in the philosophy of medicine Lalumera et al. (2020), psychology Dutilh et al. (2021), traditional epistemology Dunn (2021); Tolly (2021) to finally close shared interests in formal epistemology Romero and Sprenger (2021) even within our own department Merdes et al. (2021). Our job is now to reliably inform you about all the contributions in the papers in this special issue. Unfortunately, that task is beyond our capabilities. What we can and instead do is to summarise the contributed papers to inform your reliable inference to read them all in great detail. (shrink)