Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids are (...) incorporated into growing protein chains. Independently from and concomitantly with Crick’s hypothesis, Mahlon Hoagland and Paul Zamecnik conducted experiments with no guiding theory that culminated in discoveries of the actual adaptors, transfer RNA (tRNA) molecules, and their amino acids charging enzymes. This paper traces the parallel histories of Crick’s adaptor hypothesis and of the experimental discovery of tRNA and compares their relative impacts on the scientific community. Remarkably, despite the brilliance of Crick’s confirmed prognostication, it had marginal impact on practicing scientists. Conversely, Hoagland and Zamecnik’s experimental discoveries and their evidence-based model of protein synthesis had immediate and enduring impact. I discuss possible explanations for the different impacts of the theoretical prediction and experimental identifications of the same entities. (shrink)

Many philosophers have argued that a hypothesis is better confirmed by some data if the hypothesis was not specifically designed to fit the data. ‘Prediction’, they argue, is superior to ‘accommodation’. Others deny that there is any epistemic advantage to prediction, and conclude that prediction and accommodation are epistemically on a par. This paper argues that there is a respect in which accommodation is superior to prediction. Specifically, the information that the data was accommodated rather than predicted suggests that the (...) data is less likely to have been manipulated or fabricated, which in turn increases the likelihood that the hypothesis is correct in light of the data. In some cases, this epistemic advantage of accommodation may even outweigh whatever epistemic advantage there might be to prediction, making accommodation epistemically superior to prediction all things considered. (shrink)

"Partial realism" is a common position in the contemporary philosophy of science literature. It states that the "essential" elements of empirically successful scientific theories accurately represent corresponding features the world. This thesis makes several novel contributions related to this position. Firstly, it offers a new definition of the concept of “empirical success”, representing a principled merger between the use-novelty and unification accounts. Secondly, it provides a comparative critical analysis of various accounts of which elements are "essential" to the success of (...) a theory, including structural realism and the divide et impera strategy. A novel account of essentialness, entitled the “empirically successful sub-theory "account", is defended. Thirdly, it is argued that the realism/anti-realism debate should put to the side metaphysical questions and focus instead on partial realism's commitment to the continuity of science. Because this commitment lacks metaphysical implications, it is referred to as "deflationary realism". Anti-realists cannot reject deflationary realism as a matter of a priori principle; its overall viability can therefore only be assessed by a careful examination of the history of science. Finally, another consequence of partial realism, named "partial rationalism", is defended. Partial rationalism states that, in cases where several competing theories have been suggested, scientists are rational just in case they accept the essential elements of each of the scientific theories on offer. This novel position subverts the existing literature on scientific "revolutions", as it sometimes demands that scientists devise a synthesis between competing scientific theories, instead of "choosing" only one. The philosophical points defended in this thesis are illustrated and supported by case studies from the history of science, including Fresnel’s wave theory of light, the Copernican revolution, the "neo-Darwinian synthesis" in evolutionary biology, the "prion revolution" in molecular biology, the miasma theory of disease, and the chemical revolution. (shrink)

It is generally accepted among philosophers of science that hypothesis testing is a key methodological feature of science. As far as philosophical theories of confirmation are con...

Decision theorists have attempted to accommodate several violations of decision theory’s axiomatic requirements by modifying how agents’ choice options are individuated and formally represented. In recent years, prominent authors have worried that these modifications threaten to trivialize decision theory, make the theory unfalsifiable, impose overdemanding requirements on decision theorists, and hamper decision theory’s internal coherence. In this paper, I draw on leading descriptive and normative works in contemporary decision theory to address these prominent concerns. In doing so, I articulate and (...) assess several different criteria for individuating and formally representing agents’ choice options. (shrink)

Predictivism is the view that successful predictions of “novel” evidence carry more confirmational weight than accommodations of already known evidence. Novelty, in this context, has traditionally been conceived of as temporal novelty. However temporal predictivism has been criticized for lacking a rationale: why should the time order of theory and evidence matter? Instead, it has been proposed, novelty should be construed in terms of use-novelty, according to which evidence is novel if it was not used in the construction of a (...) theory. Only if evidence is use-novel can it fully support the theory entailing it. As I point out in this paper, the writings of the most influential proponent of use-novelty contain a weaker and a stronger version of use-novelty. However both versions, I argue, are problematic. With regard to the appraisal of Mendeleev’ periodic table, the most contentious historical case in the predictivism debate, I argue that temporal predictivism is indeed supported, although in ways not previously appreciated. On the basis of this case, I argue for a form of so-called symptomatic predictivism according to which temporally novel predictions carry more confirmational weight only insofar as they reveal the theory’s presumed coherence of facts as real. (shrink)

The aim of this paper is to put in place some cornerstones in the foundations for an objective theory of confirmation by considering lessons from the failures of predictivism. Discussion begins with a widely accepted challenge, to find out what is needed in addition to the right kind of inferential–semantical relations between hypothesis and evidence to have a complete account of confirmation, one that gives a definitive answer to the question whether hypotheses branded as “post hoc monsters” can be confirmed. (...) The predictivist view is then presented as a way to meet this challenge. Particular attention is paid to Worrall’s version of predictivism, as it appears to be the most sophisticated of the lot. It is argued that, despite its faults, his view turns our heads in the right direction by attempting to remove contingent considerations from confirmational matters. The demand to remove such considerations becomes the first of four cornerstones. Each cornerstone is put in place with the aim to steer clear of the sort of failures that plague various kinds of predictivism. In the process, it becomes obvious that the original challenge is wrongheaded and in need of revision. The paper ends with just such a revision. (shrink)

For many years—and with some energy since Laudan’s “Confutation of Convergent Realism” —the scientific realist has sought to accommodate examples of false-yet-successful theories in the history of science. One of the most prominent strategies is to identify ‘success fueling’ components of false theories that themselves are at least approximately true. In this article I develop both sides of the debate, introducing new challenges from the history of science as well as suggesting adjustments to the divide et impera realist strategy. A (...) new ‘recipe’ for the prospective identification of working/idle posits is considered. (shrink)

In a recent paper McCain (2012) argues that weak predictivism creates an important challenge for external world scepticism. McCain regards weak predictivism as uncontroversial and assumes the thesis within his argument. There is a sense in which the predictivist literature supports his conviction that weak predictivism is uncontroversial. This absence of controversy, however, is a product of significant plasticity within the thesis, which renders McCain’s argument worryingly vague. For McCain’s argument to work he either needs a stronger version of weak (...) predictivism than has been defended within the literature, or must commit to a more precise formulation of the thesis and argue that weak predictivism, so understood, creates the challenge to scepticism that he hopes to achieve. The difficulty with the former is that weak predictivism is not uncontroversial in the respect that McCain’s argument would require. I consider the prospects of saving McCain’s argument by committing to a particular version of weak predictivism, but find them unpromising for several reasons. (shrink)

The extra value of novel confirmation over accommodation is explained based on an analysis of the underdetermination of scientific theory building. Novel confirmation can provide information on the number of possible scientific alternatives to a predictively successful theory. This information, in turn, can raise the probability that the given theory is true or will be empirically viable in the future.

an observation to formulate a theory, it is no surprise that the resulting theory accurately captures that observation. However, when the theory makes a novel prediction—when it predicts an observation that was not used in its formulation—this seems to provide more substantial confirmation of the theory. This paper presents a new approach to the vexed problem of understanding the epistemic difference between prediction and accommodation. In fact, there are several problems that need to be disentangled; in all of them, the (...) key is the concept of overfitting. We float the hypothesis that accommodation is a defective methodology only when the methods used to accommodate the data fail to guard against the risk of overfitting. We connect our analysis with the proposals that other philosophers have made. We also discuss its bearing on the conflict between instrumentalism and scientific realism. Introduction Predictivisms—a taxonomy Observations Formulating the problem What might Annie be doing wrong? Solutions Observations explained Mayo on severe tests The miracle argument and scientific realism Concluding comments. (shrink)

Scientific theories are developed in response to a certain set of phenomena and subsequently evaluated, at least partially, in terms of the quality of fit between those same theories and appropriately distinctive phenomena. To differentiate between these two stages it is popular to describe the former as involving the accommodation of data and the latter as involving the prediction of data. Predictivism is the view that, ceteris paribus, correctly predicting data confers greater confirmation than successfully accommodating data. In this paper, (...) I take issue with a variety of predictivist theses, argue that their role for issues of confirmation is extremely limited, and attempt to account for the appeal that predictivism has enjoyed. Introduction Temporal Predictivism Heuristic Predictivism Weak Predictivism 4.1 Inference to better theories 4.2 Inference to better methods Arguments for Strong Heuristic Predictivism 5.1 Best explanations argument 5.2 Conditional support 5.3 Unique explanations Increased Explanatory Unification 6.1 Explaining what other theories can't 6.2 Contrived hypotheses 6.2 Strength and simplicity Conclusions CiteULike Connotea Del.icio.us What's this? (shrink)

When a theory is confronted with a problem such as a paradox, an empirical anomaly, or a vicious regress, one may change part of the theory to solve that problem. Sometimes the proposed solution is considered ad hoc. This paper gives a new definition of ‘ad hoc solution’ as used in both philosophy and science. I argue that a solution is ad hoc if it fails to live up to the explanatory requirements of a theory because the solution is not (...) backed by an explanation or because it does not diagnose the problem. Ad hoc solutions are thus magical: they solve a problem without providing insight. This definition helps to explain both why ad hoc solutions are bad and why there may be disagreement about cases. (shrink)

In this paper I distinguish two kinds of predictivism, 'timeless' and 'historicized'. The former is the conventional understanding of predictivism. However, I argue that its defense in the works of John Worrall and Patrick Maher is wanting. Alternatively, I promote an historicized predictivism, and briefly defend such a predictivism at the end of the paper.

A not unpopular thesis, when it comes to the confirmation of scientific theories, is that data which were used in the construction of a theory afford poorer support for that theory than data that played no role. Some compelling thought experiments have been offered in favour of this view, not as proof but rather to add some intuitive plausibility. In this paper I consider such thought experiments and argue that they do not support the thesis; the perceived importance of prediction (...) over accommodation, at least in these cases, is illusory. Introduction Background assumptions Strong thesis Weak thesis Conclusions. (shrink)

The paper presents a further articulation and defence of the view on prediction and accommodation that I have proposed earlier. It operates by analysing two accounts of the issue-by Patrick Maher and by Marc Lange-that, at least at first sight, appear to be rivals to my own. Maher claims that the time-order of theory and evidence may be important in terms of degree of confirmation, while that claim is explicitly denied in my account. I argue, however, that when his account (...) is analysed, Maher reveals no scientifically significant way in which the time-order counts, and that indeed his view is in the end best regarded as a less than optimally formulated version of my own. Lange has also responded to Maher by arguing that the apparent relevance of temporal considerations is merely apparent: what is really involved, according to Lange, is whether or not a hypothesis constitutes an "arbitrary conjunction." I argue that Lange's suggestion fails: the correct analysis of his and Maher's examples is that provided by my account. (shrink)

Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical (...) basis was unclear, hypotheses were only partially effective and supplementary experimentation was required for its conclusive definition. Markedly, hypotheses were entirely inept in predicting workings of complex systems that included unknown elements. Thus, hypotheses did not predict the existence and function of mRNA, the multiple unidentified components of the protein biosynthesis machinery, or the manifold unknown constituents of the ubiquitin–proteasome system of protein breakdown. Consequently, because of their inability to envision unknown entities, predictive hypotheses did not contribute to the elucidation of cation theories remained the sole instrument to explain complex bio-molecular systems, the philosophical question of alleged advantage of predictive over accommodative hypotheses became inconsequential. (shrink)