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  1. Current Bibliography of the History of Science and Its Cultural Influences 2005.Stephen P. Weldon - 2005 - Isis 96:1-242.
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  • Simplicity and model selection.Guillaume Rochefort-Maranda - 2016 - European Journal for Philosophy of Science 6 (2):261-279.
    In this paper I compare parametric and nonparametric regression models with the help of a simulated data set. Doing so, I have two main objectives. The first one is to differentiate five concepts of simplicity and assess their respective importance. The second one is to show that the scope of the existing philosophical literature on simplicity and model selection is too narrow because it does not take the nonparametric approach into account, S112–S123, 2002; Forster and Sober in The British Journal (...)
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  • Empirical agreement in model validation.Julie Jebeile & Anouk Barberousse - 2016 - Studies in History and Philosophy of Science Part A 56:168-174.
    Empirical agreement is often used as an important criterion when assessing the validity of scientific models. However, it is by no means a sufficient criterion as a model can be so adjusted as to fit available data even though it is based on hypotheses whose plausibility is known to be questionable. Our aim in this paper is to investigate into the uses of empirical agreement within the process of model validation.
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  • Probabilistic Reasoning in Cosmology.Yann Benétreau-Dupin - 2015 - Dissertation, The University of Western Ontario
    Cosmology raises novel philosophical questions regarding the use of probabilities in inference. This work aims at identifying and assessing lines of arguments and problematic principles in probabilistic reasoning in cosmology. -/- The first, second, and third papers deal with the intersection of two distinct problems: accounting for selection effects, and representing ignorance or indifference in probabilistic inferences. These two problems meet in the cosmology literature when anthropic considerations are used to predict cosmological parameters by conditionalizing the distribution of, e.g., the (...)
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  • Novel Confirmation and the Underdetermination of Scientific Theory Building.Richard Dawid - unknown
    The extra value of novel confirmation over accommodation is explained based on an analysis of the underdetermination of scientific theory building. Novel confirmation can provide information on the number of possible scientific alternatives to a predictively successful theory. This information, in turn, can raise the probability that the given theory is true or will be empirically viable in the future.
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  • Phenomenology of Social Cognition.Shannon Spaulding - 2015 - Erkenntnis 80 (5):1069-1089.
    Can phenomenological evidence play a decisive role in accepting or rejecting social cognition theories? Is it the case that a theory of social cognition ought to explain and be empirically supported by our phenomenological experience? There is serious disagreement about the answers to these questions. This paper aims to determine the methodological role of phenomenology in social cognition debates. The following three features are characteristic of evidence capable of playing a substantial methodological role: novelty, reliability, and relevance. I argue that (...)
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  • Neural Findings and Economic Models: Why Brains Have Limited Relevance for Economics.Roberto Fumagalli - 2014 - Philosophy of the Social Sciences 44 (5):606-629.
    Proponents of neuroeconomics often argue that better knowledge of the human neural architecture enables economists to improve standard models of choice. In their view, these improvements provide compelling reasons to use neural findings in constructing and evaluating economic models. In a recent article, I criticized this view by pointing to the trade-offs between the modeling desiderata valued by neuroeconomists and other economists, respectively. The present article complements my earlier critique by focusing on three modeling desiderata that figure prominently in economic (...)
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  • The No Alternatives Argument.Richard Dawid, Stephan Hartmann & Jan Sprenger - 2015 - British Journal for the Philosophy of Science 66 (1):213-234.
    Scientific theories are hard to find, and once scientists have found a theory, H, they often believe that there are not many distinct alternatives to H. But is this belief justified? What should scientists believe about the number of alternatives to H, and how should they change these beliefs in the light of new evidence? These are some of the questions that we will address in this article. We also ask under which conditions failure to find an alternative to H (...)
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  • Some surprising facts about surprising facts.D. Mayo - 2014 - Studies in History and Philosophy of Science Part A 45:79-86.
    A common intuition about evidence is that if data x have been used to construct a hypothesis H, then x should not be used again in support of H. It is no surprise that x fits H, if H was deliberately constructed to accord with x. The question of when and why we should avoid such “double-counting” continues to be debated in philosophy and statistics. It arises as a prohibition against data mining, hunting for significance, tuning on the signal, and (...)
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  • Novelty, coherence, and Mendeleev’s periodic table.Samuel Schindler - 2014 - Studies in History and Philosophy of Science Part A 45:62-69.
    Predictivism is the view that successful predictions of “novel” evidence carry more confirmational weight than accommodations of already known evidence. Novelty, in this context, has traditionally been conceived of as temporal novelty. However temporal predictivism has been criticized for lacking a rationale: why should the time order of theory and evidence matter? Instead, it has been proposed, novelty should be construed in terms of use-novelty, according to which evidence is novel if it was not used in the construction of a (...)
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  • State of the Field: Why novel prediction matters.Heather Douglas & P. D. Magnus - 2013 - Studies in History and Philosophy of Science Part A 44 (4):580-589.
    There is considerable disagreement about the epistemic value of novel predictive success, i.e. when a scientist predicts an unexpected phenomenon, experiments are conducted, and the prediction proves to be accurate. We survey the field on this question, noting both fully articulated views such as weak and strong predictivism, and more nascent views, such as pluralist reasons for the instrumental value of prediction. By examining the various reasons offered for the value of prediction across a range of inferential contexts , we (...)
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  • Two arguments for scientific realism unified.Harker David - 2010 - Studies in History and Philosophy of Science Part A 41 (2):192-202.
    Inferences from scientific success to the approximate truth of successful theories remain central to the most influential arguments for scientific realism. Challenges to such inferences, however, based on radical discontinuities within the history of science, have motivated a distinctive style of revision to the original argument. Conceding the historical claim, selective realists argue that accompanying even the most revolutionary change is the retention of significant parts of replaced theories, and that a realist attitude towards the systematically retained constituents of our (...)
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  • Novel Predictions and the No Miracle Argument.Mario Alai - 2014 - Erkenntnis 79 (2):297-326.
    Predictivists use the no miracle argument to argue that “novel” predictions are decisive evidence for theories, while mere accommodation of “old” data cannot confirm to a significant degree. But deductivists claim that since confirmation is a logical theory-data relationship, predicted data cannot confirm more than merely deduced data, and cite historical cases in which known data confirmed theories quite strongly. On the other hand, the advantage of prediction over accommodation is needed by scientific realists to resist Laudan’s criticisms of the (...)
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  • The role of Bayesian philosophy within Bayesian model selection.Jan Sprenger - 2013 - European Journal for Philosophy of Science 3 (1):101-114.
    Bayesian model selection has frequently been the focus of philosophical inquiry (e.g., Forster, Br J Philos Sci 46:399–424, 1995; Bandyopadhyay and Boik, Philos Sci 66:S390–S402, 1999; Dowe et al., Br J Philos Sci 58:709–754, 2007). This paper argues that Bayesian model selection procedures are very diverse in their inferential target and their justification, and substantiates this claim by means of case studies on three selected procedures: MML, BIC and DIC. Hence, there is no tight link between Bayesian model selection and (...)
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  • The perils of tweaking: how to use macrodata to set parameters in complex simulation models.Brian Epstein & Patrick Forber - 2013 - Synthese 190 (2):203-218.
    When can macroscopic data about a system be used to set parameters in a microfoundational simulation? We examine the epistemic viability of tweaking parameter values to generate a better fit between the outcome of a simulation and the available observational data. We restrict our focus to microfoundational simulations—those simulations that attempt to replicate the macrobehavior of a target system by modeling interactions between microentities. We argue that tweaking can be effective but that there are two central risks. First, tweaking risks (...)
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  • Why It Is Time To Move Beyond Nagelian Reduction.Marie I. Kaiser - 2012 - In D. Dieks, S. Hartmann, T. Uebel & M. Weber (eds.), Probabilities, Laws and Structure. Springer. pp. 255-272.
    In this paper I argue that it is finally time to move beyond the Nagelian framework and to break new ground in thinking about epistemic reduction in biology. I will do so, not by simply repeating all the old objections that have been raised against Ernest Nagel’s classical model of theory reduction. Rather, I grant that a proponent of Nagel’s approach can handle several of these problems but that, nevertheless, Nagel’s general way of thinking about epistemic reduction in terms of (...)
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  • Hypothetico‐Deductive Confirmation.Jan Sprenger - 2011 - Philosophy Compass 6 (7):497-508.
    Hypothetico-deductive (H-D) confirmation builds on the idea that confirming evidence consists of successful predictions that deductively follow from the hypothesis under test. This article reviews scope, history and recent development of the venerable H-D account: First, we motivate the approach and clarify its relationship to Bayesian confirmation theory. Second, we explain and discuss the tacking paradoxes which exploit the fact that H-D confirmation gives no account of evidential relevance. Third, we review several recent proposals that aim at a sounder and (...)
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  • Mathematical Modeling in Biology: Philosophy and Pragmatics.Rasmus Grønfeldt Winther - 2012 - Frontiers in Plant Evolution and Development 2012:1-3.
    Philosophy can shed light on mathematical modeling and the juxtaposition of modeling and empirical data. This paper explores three philosophical traditions of the structure of scientific theory—Syntactic, Semantic, and Pragmatic—to show that each illuminates mathematical modeling. The Pragmatic View identifies four critical functions of mathematical modeling: (1) unification of both models and data, (2) model fitting to data, (3) mechanism identification accounting for observation, and (4) prediction of future observations. Such facets are explored using a recent exchange between two groups (...)
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  • Hitchcock and Sober on Weak Predictivism.Wang-Yen Lee - 2012 - Philosophia 40 (3):553-562.
    According to Hitchcock and Sober’s argument from overfitting for weak predictivism, the fact that a theory accurately predicts a portion of its data is evidence that it has been formulated by balancing simplicity and goodness-of-fit rather than overfitting data. The core argument consists of two likelihood inequalities. In this paper I show that there is a surprising accommodation-friendly implication in their argument, and contend that it is beset by a substantial difficulty, namely, there is no good reason to think that (...)
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  • Prediction in selectionist evolutionary theory.Rasmus Gr⊘Nfeldt Winther - 2009 - Philosophy of Science 76 (5):889-901.
    Selectionist evolutionary theory has often been faulted for not making novel predictions that are surprising, risky, and correct. I argue that it in fact exhibits the theoretical virtue of predictive capacity in addition to two other virtues: explanatory unification and model fitting. Two case studies show the predictive capacity of selectionist evolutionary theory: parallel evolutionary change in E. coli, and the origin of eukaryotic cells through endosymbiosis.
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  • How to discount double-counting when it counts: Some clarifications.Deborah G. Mayo - 2008 - British Journal for the Philosophy of Science 59 (4):857-879.
    The issues of double-counting, use-constructing, and selection effects have long been the subject of debate in the philosophical as well as statistical literature. I have argued that it is the severity, stringency, or probativeness of the test—or lack of it—that should determine if a double-use of data is admissible. Hitchcock and Sober ([2004]) question whether this ‘severity criterion' can perform its intended job. I argue that their criticisms stem from a flawed interpretation of the severity criterion. Taking their criticism as (...)
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  • On the predilections for predictions.David Harker - 2008 - British Journal for the Philosophy of Science 59 (3):429-453.
    Scientific theories are developed in response to a certain set of phenomena and subsequently evaluated, at least partially, in terms of the quality of fit between those same theories and appropriately distinctive phenomena. To differentiate between these two stages it is popular to describe the former as involving the accommodation of data and the latter as involving the prediction of data. Predictivism is the view that, ceteris paribus, correctly predicting data confers greater confirmation than successfully accommodating data. In this paper, (...)
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  • Ecology.Sahotra Sarkar - 2008 - Stanford Encyclopedia of Philosophy.
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  • Scientific Realism.Richard Boyd - 1984 - Stanford Encyclopedia of Philosophy 21 (1&2):767-791.
    (i) Scientific realism is primarily a metaphysical doctrine about the existence and nature of the unobservables of science. (ii) There are good explanationist arguments for realism, most famously that from the success of science, provided abduction is allowed. Abduction seems to be on an equal footing, at least, with other ampliative methods of inference. (iii) We have no reason to believe a doctrine of empirical equivalence that would sustain the underdetermination argument against realism. (iv) The key to defending realism from (...)
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  • Realism versus instrumentalism in a new statistical framework.Gregory M. Mikkelson - 2006 - Philosophy of Science 73 (4):440-447.
    In this paper, I offer a new defense of scientific realism, tailored for the Akaikean paradigm of statistical hypothesis testing. After proposing definitions of verisimilitude and predictive success, I use computer simulations to show how the latter depends on the former, even in the kind of case featured in a recent argument for instrumentalism.
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  • Predictivism for pluralists.Eric Christian Barnes - 2005 - British Journal for the Philosophy of Science 56 (3):421-450.
    Predictivism asserts that novel confirmations carry special probative weight. Epistemic pluralism asserts that the judgments of agents (about, e.g., the probabilities of theories) carry epistemic import. In this paper, I propose a new theory of predictivism that is tailored to pluralistic evaluators of theories. I replace the orthodox notion of use-novelty with a notion of endorsement-novelty, and argue that the intuition that predictivism is true has two roots. I provide a detailed Bayesian rendering of this theory and argue that pluralistic (...)
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  • Preregistration Does Not Improve the Transparent Evaluation of Severity in Popper’s Philosophy of Science or When Deviations are Allowed.Mark Rubin - manuscript
    One justification for preregistering research hypotheses, methods, and analyses is that it improves the transparent evaluation of the severity of hypothesis tests. In this article, I consider two cases in which preregistration does not improve this evaluation. First, I argue that, although preregistration can facilitate the transparent evaluation of severity in Mayo’s error statistical philosophy of science, it does not facilitate this evaluation in Popper’s theory-centric approach. To illustrate, I show that associated concerns about Type I error rate inflation are (...)
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  • Predictivism and avoidance of ad hoc-ness: An empirical study.Samuel Schindler - 2024 - Studies in History and Philosophy of Science Part A 104 (C):68-77.
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  • Tests of Animal Consciousness are Tests of Machine Consciousness.Leonard Dung - forthcoming - Erkenntnis:1-20.
    If a machine attains consciousness, how could we find out? In this paper, I make three related claims regarding positive tests of machine consciousness. All three claims center on the idea that an AI can be constructed “ad hoc”, that is, with the purpose of satisfying a particular test of consciousness while clearly not being conscious. First, a proposed test of machine consciousness can be legitimate, even if AI can be constructed ad hoc specifically to pass this test. This is (...)
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  • (1 other version)Explaining Human Diversity: the Need to Balance Fit and Complexity.Armin W. Schulz - 2023 - Review of Philosophy and Psychology 14 (2):457-475.
    While the existence of human cognitive and behavioral diversity is now widely recognized, it is not yet well established how to explain this diversity. In particular, it is still unclear how to determine whether any given instance of human cognitive and behavioral diversity is due to a common psychology that is merely “triggered” differently in different bio-cultural environments, or whether it is due to deeply and fundamentally different psychologies. This paper suggests that, to answer this question, we need to employ (...)
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  • Model-Selection Theory: The Need for a More Nuanced Picture of Use-Novelty and Double-Counting.Charlotte Werndl & Katie Steele - 2018 - British Journal for the Philosophy of Science 69 (2):351-375.
    This article argues that common intuitions regarding (a) the specialness of ‘use-novel’ data for confirmation and (b) that this specialness implies the ‘no-double-counting rule’, which says that data used in ‘constructing’ (calibrating) a model cannot also play a role in confirming the model’s predictions, are too crude. The intuitions in question are pertinent in all the sciences, but we appeal to a climate science case study to illustrate what is at stake. Our strategy is to analyse the intuitive claims in (...)
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  • Predictivism and model selection.Alireza Fatollahi - 2023 - European Journal for Philosophy of Science 13 (1):1-28.
    There has been a lively debate in the philosophy of science over _predictivism_: the thesis that successfully predicting a given body of data provides stronger evidence for a theory than merely accommodating the same body of data. I argue for a very strong version of the thesis using statistical results on the so-called “model selection” problem. This is the problem of finding the optimal model (family of hypotheses) given a body of data. The key idea that I will borrow from (...)
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  • Optimality justifications and the optimality principle: New tools for foundation‐theoretic epistemology.Gerhard Schurz - 2022 - Noûs 56 (4):972-999.
    The background of this paper (section 1) consists in a new account to foundation‐theoretic epistemology characterized by two features: (i) All beliefs are to be justified by deductive, inductive or abductive inferences from a minimalistic class of unproblematic (introspective or analytic) basic beliefs. (ii) Higher‐order justifications for these inferences are given by means of the novel method of optimality justifications. Optimality justifications are a new tool for epistemology (section 2). An optimality justification does not attempt todemonstratethat a cognitive method is (...)
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  • Cosmological Realism.David Merritt - 2021 - Studies in History and Philosophy of Science Part A 88 (C):193-208.
    I discuss the relevance of the current predicament in cosmology to the debate over scientific realism. I argue that the existence of two, empirically successful but ontologically inconsistent cosmological theories presents difficulties for the realist position.
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  • Towards Ideal Understanding.Mario Hubert & Federica Isabella Malfatti - 2023 - Ergo 10 (22):578-611.
    What does it take to understand a phenomenon ideally, or to the highest conceivable extent? In this paper, we answer this question by arguing for five necessary conditions for ideal understanding: (i) representational accuracy, (ii) intelligibility, (iii) truth, (iv) reasonable endorsement, and (v) fitting. Even if one disagrees that there is some form of ideal understanding, these five conditions can be regarded as sufficient conditions for a particularly deep level of understanding. We then argue that grasping, novel predictions, and transparency (...)
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  • Exploratory hypothesis tests can be more compelling than confirmatory hypothesis tests.Mark Rubin & Chris Donkin - 2022 - Philosophical Psychology.
    Preregistration has been proposed as a useful method for making a publicly verifiable distinction between confirmatory hypothesis tests, which involve planned tests of ante hoc hypotheses, and exploratory hypothesis tests, which involve unplanned tests of post hoc hypotheses. This distinction is thought to be important because it has been proposed that confirmatory hypothesis tests provide more compelling results (less uncertain, less tentative, less open to bias) than exploratory hypothesis tests. In this article, we challenge this proposition and argue that there (...)
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  • Distributing epistemic and practical risks: a comparative study of communicating earthquake damages.Li-an Yu - 2022 - Synthese 360 (5):1-24.
    This paper argues that the value of openness to epistemic plurality and the value of social responsiveness are essential for epistemic agents such as scientists who are expected to carry out non-epistemic missions. My chief philosophical claim is that the two values should play a joint role in their communication about earthquake-related damages when their knowledge claims are advisory. That said, I try to defend a minimal normative account of science in the context of communication. I show that these epistemic (...)
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  • Tacking by conjunction, genuine confirmation and convergence to certainty.Gerhard Schurz - 2022 - European Journal for Philosophy of Science 12 (3):1-18.
    Tacking by conjunction is a well-known problem for Bayesian confirmation theory. In the first section, disadvantages of existing Bayesian solution proposals to this problem are pointed out and an alternative solution proposal is presented: that of genuine confirmation. In the second section, the notion of GC is briefly recapitulated and three versions of GC are distinguished: full GC, partial GC and quantitative GC. In the third section, the application of partial GC to pure post-facto speculations is explained. In the fourth (...)
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  • Theoretical Virtues: Do Scientists Think What Philosophers Think They Ought to Think?Samuel Schindler - 2022 - Philosophy of Science 89 (3):542-564.
    Theoretical virtues play an important role in the acceptance and belief of theories in science and philosophy. Philosophers have well-developed views on which virtues ought and ought not to influence one’s acceptance and belief. But what do scientists think? This paper presents the results of a quantitative study with scientists from the natural and social sciences and compares their views to those held by philosophers. Some of the more surprising results are: all three groups have a preference order regarding theoretical (...)
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  • The Impact of Meta-Induction: From Skepticism to Optimality.Gerhard Schurz - 2021 - Philosophies 6 (4):95.
    In the first section, five major attempts to solve the problem of induction and their failures are discussed. In the second section, an account of meta-induction is introduced. It offers a novel solution to the problem of induction, based on mathematical theorems about the predictive optimality of attractivity-weighted meta-induction. In the third section, how the a priori justification of meta-induction provides a non-circular a posteriori justification of object-induction, based on its superior track record, is explained. In the fourth section, four (...)
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  • The tragedy of the canon; or, path dependence in the history and philosophy of science.Agnes Bolinska & Joseph D. Martin - 2021 - Studies in History and Philosophy of Science Part A 89 (C):63-73.
    We have previously argued that historical cases must be rendered canonical before they can plausibly serve as evidence for philosophical claims, where canonicity is established through a process of negotiation among historians and philosophers of science (Bolinska and Martin, 2020). Here, we extend this proposal by exploring how that negotiation might take place in practice. The working stock of historical examples that philosophers tend to employ has long been established informally, and, as a result, somewhat haphazardly. The composition of the (...)
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  • Micro-foundations and Methodology: A Complexity-Based Reconceptualization of the Debate.Nadia Ruiz & Armin W. Schulz - 2023 - British Journal for the Philosophy of Science 74 (2):359-379.
    In a number of very influential publications, Epstein and Hoover (among other authors) have recently argued that a thoroughly micro-foundationalist approach towards economics is unconvincing for metaphysical reasons. However, as we show in this article, this metaphysical/social ontological approach to the debate fails to resolve the status of micro-foundations in the practice of economic modelling. To overcome this, we argue that endogenizing a model—that is, providing micro-foundations for it—correlates with making that model more complex. Specifically, we show that models with (...)
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  • HARKing: From Misdiagnosis to Mispescription.Aydin Mohseni - unknown
    The practice of HARKing---hypothesizing after results are known---is commonly maligned as undermining the reliability of scientific findings. There are several accounts in the literature as to why HARKing undermines the reliability of findings. We argue that none of these is right and that the correct account is a Bayesian one. HARKing can indeed decrease the reliability of scientific findings, but it can also increase it; which effect HARKing produces depends on the difference of the prior odds of hypotheses characteristically selected (...)
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  • Coincidence and reproducibility in the EHT black hole experiment.Galina Weinstein - 2021 - Studies in History and Philosophy of Science Part A 85:63-78.
    This paper discusses some philosophical aspects related to the recent publication of the experimental results of the 2017 black hole experiment, namely the first image of the supermassive black hole at the center of galaxy M87. In this paper I present a philosophical analysis of the 2017 Event Horizon Telescope (EHT) black hole experiment. I first present Hacking’s philosophy of experimentation. Hacking gives his taxonomy of elements of laboratory science and distinguishes a list of elements. I show that the EHT (...)
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  • How to be a scientific realist (if at all): a study of partial realism.Dean Peters - 2012 - Dissertation, London School of Economics
    "Partial realism" is a common position in the contemporary philosophy of science literature. It states that the "essential" elements of empirically successful scientific theories accurately represent corresponding features the world. This thesis makes several novel contributions related to this position. Firstly, it offers a new definition of the concept of “empirical success”, representing a principled merger between the use-novelty and unification accounts. Secondly, it provides a comparative critical analysis of various accounts of which elements are "essential" to the success of (...)
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  • Logical Predictivism.Ben Martin & Ole Hjortland - 2020 - Journal of Philosophical Logic 50 (2):285-318.
    Motivated by weaknesses with traditional accounts of logical epistemology, considerable attention has been paid recently to the view, known as anti-exceptionalism about logic, that the subject matter and epistemology of logic may not be so different from that of the recognised sciences. One of the most prevalent claims made by advocates of AEL is that theory choice within logic is significantly similar to that within the sciences. This connection with scientific methodology highlights a considerable challenge for the anti-exceptionalist, as two (...)
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  • The Costs of HARKing.Mark Rubin - 2022 - British Journal for the Philosophy of Science 73 (2):535-560.
    Kerr coined the term ‘HARKing’ to refer to the practice of ‘hypothesizing after the results are known’. This questionable research practice has received increased attention in recent years because it is thought to have contributed to low replication rates in science. The present article discusses the concept of HARKing from a philosophical standpoint and then undertakes a critical review of Kerr’s twelve potential costs of HARKing. It is argued that these potential costs are either misconceived, misattributed to HARKing, lacking evidence, (...)
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  • Bayesian Philosophy of Science.Jan Sprenger & Stephan Hartmann - 2019 - Oxford and New York: Oxford University Press.
    How should we reason in science? Jan Sprenger and Stephan Hartmann offer a refreshing take on classical topics in philosophy of science, using a single key concept to explain and to elucidate manifold aspects of scientific reasoning. They present good arguments and good inferences as being characterized by their effect on our rational degrees of belief. Refuting the view that there is no place for subjective attitudes in 'objective science', Sprenger and Hartmann explain the value of convincing evidence in terms (...)
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  • (2 other versions)Scientific Realism.Anjan Chakravartty - 2011 - Stanford Encyclopedia of Philosophy.
    Debates about scientific realism are closely connected to almost everything else in the philosophy of science, for they concern the very nature of scientific knowledge. Scientific realism is a positive epistemic attitude toward the content of our best theories and models, recommending belief in both observable and unobservable aspects of the world described by the sciences. This epistemic attitude has important metaphysical and semantic dimensions, and these various commitments are contested by a number of rival epistemologies of science, known collectively (...)
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  • Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.Mary Jean Walker, Justin Bourke & Katrina Hutchison - 2019 - Theoretical Medicine and Bioethics 40 (2):103-121.
    Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...)
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