In this essay, I argue that uneliminated idealizations pose a serious problem for scientific realism. I consider one method for “de-idealizing” models—robustness analysis. However, I argue that unless idealizations are eliminated from an idealized theory and robustness analysis need not do that, scientists are not justified in believing that the theory is true. I consider one example of modeling from the biological sciences that exemplifies the problem.

Some authors claim that minimal models have limited epistemic value (Fumagalli, 2016; Grüne-Yanoff, 2009a). Others defend the epistemic benefits of modelling by invoking the role of robustness analysis for hypothesis confirmation (see, e.g., Levins, 1966; Kuorikoski et al., 2010) but such arguments find much resistance (see, e.g., Odenbaugh & Alexandrova, 2011). In this paper, we offer a Bayesian rationalization and defence of the view that robustness analysis can play a confirmatory role, and thereby shed light on the potential of minimal (...) models for hypothesis confirmation. We illustrate our argument by reference to a case study from macroeconomics. At the same time, we also show that there are cases in which robustness analysis is detrimental to confirmation. We characterize these cases and link them to recent investigations on evidential variety (Landes, 2020b, 2021; Osimani and Landes, forthcoming). We conclude that robustness analysis over minimal models can confirm, but its confirmatory value depends on concrete circumstances. (shrink)

It is important to have an adequate model of uncertainty, since decisions must be made before the uncertainty can be resolved. For instance, flood defenses must be designed before we know the future distribution of flood events. It is standardly assumed that probability theory offers the best model of uncertain information. I think there are reasons to be sceptical of this claim. I criticise some arguments for the claim that probability theory is the only adequate model of uncertainty. In particular (...) I critique Dutch book arguments, representation theorems, and accuracy based arguments. Then I put forward my preferred model: imprecise probabilities. These are sets of probability measures. I offer several motivations for this model of uncertain belief, and suggest a number of interpretations of the framework. I also defend the model against some criticisms, including the so-called problem of dilation. I apply this framework to decision problems in the abstract. I discuss some decision rules from the literature including Levi’s E-admissibility and the more permissive rule favoured by Walley, among others. I then point towards some applications to climate decisions. My conclusions are largely negative: decision making under such severe uncertainty is inevitably difficult. I finish with a case study of scientific uncertainty. Climate modellers attempt to offer probabilistic forecasts of future climate change. There is reason to be sceptical that the model probabilities offered really do reflect the chances of future climate change, at least at regional scales and long lead times. Indeed, scientific uncertainty is multi-dimensional, and difficult to quantify. I argue that probability theory is not an adequate representation of the kinds of severe uncertainty that arise in some areas in science. I claim that this requires that we look for a better framework for modelling uncertainty. (shrink)

In this paper a critique to philosophical approaches that presuppose invariant knowledge for policy purposes is carried out. It is shown that socioeconomic processes do not fit to the logic of stable causal factors, but they are more suited to the logic of "open-ended results". On the basis of this ontological variation it is argued that ex-ante interventions are not appropriate in the socioeconomic realm. On the contrary, they must be understood in a “dynamic” sense. Finally, derivational robustness analysis is (...) proposed as a useful tool for overcoming the problem of “overconstraint”, a typical problem of economic models. (shrink)

In this paper I begin with a recent challenge to the Semantic Approach and identify an underlying assumption, namely that identity conditions for theories should be provided. Drawing on previous work, I suggest that this demand should be resisted and that the Semantic Approach should be seen as a philosophical device that we may use to represent certain features of scientific practice. Focussing on the partial structures variant of that approach, I then consider a further challenge that arises from a (...) concern with the role of idealisations in that practice. I argue that the partial structures approach is capable of meeting this challenge and I conclude with some broader observations about the role of such formal accounts within the philosophy of science. (shrink)

Economists reason causally. Like many other scientists, they aim at formulating justified causal claims about their object of study. This thesis contributes to our understanding of how causal reasoning proceeds in economics. By using the research on the causes of unemployment as a case study, three questions are adressed. What are the meanings of causal claims? How can a causal claim be adequately supported by evidence? How are causal beliefs affected by incoming facts? In the process of answering these semantic, (...) epistemic and dynamical questions, the richness of causal reasoning in economics is brought to the foreground. In the part on semantics, it is argued that the meaning of causal generalizations in policy-oriented economics is best captured by using the concept of ‘inferential relation’ rather than the one of ‘referential relation’. This part contributes to develop an inferentialist semantics by distinguishing among types of inferential relations. In the part on epistemology, it is argued that justification in sciences like economics often relies, and ought to rely, on evidential variety―i.e. the combination of evidence from multiple sources. An interpretation of independence among evidential sources is offered: two evidential sources are fully independent if and only if the reasons why they would be unreliable do not overlap. It is then shown that the variety-of-evidence thesis does not hold under extreme circumstances. The part on dynamics focuses on deviant-case study. A storyline is provided for what deviant-case study aims at and how it proceeds in what is characterized as an ‘eclectic science’. (shrink)

Social scientists associate agent-based simulation (ABS) models with three ideas about explanation: they provide generative explanations, they are models of mechanisms, and they implement methodological individualism. In light of a philosophical account of explanation, we show that these ideas are not necessarily related and offer an account of the explanatory import of ABS models. We also argue that their bottom-up research strategy should be distinguished from methodological individualism.

Although Bayesian methods are widely used in phylogenetic systematics today, the foundations of this methodology are still debated among both biologists and philosophers. The Bayesian approach to phylogenetic inference requires the assignment of prior probabilities to phylogenetic trees. As in other applications of Bayesian epistemology, the question of whether there is an objective way to assign these prior probabilities is a contested issue. This paper discusses the strategy of constraining the prior probabilities of phylogenetic trees by means of the Principal (...) Principle. In particular, I discuss a proposal due to Velasco (Biol Philos 23:455–473, 2008) of assigning prior probabilities to tree topologies based on the Yule process. By invoking the Principal Principle I argue that prior probabilities of tree topologies should rather be assigned a weighted mixture of probability distributions based on Pinelis’ (P Roy Soc Lond B Bio 270:1425–1431, 2003) multi-rate branching process including both the Yule distribution and the uniform distribution. However, I argue that this solves the problem of the priors of phylogenetic trees only in a weak form. (shrink)

Confirmation in evolutionary biology depends on what biologists take to be the genuine rivals. Investigating what constrains the scope of biological possibility provides part of the story: explaining how possible helps determine what counts as a genuine rival and thus informs confirmation. To clarify the criteria for genuine rivalry I distinguish between global and local constraints on biological possibility, and offer an account of how-possibly explanation. To sharpen the connection between confirmation and explaining how possible I discuss the view that (...) formal inquiry can provide a kind of confirmation-theoretic support for evolutionary models, and offer an example of how-possibly explanation interacting with testing practice. (shrink)

In 1966 the population biologist Richard Levins gave a forceful and in?uential defence of a method called “robustness analysis” (RA). RA is a way of assessing the result of a model by showing that different but related models give the same result. As Levins put it, “our truth is the intersection of independent lies” (1966, 423). Steven Orzack and Elliott Sober (1993) responded with an equally forceful critique of this method, concluding that the idea of robustness “lacks proper de?nition and (...) that its bearing on the question of whether a proposition is true is highly problematic” (533). Replies to Orzack and Sober, from Levins (1993) and Weisberg (2006b), have rejected the idea that RA, on its own, can con?rm the results of models. I argue that these replies have not properly addressed Orzack and Sober’s real criticisms, which focus not on the role of empirical data in RA but on the problem of ensuring that the models used in RA are independent. By drawing on accounts of RA in experimental science, I argue that there is in fact a fallible but viable form of RA that can both con?rm the results of models and incorporate empirical data. However, for reasons other than those of Orzack and Sober, I conclude that RA may be of limited use in model-based science, as the example of ?shery biology can show. (shrink)

What sort of claims do scientific models make and how do these claims then underwrite empirical successes such as explanations and reliable policy interventions? In this paper I propose answers to these questions for the class of models used throughout the social and biological sciences, namely idealized deductive ones with a causal interpretation. I argue that the two main existing accounts misrepresent how these models are actually used, and propose a new account. *Received July 2006; revised August 2008. †To contact (...) the author, please write to: Department of Philosophy, University of Missouri, St. Louis, 599 Lucas Hall (MC 73), One University Blvd., St. Louis, MO 63121-4400; e-mail: [email protected]. (shrink)

The aim of this thesis is to improve our understanding of how to assess and communicate uncertainty in areas of research deeply afflicted by it, the assessment and communication of which are made more fraught still by the studies’ immediate policy implications. The IPCC is my case study throughout the thesis, which consists of three parts. In Part 1, I offer a thorough diagnosis of conceptual problems faced by the IPCC uncertainty framework. The main problem I discuss is the persistent (...) ambiguity surrounding the concepts of ‘confidence’ and ‘likelihood’; I argue that the lack of a conceptually valid interpretation of these concepts compatible with the IPCC uncertainty guide’s recommendations has worrying implications for both the IPCC authors’ treatment of uncertainties and the interpretability of the information provided in the AR5. Finally, I show that an understanding of the reasons behind the IPCC’s decision to include two uncertainty scales can offer insights into the nature of this problem. In Part 2, I review what philosophers have said about model-based robustness analysis. I assess several arguments that have been offered for its epistemic import and relate this discussion to the context of climate model ensembles. I also discuss various measures of independence in the climate literature, and assess the extent to which these measures can help evaluate the epistemic import of model robustness. In Part 3, I explore the notion of the ‘weight of evidence’ typically associated with Keynes. I argue that the Bayesian is bound to struggle with this notion, and draw some lessons from this fact. Finally, I critically assess some recent proposals for a new IPCC uncertainty framework that significantly depart from the current one. (shrink)

This paper analyzes three contrasting strategies for modeling intentional agency in contemporary analytic philosophy of mind and action, and draws parallels between them and similar strategies of scientific model-construction. Gricean modeling involves identifying primitive building blocks of intentional agency, and building up from such building blocks to prototypically agential behaviors. Analogical modeling is based on picking out an exemplary type of intentional agency, which is used as a model for other agential types. Theoretical modeling involves reasoning about intentional agency in (...) terms of some domain-general framework of lawlike regularities, which involves no detailed reference to particular building blocks or exemplars of intentional agency. Given the contrasting procedural approaches that they employ and the different types of knowledge that they embody, the three strategies are argued to provide mutually complementary perspectives on intentional agency. (shrink)

This paper presents an account of how to evaluate formal models of science: models and simulations in social epistemology designed to draw normative conclusions about the social structure of scientific research. I argue that such models should be evaluated according to their representational and predictive accuracy. Using these criteria and comparisons with familiar models from science, I argue that most formal models of science are incapable of supporting normative conclusions.

Microbial model systems have a long history of fruitful use in fields that include evolution and ecology. In order to develop further insight into modelling practice, we examine how the competitive exclusion and coexistence of competing species have been modelled mathematically and materially over the course of a long research history. In particular, we investigate how microbial models of these dynamics interact with mathematical or computational models of the same phenomena. Our cases illuminate the ways in which microbial systems and (...) equations work as models, and what happens when they generate inconsistent findings about shared targets. We reveal an iterative strategy of comparative modelling in different media, and suggest reasons why microbial models have a special degree of epistemic tractability in multimodel inquiry. (shrink)

This article on the epistemology of computational models stems from an analysis of the Gaïa hypothesis. It begins with James Kirchner’s criticisms of the central computational model of GH: Daisyworld. Among other things, the model has been criticized for being too abstract, describing fictional entities and trying to answer counterfactual questions. For these reasons the model has been considered not testable and therefore not legitimate in science, and in any case not very interesting since it explores non actual issues. This (...) criticism implicitly assumes that science should only be involved in the making of models that are “actual” and “specific”. I challenge both of these criticisms in this article. First by showing that although the testability—understood as the comparison of model output with empirical data—is an important procedure for explanatory models, there are plenty of models that are not testable. The fact that these are not testable has nothing to do with their being “abstract” or “what-if” but with their being predictive models. Secondly, I argue that “abstract” and “what-if” models aim at epistemic purposes distinct from those pursued by “actual and specific models”. Abstract models are used to propose how-possibly explanation or to pursue theorizing. What-if models are used to attribute causal or explanatory power to a variable of interest. The fact that they aim at different epistemic goals entails that it may not be accurate to consider the choice between different kinds of model as a “strategy“. (shrink)

This paper considers the importance of unification in the context of developing scientific theories. I argue that unifying hypotheses are not valuable simply because they are supported by multiple lines of evidence. Instead, they can be valuable because they guide experimental research in different domains in such a way that the results from those experiments inform the scope of the theory being developed. I support this characterization by appealing to the early development of quantum theory. I then draw some comparisons (...) with discussions of robustness reasoning. (shrink)

Robert Sugden argues that robustness analysis cannot play an epistemic role in grounding model-world relationships because the procedure is only a matter of comparing models with each other. We posit that this argument is based on a view of models as being surrogate systems in too literal a sense. In contrast, the epistemic importance of robustness analysis is easy to explicate if modelling is viewed as extended cognition, as inference from assumptions to conclusions. Robustness analysis is about assessing the reliability (...) of our extended inferences, and when our confidence in these inferences changes, so does our confidence in the results. Furthermore, we argue that Sugden’s inductive account relies tacitly on robustness considerations. (shrink)

Odenbaugh and Alexandrova provide a challenging critique of the epistemic benefits of robustness analysis, singling out for particular criticism the account we articulated in Kuorikoski et al.. Odenbaugh and Alexandrova offer two arguments against the confirmatory value of robustness analysis: robust theorems cannot specify causal mechanisms and models are rarely independent in the way required by robustness analysis. We address Odenbaugh and Alexandrova’s criticisms in order to clarify some of our original arguments and to shed further light on the properties (...) of robustness analysis and its epistemic rationale. (shrink)

Amalgamating evidence from heterogeneous sources and across levels of inquiry is becoming increasingly important in many pure and applied sciences. This special issue provides a forum for researchers from diverse scientific and philosophical perspectives to discuss evidence amalgamation, its methodologies, its history, its pitfalls, and its potential. We situate the contributions therein within six themes from the broad literature on this subject: the variety-of-evidence thesis, the philosophy of meta-analysis, the role of robustness/sensitivity analysis for evidence amalgamation, its bearing on questions (...) of extrapolation and external validity of experiments, its connection with theory development, and its interface with causal inference, especially regarding causal theories of cancer. (shrink)

In experimental settings, scientists often “make” new things, in which case the aim is to intervene in order to produce experimental objects and processes—characterized as ‘effects’. In this discussion, I illuminate an important performative function in measurement and experimentation in general: intervention-based experimental production. I argue that even though the goal of IEP is the production of new effects, it can be informative for causal details in scientific representations. Specifically, IEP can be informative about causal relations in: regularities under study; (...) ‘intervention systems’, which are measurement/experimental systems; and new technological systems. (shrink)

This paper provides an inferentialist account of model-based understanding by combining a counterfactual account of explanation and an inferentialist account of representation with a view of modeling as extended cognition. This account makes it understandable how the manipulation of surrogate systems like models can provide genuinely new empirical understanding about the world. Similarly, the account provides an answer to the question how models, that always incorporate assumptions that are literally untrue of the model target, can still provide factive explanations. Finally, (...) the paper shows how the contrastive counterfactual theory of explanation can provide tools for assessing the explanatory power of models. (shrink)

(2013). Modeling herding behavior and its risks. Journal of Economic Methodology: Vol. 20, Methodology, Systemic Risk, and the Economics Profession, pp. 6-18. doi: 10.1080/1350178X.2013.774843.

The aim of this paper is to develop ideas about robustness analyses. I introduce a form of robustness analysis that I call sufficient parameter robustness, which has been neglected in the literature. I claim that sufficient parameter robustness is different from derivational robustness, the focus of previous research. My purpose is not only to suggest a new taxonomy of robustness, but also to argue that previous authors have concentrated on a narrow sense of robustness analysis, which they have inadequately distinguished (...) from other investigations of models such as sensitivity analysis. (shrink)

In recent years, the philosophical focus of the modeling literature has shifted from descriptions of general properties of models to an interest in different model functions. It has been argued that the diversity of models and their correspondingly different epistemic goals are important for developing intelligible scientific theories. However, more knowledge is needed on how a combination of different epistemic means can generate and stabilize new entities in science. This paper will draw on Rheinberger’s practice-oriented account of knowledge production. The (...) conceptual repertoire of Rheinberger’s historical epistemology offers important insights for an analysis of the modelling practice. I illustrate this with a case study on network modeling in systems biology where engineering approaches are applied to the study of biological systems. I shall argue that the use of multiple means of representations is an essential part of the dynamic of knowledge generation. It is because of – rather than in spite of – the diversity of constraints of different models that the interlocking use of different epistemic means creates a potential for knowledge production. (shrink)

All economic models involve abstractions and idealisations. Economic theory itself does not tell which idealizations are truly fatal or harmful for the result and which are not. This is why much of what is seen as theoretical contribution in economics is constituted by deriving familiar results from different modelling assumptions. If a modelling result is robust with respect to particular modelling assumptions, the empirical falsity of these particular assumptions does not provide grounds for criticizing the result. In this paper we (...) demonstrate how derivational robustness analysis does carry epistemic weight and answer criticism concerning its non-empirical nature and the problematic form of the required independence of the ways of derivation. The epistemic rationale and importance of robustness analysis also challenge some common conceptions of the role of theory in economics. (shrink)

In this paper I begin with a recent challenge to the Semantic Approach and identify an underlying assumption, namely that identity conditions for theories should be provided. Drawing on previous work, I suggest that this demand should be resisted and that the Semantic Approach should be seen as a philosophical device that we may use to represent certain features of scientific practice. Focussing on the partial structures variant of that approach, I then consider a further challenge that arises from a (...) concern with the role of idealisations in that practice. I argue that the partial structures approach is capable of meeting this challenge and I conclude with some broader observations about the role of such formal accounts within the philosophy of science. (shrink)

This article contributes to the revision of the procedure of robustness analysis of mathematical models in epistemic democracy using the systematic review method. It identifies the drawbacks of robustness analysis in epistemic democracy in terms of sample universality and inference from samples with the same results. To exemplify the effectiveness of systematic review, this article conducted a pilot review of diversity trumps ability theorem models, which are mathematical models of deliberation often cited by epistemic democrats. A review of nine models (...) extracted from 352 papers exemplifies the effectiveness of robustness analysis supplemented by systematic review in epistemic democracy. (shrink)

It is undeniable that much scientific work is model-based. Despite this, the justification for this reliance on models is still controversial. A particular difficulty here is the fact that many scientific models are based on assumptions that do not describe the exact details of many or even any empirical situations very well. This raises the question of why it is that, despite their frequent lack of descriptive accuracy, employing models is scientifically useful.One..

Philosophers of science have developed several accounts of how consideration of scientific models can prompt learning about real-world targets. In recent years, various authors advocated the thesis that consideration of so-called minimal models can prompt learning about such targets. In this paper, I draw on the philosophical literature on scientific modelling and on widely cited illustrations from economics and biology to argue that this thesis fails to withstand scrutiny. More specifically, I criticize leading proponents of such thesis for failing to (...) explicate in virtue of what properties or features minimal models supposedly prompt learning and for substantially overstating the epistemic import of minimal models. I then examine and refute several arguments one may put forward to demonstrate that consideration of minimal models can prompt learning about real-world targets. In doing so, I illustrate the implications of my critique for the wider debate on the epistemology of scientific modelling. (shrink)

This article examines a metaphilosophical issue, namely existing disagreements in philosophy of science about the significance of using multiple means of determination in scientific practice. We argue that this disagreement can, in part, be resolved by separating different questions that can be asked about the use of multiple means of determination, including the following: what can be concluded from the convergence of data or the convergence of claims about phenomena? Are the conclusions drawn from the convergence of data and of (...) statements about phenomena of special importance to the debate about realism and antirealism? Do inferences based on multiple means of determination have stronger epistemic force than inferences that are secured in other ways? Is the epistemic goal of deploying multiple means of determination well entrenched within the scientific community? Most of these questions can be discussed both in a formal and in an empirical perspective. If the differences in perspective are taken into account, some disagreements can be easily resolved. In part, however, the disagreements reflect historiographical challenges that are very difficult, if not impossible to meet. (shrink)

This paper examines a series of Schelling-like models of residential segregation, in which agents prefer to be in the minority. We demon- strate that as long as agents care about the characteristics of their wider community, they tend to end up in a segregated state. We then investigate the process that causes this, and conclude that the result hinges on the similarity of informational states amongst agents of the same type. This is quite di erent from Schelling-like behavior, and sug- (...) gests (in his terms) that segregation is an instance of macro behavior which can arise from a wide variety of micro motives. (shrink)

This paper distinguishes between two arguments based on measurement robustness and defends the epistemic value of robustness for the assessment of measurement reliability. I argue that the appeal to measurement robustness in the assessment of measurement is based on a different inferential pattern and is not exposed to the same objections as the no-coincidence argument which is commonly associated with the use of robustness to corroborate individual results. This investigation sheds light on the precise meaning of reliability that emerges from (...) measurement assessment practice. In addition, by arguing that the measurement assessment robustness argument has similar characteristics across the physical, social and behavioural sciences, I defend the idea that there is continuity in the notion of measurement reliability across sciences. (shrink)

This article examines the issue of whether consideration of so-called minimal models can prompt learning about real-world targets. Using a widely cited example as a test case, it argues against the increasingly popular view that consideration of minimal models can prompt learning about such targets. The article criticizes influential defenses of this view for failing to explicate by virtue of what properties or features minimal models supposedly prompt learning. It then argues that consideration of minimal models cannot prompt learning about (...) real-world targets unless one supplements these models with additional information or presuppositions concerning such targets. (shrink)

ABSTRACT There is a new argument form within theoretical biology. This form takes as input competing explanatory models; it yields as output the conclusion that one of these models is more plausible than the others. The driving force for this argument form is an analysis showing that one model exhibits more parametric robustness than its competitors. This article examines these inferences to the more robust explanation, analysing them as variants of inference to the best explanation. The article defines parametric robustness (...) and distinguishes it from more familiar kinds of robustness. The article also argues that parametric robustness is an explanatory virtue not subsumed by more familiar explanatory virtues, and that the plausibility verdicts in the conclusions of inferences to the more robust explanations are best interpreted as guidance for research activity, rather than claims about likely truth. 1Introducing Inference to the More Robust Explanation 2Inference to the More Robust Explanation in the Study of Apoptosis 2.1Regulating apoptosis 2.2Competing models and evidential indecision 2.3Measuring robustness 2.4Robustness as a guide to plausibility 2.5Varieties of robustness 3Inference to the More Robust Explanation as Inference to the Best Explanation 3.1The structure of inference to the best explanation 3.2Parametric robustness as an explanatory virtue rather than an explanandum 3.3Relation of parametric robustness to other explanatory virtues 4Epistemological Significance of Inference to the More Robust Explanation 4.1Plausibility in practice 4.2Plausibility in principle 5Conclusion. (shrink)

Within the modeling literature, there is often an implicit assumption about the relationship between a given model and a scientific explanation. The goal of this article is to provide a unified framework with which to analyze the myriad relationships between a model and an explanation. Our framework distinguishes two fundamental kinds of relationships. The first is metaphysical, where the model is identified as an explanation or as a partial explanation. The second is epistemological, where the model produces understanding that is (...) related to the explanation of interest. Our analysis reveals that the epistemological relationships are not always dependent on the metaphysical relationships, contrary to what has been assumed by many philosophers of science. Moreover, we identify several importantly different ways that scientific models instantiate these relationships. We argue that our framework provides novel insights concerning the nature of models, explanation, idealization, and understanding. (shrink)

The robust behavior of the patent citation network is a complex target of recent bottom-up models in science. This paper investigates the purpose and testing of three especially simple bottom-up models of the citation count distribution observed in the patent citation network. The complex causal webs in the models generate weakly emergent patterns of behavior, and this explains both the need for empirical observation of computer simulations of the models and the epistemic harmlessness of the resulting epistemic opacity.

We develop an account of how mutually inconsistent models of the same target system can provide coherent information about the system. Our account makes use of ideas from the debate surrounding rob...

Policy-makers face an uncertain world. One way of getting a handle on decision-making in such an environment is to rely on evidence. Despite the recent increase in post-fact figures in politics, evidence-based policymaking takes centre stage in policy-setting institutions. Often, however, policy-makers face large volumes of evidence from different sources. Robustness analysis can, prima facie, handle this evidential diversity. Roughly, a hypothesis is supported by robust evidence if the different evidential sources are in agreement. In this thesis, I strengthen the (...) case for the use of robustness analysis in evidence-based policymaking by answering open research questions about this inference technique. First, I argue that existing taxonomies miss a fruitful category of robustness reasoning, that is predictive stability. Second, I claim that derivational robustness analysis – the investigation of whether the results of different models are in agreement – can yield interesting insights even if not the entire relevant model space is covered by available models or if the model results are only partially in agreement. Third, I claim that expert knowledge is necessary to address questions that arise when one applies measurement robustness analysis – the investigation into whether multiple means of measurement yield the same result. Finally, I argue that, in situations where evidence from different measurements is not in agreement, it can be advisable to no longer take all of the evidence into account. This can be done in a rationally defensible way by choosing the most adequate theory or model underlying parts of the evidence set. I discuss examples from climate, medical, and economic policy-making to establish my claims. (shrink)

Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...) across the species boundary of human and personalized mouse model, historically as well as in contemporary practices. PDXs raise interesting questions about the relation between animal model and human patient, and about the capacity of hybrid or interspecies models to close existing translational gaps. We highlight that the translational potential of PDXs not only depends on representational matching of model and target, but also on temporal alignment between model development and practical uses. Aside from the importance of ensuring temporal stability of human tumors in a murine body, the mouse avatar concept rests on the possibility of aligning the temporal horizons of the clinic and the lab. We examine strategies to address temporal challenges, including cryopreservation and biobanking, as well as attempts to speed up translation through modification and use of faster developing organisms. We discuss how featured model virtues change with precision oncology, and contend that temporality is a model feature that deserves more philosophical attention. (shrink)

These preprints were automatically compiled into a PDF from the collection of papers deposited in PhilSci-Archive in conjunction with the PSA 2018.