This paper investigated the part played by collaborative practices in chaneling the work of prominent biochemists into the development of molecular biology. The RNA collaborative network that emerged in the 1960s in France encompassed a continuum of activities that linked laboratories to policy-making centers. New institutional frameworks such as the DGRST committees were instrumental in establishing new patterns of funding, and in offering arenas for multidisciplinary debates and boundary assessment. It should be stressed however, that although this collaborative network was (...) based on centralized initiatives aimed at developing molecular biology as a new biological specialty, it operated above all as a nexus of practices. The main argument of this paper is that the central allocation of funds and resources, exemplified by the DGRST operation, actually enhanced the creation of a self-conscious community of biochemists turned molecular biologists by virtue of an increased circulation of tools, skills, and results that took place within the RNA network and a few analogous systems of exchange.Having hands on “things” viewed as identical for all practical purposes was a potent factor in changing the experimental systems and their meanings. Limited but shared means of doing helped to reduce uncertainties, change representations, and turn contingent decisions into meaningful choices. The collaborative enterprises then resulted in personal contacts and the transfer of skills and materials, which gradually incorporated the biochemical tools into systems producing facts relevant to molecular biology as defined by its early practitioners. In that sense, networking was a regulatory process that stabilized new research objects and acculturated French biochemists.The mere existence of such a collaborative network also changed the scale of the disciplining process. Collaborations may have been started for contingent motives, but multiple exchanges resulted in the emergence of a new collective, and amplified small displacements. Collaborations, however, worked both ways, and the RNA network may be viewed as an efficient “trading-post.” An unexpected outcome of the development of a conversion zone is the fact that, by the late 1960s, the former biochemists dominated the “new” world of molecular biology — both in terms of research habits, since interests in structural studies dominated the field, and in terms of institutional initiatives such as the creation of laboratories and institutes for molecular biology.As an example of the cognitive displacements achieved by the network, I have focused here on the stabilization of “messenger RNA” as a new biological entity. This process illustrates the role of “boundary objects” and other mediating innovations in the development of disciplinary structures. Students of science trained in the symbolic interactionism tradition have proposed that “boundary objects” enhance the multiple interactions between heterogeneous social worlds: they are robust enough to enhance unity, but plastic enough to be manipulated in different social and cultural contexts.81 Within the emerging network, messenger RNA was a weakly structured “genetic information carrier” in common use, but it could, at the same time, be a strongly structured “macromolecular structure” adapted to practical and local uses. Consequently, messenger RNA favored the association of groups of heterogeneous scientists with backgrounds and interests in medical biochemistry, genetics, physical chemistry, organic chemistry, and so forth. This contrast between general and local uses was also instrumental in integrating the manipulation of things and the negotiation of aims. In contrast to transfer RNAs, which in the French context remained objects for chemical (and mainly structural) studies, messenger RNA became a key component of the new culture of “genetic information”. Messenger RNA was a loose theoretical entity described as a “genetic information carrier” in the policy-making documents, while operational but tacit and more conflicting definitions prevailed at the bench. In other words, messenger RNA was not only a classical “boundary object” but also a “flag object,” which tightened the collaborative network by mediating between the DGRST offices and the laboratories. (shrink)

In setting a framework for the papers that follow, I have explored some of the major characteristics of disciplines and the factors that breed ethnocentrism among disciplines, considered what factors can lead researchers to cross disciplinary boundaries, and explored the kinds of conceptual as well as social and institutional products that result from cross-disciplinary work. While drawing out the significance of these various considerations for psycholinguistics, I have presented a fairly general conceptual analysis that is not restricted to this case. (...) The following papers consider in much more detail the particular features of the historical and current endeavors in developing psycholinguistics. (shrink)

Focusing on the history of prehistoric archaeology in the 20th century, this papers shows (1) that statistical multidimensional analyses were carried out by a new kind of actors who challenged the previous common language shared by prehistorians. This fundamental change was important, considering that (2) language is a fundamental point for the epistemology of archaeology. However, a comparison of multidimensional analyses applications over time shall make clear that (3) the differences are mostly a generational matter: the transmission processes between them (...) will be addressed. (shrink)

The majority of analyses investigating the professionalisation of scientific domains tend to assume the linear and general features of this transformation. These studies focus on the shift from a non-professionalised state to a professionalised state. This dual approach, however, crucially lacks some other aspects of the process of professionalisation. This issue is discussed within the context of the growth of prehistoric archaeology in France from the 1940s, by observing scientific societies, national research organisations and their social networks. Looking at the (...) scale of Georges Laplace’s career and that of his research group, which studied the typologie analytique method, this article demonstrates the benefits of a ternary model which also encompasses the modes of refusal of professionalisation. (shrink)

The integration of ideas, methods, and data from diverse disciplines has been a transformative force in science and higher education, attracting policy interventions, program innovations, financial resources, and talented people. Much energy has been invested in producing a new generation of scientists trained to work fluidly across disciplines, sectors, and research problems, yet the success of such investments has been difficult to measure. Using the Integrative Graduate Education and Research Training (IGERT) program of the U.S. National Science Foundation as a (...) strategic research site, we conducted an experiment to determine whether and how the process and products of research of IGERT-trained scientists differ from those of scientists trained in disciplinary graduate programs. Among scientists in the early years of graduate study we found substantial and consistent differences suggesting that interdisciplinary training improved the quality and process of research, but this pattern was equally strongly reversed among students in the latter years of graduate study. Using systematic observation and other data we suggest why this might be so, then discuss the implications of these results for the design and conduct of graduate education and research. (shrink)

This article provides an overview of the origins and development of green chemistry. Aiming to contribute to the understanding of green chemistry, basically from a historical point of view, this overview argues that contextual influences and the user friendliness of the term are drivers for the explosive growth of green chemistry. It is observed that political support for its development has been significant, in which the Pollution Prevention Act of 1990 was a formal political starting-point, but informally the origins of (...) green chemistry go back to before 1990. US EPA played an important role in all this, but did not solely contribute to the growth of green chemistry. (shrink)

Many studies of the unification of science focus on the theories of different disciplines. The model for integration is the theory reduction model. This paper argues that the embodiment of theories in scientists, and the institutions in which scientists work and the instruments they employ, are critical to the sort of integration that actually occurs in science. This paper examines the integration of scientific endeavors that emerged in cell biology in the period after World War II when the development of (...) cell fractionation and electron microscopy made serious investigations of cell organelles possible. One surprising feature of such integration is that it generated further disintegration as the new institutions of cell biology separated the practitioners of the new discipline from other, closely related biological disciplines. (shrink)

During large parts of its history chemistry was seen as a science of progress, admired by many. But contemporary public debates on chemistry have been quite critical, mainly for environmental reasons. Therefore is it interesting to note that in the course of the 1990s “green chemistry” emerged. The origins, scientific meaning and drivers behind the spectacular growth of that new field are the subject of Research between Science, Society and Politics: The History and Scientific Development of Green Chemistry. The scientific (...) character of green chemistry has been a matter of dispute since its inception. This book aims to clarify that dispute. It presents a historical analysis of its birth and evolution, with a special focus on the USA, the UK and the Netherlands and the chemical societies in these countries. The emergence of green chemistry differed from one country to another, which is analyzed and compared as well. Based on quantitative and qualitive research methods and a wide range of primary sources never studied before, this book ultimately offers a new characterization of “green chemistry”. It should be of interest to chemists, policy makers and historians & philosophers of chemistry, because Research between Science, Society and Politics accounts for both internal scientific as well as socio-cultural factors that played a role during the emergence and growth of green chemistry. (shrink)

The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück’s phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA, genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at the bench than DNA due (...) to the availability of specific RNases, enzymes used as chemical tools to analyse RNA. Finally, RNA phages provided scientists with a pure source of mRNA to investigate the genetic code, genes and even a genome sequence. This paper focuses on Walter Fiers’ laboratory at Ghent University and their work on the RNA phage MS2. When setting up his Laboratory of Molecular Biology, Fiers planned a comprehensive study of the virus with a strong emphasis on the issue of structure. In his lab, RNA sequencing, now a little-known technique, evolved gradually from a means to solve the genetic code, to a tool for completing the first genome sequence. Thus, I follow the research pathway of Fiers and his ‘RNA phage lab’ with their evolving experimental system from 1960 to the late 1970s. This study illuminates two decisive shifts in post-war biology: the emergence of molecular biology as a discipline in the 1960s in Europe and of genomics in the 1990s. (shrink)

Should governments accept the principle of devoting a proportion of their resources to funding basic research? From the standpoint of economics, science should be considered as a public good and for that reason it should be protected from market forces. This article tries to show that this result can only be maintained at the price of abandoning arguments traditionally deployed by economists themselves. It entails a complete reversal of our habitual ways of thinking about public goods. In order to bring (...) this reversal about, this article draws on the central results obtained by the anthropology and sociology of science and technology over the past several years. Science is a public good, not because of its intrinsic properties but because it is a source of diversity and flexibility. (shrink)

ArgumentThis paper challenges the use of the notion of “culture” to describe a particular organization of mathematical knowledge, shared by a few mathematicians over a short period of time in the second half of the nineteenth century. This knowledge relates to “geometrical equations,” objects that proved crucial for the mechanisms of encounters between equation theory, substitution theory, and geometry at that time, although they were not well-defined mathematical objects. The description of the mathematical collective activities linked to “geometrical equations,” and (...) especially the technical aspects of these activities, is made on the basis of a sociological definition of “culture.” More precisely, after an examination of the social organization of the group of mathematicians, I argue that these activities form an intricate system of patterns, symbols, and values, for which I suggest a characterization as a “cultural system.”. (shrink)

A layered interpretation of the history of chemistry is discussed through chemical revolutions. A chemical revolution mainly by emplacement, instead of replacement, procedures were identified by: a radical reinterpretation of existing thought recognized by contemporaries themselves, which means the appearance of new concepts and the arrival of new theories; the use of new instruments changed the way in which its practitioners looked and worked in the world and through exemplars, new entities were discovered or incorporated; the opening of new subdisciplines, (...) which produced, separated scientific communities. The fourth chemical revolution, fundamentally characterized by the incorporation of new instruments in chemical practices is discussed. (shrink)

Is knowledge in the natural sciences discovered or constructed? For objectivists, scientific knowledge is discovered through investigations into a mind-independent, natural world. For constructivists, such knowledge is produced through negotiations among members of a professional guild. I examine the clash between the two positions and propose that scientific knowledge is the concurrent outcome from investigations into a natural world and from consensus reached through negotiations of a professional guild. Specifically, I introduce the general methodological notion, instituting science, which incorporates both (...) the discovery and the construction processes in the generation of scientific knowledge. To that end, I use a case study from the biomedical sciences to illustrate the notion. I conclude with a discussion of how this methodological notion helps to address the debate between objectivists and constructivists over the generation of scientific knowledge, and of how it compares with others who have also attempted to address the debate. (shrink)

An ethnographic approach to the South Indian festival Ayudha Puja reveals that the celebration plays a role in the construction of scientific communities. Ayudha Puja has the ability to absorb westerners, non-Hindus, and non-Brahmins into Indian science and engineering communities and is thus widely practiced in South Indian industry and academia. The practice of Ayudha Puja thus parallels what M. N. Srinivas labels “Sanskritization.” Within India, the process of Sanskritization refers to the adoption of high-caste habits and diet by upwardly (...) mobile lower-caste communities. While not actually an example of Sanskritization, participation in Ayudha Puja is analogous to that process: by joining a Hindu rite within the scientific and professional workspace, outsiders become part of local laboratory, department, or office culture. Such practices reveal the need for scholars to investigate scientific community building outside the domain of how scientists reveal new facts about the world. (shrink)

The issue of the conservatism of scientific research questions the nature and the role of the internal and external forces controlling the emergence of new research questions or problems, the exploration of risky directions of research, or the use of risky research methods. This issue has recently gained a new framing in connection with the growing importance of the peer-review process and of the social and economic pressures weighing on the funding of scientific research. Current literature then interrogates the external (...) and internal features that promote what are described as conservative tendencies in scientific research. In this paper, I propose to contribute to this debate by clarifying what might be internal sources of conservatism in science; that is, that are inherent to the research process itself. I distinguish two possible understandings of the sources and manifestations of this internal conservatism. I first present a representational description of the nature and origin of conservatism in science, which brings to the fore the difficulties researchers find in setting aside their conceptual framework. I then offer for consideration a larger perspective on conservatism by arguing for the existence of a practical conservatism generated by all the dimensions of scientific activities. In this framework, conservatism in science can be explained by the tendency of all practices to close in on their own local objectives. I illustrate this view by reference to an historical episode: the discovery of the chemical nature of genes by Avery. (shrink)

: This paper seeks to contribute to the development of a sociological understanding of scientific change. It first presents a conceptual framework for defining and understanding the conditions that give rise to episodes of cumulative change (both as the selective reconstruction of events and as the patterned structuring of innovations over time and across different settings). It argues that one of the most powerful structuring mechanisms is the existence of standardized research technologies. Then, the development of electroencephalography (EEG) is presented (...) as an illustrative case study. The EEG supported a dramatic episode of development in brain science, and did so primarily through technological standardization and reliability. The case shows how standard and manipulable technologies provide a framework for orderly change both in retrospective accounts and in specific historical periods of scientific practice. (shrink)

Este artículo tiene por objetivo general indagar acerca de los procesos de institucionalización de una nueva disciplina científica. En particular, se analizan los desplazamientos que se producen entre disciplinas al emerger una nueva: la biología molecular. Se presenta en este artículo el caso del Instituto Nacional de Tecnología Agropecuaria (INTA) de Argentina, institución creada en 1956 para realizar investigaciones, innovaciones y extensionismo para el sector agropecuario. De esa manera, el trabajo presenta los cambios en las disciplinas de las que provienen (...) los investigadores del INTA, desde su creación en 1956 hasta 2010. La investigación que se presenta se centra en un análisis cuantitativo en relación a las disciplinas de origen de los investigadores que se incorporaron a la institución. Al mostrar los desplazamientos entre disciplinas, este artículo pretende contribuir al estudio sobre los conflictos entre las mismas. Pues se sugiere que la emergencia de una nueva disciplina no implica solamente la apertura de nuevas profesiones, instituciones, temas y técnicas de investigación, sino también el desplazamiento de otras anteriormente instaladas, y que tales desplazamientos estarían en la raíz de las tensiones que se registran en la institucionalización de una nueva disciplina. This article aims to investigate the process of institutionalization of a new scientific discipline. In particular, the displacements that occur between disciplines with the emergence of a new one: molecular biology. The case presented in this article is the National Institute of Agricultural Technology (INTA) of Argentina, institution created in 1956 for research, innovation and extension to the agricultural sector. Thus, the paper presents the changes in the disciplines from which INTA's researchers come, since its inception in 1956 until 2010. The research presented in this article focuses on a quantitative analysis in relation to the disciplines of origin of the researchers who joined the institution. By showing the displacements between disciplines, this article aims to contribute to the study of the conflicts between them. For it suggests that the emergence of a new discipline involves not only the opening of new professions, institutions, research subjects and techniques, but also the displacement of other previously installed. These displacements would be at the root of the tensions that occur in the institutionalization of a new discipline. (shrink)

ArgumentKuhnian phases of paradigmatic development correspond to characteristic variations of citation measures. These correlations can in turn be predicted from a simple model of human information processing when applied to the common environments of scientists. By combining a scientometric and a human information processing approach to the history of scientific thought, structures of disciplinary development, and in particular paradigmatic cycles, can be more reliably assessed than before. Consequently, the quantitative historian of science is liberated to some extent from the vagaries (...) of qualitative judgment, as exemplified by traditional narrative type approaches to the history of science. (shrink)

In setting a framework for the papers that follow, I have explored some of the major characteristics of disciplines and the factors that breed ethnocentrism among disciplines, considered what factors can lead researchers to cross disciplinary boundaries, and explored the kinds of conceptual as well as social and institutional products that result from cross-disciplinary work. While drawing out the significance of these various considerations for psycholinguistics, I have presented a fairly general conceptual analysis that is not restricted to this case. (...) The following papers consider in much more detail the particular features of the historical and current endeavors in developing psycholinguistics. (shrink)