The philosophical debate around the impact of machine learning in science is often framed in terms of a choice between AI and classical methods as mutually exclusive alternatives involving difficult epistemological trade-offs. A common worry regarding machine learning methods specifically is that they lead to opaque models that make predictions but do not lead to explanation or understanding. Focusing on the field of molecular biology, I argue that in practice machine learning is often used with explanatory aims. More specifically, I (...) argue that machine learning can be tightly integrated with other, more traditional, research methods and in a clear sense can contribute to insight into the causal processes underlying phenomena of interest to biologists. One could even say that machine learning is not the end of theory in important areas of biology, as has been argued, but rather a new beginning. I support these claims with a detailed discussion of a case study involving gene regulation by microRNAs. (shrink)

I argue that ML models used in science function as highly idealized toy models. If we treat ML models as a type of highly idealized toy model, then we can deploy standard representational and epistemic strategies from the toy model literature to explain why ML models can still provide epistemic success despite their lack of similarity to their targets.

The counterfactual approach to explainable AI (XAI) seeks to provide understanding of AI systems through the provision of counterfactual explanations. In a recent systematic review, Chou et al. (Inform Fus 81:59–83, 2022) argue that the counterfactual approach does not clearly provide causal understanding. They diagnose the problem in terms of the underlying framework within which the counterfactual approach has been developed. To date, the counterfactual approach has not been developed in concert with the approach for specifying causes developed by Pearl (...) (Causality: Models, reasoning, and inference. Cambridge University Press, 2000) and Woodward (Making things happen: A theory of causal explanation. Oxford University Press, 2003). In this paper, I build on Chou et al.’s work by applying the Pearl-Woodward approach. I argue that the standard counterfactual approach to XAI is capable of delivering causal understanding, but that there are limitations on its capacity to do so. I suggest a way to overcome these limitations. (shrink)

Deep learning (DL) has become increasingly central to science, primarily due to its capacity to quickly, efficiently, and accurately predict and classify phenomena of scientific interest. This paper seeks to understand the principles that underwrite scientists’ epistemic entitlement to rely on DL in the first place and argues that these principles are philosophically novel. The question of this paper is not whether scientists can be justified in trusting in the reliability of DL. While today’s artificial intelligence exhibits characteristics common to (...) both scientific instruments and scientific experts, this paper argues that the familiar epistemic categories that justify belief in the reliability of instruments and experts are distinct, and that belief in the reliability of DL cannot be reduced to either. Understanding what can justify belief in AI reliability represents an occasion and opportunity for exciting, new philosophy of science. (shrink)

Machine learning (ML) models recently led to major breakthroughs in predictive tasks in the natural sciences. Yet their benefits for the social sciences are less evident, as even high-profile studies on the prediction of life trajectories have shown to be largely unsuccessful – at least when measured in traditional criteria of scientific success. This paper tries to shed light on this remarkable performance gap. Comparing two social science case studies to a paradigm example from the natural sciences, we argue that, (...) in addition to explanation, prediction is an important goal of social science – and we identify constraints that impede pure ML prediction from being successful in that field. As a remedy, we outline elements of an integrative modelling approach that combines explanatory models and predictive ML models. (shrink)