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The Unified Medical Language System and the Gene Ontology: Some critical reflections

In A. Günter, R. Kruse & B. Neumann (eds.), KI 2003: Advances in Artificial Intelligence. Berlin: Springer. pp. 135-148 (2003)

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  1. Coordination Instead of Consensus Classification: Insights From Systematics for Bio-Ontologies.Beckett Sterner, Joeri Witteveen & Nico Franz - forthcoming - History and Philosophy of the Life Sciences.
    Big data is opening new angles on old questions about scientific progress. Is scientific knowledge cumulative? If yes, how does it make progress? In the life sciences, what we call the Consensus Principle has dominated the design of data discovery and integration tools: the design of a formal classificatory system for expressing a body of data should be grounded in consensus. Based on current approaches in biomedicine and systematic biology, we formulate and compare three types of the Consensus Principle: realist, (...)
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  • A Plea for Complex Categories in Ontologies.Alexandra Arapinis & Laure Vieu - 2015 - Applied Ontology 10 (3-4):285-296.
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  • A Terminological and Ontological Analysis of the NCI Thesaurus.Werner Ceusters, Barry Smith & Louis Goldberg - 2005 - Methods of Information in Medicine 44 (4):498-507.
    We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad range (...)
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  • Ontology-Assisted Database Integration to Support Natural Language Processing and Biomedical Data-Mining.Jean-Luc Verschelde, Marianna C. Santos, Tom Deray, Barry Smith & Werner Ceusters - 2004 - Journal of Integrative Bioinformatics. Repr. In: Yearbook of Bioinformatics , 39–48 1:1-10.
    Successful biomedical data mining and information extraction require a complete picture of biological phenomena such as genes, biological processes, and diseases; as these exist on different levels of granularity. To realize this goal, several freely available heterogeneous databases as well as proprietary structured datasets have to be integrated into a single global customizable scheme. We will present a tool to integrate different biological data sources by mapping them to a proprietary biomedical ontology that has been developed for the purposes of (...)
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  • Saliva Ontology: An Ontology-Based Framework for a Salivaomics Knowledge Base.Jiye Ai, Barry Smith & David Wong - 2010 - BMC Bioinformatics 11 (1):302.
    The Salivaomics Knowledge Base (SKB) is designed to serve as a computational infrastructure that can permit global exploration and utilization of data and information relevant to salivaomics. SKB is created by aligning (1) the saliva biomarker discovery and validation resources at UCLA with (2) the ontology resources developed by the OBO (Open Biomedical Ontologies) Foundry, including a new Saliva Ontology (SALO). We define the Saliva Ontology (SALO; http://www.skb.ucla.edu/SALO/) as a consensus-based controlled vocabulary of terms and relations dedicated to the salivaomics (...)
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  • Towards a Proteomics Meta-Classification.Anand Kumar & Barry Smith - 2004 - In IEEE Fourth Symposium on Bioinformatics and Bioengineering, Taichung, Taiwan. IEEE Press. pp. 419–427.
    that can serve as a foundation for more refined ontologies in the field of proteomics. Standard data sources classify proteins in terms of just one or two specific aspects. Thus SCOP (Structural Classification of Proteins) is described as classifying proteins on the basis of structural features; SWISSPROT annotates proteins on the basis of their structure and of parameters like post-translational modifications. Such data sources are connected to each other by pairwise term-to-term mappings. However, there are obstacles which stand in the (...)
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  • Ontologies and Terminologies: Continuum or Dichotomy?Natalia Grabar, Thierry Hamon & Olivier Bodenreider - 2012 - Applied Ontology 7 (4):375-386.
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  • Barry Smith an Sich.Gerald J. Erion & Gloria Zúñiga Y. Postigo (eds.) - 2017 - Cosmos + Taxis.
    Festschrift in Honor of Barry Smith on the occasion of his 65th Birthday. Published as issue 4:4 of the journal Cosmos + Taxis: Studies in Emergent Order and Organization. Includes contributions by Wolfgang Grassl, Nicola Guarino, John T. Kearns, Rudolf Lüthe, Luc Schneider, Peter Simons, Wojciech Żełaniec, and Jan Woleński.
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