Sixteenth century pharmacology was still very much under the influence of a distinction going back to ancient medicine: the distinction between effects of medicaments that were taken to be explainable by the elementary qualities, their mutual modification in mixture, and the combination of these modified elementary qualities on the one hand, and the effects of medicaments that were taken not to be explicable in this manner.1 Galen coined the expression that a medicament of the latter kind possesses the capacity of (...) acting "by its whole substance,"2 and the question of how actions of the whole substance could be explicated gave rise to heated controversies in early modern pharmacology. Did Galen just... (shrink)

In Stoic physics, blending (κρᾶσις) is the relation between active pneuma and passive matter; natural bodies from rocks and logs to plants, animals and the cosmos itself are blends of pneuma and matter. Blending structures the Stoic cosmos. I develop a new interpretation of the Stoic theory of blending, based on passages from Hierocles. The theory of blending, I argue, has been misunderstood. Hierocles allows us to see in detail how the theory is supposed to work and how it fits (...) into Stoic physics. (shrink)

This paper presents Duns Scotus’s theory of mixture in the context of medieval discussions over Aristotle’s theory of mixed bodies. It revisits the accounts of mixture given by Avicenna, Averroes, and Thomas Aquinas, before presenting Scotus’s account as a reaction to Averroes. It argues that Duns Scotus rejected the Aristotelian theory of mixture altogether and that his account went contrary to the entire Latin tradition. Scotus denies that mixts arise out of the four classical elements and he maintains that both (...) the elemental forms and the elemental qualities are lost in the mixture. Consequently, he denies the distinction between the process of mixture and that of substantial change through generation and corruption. The reassessment of Scotus’s account modifies the current historical representation of this discussion, inherited from Anneliese Maier. (shrink)

Abstract This paper examines a fundamental, though relatively understudied, aspect of the physical theory of the physician Asclepiades of Bithynia, namely his doctrine of pores. My principal thesis is that this doctrine is dependent on a conception of void taken directly from Epicurean physics. The paper falls into two parts: the first half addresses the evidence for the presence of void in Asclepiades' theory, and concludes that his conception of void was basically that of Epicurus; the second half focuses on (...) the precise nature of Asclepiadean pores, and seeks to show that they represent void interstices between the primary particles of matter which are the constituents of the human body, and are thus exactly analogous to the void interstices between atoms within solid objects in Epicurus' theory. (shrink)

Porphyry's account of the nature of seeds can shed light on some less appreciated details of Neoplatonic psychology, in particular on the interaction between individual souls. The process of producing the seed and the conception of the seed offer a physical instantiation of procession and reversion, activities that are central to Neoplatonic metaphysics. In an act analogous to procession, the seed is produced by the father's nature, and as such it is ontologically inferior to the father's nature. Thus, the seed (...) does not strictly speaking contain a full-fledged vegetative soul. Rather, it acquires its vegetative soul only while it is being actualized by an actual vegetative soul. This actualization takes place primarily at conception, where the seed as it were reverts back and becomes obedient to the mother's nature, but continues through the period of gestation. In this way, Porphyry can account both for maternal resemblance and for ideoplasty. He uses the Stoic language of complete blending to describe the mother's relation to the seed and embryo, and this reveals that he thinks of individuals as having their own unique individual natures (as opposed to sharing in a single universal nature). In the course of developing this theory, Porphyry makes significant revisions to his philosophical predecessors' views in both embryology and botany. He revises Aristotle's verdict on the relative importance of the female in generation as well as Theophrastus' explanation of the biological mechanics of grafting. Although Plotinus nowhere addresses embryology in the same detail as Porphyry does, we can conclude from his remarks on seeds and plants that his own views were similar to those of his student. (shrink)

Aristotle’s On generation and corruption raises a vital question: how is mixture, or what we would now call chemical combination, possible? It also offers an outline of a solution to the problem and a set of criteria that a successful solution must meet. Understanding Aristotle’s solution and developing a viable peripatetic theory of chemical combination has been a source of controversy over the last two millennia. We describe seven criteria a peripatetic theory of mixture must satisfy: uniformity, recoverability, potentiality, equilibrium, (...) alteration, incompleteness, and the ability to distinguish mixture from generation, corruption, juxtaposition, augmentation, and alteration. After surveying the theories of Philoponus (d. 574), Avicenna(d. 1037), Averroes (d. 1198), and John M. Cooper (fl. circa2000), we argue for the merits of Richard Rufus of Cornwall’s theory. Rufus (fl. 1231–1256) was a little known scholastic philosopher who became a Franciscan theologian in 1238, after teaching Aristotelian natural philosophy as a secular master in Paris. Lecturing on Aristotle’s De generatione et corruptione, around the year 1235, he offered his students a solution to the problem of mixture that we believe satisfies Aristotle’s seven criteria. # 2004 Elsevier Ltd. All rights reserved. (shrink)

Chemistry is the study of the structure and transformation of matter. When Aristotle founded the field in the 4th century BCE, his conceptual grasp of the nature of matter was tailored to accommodate a relatively simple range of observable phenomena. In the 21st century, chemistry has become the largest scientific discipline, producing over half a million publications a year ranging from direct empirical investigations to substantial theoretical work. However, the specialized interest in the conceptual issues arising in chemistry, hereafter Philosophy (...) of Chemistry, is a relatively recent addition to philosophy of science. Philosophy of chemistry has two major parts. In the first, conceptual issues arising within chemistry are carefully articulated and analyzed. Such questions which are internal to chemistry include the nature of substance, atomism, the chemical bond, and synthesis. In the second, traditional topics in philosophy of science such as realism, reduction, explanation, confirmation, and modeling are taken up within the context of chemistry. (shrink)

Review of Salles, R.; Molina Ayala, J. Alejandro de Afrodisia. _De la mixtura y el crecimiento_.