Based on an epistemological approach, humanities and natural sciences are two completely different realms that are governed by different rules. From this position, it is usually concluded that these two should not interfere in each other's territory. This idea, which also has supporters in other categorizations such as science and theology, relies mainly on Wittgenstein's doctrines. The purpose of the article is to argue that such an approach ultimately leads to the isolation of different realms of knowledge. We argue why this position is incorrect and has adverse consequences for the development of knowledge in all domains.