The usual, comparative, conception of inference to the best explanation (IBE) takes it to be ampliative. In this paper I propose a conception of IBE ('Holmesian inference') that takes it to be a species of eliminative induction and hence not ampliative. This avoids several problems for comparative IBE (for example, how could it be reliable enough to generate knowledge?). My account of Holmesian inference raises the suspicion that it could never be applied, on the grounds that scientific hypotheses are inevitably (...) underdetermined by the evidence (i.e. are inevitably ampliative). I argue that this concern may be resisted by acknowledging, as Timothy Williamson has shown, that all knowledge is evidence. The latter suggests an approach to resisting scepticism different from those (e.g. the reliabilist approach) that embrace fallibilism. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Philosophy and Phenomenological Research (forthcoming).

Semmelweis’s investigations of puerperal fever are some of the most interesting in the history of medicine. This paper considers Hempel’s analysis of the Semmelweis case. It argues that this analysis is inadequate and needs to be supplemented by some Kuhnian ideas. Kuhn’s notion of paradigm needs to be modified to apply to medicine in order to take account of the classification schemes involved in medical theorising. However with a suitable modification it provides an explanation of Semmelweis’s failure which is argued (...) to be superior to some of the external reasons often given. Despite this success in applying Kuhn’s ideas to medicine, it is argued that these ideas must be further modified to take account of the fact that medicine is not a natural science but primarily a practice designed to prevent and cure diseases. (shrink)