Switch to: Citations

References in:

Causality in medicine with particular reference to the viral causation of cancers

Dissertation, University College London (2011)

Add references

You must login to add references.
  1. Making things happen: a theory of causal explanation.James F. Woodward - 2003 - New York: Oxford University Press.
    Woodward's long awaited book is an attempt to construct a comprehensive account of causation explanation that applies to a wide variety of causal and explanatory claims in different areas of science and everyday life. The book engages some of the relevant literature from other disciplines, as Woodward weaves together examples, counterexamples, criticisms, defenses, objections, and replies into a convincing defense of the core of his theory, which is that we can analyze causation by appeal to the notion of manipulation.
    Download  
     
    Export citation  
     
    Bookmark   1798 citations  
  • Counterfactuals.David K. Lewis - 1973 - Malden, Mass.: Blackwell.
    Counterfactuals is David Lewis' forceful presentation of and sustained argument for a particular view about propositions which express contrary to fact conditionals, including his famous defense of realism about possible worlds and his theory of laws of nature.
    Download  
     
    Export citation  
     
    Bookmark   1288 citations  
  • Causality: Models, Reasoning and Inference.Judea Pearl - 2000 - New York: Cambridge University Press.
    Causality offers the first comprehensive coverage of causal analysis in many sciences, including recent advances using graphical methods. Pearl presents a unified account of the probabilistic, manipulative, counterfactual and structural approaches to causation, and devises simple mathematical tools for analyzing the relationships between causal connections, statistical associations, actions and observations. The book will open the way for including causal analysis in the standard curriculum of statistics, artificial intelligence, business, epidemiology, social science and economics.
    Download  
     
    Export citation  
     
    Bookmark   790 citations  
  • Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research.William Bechtel & Robert C. Richardson - 2010 - Princeton.
    An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences. In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent (...)
    Download  
     
    Export citation  
     
    Bookmark   528 citations  
  • Nature's capacities and their measurement.Nancy Cartwright - 1989 - New York: Oxford University Press.
    Ever since David Hume, empiricists have barred powers and capacities from nature. In this book Cartwright argues that capacities are essential in our scientific world, and, contrary to empiricist orthodoxy, that they can meet sufficiently strict demands for testability. Econometrics is one discipline where probabilities are used to measure causal capacities, and the technology of modern physics provides several examples of testing capacities (such as lasers). Cartwright concludes by applying the lessons of the book about capacities and probabilities to the (...)
    Download  
     
    Export citation  
     
    Bookmark   683 citations  
  • Thinking about mechanisms.Peter Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
    The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.
    Download  
     
    Export citation  
     
    Bookmark   1488 citations  
  • (1 other version)Models and Analogies in Science.Mary B. Hesse - 1963 - [Notre Dame, Ind.]: University of Notre Dame Press.
    Download  
     
    Export citation  
     
    Bookmark   424 citations  
  • (2 other versions)Counterfactuals.David Lewis - 1973 - Tijdschrift Voor Filosofie 36 (3):602-605.
    Download  
     
    Export citation  
     
    Bookmark   1373 citations  
  • (2 other versions)Counterfactuals.David Lewis - 1973 - Foundations of Language 13 (1):145-151.
    Download  
     
    Export citation  
     
    Bookmark   1299 citations  
  • (1 other version)Philosophical Papers, Volume II.David Lewis - 1986 - New York, US: Oxford University Press.
    A collection of 13 papers by David Lewis, written on a variety of topics including causation, counterfactuals and indicative conditionals, the direction of time, subjective and objective probability, explanation, perception, free will, and rational decision. The conclusions reached include the claim that time travel is possible, that counterfactual dependence is asymmetrical, that events are properties of spatiotemporal regions, that the Prisoners’ Dilemma is a Newcomb problem, and that causation can be analyzed in terms of counterfactual dependence between events. These papers (...)
    Download  
     
    Export citation  
     
    Bookmark   350 citations  
  • Counterfactual Dependence and Time’s Arrow.David Lewis - 1979 - Noûs 13 (4):455-476.
    Download  
     
    Export citation  
     
    Bookmark   775 citations  
  • (2 other versions)Counterfactuals.David Lewis - 1973 - Philosophy of Science 42 (3):341-344.
    Download  
     
    Export citation  
     
    Bookmark   1160 citations  
  • Explanation: a mechanist alternative.William Bechtel & Adele Abrahamsen - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):421-441.
    Explanations in the life sciences frequently involve presenting a model of the mechanism taken to be responsible for a given phenomenon. Such explanations depart in numerous ways from nomological explanations commonly presented in philosophy of science. This paper focuses on three sorts of differences. First, scientists who develop mechanistic explanations are not limited to linguistic representations and logical inference; they frequently employ diagrams to characterize mechanisms and simulations to reason about them. Thus, the epistemic resources for presenting mechanistic explanations are (...)
    Download  
     
    Export citation  
     
    Bookmark   565 citations  
  • Causality: Models, Reasoning and Inference.Judea Pearl - 2000 - Tijdschrift Voor Filosofie 64 (1):201-202.
    Download  
     
    Export citation  
     
    Bookmark   875 citations  
  • (1 other version)Models and Analogies in Science.Mary Hesse - 1965 - British Journal for the Philosophy of Science 16 (62):161-163.
    Download  
     
    Export citation  
     
    Bookmark   284 citations  
  • Physical Causation.Phil Dowe - 2000 - New York: Cambridge University Press.
    This book, published in 2000, is a clear account of causation based firmly in contemporary science. Dowe discusses in a systematic way, a positive account of causation: the conserved quantities account of causal processes which he has been developing over the last ten years. The book describes causal processes and interactions in terms of conserved quantities: a causal process is the worldline of an object which possesses a conserved quantity, and a causal interaction involves the exchange of conserved quantities. Further, (...)
    Download  
     
    Export citation  
     
    Bookmark   238 citations  
  • Explanatory unification and the causal structure of the world.Philip Kitcher - 1962 - In Philip Kitcher & Wesley C. Salmon, Scientific Explanation. Univ of Minnesota Pr. pp. 410-505.
    Download  
     
    Export citation  
     
    Bookmark   518 citations  
  • Philosophical Theories of Probability.Donald Gillies - 2000 - New York: Routledge.
    The Twentieth Century has seen a dramatic rise in the use of probability and statistics in almost all fields of research. This has stimulated many new philosophical ideas on probability. _Philosophical Theories of Probability_ is the first book to present a clear, comprehensive and systematic account of these various theories and to explain how they relate to one another. Gillies also offers a distinctive version of the propensity theory of probability, and the intersubjective interpretation, which develops the subjective theory.
    Download  
     
    Export citation  
     
    Bookmark   201 citations  
  • Statistical explanation & statistical relevance.Wesley C. Salmon - 1971 - [Pittsburgh]: University of Pittsburgh Press. Edited by Richard C. Jeffrey & James G. Greeno.
    Through his S–R model of statistical relevance, Wesley Salmon offers a solution to the scientific explanation of objectively improbable events.
    Download  
     
    Export citation  
     
    Bookmark   176 citations  
  • (1 other version)Models and Analogies in Science.Mary B. Hesse - 1966 - Philosophy and Rhetoric 3 (3):190-191.
    Download  
     
    Export citation  
     
    Bookmark   460 citations  
  • Mechanisms and the nature of causation.Stuart S. Glennan - 1996 - Erkenntnis 44 (1):49--71.
    In this paper I offer an analysis of causation based upon a theory of mechanisms-complex systems whose internal parts interact to produce a system's external behavior. I argue that all but the fundamental laws of physics can be explained by reference to mechanisms. Mechanisms provide an epistemologically unproblematic way to explain the necessity which is often taken to distinguish laws from other generalizations. This account of necessity leads to a theory of causation according to which events are causally related when (...)
    Download  
     
    Export citation  
     
    Bookmark   472 citations  
  • (1 other version)Rethinking mechanistic explanation.Stuart Glennan - 2002 - Proceedings of the Philosophy of Science Association 2002 (3):S342-353.
    Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain (...)
    Download  
     
    Export citation  
     
    Bookmark   419 citations  
  • (1 other version)Rethinking Mechanistic Explanation.Stuart Glennan - 2002 - Philosophy of Science 69 (S3):S342-S353.
    Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain (...)
    Download  
     
    Export citation  
     
    Bookmark   440 citations  
  • The Direction of Time.Hans Reichenbach - 1956 - Philosophy 34 (128):65-66.
    Download  
     
    Export citation  
     
    Bookmark   431 citations  
  • Probabilistic Causality.Ellery Eells - 1991 - Cambridge, England: Cambridge University Press.
    In this important book, Ellery Eells explores and refines philosophical conceptions of probabilistic causality. In a probabilistic theory of causation, causes increase the probability of their effects rather than necessitate their effects in the ways traditional deterministic theories have specified. Philosophical interest in this subject arises from attempts to understand population sciences as well as indeterminism in physics. Taking into account issues involving spurious correlation, probabilistic causal interaction, disjunctive causal factors, and temporal ideas, Professor Eells advances the analysis of what (...)
    Download  
     
    Export citation  
     
    Bookmark   123 citations  
  • 1953 and all that. A tale of two sciences.Philip Kitcher - 1984 - Philosophical Review 93 (3):335-373.
    Download  
     
    Export citation  
     
    Bookmark   295 citations  
  • Role functions, mechanisms, and hierarchy.Carl F. Craver - 2001 - Philosophy of Science 68 (1):53-74.
    Many areas of science develop by discovering mechanisms and role functions. Cummins' (1975) analysis of role functions-according to which an item's role function is a capacity of that item that appears in an analytic explanation of the capacity of some containing system-captures one important sense of "function" in the biological sciences and elsewhere. Here I synthesize Cummins' account with recent work on mechanisms and causal/mechanical explanation. The synthesis produces an analysis of specifically mechanistic role functions, one that uses the characteristic (...)
    Download  
     
    Export citation  
     
    Bookmark   294 citations  
  • Causing and Nothingness.Helen Beebee - 2004 - In John Collins, Ned Hall & Laurie Paul, Causation and Counterfactuals. MIT Press. pp. 291--308.
    Download  
     
    Export citation  
     
    Bookmark   167 citations  
  • Interpreting causality in the health sciences.Federica Russo & Jon Williamson - 2007 - International Studies in the Philosophy of Science 21 (2):157 – 170.
    We argue that the health sciences make causal claims on the basis of evidence both of physical mechanisms, and of probabilistic dependencies. Consequently, an analysis of causality solely in terms of physical mechanisms or solely in terms of probabilistic relationships, does not do justice to the causal claims of these sciences. Yet there seems to be a single relation of cause in these sciences - pluralism about causality will not do either. Instead, we maintain, the health sciences require a theory (...)
    Download  
     
    Export citation  
     
    Bookmark   210 citations  
  • (1 other version)What is a mechanism? A counterfactual account.Jim Woodward - 2002 - Proceedings of the Philosophy of Science Association 2002 (3):S366-S377.
    This paper presents a counterfactual account of what a mechanism is. Mechanisms consist of parts, the behavior of which conforms to generalizations that are invariant under interventions, and which are modular in the sense that it is possible in principle to change the behavior of one part independently of the others. Each of these features can be captured by the truth of certain counterfactuals.
    Download  
     
    Export citation  
     
    Bookmark   224 citations  
  • Physical Causation.Phil Dowe - 2003 - Philosophy and Phenomenological Research 67 (1):244-248.
    Download  
     
    Export citation  
     
    Bookmark   275 citations  
  • Causation as a secondary quality.Peter Menzies & Huw Price - 1993 - British Journal for the Philosophy of Science 44 (2):187-203.
    In this paper we defend the view that the ordinary notions of cause and effect have a direct and essential connection with our ability to intervene in the world as agents.1 This is a well known but rather unpopular philosophical approach to causation, often called the manipulability theory. In the interests of brevity and accuracy, we prefer to call it the agency theory.2 Thus the central thesis of an agency account of causation is something like this: an event A is (...)
    Download  
     
    Export citation  
     
    Bookmark   175 citations  
  • A Probabilistic Theory of Causality.P. Suppes - 1973 - British Journal for the Philosophy of Science 24 (4):409-410.
    Download  
     
    Export citation  
     
    Bookmark   248 citations  
  • Explanation and invariance in the special sciences.James Woodward - 2000 - British Journal for the Philosophy of Science 51 (2):197-254.
    This paper describes an alternative to the common view that explanation in the special sciences involves subsumption under laws. According to this alternative, whether or not a generalization can be used to explain has to do with whether it is invariant rather than with whether it is lawful. A generalization is invariant if it is stable or robust in the sense that it would continue to hold under a relevant if it is stable or robust in the sense that it (...)
    Download  
     
    Export citation  
     
    Bookmark   176 citations  
  • Causation and Explanation.Stathis Psillos - 2002 - Routledge.
    What is the nature of causation? How is causation linked with explanation? And can there be an adequate theory of explanation? These questions and many others are addressed in this unified and rigorous examination of the philosophical problems surrounding causation, laws and explanation. Part 1 of this book explores Hume's views on causation, theories of singular causation, and counterfactual and mechanistic approaches. Part 2 considers the regularity view of laws and laws as relations among universals, as well as recent alternative (...)
    Download  
     
    Export citation  
     
    Bookmark   86 citations  
  • Independence, invariance and the causal Markov condition.Daniel M. Hausman & James Woodward - 1999 - British Journal for the Philosophy of Science 50 (4):521-583.
    This essay explains what the Causal Markov Condition says and defends the condition from the many criticisms that have been launched against it. Although we are skeptical about some of the applications of the Causal Markov Condition, we argue that it is implicit in the view that causes can be used to manipulate their effects and that it cannot be surrendered without surrendering this view of causation.
    Download  
     
    Export citation  
     
    Bookmark   181 citations  
  • The reference class problem is your problem too.Alan Hájek - 2007 - Synthese 156 (3):563--585.
    The reference class problem arises when we want to assign a probability to a proposition (or sentence, or event) X, which may be classified in various ways, yet its probability can change depending on how it is classified. The problem is usually regarded as one specifically for the frequentist interpretation of probability and is often considered fatal to it. I argue that versions of the classical, logical, propensity and subjectivist interpretations also fall prey to their own variants of the reference (...)
    Download  
     
    Export citation  
     
    Bookmark   134 citations  
  •  .Stathos Psillos - unknown
    means exhaust the insults. This is unfortunate as their attitude turns a useful book, with valuable contributions from a number of writers, into a polemic.
    Download  
     
    Export citation  
     
    Bookmark   164 citations  
  • (1 other version)What Is a Mechanism? A Counterfactual Account.James Woodward - 2002 - Philosophy of Science 69 (S3):S366-S377.
    This paper presents a counterfactual account of what a mechanism is. Mechanisms consist of parts, the behavior of which conforms to generalizations that are invariant under interventions, and which are modular in the sense that it is possible in principle to change the behavior of one part independently of the others. Each of these features can be captured by the truth of certain counterfactuals.
    Download  
     
    Export citation  
     
    Bookmark   170 citations  
  • Causation and the flow of energy.David Fair - 1979 - Erkenntnis 14 (3):219 - 250.
    Causation has traditionally been analyzed either as a relation of nomic dependence or as a relation of counterfactual dependence. I argue for a third program, a physicalistic reduction of the causal relation to one of energy-momentum transference in the technical sense of physics. This physicalistic analysis is argued to have the virtues of easily handling the standard counterexamples to the nomic and counterfactual analyses, offering a plausible epistemology for our knowledge of causes, and elucidating the nature of the relation between (...)
    Download  
     
    Export citation  
     
    Bookmark   164 citations  
  • Activities and causation: The metaphysics and epistemology of mechanisms.Peter Machamer - 2004 - International Studies in the Philosophy of Science 18 (1):27 – 39.
    This article deals with mechanisms conceived as composed of entities and activities. In response to many perplexities about the nature of activities, a number of arguments are developed concerning their epistemic and ontological status. Some questions concerning the relations between cause and causal explanation and mechanisms are also addressed.
    Download  
     
    Export citation  
     
    Bookmark   157 citations  
  • Modeling mechanisms.Stuart Glennan - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):443-464.
    Philosophers of science increasingly believe that much of science is concerned with understanding the mechanisms responsible for the production of natural phenomena. An adequate understanding of scientific research requires an account of how scientists develop and test models of mechanisms. This paper offers a general account of the nature of mechanical models, discussing the representational relationship that holds between mechanisms and their models as well as the techniques that can be used to test and refine such models. The analysis is (...)
    Download  
     
    Export citation  
     
    Bookmark   136 citations  
  • On bayesian measures of evidential support: Theoretical and empirical issues.Vincenzo Crupi, Katya Tentori & and Michel Gonzalez - 2007 - Philosophy of Science 74 (2):229-252.
    Epistemologists and philosophers of science have often attempted to express formally the impact of a piece of evidence on the credibility of a hypothesis. In this paper we will focus on the Bayesian approach to evidential support. We will propose a new formal treatment of the notion of degree of confirmation and we will argue that it overcomes some limitations of the currently available approaches on two grounds: (i) a theoretical analysis of the confirmation relation seen as an extension of (...)
    Download  
     
    Export citation  
     
    Bookmark   119 citations  
  • Aggregativity: Reductive heuristics for finding emergence.William C. Wimsatt - 1997 - Philosophy of Science 64 (4):372-84.
    Most philosophical accounts of emergence are incompatible with reduction. Most scientists regard a system property as emergent relative to properties of the system's parts if it depends upon their mode of organization--a view consistent with reduction. Emergence can be analyzed as a failure of aggregativity--a state in which "the whole is nothing more than the sum of its parts." Aggregativity requires four conditions, giving tools for analyzing modes of organization. Differently met for different decompositions of the system, and in different (...)
    Download  
     
    Export citation  
     
    Bookmark   114 citations  
  • Salmon on explanatory relevance.Christopher Read Hitchcock - 1995 - Philosophy of Science 62 (2):304-320.
    One of the motivations for Salmon's (1984) causal theory of explanation was the explanatory irrelevance exhibited by many arguments conforming to Hempel's covering-law models of explanation. However, the nexus of causal processes and interactions characterized by Salmon is not rich enough to supply the necessary conception of explanatory relevance. Salmon's (1994) revised theory, which is briefly criticized on independent grounds, fares no better. There is some possibility that the two-tiered structure of explanation described by Salmon (1984) may be pressed into (...)
    Download  
     
    Export citation  
     
    Bookmark   104 citations  
  • (1 other version)Interlevel experiments and multilevel mechanisms in the neuroscience of memory.Carl F. Craver - 2002 - Philosophy of Science Supplemental Volume 69 (3):S83-S97.
    The dominant neuroscientific theory of spatial memory is, like many theories in neuroscience, a multilevel description of a mechanism. The theory links the activities of molecules, cells, brain regions, and whole organisms into an integrated sketch of an explanation for the ability of organisms to navigate novel environments. Here I develop a taxonomy of interlevel experimental strategies for integrating the levels in such multilevel mechanisms. These experimental strategies include activation strategies, interference strategies, and additive strategies. These strategies are mutually reinforcing, (...)
    Download  
     
    Export citation  
     
    Bookmark   98 citations  
  • (4 other versions)The cement of the universe, a study of causation.J. Mackie - 1975 - Revue Philosophique de la France Et de l'Etranger 165 (2):179-179.
    Download  
     
    Export citation  
     
    Bookmark   106 citations  
  • Synthesizing activities and interactions in the concept of a mechanism.James G. Tabery - 2004 - Philosophy of Science 71 (1):1-15.
    Stuart Glennan, and the team of Peter Machamer, Lindley Darden, and Carl Craver have recently provided two accounts of the concept of a mechanism. The main difference between these two versions rests on how the behavior of the parts of the mechanism is conceptualized. Glennan considers mechanisms to be an interaction of parts, where the interaction between parts can be characterized by direct, invariant, change-relating generalizations. Machamer, Darden, and Craver criticize traditional conceptualizations of mechanisms which are based solely on parts (...)
    Download  
     
    Export citation  
     
    Bookmark   96 citations  
  • Inferring causation in epidemiology: mechanisms, black boxes, and contrasts.Alex Broadbent - 2011 - In Phyllis McKay Illari Federica Russo, Causality in the Sciences. Oxford University Press. pp. 45--69.
    This chapter explores the idea that causal inference is warranted if and only if the mechanism underlying the inferred causal association is identified. This mechanistic stance is discernible in the epidemiological literature, and in the strategies adopted by epidemiologists seeking to establish causal hypotheses. But the exact opposite methodology is also discernible, the black box stance, which asserts that epidemiologists can and should make causal inferences on the basis of their evidence, without worrying about the mechanisms that might underlie their (...)
    Download  
     
    Export citation  
     
    Bookmark   34 citations  
  • (4 other versions)The Cement of the Universe: A Study of Causation.J. L. Mackie - 1975 - Philosophy 50 (193):362-364.
    Download  
     
    Export citation  
     
    Bookmark   99 citations