Charles Sanders Peirce has been characterized as the greatest American philosophic genius. He is the creator of pragmatism and one of the founders of modern logic. James, Royce, Schroder, and Dewey have acknowledged their great indebtedness to him. A laboratory scientist, he made notable contributions to geodesy, astronomy, psychology, induction, probability, and scientific method. He introduced into modern philosophy the doctrine of scholastic realism, developed the concepts of chance, continuity, and objective law, and showed the philosophical significance of the theory (...) of signs and mathematical logic. The present series is the first published edition of his systematic works. (shrink)

On this tour of the universe of signs, Jesper Hoffmeyer travels back to the Big Bang, visits the tiniest places deep within cells, and ends his journey with us - complex organisms capable of speech and reason. He shows that life at its most basic depends on the survival of messages written in the code of DNA molecules, and on the tiny cell - the fertilized egg - that must interpret the message and from it construct an organism. What propels (...) this journey is Hoffmeyer's attempt to discover how nature could come to mean something to someone; indeed, how "something" could become "someone." How could a biological self become a semiotic self? (shrink)

Several analyses of biological function — for example, those of Williams, Millikan, and Kitcher — identify an item’s function with what natural selection designed it to do. Allen and Bekoff have disagreed, claiming that natural design is a special case of biological function. I argue that Allen and Bekoff’s account of natural design is unduly restrictive and that it fails to mark a principled distinction between function and design. I distinguish two approaches to the phenomenon of natural design — the (...) “trait-centered” approach of Allen and Bekoff and the “organism-centered” approach — and defend the latter. When design is understood according to the organism-centered approach, biological function and design are co-instantiated phenomena. (shrink)

A life form and its environment constitute an essential unit, a microcosm. This microcosm is sustained by a privileged dialectic relationship in which the embedded agent- an entity endowed with a particular physical architecture- and its specific environment, coupled, mutually influence each other. Identical principles rule both the basic forms of semiotic organisation and the upper forms. When we distinguish these two levels of semiotic structuring we are distinguishing the semiotic relations that involve a stimulus-response relationship, which is dyadic in (...) nature, from those that involve a more complex relationship where the capacity of symbolically encoding allows organisms to go beyond the immediacy of sensory awareness. However in all instances of semiotic structuring, there is the presence of a living system that evolves in an environment individuating and assigning a value to typical environmental features. Acknowledging this fact is crucial: the inquiry into how elemental life forms interact with their environments leads to the identification of the fundamental role played by the physical architecture of the agent and sheds light on the semiotic process that is common to all life forms, ultimately highlighting the very nature of meaning and reality. (shrink)

Theses on the semiotic study of life as presented here provide a collectively formulated set of statements on what biology needs to be focused on in order to describe life as a process based on semiosis, or sign action. An aim of the biosemiotic approach is to explain how life evolves through all varieties of forms of communication and signification (including cellular adaptive behavior, animal communication, and human intellect) and to provide tools for grounding sign theories. We introduce the concept (...) of semiotic threshold zone and analyze the concepts of semiosis, function, umwelt, and the like as the basic concepts for theoretical biology. (shrink)

Introduction: Science and Common Sense Long before the beginnings of modern civilization, men ac- quired vast funds of information about their environment. ...

The philosophical theory of scientific explanation proposed here involves a radically new treatment of causality that accords with the pervasively statistical character of contemporary science. Wesley C. Salmon describes three fundamental conceptions of scientific explanation--the epistemic, modal, and ontic. He argues that the prevailing view is untenable and that the modal conception is scientifically out-dated. Significantly revising aspects of his earlier work, he defends a causal/mechanical theory that is a version of the ontic conception. Professor Salmon's theory furnishes a robust (...) argument for scientific realism akin to the argument that convinced twentieth-century physical scientists of the existence of atoms and molecules. To do justice to such notions as irreducibly statistical laws and statistical explanation, he offers a novel account of physical randomness. The transition from the "reviewed view" of scientific explanation to the causal/mechanical model requires fundamental rethinking of basic explanatory concepts. (shrink)

In this note some epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, semiosis, closure and life.

The etiological approach to ‘proper functions’ in biology can be strengthened by relating it to Robert Cummins' general treatment of function ascription. The proper functions of a biological trait are the functions it is assigned in a Cummins-style functional explanation of the fitness of ancestors. These functions figure in selective explanations of the trait. It is also argued that some recent etiological theories include inaccurate accounts of selective explanation in biology. Finally, a generalization of the notion of selective explanation allows (...) an analysis of the proper functions of human artifacts. (shrink)

A key topic in the work of Burghard Rieger is the notion of meaning. To explore this notion, he and his collaborators developed a most sophisticated approach combining theoretical ideas and concepts of semiotics with empirical and numerical tools of computational linguistics. In the present contribution, relations of Rieger’s achievements to some issues of interest in the physics and philosophy of complex systems will be addressed.

The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...) the number of cell functions they can actually control, both GPCRs and their associated signal transduction pathways are extremely well conserved, for only a few alleles with null or minor functional alterations have so far been found. This would seem to suggest that, beside a mechanism for DNA repairing, there must be another level of quality control that may help maintaining GPCRs rather stable throughout evolution. We propose here receptor oligomerization to be a basic molecular mechanism controlling GPCRs redundancy in many different cell types, and the plasma membrane as the first hierarchical cell structure at which selective categorical sensing may occur. Categorical sensing can be seen as the cellular capacity for identifying and ordering complex patterns of mixed signals out of a contextual matrix, i.e., the recognition of meaningful patterns out of ubiquitous signals. In this context, redundancy and degeneracy may appear as the required feature to integrate the cell system into functional units of progressively higher hierarchical levels. (shrink)

In this note some epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, semiosis, closure and life.

This article considers categorical perception (CP) as a crucial process involved in all sort of communication throughout the biological hierarchy, i.e. in all of biosemiosis. Until now, there has been consideration of CP exclusively within the functional cycle of perception–cognition–action and it has not been considered the possibility to extend this kind of phenomena to the mere physiological level. To generalise the notion of CP in this sense, I have proposed to distinguish between categorical perception (CP) and categorical sensing (CS) (...) in order to extend the CP framework to all communication processes in living systems, including intracellular, intercellular, metabolic, physiological, cognitive and ecological levels. The main idea is to provide an account that considers the heterarchical embeddedness of many instances of CP and CS. This will take me to relate the hierarchical nature of categorical sensing and perception with the equally hierarchical issues of the “binding problem”, “triadic causality”, the “emergent interpretant” and the increasing semiotic freedom observed in biological and cognitive systems. (shrink)