Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

The purpose of the two studies reported here was to develop an integrated model of the scientific reasoning process. Subjects were placed in a simulated scientific discovery context by first teaching them how to use an electronic device and then asking them to discover how a hitherto unencountered function worked. To do this task, subjects had to formulate hypotheses based on their prior knowledge, conduct experiments, and evaluate the results of their experiments. In the first study, using 20 adult subjects, (...) we identified two main strategies that subjects used to generate new hypotheses. One strategy was to search memory and the other was to generalize from the results of previous experiments. We described the former group as searching an hypothesis space, and the latter as searching an experiment space. In a second study, with 10 adults, we investigated how subjects search the hypothesis space by instructing them to state all the hypotheses that they could think of prior to conducting any experiments. Following this phase, subjects were then allowed to conduct experiments. Subjects who could not think of the correct rule in the hypothesis generation phase discovered the correct rule only by generalizing from the results of experiments in the experimental phase.Both studies provide support for the view that scientific reasoning can be characterized as search in two problem spaces. By extending Simon and Lea's (1974) Generalized Rule Inducer, we present a general model of Scientific Discovery as Dual Search (SDDS) that shows how search in two problem spaces (an hypothesis space and an experiment space) shapes hypothesis generation, experimental design, and the evaluation of hypotheses. The model also shows how these processes interact with each other. Finally, we interpret earlier findings about the psychology of scientific reasoning in terms of the SDDS model. (shrink)

Narrative accounts misrepresent discovery by reconstructing worlds ordered by success rather than the world as explored. Such worlds rarely contain the personal knowledge that informed actual exploration and experiment. This article describes an attempt to recover situated learning in a material environment, tracing the discovery of the first electromagnetic motor by Michael Faraday in September 1821 to show how he modeled new experience and invented procedures to communicate that novelty. The author introduces a notation to map experiment as an active (...) process in a real-world environment and to display the human agency written out of most narratives. Comparing maps of accounts shows how knowledge-construction depends on narrative reconstruction. It is argued that invention processes can be interpreted in the same way as discovery, and a study is proposed to compare packaging learned skills into demonstration devices with the innovative strategies of inventors such as Edison. If situational knowledge is as important as is claimed, computationalists need to join science studies scholars in coming to grips with nonverbal and procedural aspects of discovery and invention. (shrink)