Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

This target article presents a new computational theory of explanatory coherence that applies to the acceptance and rejection of scientific hypotheses as well as to reasoning in everyday life, The theory consists of seven principles that establish relations of local coherence between a hypothesis and other propositions. A hypothesis coheres with propositions that it explains, or that explain it, or that participate with it in explaining other propositions, or that offer analogous explanations. Propositions are incoherent with each other if they (...) are contradictory, Propositions that describe the results of observation have a degree of acceptability on their own. An explanatory hypothesis is acccpted if it coheres better overall than its competitors. The power of the seven principles is shown by their implementation in a connectionist program called ECHO, which treats hypothesis evaluation as a constraint satisfaction problem. Inputs about the explanatory relations are used to create a network of units representing propositions, while coherende and incoherence relations are encoded by excitatory and inbihitory links. ECHO provides an algorithm for smoothly integrating theory evaluation based on considerations of explanatory breadth, simplicity, and analogy. It has been applied to such important scientific cases as Lovoisier's argument for oxygen against the phlogiston theory and Darwin's argument for evolution against creationism, and also to cases of legal reasoning. The theory of explanatory coherence has implications for artificial intelligence, psychology, and philosophy. (shrink)

In informal terms, abductive reasoning involves inferring the best or most plausible explanation from a given set of facts or data. It is a common occurrence in everyday life and crops up in such diverse places as medical diagnosis, scientific theory formation, accident investigation, language understanding, and jury deliberation. In recent years, it has become a popular and fruitful topic in artificial intelligence research. This volume breaks new ground in the scientific, philosophical, and technological study of abduction. It presents new (...) ideas about inferential and information-processing foundations for knowledge and certainty. The authors argue that knowledge arises from experience by processes of abductive inference, in contrast to the view that it arises non-inferentially, or that deduction and inductive generalization are enough to account for knowledge. Much AI research is hypothetical, so the importance of this book is that it reports key discoveries about abduction that have been made as a result of designing, building, testing, and analyzing actual working knowledge-based systems for medical diagnosis and other abductive tasks. The book tells the story of six generations of increasingly sophisticated generic abduction machines, RED-1, RED-2, PEIRCE, MDX2, TIPS, QUAWDS, and the discovery of reasoning strategies that make it computationally feasible to form well-justified composite explanatory hypotheses, despite the threat of combinatorial explosion. The final chapter argues that perception is logically abductive and presents a layered-abduction computational model of perceptual information processing. This book will be of great interest to researchers in AI, cognitive science, and philosophy of science. (shrink)

The purpose of the two studies reported here was to develop an integrated model of the scientific reasoning process. Subjects were placed in a simulated scientific discovery context by first teaching them how to use an electronic device and then asking them to discover how a hitherto unencountered function worked. To do this task, subjects had to formulate hypotheses based on their prior knowledge, conduct experiments, and evaluate the results of their experiments. In the first study, using 20 adult subjects, (...) we identified two main strategies that subjects used to generate new hypotheses. One strategy was to search memory and the other was to generalize from the results of previous experiments. We described the former group as searching an hypothesis space, and the latter as searching an experiment space. In a second study, with 10 adults, we investigated how subjects search the hypothesis space by instructing them to state all the hypotheses that they could think of prior to conducting any experiments. Following this phase, subjects were then allowed to conduct experiments. Subjects who could not think of the correct rule in the hypothesis generation phase discovered the correct rule only by generalizing from the results of experiments in the experimental phase.Both studies provide support for the view that scientific reasoning can be characterized as search in two problem spaces. By extending Simon and Lea's (1974) Generalized Rule Inducer, we present a general model of Scientific Discovery as Dual Search (SDDS) that shows how search in two problem spaces (an hypothesis space and an experiment space) shapes hypothesis generation, experimental design, and the evaluation of hypotheses. The model also shows how these processes interact with each other. Finally, we interpret earlier findings about the psychology of scientific reasoning in terms of the SDDS model. (shrink)