Louis Pasteur plays a role in the creation myth of biotechnology which resembles the heroic position of his great antagonist Liebig in the story of agricultural chemistry. His intellectual development, expressed in a great book, supposedly underlay a revolution in practice. Similarly, biotechnology is conventionally traced back to Pasteur, through whose influence, it has been assumed, ancient crafts were transformed into an applicable science of microbiology. The emphasis on Pasteur's work in the history of biotechnology has served to bolster the (...) image of progress in the technology following from periodic scientific breakthroughs. Elsewhere I have argued that biotechnology can be better seen as a boundary object, to use Star and Griesemer's terminology, between biology and engineering. As such it has been significant throughout this century, and the word has been used since 1917. (shrink)

The focus of this paper is the emergence of the research laboratory as an organizational entity within the company structure of industrial firms. The thesis defended is that, after some groundwork by British and French firms, the managements of several of the larger German dye companies set up their own research organizations between the years 1877 and 1883. The analysis of the emergence of the industrial research laboratory in the dyestuffs industry presented here makes clear that both the older study (...) on the subject by John J. Beer and a later paper by Georg Mseyer-Thurow contain some serious defects. Beer, like so many other authors of the 1950s who studied the ‘marriage’ between science and industry during the ‘Second Industrial Revolution’, incorrectly correlates the engagement of university-educated chemists with the rise of industrial research. The appointment of academic chemists by BASF and Hoechst at the end of the 1860s, for instance, was described as ‘the…acquisition of a research staff’. This reveals a misunderstanding of the roles of chemists within the nineteenth-century chemical industry. University-trained personnel were, in fact, working in industry as early as the start of the nineteenth century. However, they were employed as managers, works chemists and analysts, and only exceptionally in research. (shrink)

Since the eighteenth century chemistry has been deemed to be useful, yet how it might find widespread application, particularly in the case of its most advanced developments, was generally unclear. The discovery of synthetic dyestuffs has often been considered as the turning point towards much closer linkage between chemistry and the manufacture of useful products. How this occurred can best be seen in the case of August Wilhelm Hofmann, who for two decades after 1845 was director of the Royal College (...) of Chemistry in London. As the teacher of many pioneers of the dye industry, Hofmann can be considered its first scientific leader. Indeed, the compounds he studied from 1860 were products made in the factories of his former students and assistants. They in turn were the first to recognize Hofmann's role in stimulating the practical application of science. Henry Armstrong, the chemist and educator, went so far as to imply that this was germane to Hofmann's pedagogic and research strategies: ‘it is clear that the influence he exercised in introducing scientific method into industry was in no sense accidental, but the considered expression of innate convictions’. These convictions were also encouraged by the need to attract funds from industrial sponsors for the Royal College of Chemistry, and they charged the rhetoric that served to enhance Hofmann's ambition and the discipline of chemistry before international audiences. (shrink)

Relations between J. A. C. Chaptal, pioneer of heavy chemical industry in France, and A. L. Lavoisier, reformer of chemical theory, are examined in the light of unpublished correspondence they exchanged in the period 1784–1790. The letters, together with Chaptal's early publications, allow a reconstruction of his conversion to Lavoisier's antiphlogistic chemistry. They also reveal a series of petitions that Chaptal made to Lavoisier, in the latter's official capacity as a director of the Régie des poudres et salpêtres, for relief (...) from the controlled price of saltpetre for his acid works in Languedoc. Finally, the relationship is explored as a window on the interplay between chemical theory and industrial practice during the period of the Industrial Revolution. (shrink)

Jean Antoine Claude Chaptal was not only a chemical manufacturer and one of the first ‘industrial scientists’ but was also, according to his own testimony, one of the early supporters of Lavoisier's system of chemistry. It might be assumed that Chaptal's pioneering work in industrial chemistry was intimately linked with his acceptance of the oxygen system of chemistry; more specifically, that this theory served to direct and inform his applied research and contributed not a little to its success. Indeed, he (...) himself in 1790 explicitly stated this to have been the case. A close study of his work prior to 1790 fails, however, to establish the importance of such a linkage. First, his selection of research topics proves to have owed little to the ‘new chemistry’ but much to the scientific and economic milieu of his province of Languedoc and of Montpellier, its administrative seat. Second, the significance of his acceptance of the ‘new chemistry’ appears rather problematic, not the least because of the rather hazy boundaries between the phlogistic and Lavoisian theories in the 1780s. Third, it is not clear from the evidence available how the new theory helped solve the various problems of industrial chemistry he faced, or could have done so, other than to offer alternative explanations for processes with which he was already familiar and indeed had often mastered. It will be suggested that it is precisely this less dramatic role which was filled by the new chemistry: that of ‘rectifying’ his ideas by providing alternative and more satisfactory rationalizations of his experiences and experiments in the laboratory and the factory, not that of enabling him to simplify and perfect old processes nor to invent new ones. To put the point more bluntly: Chaptal's early successes and reputation in industrial chemistry were not a by-product of his allegiance to the new chemistry; rather, his growing adherence to that system was a by-product of its ability to provide satisfactory post-hoc explanations of the chemical processes and products with which he was concerned. (shrink)

In Éléments de l'art de la teinture, Claude-Louis Berthollet organized and described knowledge of a chemical craft in terms of contemporary chemical science. The resulting intellectual structure of his treatise established a programme and method for the subsequent improvement of dyeing. Berthollet's descriptive and hierarchical systematization of knowledge rendered problems intelligible and isolated them so that they could be attacked and solved by methodical experimentation. This double-edged processes of solving practical problems, first cognitively and then experimentally, provides a key to (...) understanding the way science has contributed to rapid and systematic technological change. (shrink)