Starting with some illustrative examples, I develop a systematic account of a specific type of experimentation--an experimentation which is not, as in the "standard view", driven by specific theories. It is typically practiced in periods in which no theory or--even more fundamentally--no conceptual framework is readily available. I call it exploratory experimentation and I explicate its systematic guidelines. From the historical examples I argue furthermore that exploratory experimentation may have an immense, but hitherto widely neglected, epistemic significance.

Described by the philosopher A.J. Ayer as a work of 'great originality and power', this book revolutionized contemporary thinking on science and knowledge. Ideas such as the now legendary doctrine of 'falsificationism' electrified the scientific community, influencing even working scientists, as well as post-war philosophy. This astonishing work ranks alongside _The Open Society and Its Enemies_ as one of Popper's most enduring books and contains insights and arguments that demand to be read to this day.

This two-volume work, first published in 1843, was John Stuart Mill's first major book. It reinvented the modern study of logic and laid the foundations for his later work in the areas of political economy, women's rights and representative government. In clear, systematic prose, Mill (1806–73) disentangles syllogistic logic from its origins in Aristotle and scholasticism and grounds it instead in processes of inductive reasoning. An important attempt at integrating empiricism within a more general theory of human knowledge, the work (...) constitutes essential reading for anyone seeking a full understanding of Mill's thought. Volume 1 contains Mill's introduction, which elaborates upon his definition of logic as 'not the science of Belief, but the science of Proof, or Evidence'. It also features discussions of the central components of logical reasoning - propositions and syllogisms - in relation to Mill's theories of inductive reasoning and experimental method. (shrink)

In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things. A central concern of the book is the basic question of how novelty is generated in the empirical sciences. In addressing this question, (...) the author brings French poststructuralist thinking—notably Jacques Derrida’s concepts of “différance” and “historiality”—to bear on the construction of epistemic things. Historiographical perspective shifts from the actors’ minds to their objects of manipulation. These epistemological and historical issues are illuminated in a detailed case study of a particular laboratory, that of the oncologist and biochemist Paul C. Zamecnik and his colleagues, located in a specific setting—the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital of Boston. The author traces how, between 1945 and 1965, this group developed an experimental system for synthesizing proteins in the test tube that put Zamecnik’s research team at the forefront of those who led biochemistry into the era of molecular biology. (shrink)

Ethics and jurisprudence are liable to the remark in common with logic. Almost every writer having taken a different view of some of the particulars which ...

The sociological dimension of science is studied using the discovery of the Wasserman reaction and its accidental application as a test for syphilis as a basis, ...

Karl Raimund Poppers (1902-1994) Hauptwerk, die Logik der Forschung (1934), gilt als Grundlagenwerk des kritischen Rationalismus. Der kritische Rationalismus zeigt, warum unser Wissen fehlbar ist und versteht den Erkenntnisfortschritt als Resultat von Hypothesenbildung und -widerlegung. Der Sammelband orientiert sich an der Gliederung der Logik der Forschung. Seine Beiträge kommentieren die jeweiligen Themen nach aktueller Forschungslage.

This 1983 book is a lively and clearly written introduction to the philosophy of natural science, organized around the central theme of scientific realism. It has two parts. 'Representing' deals with the different philosophical accounts of scientific objectivity and the reality of scientific entities. The views of Kuhn, Feyerabend, Lakatos, Putnam, van Fraassen, and others, are all considered. 'Intervening' presents the first sustained treatment of experimental science for many years and uses it to give a new direction to debates about (...) realism. Hacking illustrates how experimentation often has a life independent of theory. He argues that although the philosophical problems of scientific realism can not be resolved when put in terms of theory alone, a sound philosophy of experiment provides compelling grounds for a realistic attitude. A great many scientific examples are described in both parts of the book, which also includes lucid expositions of recent high energy physics and a remarkable chapter on the microscope in cell biology. (shrink)

La theorie physique? Ce titre, qui fut au debut de notre siecle celui d'un ouvrage controverse, suggere bien une question, celle de savoir si en matiere de science la theorie doit se qualifier en fonction d'un domaine plus particulier d'application. L'auteur, Pierre Duhem, n'aurait pas hesite, semble-t-il, a repondre par l'affirmative en ce qui concerne le vaste champ de la recherche que l'on peut signifier sous le nom de physique. Son ouvrage est en fait construit comme une preparation rigoureuse a (...) une telle reponse et bien que les annees aient modifie considerablement le contexte du champ sus-dit, les analyses proposees ont ete jugees suggestives par de nombreux epistemologues d'aujourd'hui. (shrink)

Introduction: Science and Common Sense Long before the beginnings of modern civilization, men ac- quired vast funds of information about their environment. ...

I outline a pragmatic view of scientists' use of observation which draws attention to non-discursive, instrumental and social contexts of observation, in order to explain scientists' agreement about the appearance and significance of new phenomena. I argue that: observation is embedded in a network of activities, techniques, and interests; that experimentalists make construals of new phenomena which enable them communicate exploratory techniques and their outcomes, and that empirical enquiry consists of communicative, exploratory and predictive strategies whose interdependence ensures that, notwithstanding (...) the constructedness of representations and the empirical underdetermination of theories, observations contain information about the natural world. (shrink)

This two-volume work, first published in 1843, was John Stuart Mill's first major book. It reinvented the modern study of logic and laid the foundations for his later work in the areas of political economy, women's rights and representative government. In clear, systematic prose, Mill disentangles syllogistic logic from its origins in Aristotle and scholasticism and grounds it instead in processes of inductive reasoning. An important attempt at integrating empiricism within a more general theory of human knowledge, the work constitutes (...) essential reading for anyone seeking a full understanding of Mill's thought. Continuing the discussion of induction, Volume 2 concludes with Book VI, 'On the Logic of the Moral Sciences', in which Mill applies empirical reasoning to human behaviour. A crucial early formulation of his thinking regarding free will and necessity, this book establishes the centrality of 'the social science' to Mill's philosophy. (shrink)

Absorbing biography of the creative and destructive scientific genius and tragic life of Andr?-Marie Amp're.

This paper focuses on the empiricism/realism debate. The initial portion of the paper is a short sketch of the nature of the enterprise of philosophy of science. What are taken as empiricist views on theory construction and experiment are described. The paper concludes with a simple recasting of the main points at issue in the empiricism/realism debate.

The ArgumentThe overall portrayal of early modern experimentation as a new method of securing assent within a philosophical discourse sketched in many of the recent studies on the historical origin of experimentation is questioned by the analysis of the experimental practice of chemistry at the Paris Academy. Chemical experimentation at the Paris Academy in the late seventeenth and early eighteenth century originated in a different tradition than the philosophical. It continued and developed the material culture of the chemical work shops (...) of the sixteenth and seventeenth centuries, and explored epistemic objects which had rather loose connections to philosophy. On the other hand, I argue against the classical dichotomy between the work of the mind that of the hand, and for an epistemology of experimentation that acknowledges that experimental manipulation goes hand in hand with reflexion. In particuler, I argue against the view that chemists at the Paris Academy were “pragmatists” who merely gathered experimental facts and classified substances and operations without perplexing themselves over general conceptions. I claim that the chemists at the Paris Academy constructed a general conception framework which shaped the significance of their experiments. This conception that I call conception of the chemical combination, compound and reaction was rather quickly reified into an experimental fact. Despite its generality it was a genuine chemical conception rather independent of philosophy. (shrink)

The ArgumentMost historians of science share the conviction that the incorporation of the corpuscular theory into seventeenth-century chemistry was the beginning of modern chemistry. My thesis in this paper is that modern chemisty started with the concept of the chemicl compound, which emerged at the end of the seventeenth and the beginning of the eighteenth century, without any signifivant influence of the corpuscular theory. Rather the historical reconstruction of the emergence of this concept shows that it resulted from the reflection (...) on the chemical operations in the sixteenth-century metallurgy and seventeenth-century pharmacy. I argue that the reversibility of these operations and their understanding as crafts (metallurgy) or chemical arts (pharmacy) were decisive factors for the emergence of the first ideas about chemical compounds in the seventeenth-century pharmaceutical works written by pharmaceutically trained authors, influenced by the Paracelsian image of nature. There is a direct line of descent from these authors to E.F.Geoffroy (1675–1742), who integrated the first scattered ideas of chemical compound into a general concept comprising chemical artefacts as well as natural bodies. (shrink)

Faraday's view of the mutual relation of speculative theories and laws of nature implies that there should be a procedure, leading from speculative considerations to a system of facts and laws in which theories do no longer play any role. In order to make out the degree in which Faraday's claims correspond to his practice, the way in which he gains an explanation of Arago's effect is analyzed. The thesis is proposed that he indeed has a procedure of leaving theories (...) aside. It is intimately connected with certain methodological guidelines of his experimentation. (shrink)

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Based on the historical case of galvanic experimentation in Germany, I identify five types of experimentation which explored and shaped the new phenomenon rather than tested theoretical predictions. Verification evaluated initial reports of Galvani's phenomenon. Simplification reduced the experimental protocol to the fewest and most basic steps. Optimization found experimental conditions that magnified the observed effect. Exploration tested a wide variety of metals, animals or configurations. Application modified the experiment to address unresolved related problems. Attempts to derive laws of the (...) phenomenon or establish its underlying causes were unsuccessful primarily due to the great variability of the experimental results. (shrink)