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Molecular Epigenesis: Distributed Specificity as a Break in the Central Dogma

History and Philosophy of the Life Sciences 28 (4):533 - 548 (2006)

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Genetic information: A metaphor in search of a theory.Paul Edmund Griffiths - 2001 - Philosophy of Science 68 (3):394-412.details John Maynard Smith has defended against philosophical criticism the view that developmental biology is the study of the expression of information encoded in the genes by natural selection. However, like other naturalistic concepts of information, this ‘teleosemantic’ information applies to many non-genetic factors in development. Maynard Smith also fails to show that developmental biology is concerned with teleosemantic information. Some other ways to support Maynard Smith’s conclusion are considered. It is argued that on any definition of information the view that (...) Download Export citation Bookmark 127 citations
2001 and all that: A tale of a third science.Karola Stotz - unknowndetails The paper describes the change from molecular genetics to postgenomic biology. It focuses on phenomena in the regulation of gene expression that provide a break with the central dogma, according to which sequence specificity for a gene product must be template derived. In its place we find what is called here ‘constitutive molecular epigenesis’. Its three classes of phenomena, which I call sequence ‘activation’, ‘selection’ and ‘creation’, are exemplified by processes such as transcriptional activation, alternative cis- and trans-splicing, and RNA (...) Download Export citation Bookmark 4 citations
With ‘Genes’ Like That, Who Needs an Environment? Postgenomics’s Argument for the ‘Ontogeny of Information’.Karola Stotz - 2006 - Philosophy of Science 73 (5):905-917.details The linear sequence specification of a gene product is not provided by the target DNA sequence alone but by the mechanisms of gene expressions. The main actors of these mechanisms, proteins and functional RNAs, relay environmental information to the genome with important consequences to sequence selection and processing. This `postgenomic' reality has implications for our understandings of development not as predetermined by genes but as an epigenetic process. Critics of genetic determinism have long argued that the activity of `genes' and (...) Download Export citation Bookmark 35 citations

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