The essays included here represent Fox Keller's attempts to integrate the insights of feminist theory with those of her contemporaries in the history and philosophy of science.

Under the leadership of Joshua Lederberg, some American biologists and chemists proposed exobiology as the most legitimate program for space research. These scientists used the fear of contamination—of earth and other planets—as a central argument for funding “nonpolitical,” “scientifically valid” experiments in extraterrestrial life detection. Exobiology's resemblance to popular science fiction narratives presented a significant challenge to its advocates' scientific authority. Its most practical applications, moreover, bore an unseemly resemblance to the United States Army's research on biological weapons. At the (...) same time that exobiologists wanted to use the media to attract support for their program, they had to monitor their statements carefully in order to maintain their view of exobiology as a peaceful, scientifically valid research program. In examining how exobiology's creators positioned their work in comparison to other space sciences as well as science fiction, this case study highlights how cultural and political imperatives entered science through practice and narrative during the Cold War. Since there are still so many unanswered scientific questions and problems all around us on earth, why should we start asking new questions and seeking out new problems in space? How can the results justify the costs?—“Introduction to Outer Space” (1958). (shrink)

Under the leadership of Joshua Lederberg, some American biologists and chemists proposed exobiology as the most legitimate program for space research. These scientists used the fear of contamination—of earth and other planets—as a central argument for funding “nonpolitical,” “scientifically valid” experiments in extraterrestrial life detection. Exobiology's resemblance to popular science fiction narratives presented a significant challenge to its advocates' scientific authority. Its most practical applications, moreover, bore an unseemly resemblance to the United States Army's research on biological weapons. At the (...) same time that exobiologists wanted to use the media to attract support for their program, they had to monitor their statements carefully in order to maintain their view of exobiology as a peaceful, scientifically valid research program. In examining how exobiology's creators positioned their work in comparison to other space sciences as well as science fiction, this case study highlights how cultural and political imperatives entered science through practice and narrative during the Cold War. Since there are still so many unanswered scientific questions and problems all around us on earth, why should we start asking new questions and seeking out new problems in space? How can the results justify the costs?—“Introduction to Outer Space” (1958). (shrink)

ArgumentThis paper explores the connection between the epistemic and the “political” dimensions of the metaphor of information during the early days of the study of Molecular Evolution. While preserving some of the meanings already documented in the history of molecular biology, the metaphor acquired a new, powerful use as a substitute for “history.” A rhetorical analysis of Emilé Zuckerkandl's paper, “Molecules as Documents of Evolutionary History,” highlights the ways in which epistemic claims on the validity and superiority of molecular evidence (...) for evolution were intimately connected with authority issues in evolutionary biology. The debate is situated within the framework of the battle for resources between traditional evolutionists and molecular biologists at the beginning of the 1960s. The architects of evolutionary synthesis questioned the idea that molecular characters constitute “cleaner” and “more direct” evidence of evolution. Nevertheless, the information discourse constituted a productive space for the development of a new research program that, paradoxically, has made explicit the limitations of the information metaphor in reconstructing life's history. (shrink)

The new discipline of exobiology formed from the intertwining of origin of life research with the search for life or its building blocks on other planets, from 1957-1973. The field was inherently highly interdisciplinary, yet it coalesced very quickly and was responsible in its first twenty years for numerous important contributions to twentieth century life science and planetary sciences such as climatology, the study of mass extinctions, etc. NASA played a very important role in catalyzing the rapid consolidation of exobiology, (...) both through research grants and through sponsored meetings that overcame disciplinary boundaries, bringing together scientists from diverse backgrounds. The presence of a handful of prominent senior scientists such as Joshua Lederberg, Melvin Calvin and Norman Horowitz helped gain credibility for exobiology, in the face of criticism and competition from existing life sciences disciplines. Tensions within the exobiology research community and between NASA-funded science and the academic research community are explored, as are such milestones of discipline formation as journals and professional societies. (shrink)

The new discipline of exobiology formed from the intertwining of origin of life research with the search for life or its building blocks on other planets, from 1957-1973. The field was inherently highly interdisciplinary, yet it coalesced very quickly and was responsible in its first twenty years for numerous important contributions to twentieth century life science and planetary sciences such as climatology, the study of mass extinctions, etc. NASA played a very important role in catalyzing the rapid consolidation of exobiology, (...) both through research grants and through sponsored meetings that overcame disciplinary boundaries, bringing together scientists from diverse backgrounds. The presence of a handful of prominent senior scientists such as Joshua Lederberg, Melvin Calvin and Norman Horowitz helped gain credibility for exobiology, in the face of criticism and competition from existing life sciences disciplines. Tensions within the exobiology research community and between NASA-funded science and the academic research community are explored, as are such milestones of discipline formation as journals and professional societies. (shrink)

In the advertising discourse of human genetic database projects, of genetic ancestry tracing companies, and in popular books on anthropological genetics, what I refer to as the anthropological gene and genome appear as documents of human history, by far surpassing the written record and oral history in scope and accuracy as archives of our past. How did macromolecules become "documents of human evolutionary history"? Historically, molecular anthropology, a term introduced by Emile Zuckerkandl in 1962 to characterize the study of primate (...) phylogeny and human evolution on the molecular level, asserted its claim to the privilege of interpretation regarding hominoid, hominid, and human phylogeny and evolution vis-à-vis other historical sciences such as evolutionary biology, physical anthropology, and paleoanthropology. This process will be discussed on the basis of three key conferences on primate classification and evolution that brought together exponents of the respective fields and that were held in approximately ten-years intervals between the early 1960s and the 1980s. I show how the anthropological gene and genome gained their status as the most fundamental, clean, and direct records of historical information, and how the prioritizing of these epistemic objects was part of a complex involving the objectivity of numbers, logic, and mathematics, the objectivity of machines and instruments, and the objectivity seen to reside in the epistemic objects themselves. (shrink)

ABSTRACT Historians of science, inasmuch as they are concerned with knowledges and practices rather than institutions, have tended of late to focus on case studies of common processes such as experiment and publication. In so doing, they tend to treat science as a single category, with various local instantiations. Or, alternatively, they relate cases to their specific local contexts. In neither approach do the cases or their contexts build easily into broader histories, reconstructing changing knowledge practices across time and space. (...) This essay argues that by systematically deconstructing the practices of science and technology and medicine (STM) into common, recurrent elements, we can gain usefully “configurational” views, not just of particular cases and contexts but of synchronic variety and diachronic changes, both short term and long. To this end, we can begin with the customary actors’ disciplines of early modern knowledge (natural philosophy, natural history, mixed mathematics, and experimental philosophy), which can be understood as elemental “ways of knowing and working,” variously combined and disputed. I argue that these same working knowledges, together with a later mode—synthetic experimentation and systematic invention—may also serve for the analysis of STM from the late eighteenth century to the present. The old divisions continued explicitly and importantly after circa 1800, but they were also “built into” an array of new sciences. This historiographic analysis can help clarify a number of common problems: about the multiplicity of the sciences, the importance of various styles in science, and the relations between science and technology and medicine. It suggests new readings of major changes in STM, including the first and second scientific revolutions and the transformations of biomedicine from the later twentieth century. It offers ways of recasting both microhistories and macrohistories, so reducing the apparent distance between them. And it may thus facilitate both more constructive uses of case studies and more innovative and acceptable longer histories. (shrink)

Among the many groups of scholars whose work now illuminates science, technology and medicine (STM), historians, it seems to me, have a key responsibility not just to elucidate change but to establish and explain variety. One of the big pictures we need is a model of the varieties of STM over time; one which does not presume the timeless existence of disciplines, or the distinctions between science, technology and medicine; a model which is both synchronic and diachronic, and both cognitive (...) and social. To that end, this brief paper presents a historical typology of STM from about 1700 to the present by focusing on four ‘ideal’ socio-cognitive types – four knowledge structures which correspond to four sets of social relations. To some extent these are period specific, but they do not have to be – hence, one may hope, the flexibility and usefulness of the model. (shrink)

Biologists and historians often present natural history and molecular biology as distinct, perhaps conflicting, fields in biological research. Such accounts, although supported by abundant evidence, overlook important areas of overlap between these areas. Focusing upon examples drawn particularly from systematics and molecular evolution, I argue that naturalists and molecular biologists often share questions, methods, and forms of explanation. Acknowledging these interdisciplinary efforts provides a more balanced account of the development of biology during the post-World War II era.

Despite the promises made by molecular evolutionists since the early 1960s that phylogenies would be readily reconstructed using molecular data, the construction of molecular phylogenies has both retained many methodological problems of the past and brought up new ones of considerable epistemic relevance. The field is driven not only by changes in knowledge about the processes of molecular evolution, but also by an ever-present methodological anxiety manifested in the constant search for an increased objectivity—or in its converse, the avoidance of (...) subjectivity.This paper offers an exhaustive account of the methodological and conceptual difficulties embedded in each of the steps required to elaborate molecular phytogenies. The authors adopt a historical perspective on the field in order to follow the development of practices that seek to increase the objectivity of their methods and representations. These include the adoption and development of explicit criteria for evaluation of evidence, and of procedures associated with methods of statistical inference, quantification and automation. All these are linked to an increasing use of computers in research since the mid 1960s. We will show that the practices of objectivity described are highly dependent on the problems and tools of molecular phylogenetics. (shrink)

This paper focuses on the consolidation of Molecular Evolution, a field originating in the 1960s at the interface of molecular biology, biochemistry, evolutionary biology, biophysics and studies on the origin of life and exobiology. The claim is made that Molecular Evolution became a discipline by integrating different sorts of scientific traditions: experimental, theoretical and comparative. The author critically incorporates Timothy Lenoir’s treatment of disciplines , as well as ideas developed by Stephen Toulmin on the same subject. On their account disciplines (...) are spaces where the social and epistemic dimensions of science are deeply and complexly interwoven. However, a more detailed account of discipline formation and the dynamics of an emerging disciplinary field is lacking in their analysis. The present essay suggests focusing on the role of scientific concepts in the double configuration of disciplines: the social/political and the epistemic order. In the case of Molecular Evolution the concepts of molecular clock and informational molecules played a central role, both in differentiating molecular from classical evolutionists, and in promoting communication between the different sorts of traditions integrated in Molecular Evolution. The paper finishes with a reflection on the historicity of disciplines, and the historicity of our concepts of disciplines. (shrink)

Between the 1930s and 1950s, life science had evolved into a sophisticated and expensive scientific enterprise. Under the influence of the Rockefeller Foundation's program of molecular biology, vital processes, especially the properties of proteins, were increasingly probed through systematic applications of tools from the physical sciences. This trend altered the nature of biological knowledge, the organization of research, and patterns of funding for the life sciences, transforming laboratory research into 'big science' — a team activity centered around massive apparatus. The (...) development of the Tiselius apparatus during the 1930s and 1940s serves as an example par excellence of these nascent intellectual and institutional trends. The paper shows that the Tiselius apparatus and the research it spawned represented one of the early collaborative projectes organized around a major laboratory technology. From its inception, design, construction, and early uses the new electrophoresis technology was a joint-effort between Svedberg's group at the University of Uppsala, the Rockefeller Institute, and a few other elite institutions. These collaborations reflected access to resources, and a commitment to a scientific agenda which stressed the physico-chemical approach to biological phenomena. The collaborations were based on the 'protein paradigm' — the view that proteins were the primary determinants of biological specificity. By examining the intellectual programs and the institutional network around the Tiselius apparatus, this paper also underscores the fruitfulness of studying the history of laboratory technology of the life sciences. (shrink)

In this paper, I analyze George Gaylord Simpson's response to the molecularization of evolutionary biology from his unique perspective as a paleontologist. I do so by exploring his views on early attempts to reconstruct phylogenetic relationships among primates using molecular data. Particular attention is paid to Simpson's role in the evolutionary synthesis of the 1930s and 1940s, as well as his concerns about the rise of molecular biology as a powerful discipline and world-view in the 1960s. I argue that Simpson's (...) belief in the supremacy of natural selection as the primary driving force of evolution, as well as his view that biology was a historical science that seeks ultimate causes and highlights contingency, prevented him from acknowledging that the study of molecular evolution was an inherently valuable part of the life sciences. (shrink)