The action-reaction principle (AR) is examined in three contexts: (1) the inertial-gravitational interaction between a particle and space-time geometry, (2) protective observation of an extended wave function of a single particle, and (3) the causal-stochastic or Bohm interpretation of quantum mechanics. A new criterion of reality is formulated using the AR principle. This criterion implies that the wave function of a single particle is real and justifies in the Bohm interpretation the dual ontology of the particle and its associated wave (...) function. But it is concluded that the Bohm theory is not dynamically complete because the particle and its associated wave function do not satisfy the AR principle. (shrink)