Synthetic biology is described as a new field of biotechnology that models itself on engineering sciences. However, this view of synthetic biology as an engineering field has received criticism, and both biologists and philosophers have argued for a more nuanced and heterogeneous understanding of the field. This paper elaborates the heterogeneity of synthetic biology by clarifying the role of design and the variability of design methodologies in synthetic biology. I focus on two prominent design methodologies: rational design and directed evolution. (...) Rational design resembles the design methodology of traditional engineering sciences. However, it is often replaced and complemented by the more biologically-inspired method of directed evolution, which models itself on natural evolution. These two approaches take philosophically different stances to the design of biological systems. Rational design aims to make biological systems more machine-like, whereas directed evolution utilizes variation and emergent features of living systems. I provide an analysis of the methodological basis of these design approaches, and highlight important methodological differences between them. By analyzing the respective benefits and limitations of these approaches, I argue against the engineering-dominated conception of synthetic biology and its “methodological monism”, where the rational design approach is taken as the default design methodology. Alternative design methodologies, like directed evolution, should be considered as complementary, not competitive, to rational design. (shrink)

Synthetic biology offers a powerful method to design and construct biological devices for human purposes. Two prominent design methodologies are currently used. Rational design adapts the design methodology of traditional engineering sciences, such as mechanical engineering. Directed evolution, in contrast, models its design principles after natural evolution, as it attempts to design and improve systems by guiding them to evolve in a certain direction. Previous work has argued that the primary difference between these two is the way they treat variation: (...) rational design attempts to suppress it, whilst direct evolution utilizes variation. I argue that this contrast is too simplistic, as it fails to distinguish different types of variation and different phases of design in synthetic biology. I outline three types of variation and show how they influence the construction of synthetic biological systems during the design process. Viewing the two design approaches with these more fine-grained distinctions provides a better understanding of the methodological differences and respective benefits of rational design and directed evolution, and clarifies the constraints and choices that the different design approaches must deal with. (shrink)

Katarzyna de Lazari-Radek and Peter Singer have recently provided an evolutionary argument for utilitarianism. They argue that most of our deontological beliefs were shaped by evolution, from which they conclude that these beliefs are unjustified. By contrast, they maintain that the utilitarian belief that everyone’s well-being matters equally is immune to such debunking arguments because it wasn’t similarly influenced. However, Guy Kahane remarks that this belief lacks substantial content unless it is paired with an account of well-being, and he (...) adds that utilitarian beliefs about wellbeing—e.g. the belief that pleasure is good and pain is bad—were probably shaped by evolution. Logically, de Lazari-Radek and Singer should therefore reject these beliefs along with the deontological beliefs that evolved. The present paper is a defense of their argument. After considering a number of unsuccessful replies to Kahane’s objection, I put forward a more promising solution: de Lazari-Radek and Singer should combine their objectivist view in metaethics with a subjectivist account of well-being, such as the desire theory. Such a hybrid account would tackle Kahane’s challenge because subjective accounts of value are immune from evolutionary debunking arguments. And it would be compatible with utilitarianism, which doesn’t fit very well with metaethical subjectivism. Before concluding, I deal with two concerns that this solution might raise: I argue that the desire theory is actually subjective enough to escape Kahane’s objection, and I deny that retreating to the combination of ethical objectivism and prudential subjectivism is ad hoc. (shrink)

Katarzyna de Lazari-Radek and Peter Singer’s wonderful book, The Point of View of the Universe: Sidgwick and Contemporary Ethics, contains a wealth of intriguing arguments and compelling ideas. The present paper focuses on areas of continuing dispute. The paper first attacks LazariRadek’s and Singer’s evolutionary debunking arguments against both egoism and parts of common-sense morality. The paper then addresses their discussion of the role of rules in utilitarianism. De Lazari-Radek and Singer concede that rules should constitute our moral (...) decision procedure and our public morality. This paper argues that, if no one should be blamed for complying with the optimal decision procedure and optimal public rules, there are strong reasons to accept that these same rules determine what is morally permissible from what is morally wrong. (shrink)

A number of philosophers from Hobbes to Mill to Parfit have held some combination of the following views about the Golden Rule: (a) It is the cornerstone of morality across many if not all cultures. (b) It affirms the value of moral impartiality, and potentially the core idea of utilitarianism. (c) It is immune from evolutionary debunking, that is, there is no good naturalistic explanation for widespread acceptance of the Golden Rule, ergo the best explanation for its appearance in different (...) traditions is that people have perceived the same non-natural moral truth. De Lazari-Radek and Singer employ all three of these claims in an argument meant to vindicate Sidgwick's ‘principle of universal benevolence’. I argue that the Golden Rule is the cornerstone of morality only in Christianity, it does not advocate moral impartiality, and there is a naturalistic explanation for why versions of the Golden Rule appear in different traditions. (shrink)

The thesis investigates the implications for moral philosophy of research in psychology. In addition to an introduction and concluding remarks, the thesis consists of four chapters, each exploring various more specific challenges or inputs to moral philosophy from cognitive, social, personality, developmental, and evolutionary psychology. Chapter 1 explores and clarifies the issue of whether or not morality is innate. The chapter’s general conclusion is that evolution has equipped us with a basic suite of emotions that shape our moral judgments in (...) important ways. Chapter 2 presents and investigates the challenge presented to deontological ethics by Joshua Greene’s so-called dual process theory. The chapter partly agrees with his conclusion that the dual process view neutralizes some common criticisms against utilitarianism founded on deontological intuitions, but also points to avenues left to explore for deontologists. Chapter 3 focuses on Katarzyna de Lazari-Radek and Peter Singer’s suggestion that utilitarianism is less vulnerable to so-called evolutionary debunking than other moral theories. The chapter is by and large critical of their attempt. In the final chapter 4, attention is directed at the issue of whether or not social psychology has shown that people lack stable character traits, and hence that the virtue ethical view is premised on false or tenuous assumptions. Though this so-called situationist challenge at one time seemed like a serious threat to virtue ethics, the chapter argues for a moderate position, pointing to the fragility of much of the empirical research invoked to substantiate this challenge while also suggesting revisions to the virtue-ethical view as such. (shrink)

THE EXISTENTIAL CONDITION OF THE IJAWS IN THE EMERGING SOCIO-ECONOMIC AND POLITICAL MILIEU OF NIGERIA. By Ebo Socrates, PhD. -/- Nigeria is a hybrid nation of over two hundred and fifty ethnic nationalities. The Ijaws as a people among the multitude of peoples that have come to constitute the geographic expression and sovereign entity known as Nigeria, find themselves enmeshed in the fluctuating socio-economic milieu of Nigeria. They as well as other ethnic nationalities that constitute Nigeria, found themselves bound to (...) the contingencies and exigencies of the nation-state called Nigeria not by act of will or treaty but by the Lugardian fiat which in itself was a full expression of the British imperialist will to power. By fiat and history, a country was made; the country is Nigeria, its people simply are; a fact of history. Their mode of being however, is a confluence of contraction and progress. So many models of nationhood explicates Nigeria. But Nigeria, is undeniably a “torn” nation. In the words of Samuel Huntington, a nation of conflicting civilizations: the Islamic civilization and the Judeo-Christian civilization. The Ijaws, an oil rich minority tribe found themselves entwined and involved in the destiny of this phenomenal nation called Nigeria. Has such an entwinement been a curse or blessing? Have the Ijaws significant power in the organogram of the Nigerian nationhood? Are they tossed about by the tide and flow of events or are they active movers in the making of the Nigerian history? This paper critically looks at these existential realities and elucidates the existential condition of the Ijaws in the contemporary Nigeria . (shrink)

This article responds to an argument from Katarzyna de Ladari-Radek and Peter Singer in their article, "The Objectivity of Ethics and the Unity of Practical Reason.".

Among critical concepts in Mulla Sadra's thought, which, of course, cannot be discussed separately between the parts. This is because the basic rules in philosophical discourse are universal traits that make it approached from various directions as a unified form of reality. One of Sadra's famous thoughts is the concept of the soul, which is related to the roots of his philosophical doctrine of being. The significance of the discussion of the soul by Mulla Sadra becomes increasingly crucial given the (...) discourse about the soul, especially in the debate of modern European philosophy in such a way that are absurd forms in Islamic religious doctrine. Therefore, seeing the relationship between the two models of approach to the soul is not only the only way to understand the universal message of the Islamic treatise about the soul but also creates a model of dialogue volume two of Ibn Rusyd-Ghazali becoming Mulla Sadra versus Modern Europe. (shrink)