Background: Leprosy is a chronic granulomatous infectious disease having major burden on humans over thousands of years. If untreated, it results in permanent damage to various systems and organs. So we designed this study to evaluate the neurological complications in early stage in adult leprosy patients. Objective: The aim of this study was to find out the pattern of neurological manifestations among adult leprosy patients. Materials and Methods: This cross-sectional hospital-based study on 85 adult tribal leprosy (...) patients was conducted in a district level health care facility from January to December 2014 using simple, direct, standardized questionnaire including history and neurological examinations. Results: The commonest age group affected was 18–30 years (62.4%). Male group was predominant (68.2%). Majority cases (66%) had multibacillary leprosy. At first visit 72.7% cases with neurological findings could not be diagnosed correctly by primary health care personnel. More than six months were required for correct diagnosis in 61.2% cases. Numbness was the commonest (74.5%) neurological symptom. In upper limb, motor findings were predominant with wasting in 50.9% cases. In lower limb, sensory findings were predominant with stock pattern sensory impairment being the commonest (56.4%). Ulnar nerve was the commonest peripheral nerve to enlarge with tenderness. Facial nerve was the commonest cranial nerve involved. All cases with multiple cranial nerves involvement were of multibacillary type. Due to physical disability 92.7% cases lost their jobs. (shrink)

Background: Leprosy is a chronic granulomatous infectious disease having major burden on humans over thousands of years. If untreated, it results in permanent damage to various systems and organs. So we designed this study to evaluate the neurological complications in early stage in adult leprosy patients. Objective: The aim of this study was to find out the pattern of neurological manifestations among adult leprosy patients. Materials and Methods: This cross-sectional hospital-based study on 85 adult tribal leprosy (...) patients was conducted in a district level health care facility from January to December 2014 using simple, direct, standardized questionnaire including history and neurological examinations. Results: The commonest age group affected was 18–30 years (62.4%). Male group was predominant (68.2%). Majority cases (66%) had multibacillary leprosy. At first visit 72.7% cases with neurological findings could not be diagnosed correctly by primary health care personnel. More than six months were required for correct diagnosis in 61.2% cases. Numbness was the commonest (74.5%) neurological symptom. In upper limb, motor findings were predominant with wasting in 50.9% cases. In lower limb, sensory findings were predominant with stock pattern sensory impairment being the commonest (56.4%). Ulnar nerve was the commonest peripheral nerve to enlarge with tenderness. Facial nerve was the commonest cranial nerve involved. All cases with multiple cranial nerves involvement were of multibacillary type. Due to physical disability 92.7% cases lost their jobs. Conclusion: In this study neurological involvement was found associated with severe disability. ! (shrink)

Background: Multi Drug Therapy approved by WHO is the best treatment option for Leprosy. There is a significant decline of mortality and morbidity after the introduction of multi drug therapy. But the adverse effects causing changes in clinical and laboratory parameters to multi drug therapy are the main limiting obstacle for the treatment course completion. Objective: The aim of this study is to find out the effects on routine laboratory parameters including hematological and biochemical changes before, during and after (...) the treatment of multi drug therapy in leprosy. Methodology: A descriptive cohort hospital based study on 85 multi drug therapy treated leprosy patients using standard laboratory tools for routine investigations for 18 months. Results: During the one year multidrug treatment period, most of the routine laboratory parameters showed mild to moderate change from normal level during the first 3 months with gradual recovery in the following months. Complete blood count assessment revealed mild decline in Hb, PCV, MCH, MCHC, and moderate decline in WBC and Platelet count. A mild increase in liver function tests (Bilirubin, AST, ALT, Alkaline phosphatase) and renal function tests (S.Creatinine, b. Urea) was observed. A moderate decline in S. Sodium with mild increase in S. Potassium was found on investigating S. Electrolytes. Patients were fully recovered from all hemato-biochemical adverse effects after 6 months of completion of the multi drug therapy. Conclusion: Despite of mild to moderate hematological and biochemical adverse reactions with multi drug therapy, recovery was excellent after 6 months of completion of therapy. (shrink)

Ācārya Vādirāja, the composer of ‘Ekībhāva Stotra’ lived around the 11th century Vikrama Samvat. ‘Vādirāja’ was an honour bestowed on him; this was not his actual name. Being the undisputed master of the debating skills – vāditva – in regard to philosophical reasoning, he became famous as ‘Vādirāja’. Ācārya Vādirāja is considered as one of the great contributors to the Jaina literature. Due to the fruition of the past evil karmas, Ācārya Vādirāja’s body got inflicted with leprosy. In spite (...) of this infliction, the dispassionate saint used to remain engrossed in his meditation, unmindful of his bodily suffering. As per the anecdotal story, in order to save the glory of the Jaina saints, Ācārya Vādirāja got himself engrossed in the devotion of Lord Ādinātha and during the course of one night composed the famous ‘Ekībhāva Stotra’. He implores in ‘Ekībhāva Stotra’: “O Lord! On account of the merit of the worthy souls, you had descended on this earth from the celestial world (the Sarvārthasiddhi heaven) and earlier (six months before you entered your mother’s womb) this part of the earth was imparted the lustre of gold (due to the incessant rain of the choicest gems by Kubera). O Lord Jina! Now you have entered the home of my heart that has the door of your meditation and is attractive; is there any wonder in your imparting the lustre of gold to my body?” By virtue of his devotion to Lord Jina, the leprosy of Ācārya Vādirāja got quelled during the night and by the morning his body attained lustre and glow like that of the tempered gold. (shrink)

This paper deals with the problematic relationship between thought and nature in Hegel. This entails looking at the philosophy of nature and discovering to what extent it claims to incorporate natural otherness or contingency and how it does so. I briefly summarize other approaches to this question (Maker, Winfield, Braun, Wandschneider, Hoffheimer...) while putting forward my own solution. This is expressed in an argument articulated around the three Hegelian images (and their texts) in the paper’s title. We discover how the (...) relation between philosophy and nature is a dynamic one, mediated by the actual content of the positive natural sciences. In other words, thought and nature are mediated by the human activity of scientific knowing, within the systematic project of knowing all of nature. This raises the possibility of conceiving Hegel’s system as open to the future. (shrink)

This article aims to highlight the resounding issue regarding the pandemic caused by COVID-19 in the Philippines. In hindsight, it seems that contemporary Filipinos treat its spread as a new and first disease that our society has experienced. It only reflects the inexhaustible study of Filipino pathology. So there is a tendency for the Filipino government to tarnish or not take the future pandemic seriously because apart from the lack of knowledge about pandemics, it is possible that our society does (...) not know the challenges recognized and responses done to past diseases (which is even worse than COVID-19). So I utilized the neologisms that were popular these days of COVID-19 and no doubt had entered the body of modern Filipino vocabulary and corpora. It is ensured that through this comparison, the significance of previous diseases in the Philippines can be easily traced and understood. Although the motion of the argument is reversed; the present will be used to comprehend the past. With this move, it will be proven that the neologisms I have noticed are not that new. This study focuses on re-examining Hansen’s disease or leprosy that plagued the Philippines in the early 20th century. It has created great concern and fear among Filipinos. Nearly a hundred years later, COVID-19 emerged in the early 21st century. In addition to the comparative lens presented by this study, two diseases can be identified and compared in measuring the experiences of Filipinos. Although in different epochs and intensities, both diseases have given rise to extreme fear in Filipino society. (shrink)

Lezama, and later Deleuze, discovered that the baroque does not refer to an essence, but to an operative function. That operative function is the fold, which "curls and multiplies", as Lezama writes, and proliferates to infinity. We all know the examples with which Lezama placed his concept of the American baroque: the poems of Domínguez Camargo, those of Sor Juana, the architectures of the Kondori Indian, the baptismal fonts of Aleijadinho, "ornamented like accordions, with spiraloid leaves that ascend"; the chapel (...) of the Rosary, in Puebla, omamentada "without truce or free spatial parenthesis". This is how the fold operates, it is like a leprosy or a lichen -in the past, certain lichens were called leprosy-: it infests by enveloping and developing, it proliferates by setting in motion the fold-unfold pair. Lezama does not seek to reconfigure the sequences of history, but to superimpose other cycles on them, create gaps and vanishing points in chronological and causal narratives, divert the emphasis placed on cultures and redirect it to imaginary eras, until the meaning comes from a series of scales established in the historical. The eras would be ordered according to their potentiality to create images; thus it would be possible to establish the points where the image was imposed as history. The Carolingian imaginary era, for example, forged a link between the prodigies, the marvelous islands, the battles against the Saracens and theocratic reason. How are these scales established and how do they operate? How do counterpoint, images and links work? (shrink)

This paper aims to recover the history of health concept evolution from its birth in Ancient Greece to the contemporary days, drawing an overview of the firsts philosophical thoughts about health in distinctive historical periods, analyzing how this concept has been impacted by knowledge improvement and both research and technological discoveries over time. In order to understand the persistence of Neglected Tropical Diseases which causes physical disabilities and social discrimination, this paper will focus on Leprosy and Cutaneous Leishmaniasis and (...) its relation to social inequality mainly in developing countries. These approaches on the understanding of the health-disease binomial are necessary to reflect on health in the course of human history and, from there, to promote joint actions both in the area of scientific research and health education. (shrink)