Humanists and philosophers in the Quattrocento find inspiration for their treatises on human dignity not only in Classical Antiquity, but also in the works of the Church Fathers. The present paper examines the influence of the latter on the theories of freedom at the dawn of Modernity, especially regarding the Patristic conception of human self as person or hypostasis, whose free decision is considered inviolable, creative and irreducible to its own nature or essence.