Preimplantation genetic testing for polygenic disorders (PGT-P) has been commercially available since 2019. PGT-P makes use of polygenic risk scores for conditions which are multifactorial and are significantly influenced by environmental and lifestyle factors. If current predictions are accurate, then absolute risk reductions range from about 0.02% to 10.1%, meaning that between 10 and 5,000 in vitro fertilization patients would need to be tested with PGT-P to prevent one offspring from becoming affected in the future, depending on the condition and (...) the number of embryos available. Survey and interview data reveal that patients and the public have largely favorable views regarding the use of PGT-P for disease prevention; however, clinicians and professional organizations have many reservations. The use of PGT-P raises multiple social and ethical concerns including the need for adequate counseling, the setting of realistic expectations, the application of distributive justice, the impact of environmental and social determinants of health, and the potential exacerbation of health inequities. Clinicians expressed significant concerns relating to the cost of PGT-P, the potential time-consuming counseling for reproductive endocrinologists and genetic counselors, the intentional creation of supernumerary embryos, and patients’ unrealistic expectations regarding “healthiest disease-free” embryos. Furthermore, current evidence lacks long-term outcome data and generalizability. Prior to offering PGT-P to patients, additional clinical validation studies are needed. Also, ethical and social considerations raised by PGT-P should be carefully delineated. Systemic practices to increase equitable access to unbiased genetic counseling and reproductive services would be desirable prior to the ethical implementation of PGT-P. (shrink)

One of the most popular facets of Schmitt's philosophy is his theory of sovereignty and decisionism, as developed in his early essay Political Theology (1922). There, Schmitt offers an original outlook on the political implications of the secularization of modern Europe and philosophy's purported turn away from theology. The “death of God,” along with the gradual disappearance of the political institution of monarchy, are only symbols of the decline of sovereignty in general. What is lost in the process is not (...) sovereignty as such, since it can assume new forms, such as “reason,” “nature,” “the people,” or “the state.” What…. (shrink)

The Event of the Thing by Michael Marder is probably one of the most comprehensive and integrative readings of Derrida's oeuvre to date. A virtue of the book is that, despite the comprehensiveness of its subject matter, it does not assume the removed posture of an introduction, an exposition, or an explication. Its relation to the Derridian text is much more internal and intimate, and it should be noted that it presupposes a rather thorough knowledge of Derrida's oeuvre as well (...) as of Derrida's philosophical “reading list” (primarily Husserl, Heidegger, Freud, Marx, and Kant). Marder's confident and elegant prose reveals…. (shrink)

Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data (...) Analysis, and Resources—for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the ImmPort Shared Data portal , which allows research data to be repurposed to accelerate the translation of new insights into discoveries. (shrink)