Results for 'neuromodulators'

8 found
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  1. Using neurons to maintain autonomy: Learning from C. elegans.William Bechtel & Leonardo Bich - 2023 - Biosystems 232:105017.
    Understanding how biological organisms are autonomous—maintain themselves far from equilibrium through their own activities—requires understanding how they regulate those activities. In multicellular animals, such control can be exercised either via endocrine signaling through the vasculature or via neurons. In C. elegans this control is exercised by a well-delineated relatively small but distributed nervous system that relies on both chemical and electric transmission of signals. This system provides resources to integrate information from multiple sources as needed to maintain the organism. Especially (...)
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  2. Model Organisms for Studying Decision-Making: A Phylogenetically Expanded Perspective.Linus Ta-Lun Huang, Leonardo Bich & William Bechtel - 2021 - Philosophy of Science 88 (5):1055-1066.
    This article explores the use of model organisms in studying the cognitive phenomenon of decision-making. Drawing on the framework of biological control to develop a skeletal conception of decision-making, we show that two core features of decision-making mechanisms can be identified by studying model organisms, such as E. coli, jellyfish, C. elegans, lamprey, and so on. First, decision mechanisms are distributed and heterarchically structured. Second, they depend heavily on chemical information processing, such as that involving neuromodulators. We end by (...)
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  3. The Memory-Modifying Potential of Optogenetics and the Need for Neuroethics.Agnieszka K. Adamczyk & Przemysław Zawadzki - 2020 - NanoEthics 14 (3):207-225.
    Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers (...)
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  4. Bridging emotion theory and neurobiology through dynamic systems modeling.Marc D. Lewis - 2005 - Behavioral and Brain Sciences 28 (2):169-194.
    Efforts to bridge emotion theory with neurobiology can be facilitated by dynamic systems (DS) modeling. DS principles stipulate higher-order wholes emerging from lower-order constituents through bidirectional causal processes cognition relations. I then present a psychological model based on this reconceptualization, identifying trigger, self-amplification, and self-stabilization phases of emotion-appraisal states, leading to consolidating traits. The article goes on to describe neural structures and functions involved in appraisal and emotion, as well as DS mechanisms of integration by which they interact. These mechanisms (...)
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  5. Personality and Authenticity in Light of the Memory-Modifying Potential of Optogenetics.Przemysław Zawadzki & Agnieszka K. Adamczyk - 2021 - American Journal of Bioethics Neuroscience 12 (1):3-21.
    There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...)
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  6. Apical amplification—a cellular mechanism of conscious perception?Tomas Marvan, Michal Polák, Talis Bachmann & William A. Phillips - 2021 - Neuroscience of Consciousness 7 (2):1-17.
    We present a theoretical view of the cellular foundations for network-level processes involved in producing our conscious experience. Inputs to apical synapses in layer 1 of a large subset of neocortical cells are summed at an integration zone near the top of their apical trunk. These inputs come from diverse sources and provide a context within which the transmission of information abstracted from sensory input to their basal and perisomatic synapses can be amplified when relevant. We argue that apical amplification (...)
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  7. Is punishment backward? On neurointerventions and forward‐looking moral responsibility.Przemysław Zawadzki - 2022 - Bioethics 37 (2):183-191.
    This article focuses on justified responses to “immoral” behavior and crimes committed by patients undergoing neuromodulation therapies. Such patients could be held morally responsible in the basic desert sense—the one that serves as a justification of severe practices such as backward‐looking moral outrage, condemnation, and legal punishment—as long as they possess certain compatibilist capabilities that have traditionally served as the quintessence of free will, that is, reasons‐responsiveness; attributability; answerability; the abilities to act in accordance with moral reasons, second‐order volitions, or (...)
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  8. Neurological, Digestive, and Nephrological Emergencies in Pediatric Medicine.David Tomasi - 2020 - Uccuyo - Pediatric Medicine 1.
    A precise overview of pediatric emergencies would require taxological considerations around the differences between strictly neurological factors, as modulated both via neuroanatomical differentiation in the context of normal vs. abnormal biological development, and underlying neurofunctional mechanisms, and the connection with such processes with the neuromodulated activation of digestive processes. Furthermore, an important distinction between nephrological considerations and urological considerations is necessary, more specifically, by focusing on the treatment of diseases affecting the kidneys and their ability to function in the first (...)
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