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  1. Should Mitochondrial Replacement Therapy Be Funded by the National Health Service?Sophie Rhys-Evans - 2021 - Journal of Medical Ethics 47 (3):194-198.
    A clinical trial on mitochondrial replacement therapy is currently being conducted and if this technique proves effective, National Health Service England will fund MRT through the highly specialised services funding stream. This paper considers whether MRT should be publicly funded by the NHS. Given the current financial pressure the NHS is experiencing, a comprehensive discussion is essential. There is yet to be a thorough discussion on MRT funding, perhaps because this is a small-scale issue and presumed to be covered by (...)
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  • Genome Editing and Assisted Reproduction: Curing Embryos, Society or Prospective Parents?Giulia Cavaliere - 2018 - Medicine, Health Care and Philosophy 21 (2):215-225.
    This paper explores the ethics of introducing genome-editing technologies as a new reproductive option. In particular, it focuses on whether genome editing can be considered a morally valuable alternative to preimplantation genetic diagnosis. Two arguments against the use of genome editing in reproduction are analysed, namely safety concerns and germline modification. These arguments are then contrasted with arguments in favour of genome editing, in particular with the argument of the child’s welfare and the argument of parental reproductive autonomy. In addition (...)
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  • Genetic Ethics and mtDNA Replacement Techniques.Courtney A. Brenner - 2021 - The New Bioethics 27 (1):3-18.
    The United Kingdom parliament made history in 2015 when they voted to allow the use of mitochondrial replacement techniques. Mitochondrial diseases are genetically inherited and currently,...
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  • Mitochondrial Replacement Techniques: Egg Donation, Genealogy and Eugenics.César Palacios-González - 2016 - Monash Bioethics Review 34 (1):37-51.
    Several objections against the morality of researching or employing mitochondrial replacement techniques have been advanced recently. In this paper, I examine three of these objections and show that they are found wanting. First I examine whether mitochondrial replacement techniques, research and clinical practice, should not be carried out because of possible harms to egg donors. Next I assess whether mitochondrial replacement techniques should be banned because they could affect the study of genealogical ancestry. Finally, I examine the claim that mitochondrial (...)
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  • Mitochondrial/Nuclear Transfer: A Literature Review of the Ethical, Legal and Social Issues.Raphaëlle Dupras-Leduc, Stanislav Birko & Vardit Ravitsky - unknown
    Mitochondrial/nuclear transfer to avoid the transmission of serious mitochondrial disease raises complex and challenging ethical, legal and social issues. In February 2015, the United Kingdom became the first country in the world to legalize M/NT, making the heated debate surrounding this technology even more relevant. This critical interpretive review identified 95 relevant papers discussing the ELSI of M/NT, including original research articles, government-commissioned reports, editorials, letters to editors and research news. The review presents and synthesizes the arguments present in the (...)
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  • The (Re) Production of the Genetically Related Body in Law, Technology and Culture: Mitochondria Replacement Therapy.Danielle Griffiths - 2016 - Health Care Analysis 24 (3):196-209.
    Advances in medicine in the latter half of the twentieth century have dramatically altered human bodies, expanding choices around what we do with them and how they connect to other bodies. Nowhere is this more so than in the area of reproductive technologies. Reproductive medicine and the laws surrounding it in the UK have reconfigured traditional boundaries surrounding parenthood and the family. Yet culture and regulation surrounding RTs have combined to try to ensure that while traditional boundaries may be pushed, (...)
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  • Should Mitochondrial Donation Be Anonymous?John B. Appleby - 2018 - Journal of Medicine and Philosophy 43 (2):261-280.
    Currently in the United Kingdom, anyone donating gametes has the status of an open-identity donor. This means that, at the age of 18, persons conceived with gametes donated since April 1, 2005 have a right to access certain pieces of identifying information about their donor. However, in early 2015, the UK Parliament approved new regulations that make mitochondrial donors anonymous. Both mitochondrial donation and gamete donation are similar in the basic sense that they involve the contribution of gamete materials to (...)
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  • Ethische Und Konzeptuelle Aspekte des Mitochondrien-Transfers („Drei-Eltern-Kind“)Ethical and Conceptual Aspects of Mitochondrial Replacement Techniques.Giovanni Rubeis & Florian Steger - 2019 - Ethik in der Medizin 31 (2):143-158.
    ZusammenfassungDer weltweit erste Mitochondrien-Transfer, auch als Erzeugung eines „Drei-Eltern-Kindes“ bezeichnet, hat 2016 eine intensive Debatte ausgelöst. Hinsichtlich des Verfahrens, das bisher nur in Großbritannien zugelassen ist, werden auch verschiedene ethische Aspekte angesprochen. Dazu gehören die Risikoabwägung, die reproduktive Selbstbestimmung und die psychosoziale Entwicklung eines Kindes, das von drei Individuen abstammt. Dabei fällt auf, dass zentrale konzeptuelle Fragen hinsichtlich des Mitochondrien-Transfers nicht geklärt sind. Ist der Mitochondrien-Transfer eine genetische Intervention in die Keimbahn? Handelt es sich bei dem Verfahren um eine medizinisch (...)
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  • Should Long-Term Follow-Up Post-Mitochondrial Replacement Be Left Up to Physicians, Parents, or Offspring?Tetsuya Ishii - 2019 - The New Bioethics 25 (4):318-331.
    UK law permits parents to use mitochondrial replacement to have genetically-related children without serious mitochondrial disease. However, long-term follow-up is required for each case. Whet...
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  • Genome Modifying Reproductive Procedures and Their Effects on Numerical Identity.Calum MacKellar - 2019 - The New Bioethics 25 (2):121-136.
    The advantages and risks of a number of new genome modifying procedures seeking to create healthy or enhanced individuals, such as Maternal Spindle Transfer, Pronuclear Transfer, Cytoplasmic Transfer and Genome Editing, are currently being assessed from an ethical perspective, by national and international policy organizations. One important aspect being examined concerns the effects of these procedures on different kinds of identity. In other words, whether or not a procedure only modifies the qualities or properties of an existing human being, meaning (...)
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