This thesis starts with three challenges to the structuralist accounts of applied mathematics. Structuralism views applied mathematics as a matter of building mapping functions between mathematical and target-ended structures. The first challenge concerns how it is possible for a non-mathematical target to be represented mathematically when the mapping functions per se are mathematical objects. The second challenge arises out of inconsistent early calculus, which suggests that mathematical representation does not require rigorous mathematical structures. The third challenge comes from renormalisation group (...) (RG) explanations of universality. It is argued that the structural mapping between the world and a highly abstract minimal model adds little value to our understanding of how RG obtains its explanatory force. I will address the first and second challenges from the similarity perspective. The similarity account captures representations as similarity relations, providing a more flexible and broader conception of representation than structuralism. It is the specification of the respect and degree of similarity that forges mathematics into a context of representation and directs it to represent a specific system in reality. Structuralism is treatable as a tool for explicating similarity rela-tions set-theoretically. The similarity account, combined with other approaches (e.g., Nguyen and Frigg’s extensional abstraction account and van Fraassen’s pragmatic equivalence), can dissolve the first challenge. Additionally, I will make a structuralist response to the second challenge, and suggestions regarding the role of infinitesimals from the similarity perspective. In light of the similarity account, I will propose the “hotchpotch picture” as a method-ological reflection of our study of representation and explanation. Its central insight is to dissect a representation or an explanation into several aspects and use different theories (that are usually thought of competing) to appropriate each of them. Based on the hotchpotch picture, RG explanations can be dissected to the “indexing” and “inferential” conceptions of explanation, which are captured or characterised by structural mappings. Therefore, structuralism accommodates RG explanations, and the third challenge is resolved. (shrink)

To demarcate the limits of experimental knowledge, we probe the limits of what might be called an experiment. By appeal to examples of scientific practice from astrophysics and analogue gravity, we demonstrate that the reliability of knowledge regarding certain phenomena gained from an experiment is not circumscribed by the manipulability or accessibility of the target phenomena. Rather, the limits of experimental knowledge are set by the extent to which strategies for what we call ‘inductive triangulation’ are available: that is, the (...) validation of the mode of inductive reasoning involved in the source-target inference via appeal to one or more distinct and independent modes of inductive reasoning. When such strategies are able to partially mitigate reasonable doubt, we can take a theory regarding the phenomena to be well supported by experiment. When such strategies are able to fully mitigate reasonable doubt, we can take a theory regarding the phenomena to be established by experiment. There are good reasons to expect the next generation of analogue experiments to provide genuine knowledge of unmanipulable and inaccessible phenomena such that the relevant theories can be understood as well supported. This article is part of a discussion meeting issue ‘The next generation of analogue gravity experiments’. (shrink)

This paper attempts to argue for the theory-ladenness of evidence. It does so by employing and analysing an episode from the history of eighteenth century chemistry. It delineates attempts by Joseph Priestley and Antoine Lavoisier to construct entirely different kinds of evidence for and against a particular hypothesis from a set of agreed upon observations or data. Based on an augmented version of a distinction, drawn by J. Bogen and J. Woodward, between data and phenomena it is shown that the (...) role of theoretical auxiliary assumptions is very important in constructing evidence for a theory from observation or data. In revolutionary situations, rival groups hold radically different theories and theoretical auxiliary assumptions. These are employed to construct very different evidence from the agreed upon set of observations or data. Hence, theory resolution becomes difficult. It is argued that evidence construction is a multi-layered exercise and can be disputed at any level. What counts as unproblematic observation or data at one level may become problematic at another level. The contingency of these constructions and the problematic nature of evidence are shown to be partially dependent upon the scientific knowledge that the scientific community possesses.Author Keywords: Theory-ladenness of evidence; Eighteenth century chemical philosophy; Construction of evidence; Observation/data; Theory resolution. (shrink)

This paper defends the naïve thesis that the method of experiment has per se an epistemic superiority over the method of computer simulation, a view that has been rejected by some philosophers writing about simulation, and whose grounds have been hard to pin down by its defenders. I further argue that this superiority does not come from the experiment’s object being materially similar to the target in the world that the investigator is trying to learn about, as both sides of (...) dispute over the epistemic superiority thesis have assumed. The superiority depends on features of the question and on a property of natural kinds that has been mistaken for material similarity. Seeing this requires holding other things equal in the comparison of the two methods, thereby exposing that, under the conditions that will be specified, the simulation is necessarily epistemically one step behind the corresponding experiment. Practical constraints like feasibility and morality mean that scientists do not often face an other-things- equal comparison when they choose between experiment and simulation. Nevertheless, I argue, awareness of this superiority and of the general distinction between experiment and simulation is important for maintaining motivation to seek answers to new questions. (shrink)

A core, constitutive norm of science is to remove or remedy the artefacts in one’s data. Here, we consider examples of artefacts from many fields of science (for example, astronomy, economics, electrophysiology, psychology, and systems neuroscience) and discuss their contribution to a more general evidential selection problem at the heart of the epistemology of evidence. Synthesizing and building on previously disparate discussions in many areas of the philosophy of science, we provide a novel, causal–pragmatic account that fits the examples and (...) clarifies the practices by which artefacts are discovered and remedied. (shrink)

I argue that non-epistemic values are necessarily embedded in the measure of evidential strength of contrastive evidence. When evidence is contrastive, evidence is stronger the more it favours a hypothesis over a set of plausible, mutually exclusive alternative hypotheses. In such a contrastive epistemic setting, evidence has an effect not only on a particular hypothesis, but on the whole probability distribution over the set of alternative hypotheses. A natural way of analysing the incremental impact of new evidence on a set (...) of alternative hypotheses is in terms of uncertainty or ‘entropy’ reduction. There is no unique single measure of uncertainty/entropy, however, and, consequently, no single unique measure of uncertainty reduction. Finally, I argue that the ‘right’ measure of entropy reduction, and hence of evidential strength, depends on the pragmatic context and non-epistemic values. (shrink)

Experimental activity is traditionally identified with testing the empirical implications or numerical simulations of models against data. In critical reaction to the ‘tribunal view’ on experiments, this essay will show the constructive contribution of experimental activity to the processes of modeling and simulating. Based on the analysis of a case in fluid mechanics, it will focus specifically on two aspects. The first is the controversial specification of the conditions in which the data are to be obtained. The second is conceptual (...) clarification, with a redefinition of concepts central to the understanding of the phenomenon and the conditions of its occurrence. (shrink)

Paul M. Pietroski, University of Maryland I had heard it said that Chomsky’s conception of language is at odds with the truth-conditional program in semantics. Some of my friends said it so often that the point—or at least a point—finally sunk in.

Selection explanations explain some non-accidental generalizations in virtue of a selection process. Such explanations are not particulaizable - they do not transfer as explanations of the instances of such generalizations. This is unlike many explanations in the physical sciences, where the explanation of the general fact also provides an explanation of its instances (i.e. standard D-N explanations). Are selection explanations (e.g. in biology) therefore a different kind of explanation? I argue that to understand this issue, we need to see that (...) a standard D-N explanation of some non-accidental generalization (al Fs are Gs) may also ipso facto explain its contrapositive (all non-Gs are non-Fs), but the explanation is particularizable with respect to the former but not to the latter. This can be seen by noting that the Raven Paradox counterexample to the H-D model of confirmation also generates a counterexample to the D-N model of explanation (all ravens are black does not explain why the non-black shoe is a non-raven). In such cases it is natural to take the generalization with the positive predicates to have a particularizable explanation. However, this need not be the case, and in selection explanations it is the generalization with the positive predicates whose explanation is no particularizable. Thus there is no need to suppose that selection explanations are fundamentally different. (shrink)

A stalwart view in the philosophy of science holds that, even when broadly construed so as to include theoretical auxiliaries, theories cannot make direct contact with observations. This view owes much to Bogen and Woodward’s influential distinction between data and phenomena. According to them, data are typically the kind of things that are observable or measurable like "bubble chamber photographs, patterns of discharge in electronic particle detectors and records of reaction times and error rates in various psychological experiments". Phenomena are (...) physical processes that are typically unobservable. Examples of the latter category include "weak neutral currents, the decay of the proton, and chunking and recency effects in human memory". Theories, in Bogen and Woodward’s view, are utilised to systematically explain, infer and predict phenomena, not data. The relationship between theories and data is rather indirect. Data count as evidence for phenomena and the latter in turn count as evidence for theories. This view is becoming increasingly influential, Stathis Psillos and Mauricio Suárez ). In this paper I argue contrary to this view that in various significant and well-known cases theories do make direct contact with the help of suitable auxiliaries. (shrink)

According to conventional wisdom, local gauge symmetry is not a symmetry of nature, but an artifact of how our theories represent nature. But a study of the so-called theta-vacuum appears to refute this view. The ground state of a quantized non-Abelian Yang-Mills gauge theory is characterized by a real-valued, dimensionless parameter theta—a fundamental new constant of nature. The structure of this vacuum state is often said to arise from a degeneracy of the vacuum of the corresponding classical theory, which degeneracy (...) allegedly arises from the fact that “large” (but not “small”) local gauge transformations connect physically distinct states of zero field energy. If that is right, then some local gauge transformations do generate empirical symmetries. In defending conventional wisdom against this challenge I hope to clarify the meaning of empirical symmetry while deepening our understanding of gauge transformations. I distinguish empirical from theoretical symmetries. Using Galileo’s ship and Faraday’s cube as illustrations, I say when an empirical symmetry is implied by a theoretical symmetry. I explain how the theta-vacuum arises, and how “large” gauge transformations differ from “small” ones. I then present two analogies from elementary quantum mechanics. By applying my analysis of the relation between empirical and theoretical symmetries, I show which analogy faithfully portrays the character of the vacuum state of a classical non-Abelian Yang-Mills gauge theory. The upshot is that “large” as well as “small” gauge transformations are purely formal symmetries of non-Abelian Yang-Mills gauge theories, whether classical or quantized. It is still worth distinguishing between these kinds of symmetries. An analysis of gauge within the constrained-Hamiltonian formalism yields the result that “large” gauge transformations should not be classified as gauge transformations; indeed, nor should “global” gauge transformations. In a theory in which boundary conditions are modeled dynamically, “global” gauge transformations may be associated with physical symmetries, corresponding to translations of these extra dynamical variables. Such translations are symmetries if and only if charge is conserved. But it is hard to argue that these symmetries are empirical, and in any case they do not correspond to any constant phase change in a quantum state. (shrink)

This paper draws on the notion of “objects of research” in psychology as clusters of phenomena (Feest in Philos Sci 84:1165–1176, 2017) to analyze the productive role of folk psychological concepts—and the operational definitions that arise from them—in the development of concepts in scientific psychology. Using the case study of similarity, I discuss the role of the folk psychological concept in the regimentation of different measures of similarity judgments. I propose that by giving rise to operational definitions that lead to (...) experimental dissociation on the one hand, and by providing the concept with unity on the other hand, the folk psychological concept generates a productive tension that facilitates empirical and theoretical development of the scientific concept. (shrink)

In this paper I offer an appraisal of James Bogen and James Woodward’s distinction between data and phenomena which pursues two objectives. First, I aim to clarify the notion of a scientific phenomenon. Such a clarification is required because despite its intuitive plausibility it is not exactly clear how Bogen and Woodward’s distinction has to be understood. I reject one common interpretation of the distinction, endorsed for example by James McAllister and Bruce Glymour, which identifies phenomena with patterns in data (...) sets. Furthermore, I point out that other interpretations of Bogen and Woodward’s distinction do not specify the relationship between phenomena and theories in a satisfying manner. In order to avoid this problem I propose a contextual understanding of scientific phenomena according to which phenomena are states of affairs which play specific roles in scientific practice and to which we adopt a special epistemic attitude. Second, I evaluate the epistemological significance of Bogen and Woodward’s distinction with respect to the debate between scientific realists and constructive empiricists. Contrary to what Bogen and Woodward claim, I argue that the distinction does not provide a convincing argument against constructive empiricism. (shrink)

Discusses philosophy and the science of its lesson. Observation of the perspective that laws of nature exist in theories thereby quantifying statements capable of sustaining counterfactuals; Belief on the confirmation or falsification of theories by treating putative laws as premises of hypothetical argument; Aim of science to use fewer laws to explain greater facts; Similarity between prediction and explanation.

The way metrologists conceive of measurement has undergone a major shift in the last two decades. This shift can in great part be traced to a change in the statistical methods used to deal with the expression of measurement results, and, more particularly, with the calculation of measurement uncertainties. Indeed, as we show, the incapacity of the frequentist approach to the calculus of uncertainty to deal with systematic errors has prompted the replacement of the customary frequentist methods by fully Bayesian (...) procedures. The epistemological ramifications of the Bayesian approach merge with a deep empiricist mood tantamount to an “epistemic turn”: measurement results are analysed in terms of degrees of belief, and central concepts such as error and accuracy are called into question. We challenge the perspective entailed by this epistemic turn: we insist on the centrality of the concepts of error and accuracy by underlining the intentional character of measurement that is intimately linked to the process of correction of experimental data. We further circumvent the difficulties posed by the classical analysis of measurement by stressing the social rather than the epistemic dimension of measurement activities. (shrink)

The guest editors would like to thank the University of Paris and the ENSA Paris-Val de Seine for having provided premises to successfully host the 2018 "Measurement at the Crossroads" conference in Paris.Our thanks extend to our funding sources: the conference was made possible thanks to the generous support of the Institut Humanités, Sciences et Sociétés, the SPHERE laboratory and the Laboratoire Matériaux et Phénomènes Quantiques of the University of Paris, the department of History and Philosophy of Science of the (...) University of Paris, the Laboratoire National de métrologie et d'Essais, and the University of Geneva.We would like to thank the many people who contributed to the organization of... (shrink)

The advancement of computing technology makes it possible to build extremely accurate digital reconstructions of brain circuits. Are such unprecedented levels of biological accuracy essential for brain simulations to play the roles they are expected to play in neuroscientific research? The main goal of this paper is to clarify this question by distinguishing between various roles played by large-scale simulations in contemporary neuroscience, and by reflecting about what makes a simulation biologically accurate. It is argued that large-scale simulations may play (...) model-oriented and prediction-oriented roles in brain research, and that the concept of biological accuracy can be interpreted as related to the plausibility of the theoretical model implemented in the simulation system, to the accuracy of the computer implementation, and to the level of details of the implemented model. Building on these observations and distinctions, it is argued that biological accuracy is not essential for a computer simulation to play the epistemic roles it is expected to play in brain research. (shrink)

Current discussion of scientific realism and antirealism often cites Pierre Duhem’s argument for the underdetermination of theory choice by evidence. Participants draw on an account of his underdetermination thesis that is familiar, but incomplete. The purpose of this article is to complete the familiar account. I argue that a closer look at Duhem’s The aim and structure of physical theory suggests that the rationale for his underdetermination thesis comes from his philosophy of scientific language. I explore how an understanding of (...) physical laws as symbolic is meant to support the thesis. In the course of my argument, I point out that Duhemian underdetermination is not meta-practical but grounded in the practice of science, specifically in the scientist’s use of instruments and measurement techniques. Measurement has a significant limitation, according to Duhem: it always involves approximation and a degree of experimental error. Consequently, it cannot overcome the gap between the ordinary, concrete language of observation and the mathematical language of science. Moreover, Duhem argues that the use of instruments in experiment invokes whole groups of theories. I contend that, ultimately, this reliance on auxiliary assumptions—which makes possible the use of instruments—is the foundation of his thesis and that recognizing this completes the familiar account of his underdetermination argument.Author Keywords: Duhem; Suppes; Underdetermination; Measurement; Physical theory. (shrink)

Philosophers have proposed various kinds of relations between Mendelian genetics and molecular biology: reduction, replacement, explanatory extension. This paper argues that the two fields are best characterized as investigating different, serially integrated, hereditary mechanisms. The mechanisms operate at different times and contain different working entities. The working entities of the mechanisms of Mendelian heredity are chromosomes, whose movements serve to segregate alleles and independently assort genes in different linkage groups. The working entities of numerous mechanisms of molecular biology are larger (...) and smaller segments of DNA plus related molecules. Discovery of molecular DNA mechanisms filled black boxes that were noted, but unilluminated, by Mendelian genetics. (shrink)

The analysis of theory-confirmation generally takes the deductive form: show that a theory in conjunction with physical data and auxiliary hypotheses yield a prediction about phenomena; verify the prediction; provide a quantitative measure of the degree of theory-confirmation this yields. The issue of confirmation for an entire framework either does not arise, or is dismissed in so far as frameworks are thought not to be the kind of thing that admits scientific confirmation. I argue that there is another form of (...) scientific reasoning that has not received philosophical attention, what I call Newtonian abduction, that does provide confirmation for frameworks as a whole, and does so in two novel ways. I further argue that Newtonian abduction is at least as important a form of reasoning in science as standard deductive and inductive forms. The form is beautifully summed up by Maxwell : “The true method of physical reasoning is to begin with the phenomena and to deduce the forces from them by a direct application of the equations of motion.”. (shrink)

The analysis of theory-confirmation generally takes the deductive form: show that a theory in conjunction with physical data and auxiliary hypotheses yield a prediction about phenomena; verify the prediction; provide a quantitative measure of the degree of theory-confirmation this yields. The issue of confirmation for an entire framework (e.g., Newtonian mechanics en bloc, as opposed, say, to Newton’s theory of gravitation) either does not arise, or is dismissed in so far as frameworks are thought not to be the kind of (...) thing that admits scientific confirmation. I argue that there is another form of scientific reasoning that has not received philosophical attention, what I call Newtonian abduction, that does provide confirmation for frameworks as a whole, and does so in two novel ways. (In particular, Newtonian abduction is not inference to the best explanation, but rather is closer to Peirce’s original idea of abduction.) I further argue that Newtonian abduction is at least as important a form of reasoning in science as standard deductive and inductive forms. The form is beautifully summed up by Maxwell (Proc Camb Philos Soc II:292–294, 1876): “The true method of physical reasoning is to begin with the phenomena and to deduce the forces from them by a direct application of the equations of motion.”. (shrink)

Abstract‘Behavioural modernity’ isn’t what it used to be. Once conceived as an integrated package of traits demarcated by a clear archaeological signal in a specific time and place, it is now disparate, archaeologically equivocal, and temporally and spatially spread. In this paper we trace behavioural modernity’s empirical and theoretical developments over the last three decades, as surprising discoveries in the material record, as well the reappraisal of old evidence, drove increasingly sophisticated demographic, social and cultural models of behavioural modernity. We (...) argue, however, that some approaches to identifying and categorizing modernity have not kept up with this new picture. This is due to what we term ‘Rubicon expectations’: classificatory and interpretive practices which look for or assume clear demarcations in behavioural and cultural processes. We develop a philosophical account of ‘investigative disintegration’ to capture how our understanding of behavioural modernity has changed, and how Rubicon-based practices have become inadequate. Disintegration, in the form we analyse, occurs when scientists’ conception of a phenomenon shifts sufficiently to reshape an investigation’s epistemic structure. For behavioural modernity, the explanatory weight which once lay on identifying ‘switch-points’ in the innate suite of hominin cognitive capacities, lies now in understanding the social and demographic environments that were capable of sustaining and nourishing more complex material cultures. Finally, we argue that the phenomenon itself has not disintegrated to the point that we are left with no interesting explanandum: for all its mosaic, disparate nature, there are still good reasons for behavioural modernity to retain its central place in investigation of our species' origins. (shrink)

Michael Devitt ([2006a], [2006b]) argues that, insofar as linguists possess better theories about language than non-linguists, their linguistic intuitions are more reliable. (Culbertson and Gross [2009]) presented empirical evidence contrary to this claim. Devitt ([2010]) replies that, in part because we overemphasize the distinction between acceptability and grammaticality, we misunderstand linguists' claims, fall into inconsistency, and fail to see how our empirical results can be squared with his position. We reply in this note. Inter alia we argue that Devitt's focus (...) on grammaticality intuitions, rather than acceptability intuitions, distances his discussion from actual linguistic practice. We close by questioning a demand that drives his discussion—viz., that, for linguistic intuitions to supply evidence for linguistic theorizing, a better account of why they are evidence is required. (shrink)

This paper investigates the adequacy of evidential relevance relations proposed by Glymour and others. These accounts incorporate, as a necessary condition, what I call the Positive Instance Condition (PIC): the evidence statement and auxiliary assumptions entail a "positive instance" of the hypothesis. I argue that any account which incorporates PIC as a necessary condition while allowing "bootstrap testing" is doomed to fail. A nonbootstrapping evidential relevance relation of similar form is proposed, and it is argued that, in addition to avoiding (...) published counter examples, this new relation meets two general requirements which, if not met, would undermine the ability of any account that incorporates PIC to accord with our intuitions of evidential relevance. (shrink)

In just a few years, children achieve a stable state of linguistic competence, making them effectively adults with respect to: understanding novel sentences, discerning relations of paraphrase and entailment, acceptability judgments, etc. One familiar account of the language acquisition process treats it as an induction problem of the sort that arises in any domain where the knowledge achieved is logically underdetermined by experience. This view highlights the cues that are available in the input to children, as well as childrens skills (...) in extracting relevant information and forming generalizations on the basis of the data they receive. Nativists, on the other hand, contend that language-learners project beyond their experience in ways that the input does not even suggest. Instead of viewing language acqusition as a special case of theory induction, nativists posit a Universal Grammar, with innately specified linguistic principles of grammar formation. The nature versus nurture debate continues, as various poverty of stimulus arguments are challenged or supported by developments in linguistic theory and by findings from psycholinguistic investigations of child language. In light of some recent challenges to nativism, we rehearse old poverty-of stimulus arguments, and supplement them by drawing on more recent work in linguistic theory and studies of child language. (shrink)

In this paper, I investigate how researchers evaluate their characterizations of scientific phenomena. Characterizing phenomena is an important – albeit often overlooked – aspect of scientific research, as phenomena are targets of explanation and theorization. As a result, there is a lacuna in the literature regarding how researchers determine whether their characterization of a target phenomenon is appropriate for their aims. This issue has become apparent for accounts of scientific explanation that take phenomena to be explananda. In particular, philosophers who (...) endorse mechanistic explanation suggest that the discovery of the mechanisms that explain a phenomenon can lead to its recharacterization. However, they fail to make clear how these explanations provide warrant for recharacterizing their explananda phenomena. Drawing from cases of neurobiological research on potentiation phenomena, I argue that attempting to explain a phenomenon may provide reason to suspend judgment about its characterization, but this cannot provide warrant to recharacterize it if researchers cannot infer a phenomenon’s characteristics from this explanation. To explicate this, I go beyond explanation – mechanistic or otherwise – to analyze why and how researchers change their epistemic commitments in light of new evidence. (shrink)

Life-science phenomena are often explained by specifying the mechanisms that bring them about. The new mechanistic philosophers have done much to substantiate this claim and to provide us with a better understanding of what mechanisms are and how they explain. Although there is disagreement among current mechanists on various issues, they share a common core position and a seeming commitment to some form of scientific realism. But is such a commitment necessary? Is it the best way to go about mechanistic (...) explanation? In this article, we propose an alternative antirealist account that also fits explanatory practice in the life sciences. We pay special attention to mechanistic models, i.e. scientific models that involve a mechanism, and to the role of coherence considerations in building such models. To illustrate our points, we consider the mechanism for the action potential. 1 Introduction2 Some Core Features of Mechanistic Explanation3 Scientific Realism and Mechanistic Explanation4 Antirealist Mechanistic Explanation: The Case of the Action Potential5 Some Outstanding Issues for the Antirealist Mechanist6 Two Problems for the Realist Mechanist7 Conclusions. (shrink)

This paper presents a cognitive account of the process of evaluating scientific data. Our account assumes that when individuals evaluate data, they construct a mental model of a data-interpretation package, in which the data and theoretical interpretations of the data are integrated. We propose that individuals attempt to discount data by seeking alternative explanations for events within the mental model; data-interpretation packages are accepted when the individual cannot find alternative accounts for these events. Our analysis indicates that there are many (...) levels at which data-interpretation packages can be accepted or denied. (shrink)

I develop a concept of observability that pertains to qualities rather than objects: a quality is observable if it can be registered by human sensation (possibly with the aid of instruments) without involving optional interpretations. This concept supports a better description of observations in science and everyday life than the object-based observability concepts presupposing causal information-transfer from the object to the observer. It also allows a rehabilitation of the traditional empiricist distinction between observations and their interpretations, but without a presumption (...) that observations are infallible. Using this concept of observability, I also propose a re-formulation of constructive empiricism that is easier to defend against realist attacks, while open to reasonable realist intuitions. (shrink)

In current philosophical discussions on evidence in the medical sciences, epidemiology has been used to exemplify a specific version of evidential pluralism. According to this view, known as the Russo–Williamson Thesis, evidence of both difference-making and mechanisms is produced to make causal claims in the health sciences. In this paper, I present an analysis of data and evidence in epidemiological practice, with a special focus on research on the exposome, and I cast doubt on the extent to which evidential pluralism (...) holds in this case. I start by focusing on the claim that molecular data allows for the production of mechanistic evidence. On the basis of a close look at the ways in which molecular data is used in exposome research, I caution against interpretations in terms of mechanistic evidence. Secondly, I expand my critical remarks on the thesis by addressing the conditions under which data is categorised as evidence in exposome research. I argue that these show that the classification of a dataset as a type of evidence is dependent on the ways in which the data is used. This is in contrast with the approach of evidential pluralism, where evidence is classified in different types on the basis of its intrinsic properties. Finally, I come back to what I consider the core of the thesis and suggest that the epidemiological research analysed in the paper indicates different interpretations of evidential pluralism and its applicability in the health sciences. (shrink)

Operationalism and theoretical entities. The thesis of the“theory ladenness” of observation leads to an antinomy. In order to solve this antinomy a technical operationalism is sketched, according to which theories should in principle not contain anything that cannot be reduced to technical procedures. This implies the rejection of Quine's underdeterminacy thesis and of many views about the theoretical-observational distinction, e.g. neopositivistic views, van Fraassen's view, Sneed-Stegmüller's view. Then I argue for the following theses: 1. All scientific concepts are theory laden (...) in the sense that they allow us to anticipate possible experiences, but they have to be in principle fully observable, i.e. integrally convertible into operational-technical applications. 2. The observation/theory distinction can be maintained as a historical one: what is observable depends on the instruments that are available at any stage of the development of science. 3.In principle theoretical entities are empirically real in Hacking's sense. However, some aspects of Hacking's realism are to be criticized. Theoretical entities are to be resolved into the totality of the interrelated properties accessible to us by means of theoretical points of view embodied in scientific instruments. (shrink)

This is a companion to another paper. Together they rebut two widespread philosophical doctrines about emergence. The first, and main, doctrine is that emergence is incompatible with reduction. The second is that emergence is supervenience; or more exactly, supervenience without reduction.In the other paper, I develop these rebuttals in general terms, emphasising the second rebuttal. Here I discuss the situation in physics, emphasising the first rebuttal. I focus on limiting relations between theories and illustrate my claims with four examples, each (...) of them a model or a framework for modelling, from well-established mathematics or physics.I take emergence as behaviour that is novel and robust relative to some comparison class. I take reduction as, essentially, deduction. The main idea of my first rebuttal will be to perform the deduction after taking a limit of some parameter. Thus my first main claim will be that in my four examples (and many others), we can deduce a novel and robust behaviour, by taking the limit N→∞ of a parameter N.But on the other hand, this does not show that the N=∞ limit is “physically real”, as some authors have alleged. For my second main claim is that in these same examples, there is a weaker, yet still vivid, novel and robust behaviour that occurs before we get to the limit, i.e. for finite N. And it is this weaker behaviour which is physically real.My examples are: the method of arbitrary functions (in probability theory); fractals (in geometry); superselection for infinite systems (in quantum theory); and phase transitions for infinite systems (in statistical mechanics). (shrink)

In this paper a constructive empiricist account of scientific change is put forward. Based on da Costa's and French's partial structures approach, two notions of empirical adequacy are initially advanced (with particular emphasis on the introduction of degrees of empirical adequacy). Using these notions, it is shown how both the informativeness and the empirical adequacy requirements of an empiricist theory of scientific change can then be met. Finally, some philosophical consequences with regard to the role of structures in this context (...) are drawn.Now, we daily see what science is doing for us. This could not be unless it taught us something about reality; the aim of science is not things themselves, as the dogmatists in their simplicity imagine, but the relations between things; outside those relations there is no reality knowable. (shrink)

Based on da Costa's and French's notions of partial structures and pragmatic truth, this paper examines two possible characterizations of the concept of empirical adequacy, one depending on the notion of partial isomorphism, the other on the hierarchy of partial models of phenomena, and both compatible with an empiricist view. These formulations can then be employed to illuminate certain aspects of scientific practice.An empirical theory must single out a specific part of the world, establish reference to that part, and say—by (...) way of contingent, substantial claim about the world—that its models fit that. Now, how exactly can this be done? Bas C. van Fraassen. (shrink)

From its inception Darwinian evolutionary biology has been seen as having a problematic relationship of fact and theory. While the forging of the modern evolutionary synthesis resolved most of these issues for biologists, critics continue to argue that natural selection and common descent are “only theories.” Much of the confusion engendered by the “evolution wars” can be clarified by applying the concept of phenomena, inferred from fact, and explained by theories, thus locating where legitimate dissent may still exist. By setting (...) such analysis in the context of research traditions, it is possible to gain further insight into the complex interplay of facts, phenomena, and theories. Two case studies are explored to assess the value of such approaches, one from within evolutionary biology, the Baldwin effect, and one from outside, intelligent design. (shrink)

This article sketches the main features of traditional philosophical models of evidence, indicating idealizations in such models that it regards as doing more harm than good. It then proceeds to elaborate on an alternative model of evidence that is functionalist, complex, dynamic, and contextual, a view the author calls dynamic evidential functionalism (DEF). This alternative builds on insights from philosophy of scientific practice, Kuhnian philosophy of science, pragmatist epistemology, philosophy of experimentation, and functionalist philosophy of mind. Along the way, the (...) article raises concerns about the total evidence condition, requirements of certainty or incorrigibility on evidence, and accounts that restrict the type of things that can serve as evidence (to, for example, sense data, facts about particulars). DEF can also help us see the special value of novel predictions and experiments as evidence, as well as help us think about how to critically evaluate the putative evidence to determine whether it is evidence. (shrink)

Three major views of the observation?theory relation are now extant: (1) Observation and theory are mutually independent and observation provides the basis for evaluating theories. (2) Observations are theory?dependent and do not provide objective grounds for evaluating theories. (3) The concept of observation should be extended in a way that includes many so?called ?theoretical?entities? among the observables. Analyses of these views set the stage for a new approach that incorporates lessons learned from discussions of earlier accounts. The central idea of (...) this new approach is that empirical testing requires comparison of results arrived at by derivation from the theory being tested (plus appropriate auxiliary premises) with results derived from an interaction with aspects of nature in the theory's domain. These routes are independent in that each can be pursued without knowledge of the details or results of the alternative route. The approach accounts for the role of empirical results in evaluating theories without requiring that these results be theory?free or more certain than theoretical results. It also provides a basis for understanding the conditions under which a conflict between observation and theory can result in rejection of the observational result. (shrink)

Theories often run into paradoxes. Some of these are outright contradictions, sending the would-be champions of the theory back to the drawing board. Others are paradoxical in the sense of being bizarre and unexpected. The latter are sometimes mistakenly thought to be instances of the former. That is, they are thought to be more than merely weird; they are mistakenly thought to be self-refuting. Showing that they are not self-contradictory but merely a surprise is often a challenge. Notions of explanation (...) and understanding are often at issue. For instance, we might explain—or explain away—a paradox by invoking some mechanism provided by the theory and showing how it does not really lead to a logically incoherent .. (shrink)

We use evidence from cognitive psychology and the history of science to examine the issue of the theory-ladenness of perceptual observation. This evidence shows that perception is theory-laden, but that it is only strongly theory-laden when the perceptual evidence is ambiguous or degraded, or when it requires a difficult perceptual judgment. We argue that debates about the theory-ladenness issue have focused too narrowly on the issue of perceptual experience, and that a full account of the scientific process requires an examination (...) of theory-ladenness in attention, perception, data interpretation, data production, memory, and scientific communication. We conclude that the evidence for theory-ladenness does not lead to a relativist account of scientific knowledge. (shrink)

Taking Bogen and Woodward's discussion of data and phenomena as his starting point, McAllister presents a challenge to scientific realism. I discuss this challenge and offer a suggestion for how the scientific realist could respond to both its epistemic and ontological aspects. In so doing, I urge that the scientific realist should not reject ontological pluralism from the start, but should seek to explore versions of scientific realism that leave open the possibility of certain kinds of pluralist ontology. I investigate (...) the available options and use a law-constitutive approach to offer a strategy for the scientific realist who is open-minded about ontological pluralism. (shrink)

RESUMEN Un experimento mental en ciencias fácticas consiste en la representación de un escenario imaginario. A partir de la presentación de condiciones iniciales y la postulación de una situación hipotética o contrafáctica, se solicita al lector que realice mentalmente alguna operación, manipule ciertas variables o ponga en funcionamiento algún aparato o instrumento. En virtud de este ejercicio sería posible, en principio, obtener nuevo conocimiento acerca de algún aspecto del mundo natural. El debate acerca de las funciones de los experimentos mentales (...) en las ciencias fácticas está centrado en establecer la validez del conocimiento acerca del mundo empírico que estos dispositivos son capaces de proporcionar. La propuesta interpretativa de Brown da sustento a la idea de que, en casos excepcionales, los experimentos mentales pueden cumplir funciones probatorias. Los denominados “experimentos mentales platónicos” permiten intuir leyes de la naturaleza y justificar a priori las hipótesis propuestas. Sostenemos que la conexión trazada por Brown entre los experimentos mentales y leyes naturales exhibe un aspecto problemático de su filosofía: el compromiso injustificado con una metafísica inflacionaria. Mostramos que es posible explicar el mecanismo a través del cual estos dispositivos proporcionan conocimiento nuevo y dar cuenta tanto de su poder heurístico cómo de su valor evidencial a partir compromisos metafísicos más modestos. ABSTRACT Thought experiments in factual science consists on the representation of an imaginary scenario. Starting with the presentation of a hypothetical or counterfactual situation and the description of initial conditions, the reader is asked to mentally perform some operation, to manipulate certain variables or to put into operation some apparatus or instrument. In virtue of this exercise, it would be possible to obtain new knowledge about the natural world. The debate on the functions of thought experiments in physics is focused on determining the validity of the empirical knowledge that these devices are capable of providing. Brown supports the idea that, in exceptional cases, thought experiments can perform probative functions. The so-called “Platonic Thought Experiments” allow us to intuit laws of nature and provide an a priori justification of the proposed hypotheses. We hold that Brown's connection between thought experiments and laws of nature exhibits a problematic aspect of his philosophy: the unjustified commitment with an inflationary metaphysics. We show that it is possible to explain the mechanism through which these devices provide new knowledge and give an account of both their heuristic power and their evidential value from modest metaphysical commitments. (shrink)

This article outlines a philosophy of science in practice that focuses on the engineering sciences. A methodological issue is that these practices seem to be divided by two different styles of scientific reasoning, namely, causal-mechanistic and mathematical reasoning. These styles are philosophically characterized by what Kuhn called ?disciplinary matrices?. Due to distinct metaphysical background pictures and/or distinct ideas of what counts as intelligible, they entail distinct ideas of the character of phenomena and what counts as a scientific explanation. It is (...) argued that the two styles cannot be reduced to each other. At the same time, although they are incompatible, they must not be regarded as competing. Instead, they produce different kinds of epistemic results, which serve different kinds of epistemic functions. Moreover, some scientific breakthroughs essentially result from relating them. This view of complementary styles of scientific reasoning is supported by pluralism about metaphysical background pictures. (shrink)

The purpose of this article is to develop an epistemology of scientific models in scientific research practices, and to show that disciplinary perspectives have crucial role in such an epistemology. A transcendental approach is taken, aimed at explanations of the kinds of questions relevant to the intended epistemology, such as “How is it possible that models provide knowledge about aspects of reality?” The approach is also pragmatic in the sense that the questions and explanations must be adequate and relevant to (...) concrete scientific practice. First it is explained why the idea of models as representations in terms of similarity or isomorphism between a model and its target is too limited as a basis for this epistemology. An important finding is that the target-phenomenon is usually not something that can be observed in a straightforward manner, but requires both characterization in terms of measurable variables and subsumption under concepts. The loss of this basis leads to a number of issues, such as: how can models be interpreted as representations if models also include conceptually meaningful linguistic content; how can researchers identify non-observable real-world target-phenomena that are then represented in the model; how do models enable inferential reasoning in performing epistemic tasks by researchers; and, how to justify scientific models. My proposal is to deal with these issues by analyzing how models are constructed, rather than by looking at ready-made models. Based on this analysis, I claim that the identification of phenomena and the construction of scientific models is guided and also confined by the disciplinary perspective within which researchers in a scientific discipline have learned to work. I propose a Kuhnian framework by which the disciplinary perspective can be systematically articulated. Finally, I argue that harmful forms of subjectivism, due to the loss of the belief that models objectively represent aspects of reality, can be overcome by making the disciplinary perspective in a research project explicit, thereby enabling its critical assessment, for which the proposed Kuhnian framework provides a tool. (shrink)

Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development of mechanistic (...) models, identifying five constraints which guide the articulation of models in molecular systems biology. These constraints are not independent of one another, with the result that modeling becomes an iterative process. We illustrate the use of these constraints in the modeling of the mechanism for bistability in the lac operon. (shrink)

The complex societal challenges of the twenty-first Century require scientific researchers and academically educated professionals capable of conducting scientific research in complex problem contexts. Our central claim is that educational approaches inspired by a traditional empiricist epistemology insufficiently foster the required deep conceptual understanding and higher-order thinking skills necessary for epistemic tasks in scientific research. Conversely, we argue that constructivist epistemologies provide better guidance to educational approaches to promote research skills. We also argue that teachers adopting a constructivist learning theory (...) do not necessarily embrace a constructivist epistemology. On the contrary, in educational practice, novel educational approaches that adopt constructivist learning theories often maintain traditional empiricist epistemologies. Philosophers of science can help develop educational designs focused on learning to conduct scientific research, combining constructivist learning theory with constructivist epistemology. We illustrate this by an example from a bachelor’s program in Biomedical Engineering, where we introduce conceptual models and modeling as an alternative to the traditional focus on hypothesis testing in conducting scientific research. This educational approach includes the so-called B&K method for constructing scientific models to scaffold teaching and learning conceptual modeling. (shrink)

New Mechanist philosophical models of "phenomenon reconstitution" understand the process to be driven by explanatory considerations. Here I discuss an episode of phenomenon reconstitution that occurred entirely within an experimental program dedicated to characterizing the phenomenon of kinesin motility. Rather than being driven by explanatory considerations, as standard mechanist views maintain, I argue that the phenomenon of kinesin motility was reconstituted to enhance researchers’ primary experimental tool—the single molecule motility assay.

According to a received doctrine, espoused, by Karl Popper and Harry Collins, and taken for granted by many others, poorly replicated evidence should be epistemically defective and incapable of persuading scientists to accept the views it is used to argue for. But John Hughlings Jackson used poorly replicated clinical and post-mortem evidence to mount rationally compelling and influential arguments for a highly progressive theory of the organization of the brain and its functions. This paper sets out a number of Jackson's (...) arguments from his evidence and argues that they constitute a counter example against the received doctrine. (shrink)

Scientists obtain a great deal of the evidence they use by observingnatural and experimentally generated objects and effects. Much of thestandard philosophical literature on this subject comes from20th century logical positivists and empiricists, theirfollowers, and critics who embraced their issues and accepted some oftheir assumptions even as they objected to specific views. Theirdiscussions of observational evidence tend to focus on epistemologicalquestions about its role in theory testing. This entry follows theirlead even though observational evidence also plays important andphilosophically interesting roles (...) in other areas including scientificdiscovery and the application of scientific theories to practicalproblems. (shrink)