Vopěnka’s Principle is a natural large cardinal axiom that has recently found applications in category theory and algebraic topology. We show that Vopěnka’s Principle and Vopěnka cardinals are relatively consistent with a broad range of other principles known to be independent of standard (ZFC) set theory, such as the Generalised Continuum Hypothesis, and the existence of a definable well-order on the universe of all sets. We achieve this by showing that they are indestructible under a broad class of forcing constructions, (...) specifically, reverse Easton iterations of increasingly directed closed partial orders. (shrink)