Patient-reported outcome measures (PROMs) are increasingly used to assess multiple facets of healthcare, including effectiveness, side effects of treatment, symptoms, health care needs, quality of care, and the evaluation of health care options. There are thousands of these measures and yet there is very little discussion of their theoretical underpinnings. In her 2008 Presidential address to the Society for Quality of Life Research (ISOQoL), Professor Donna Lamping challenged researchers to grapple with the theoretical issues that arise from these measures. In (...) this paper, I attempt to do so by arguing for an analogy between PROMs and Hans-Georg Gadamer’s logic of question and answer. While researchers readily admit that the constructs involved in PROMs are imperfectly understood and lack a gold standard, they often ignore the consequences of this fact. Gadamer’s work on questions and their importance to philosophical hermeneutics helps to show that the questions researchers ask about such constructs are also imperfectly understood. I argue that these questions should not be standardized, and I instead propose a theoretical framework that understands PROMs as posing genuine questions to respondents—questions that are open to reinterpretation. (shrink)

In an instant classic paper ; 2002: 179–182) biologist Yuri Lazebnik deplores the poor effectiveness of the approach adopted by biologists to understand and “fix” biological systems. Lazebnik suggests that to remedy this state of things biologist should take inspiration from the approach used by engineers to design, understand, and troubleshoot technological systems. In the present paper I substantiate Lazebnik’s analysis by concretely showing how to apply the engineering approach to biological problems. I use an actual example of electronic circuit (...) troubleshooting to ground the thesis that, in engineering, the crucial phases of any non-trivial troubleshooting process are aimed at generating a mechanistic explanation of the functioning of the system, which makes extensive recourse to problem-driven qualitative reasoning possibly based on cognitive artifacts applied to systems that are known to have been designed for function. To show how to translate these findings into biological practice I consider a concrete example of biological model building and “troubleshooting”, aimed at the identification of a “fix” for the human immune system in presence of progressing cancer, autoimmune disease, and transplant rejection. The result is a novel immune system model—the danger model with regulatory cells— and new, original hypotheses concerning the development, prophylaxis, and therapy of these unwanted biological processes. Based on the manifest efficacy of the proposed approach, I suggest a refocusing of the activity of theoretical biologists along the engineering-inspired lines illustrated in the paper. (shrink)

We consider question-answer dialogues between participants who may disagree with each other. The main problems are: (a) How different speech-acts affect the information in the dialogue; and (b) How to represent what was said in a dialogue, so that we can summarize it even when it involves disagreements (i.e., inconsistencies).We use a fully-typed many-sorted language L with a possible-worlds semantics. L contains nominals representing short answers. The speech-acts are uniformly represented in a dialogue language DL by focus structures, consisting of (...) a mood operator, a topic component and a focus component. Each stage of the dialogue is associated with a set of information functions (g-functions), which are partial functions taking a topic component (representing a question raised) to a set of propositions determined by the corresponding focus component (to the set of answers given to it). (shrink)

This paper examines the theories of the soul proposed by Girolamo Cardano in his De immortalitate animorum (1545) and his De subtilitate (1550-4), Julius Caesar Scaliger's comprehensive critique of these views in the Exercitationes exotericae de subtilitate of 1557, and Cardano's reply to this critique in his Actio in calumniatorem of 1559. Cardano argues that the passive intellect is individuated and mortal, and that the agent intellect is immortal but subject to constant reincarnation in different human beings. His theory of (...) cognition leads him to claim that at its highest level, the intellect is converted into the object of its perception. In his refutation of the various elements of Cardano's theories, Scaliger uses his knowledge of the Greek text of Aristotle to stress the reflexive faculty of the soul, its ability to conceive of objects greater than itself, and its status as the individuating principle of the hylemorphic human being. In spite of Cardano's pretention to novelty and Scaliger's humanist credentials, both thinkers are shown to conduct their discussions in an inherited scholastic matrix of thought. (shrink)

Both questions as abstract objects and the speech acts, here called requests, by which we ask them play an enormous role in all argumentative practices. Nonetheless, there is hardly a proper systematic treatment of questions and requests in current argumentation theories. This paper is a first attempt at providing such a systematic treatment. This is achieved by following the ideal model of a critical discussion as elaborated over the years by the Amsterdam school of pragma-dialectics. After introducing the distinction between (...) questions and requests, the paper sets forth and illustrates the norms of questioning which implicitly underlie the four stages of a critical discussion in the standard order: confrontation, opening, argumentation, and conclusion. Among other things, it is shown that crucial insights of pragma-dialectics are illuminated by the questioning perspective, in particular the distinction between single and multiple differences of opinion, the duties of the antagonist and protagonist roles, the precise character of the argumentation stage, and the different ways in which a disagreement can be resolved. (shrink)

This article canvasses five senses in which one might introduce an historical element into the philosophy of mathematics: 1. The temporal dimension of logic; 2. Explanatory Appeal to Context rather than to General Principles; 3. Heraclitean Flux; 4. All history is the History of Thought; and 5. History is Non-Judgmental. It concludes by adapting Bernard Williams’ distinction between ‘history of philosophy’ and ‘history of ideas’ to argue that the philosophy of mathematics is unavoidably historical, but need not and must not (...) merge with historiography. (shrink)

This article suggests that the enterprise of Mark Bevir's book (The Logic of the History of Ideas, Cambridge, 1999), is the reverse of what his title implies. Bevir seeks not to delineate the peculiar logic of a specialised subfield of history called the ‘history of ideas’, but rather the logic which underlies historical pursuit considered in general as the ‘explanation of belief’. If this is so, then the relationship between belief, meaning, and speech act in intellectual texts, and the task (...) and method of the intellectual historian, must be reinterpreted along lines closer to those of Quentin Skinner than Bevir would allow. Indeed, Bevir's criticism of Skinner, which hinges on his own account of malapropism, is shown here to fail. The article concludes with brief reflections on the purpose and nature of studying the ‘history of ideas’. (shrink)

Since the late 1960s Quentin Skinner has defended a highly influential form of linguistic contextualism for the history of ideas, originally devised in opposition to established methodological orthodoxies like the `great text' tradition and a mainly Marxist epiphenomenalism. In 2002, he published Regarding Method, a collection of his revised methodological essays that provides a uniquely systematic expression of his contextualist philosophy of history. Skinner's most arresting theoretical contention in that work remains his well-known claim that past works of political theory (...) cannot be read as contributions to `perennial' debates but must instead be understood as particularistic, ideological speech acts. In this article I argue that he fails to justify these claims and that there is actually nothing wrong at all with (where appropriate) treating past works of political theory as engaged in perennial philosophical debates. Not only do Skinner's arguments not support the form of contextualism he defends, their flaws are actually akin to those he identified in his critique of previous methodological orthodoxies. (shrink)

This article considers the implications of inferentialist philosophy of language for debates in the historiography of philosophy. My intention is to mediate and refine the polemics between contextualist historians and ‘analytic’ or presentist historians. I claim that much of Robert Brandom’s nuanced defence of presentism can be accepted and even adopted by contextualists, so that inferentialism turns out to provide an important justification for orthodox history of philosophy. In the concluding sections I argue that the application of Brandom’s theory has (...) important limits, and that some polemics by contextualists against presentists are therefore justified. (shrink)

What is it we do when we philosophize about a word? How are we to act as we ask the philosophical question par excellence, “What is …?” These questions are addressed here with particular focus on Troy Jollimore's Love's Vision and contemporary theories of love. Jollimore's rationalist account of love, based on a specific understanding of “reasons for love,” illustrates a particular philosophical mistake: When we think about a word, we are prone to believe that even though “the sense of (...) the word” that we investigate may be up for grabs, the other words we use when we do these investigations are not. Jollimore's exploration of love is guided by specific conceptions of “reasons” and “rationality” that remain unquestioned. The article argues that we may have to rethink a great number of words as we embark on the task of uncovering the sense of one word. (shrink)

Quentin Skinner has enduringly insisted that a past text cannot be ‘understood’ without the reader knowing something about its historical and linguistic context. But since the 1970s he has been attacked on this central point of all his work by authors maintaining that the text itself is the fundamental guide to the author’s intention, and that a separate study of the context cannot tell the historian anything that the text itself could not. Mark Bevir has spent much of the last (...) 20 years repeating a similar counter-argument. Although ‘study the linguistic context’ might be a useful heuristic maxim, Bevir says, it does not express a necessary or sufficient condition for understanding. But Skinner is right, and one of the figures he has consistently identified as a formative inspiration, R. G. Collingwood, has already (in his work of the 1930s) shown why. What Collingwood calls his ‘logic of question and answer’ explains why the historian cannot answer his characteristic ‘intention’ question about past texts without knowing the context of problems to which authors think they are offering solutions. The study of context is neither ‘prior’ (as Bevir incorrectly supposes) nor ‘separate’ (as Skinner inaccurately says), but it is, as Skinner maintains, nevertheless impossible to grasp an author’s intention without it. This ‘logic of question and answer’ also explains why, in history, dismissing the study of context is in fact a pre-judgement of evidence yet unseen. (shrink)

To better understand the work of pre-Darwinian British life researchers in their own right, this paper discusses two different styles of reasoning. On the one hand there was analysis:synthesis, where an organism was disintegrated into its constituent parts and then reintegrated into a whole; on the other hand there was palaetiology, the historicist depiction of the progressive specialization of an organism. This paper shows how each style allowed for development, but showed it as moving in opposite directions. In analysis:synthesis, development (...) proceeded centripetally, through the fusion of parts. In palaetiology, development moved centrifugally, through the ramifying specialization of an initially simple substance. I first examine a community of analytically oriented British life researchers, exemplified by Richard Owen, and certain technical questions they considered important. These involved the neurosciences, embryology, and reproduction and regeneration. The paper then looks at a new generation of British palaetiologists, exemplified by W.B. Carpenter and T.H. Huxley, who succeeded at portraying analysts' questions as irrelevant. The link between styles of reasoning and physical sites is also explored. Analysts favored museums, which facilitated the examination and display of unchanging marine organisms while providing a power base for analysts. I suggest that palaetiologists were helped by vivaria, which included marine aquaria and Wardian cases. As they became popular in the early 1850s, vivaria provided palaetiologists with a different kind of living and changing evidence. Forms of evidence, how they were preserved and examined, and career options all reinforced each other: social and epistemic factors thus merged. (shrink)

To better understand the work of pre-Darwinian British life researchers in their own right, this paper discusses two different styles of reasoning. On the one hand there was analysis:synthesis, where an organism was disintegrated into its constituent parts and then reintegrated into a whole; on the other hand there was palaetiology, the historicist depiction of the progressive specialization of an organism. This paper shows how each style allowed for development, but showed it as moving in opposite directions. In analysis:synthesis, development (...) proceeded centripetally, through the fusion of parts. In palaetiology, development moved centrifugally, through the ramifying specialization of an initially simple substance. I first examine a community of analytically oriented British life researchers, exemplified by Richard Owen, and certain technical questions they considered important. These involved the neurosciences, embryology, and reproduction and regeneration. The paper then looks at a new generation of British palaetiologists, exemplified by W.B. Carpenter and T.H. Huxley, who succeeded at portraying analysts' questions as irrelevant. The link between styles of reasoning and physical sites is also explored. Analysts favored museums, which facilitated the examination and display of unchanging marine organisms while providing a power base for analysts. I suggest that palaetiologists were helped by vivaria, which included marine aquaria and Wardian cases. As they became popular in the early 1850s, vivaria provided palaetiologists with a different kind of living and changing evidence. Forms of evidence, how they were preserved and examined, and career options all reinforced each other: social and epistemic factors thus merged. (shrink)

It is a cliché to say science and religion are antagonistic. The outlook is often promoted by religious people uneducated in the workings of science, and equally by scientifically-oriented individuals with little experience of religion. This essay challenges presumptions about the irreconcilability of science and religion, focusing on action organizing metaphysical principles infusing both. The aim, however, is not to evaluate proofs for God’s existence, nor defend young earth creationism, nor the notion that there is one true religion, nor still (...) the thesis that morality demands divine guidance – all positions that critics commonly raise to demonstrate the stupidity of religion, even though such views are hardly universal among theists. The aim is instead to expand what one can rationally accept, leaving it to individuals to decide what to believe. Central to my arguments is the concept of pragmatic faith. The notion holds that willingness to act measures strength of conviction and that actions generate empirical results that may either verify or disconfirm what was initially held without adequate evidence. Such a stance is a necessary ingredient in both scientific and spiritual activities, suggesting a rebuttal to New Atheists, who narrowly identify religion with superstitious irrationality -/- . (shrink)

This dissertation investigates the ways in which natural language restricts the domains of quantifiers. Adverbs of quantification are analyzed as quantifying over situations. The domain of quantifiers is pragmatically constrained: apparent processes of "semantic partition" are treated as pragmatic epiphenomena. The introductory Chapter 1 sketches some of the background of work on natural language quantification and begins the analysis of adverbial quantification over situations. Chapter 2 develops the central picture of "semantic partition" as a side-effect of pragmatic processes of anaphora (...) resolution. I argue that the apparent effects of topic/focus articulation and presuppositional information on the interpretation of quantifiers are not the result of a direct and local mechanism of sentence grammar. Instead, I develop an analysis where the link is established via the anaphoric dependence of quantifier domains on the discourse context. Chapter 3 discusses the analysis of conditional clauses as quantifier restrictors, concentrating on the question whether conditional clauses restrict quantifiers directly or indirectly. A treatment is explored which has if-clauses constrain the value of the hidden domain variable of the restricted quantifier. Chapter 4, on unless-clauses, and Chapter 5, on only if- and even if-clauses, present some issues in the compositional analysis of complex conditional clauses. These chapters significantly expand the data coverage of the theory of A-quantification. Building on previous work of mine on exceptives, I analyze unless-clauses as exceptive operators on A-quantifiers. The analysis of only if-clauses, treated as conditional clauses that combine if with the focus adverb only, unearthes some interesting new properties. Chapter 6, finally, examines the phenomenon of donkey-anaphora in the light of the results of the previous chapters. I show that a solution to the proportion problem may become possible once we combine the situation-semantic approach to adverbial quantification with the pragmatic theory developed in Chapter 2 and further elaborated in the analysis of donkey anaphora in complex conditionals. (shrink)

This well-written volume is an introduction, not to world history, but to the special genre of "Big History," as the subtitle indicates. Christian and his fellow big historians, reacting against popular scepticism toward "master narratives," seek to create a new class of grand works that incorporate not only the history of human society, but also of the Earth, its life, and the universe as a whole. Specialists in any of the fields covered by the volume may find rough spots in (...) the treatment of topics they know well, but given the scope of the effort I think it is fair to regard this as something like the first edition of a continuing work. Later editions would be strengthened—as would the Big History movement as a whole—by explicitly incorporating some discussion of teleological reasoning in science, and by deploying clear distinctions between processes that are teleomatic (such as star formation), teleonomic (such as organismal development), and classically teleological (such as intentional behaviour on the part of humans). In "Maps of Time," David Christian has given us a book full of interesting facts, and with ideas to argue for and against in every chapter. It should provoke lively discussion across a whole range of academic disciplines. (shrink)