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Explaining the Brain

Oxford, GB: Oxford University Press (2007)

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  1. Psychoanalysis and Neuroscience: The Bridge Between Mind and Brain.Filippo Cieri & Roberto Esposito - 2019 - Frontiers in Psychology 10.
    In 1895 in the Project for a Scientific Psychology Freud tried to integrate psychology and neurology in order to develop a neuroscientific psychology. Since 1880 Freud made no distinction between psychology and physiology. His papers from the end of the 1880s to1890 were very clear on this scientific overlap: as with many of its contemporaries, Freud thought about psychology essentially as the physiology of the brain. Years later he had to surrender, realizing a technological delay, not capable to pursue its (...)
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  • Minimal models and canonical neural computations: the distinctness of computational explanation in neuroscience.M. Chirimuuta - 2014 - Synthese 191 (2):127-153.
    In a recent paper, Kaplan (Synthese 183:339–373, 2011) takes up the task of extending Craver’s (Explaining the brain, 2007) mechanistic account of explanation in neuroscience to the new territory of computational neuroscience. He presents the model to mechanism mapping (3M) criterion as a condition for a model’s explanatory adequacy. This mechanistic approach is intended to replace earlier accounts which posited a level of computational analysis conceived as distinct and autonomous from underlying mechanistic details. In this paper I discuss work in (...)
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  • Extending, changing, and explaining the brain.Mazviita Chirimuuta - 2013 - Biology and Philosophy 28 (4):613-638.
    This paper addresses concerns raised recently by Datteri (Biol Philos 24:301–324, 2009) and Craver (Philos Sci 77(5):840–851, 2010) about the use of brain-extending prosthetics in experimental neuroscience. Since the operation of the implant induces plastic changes in neural circuits, it is reasonable to worry that operational knowledge of the hybrid system will not be an accurate basis for generalisation when modelling the unextended brain. I argue, however, that Datteri’s no-plasticity constraint unwittingly rules out numerous experimental paradigms in behavioural and systems (...)
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  • Artificial consciousness: from impossibility to multiplicity.Chuanfei Chin - 2017 - In Vincent C. Müller (ed.), Philosophy and theory of artificial intelligence 2017. Berlin: Springer. pp. 3-18.
    How has multiplicity superseded impossibility in philosophical challenges to artificial consciousness? I assess a trajectory in recent debates on artificial consciousness, in which metaphysical and explanatory challenges to the possibility of building conscious machines lead to epistemological concerns about the multiplicity underlying ‘what it is like’ to be a conscious creature or be in a conscious state. First, I analyse earlier challenges which claim that phenomenal consciousness cannot arise, or cannot be built, in machines. These are based on Block’s Chinese (...)
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  • Intervals of quasi-decompositionality and mechanistic explanations.Emilio Cáceres - 2019 - Quaderns de Filosofia 6 (1):15.
    It is commonly assumed that the concept of mechanism is a keytool for the scientific understanding of observable phenomena. However, there is no single definition of mechanism in the current philosophy of science. In fact, philosophers have developed several characterizations of what seemed to be a clear intuitive concept for scientists. In this paper, I will analyze these philosophical conceptions of mechanism, highlighting their problematic aspects and proposing a new mechanistic approach based on the idea that the pertinent levels of (...)
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  • Stuck in between. Phenomenology’s Explanatory Dilemma and its Role in Experimental Practice.Mark-Oliver Casper & Philipp Haueis - 2023 - Phenomenology and the Cognitive Sciences 22 (3):575-598.
    Questions about phenomenology’s role in non-philosophical disciplines gained renewed attention. While we claim that phenomenology makes indispensable, unique contributions to different domains of scientific practice such as concept formation, experimental design, and data collection, we also contend that when it comes to explanation, phenomenological approaches face a dilemma. Either phenomenological attempts to explain conscious phenomena do not satisfy a central constraint on explanations, i.e. the asymmetry between explanans and explanandum, or they satisfy this explanatory asymmetry only by largely merging with (...)
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  • Possibilist Explanation: Explaining How-Possibly Through Laws.Gustavo A. Castañon - 2021 - Erkenntnis:835-852.
    ‘Possibilist Explanation’ is a promising account of scientific explanation which avoids the familiar problems of “how-possibly explanations”. It explains an event by showing how-actually it was epistemically possible, instead of why it was epistemically necessary. Its explanandum is the epistemic possibility of an actual event previously considered epistemically impossible. To define PE, two new concepts are introduced: ‘permissive condition’ and ‘possibilist law’. A permissive condition for an event is something that does not entail the event itself, but a necessary condition (...)
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  • Possibilist Explanation: Explaining How-Possibly Through Laws.Gustavo A. Castañon - 2019 - Erkenntnis 86 (4):835-852.
    Abstract‘Possibilist Explanation’ is a promising account of scientific explanation which avoids the familiar problems of “how-possibly explanations”. It explains an event by showing how-actually it was epistemically possible, instead of why it was epistemically necessary. Its explanandum is the epistemic possibility of an actual event previously considered epistemically impossible. To define PE, two new concepts are introduced: ‘permissive condition’ and ‘possibilist law’. A permissive condition for an event is something that does not entail the event itself, but a necessary condition (...)
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  • Models for Prediction, Explanation and Control: Recursive Bayesian Networks.Lorenzo Casini, Phyllis McKay Illari, Federica Russo & Jon Williamson - 2011 - Theoria 26 (1):5-33.
    The Recursive Bayesian Net formalism was originally developed for modelling nested causal relationships. In this paper we argue that the formalism can also be applied to modelling the hierarchical structure of mechanisms. The resulting network contains quantitative information about probabilities, as well as qualitative information about mechanistic structure and causal relations. Since information about probabilities, mechanisms and causal relations is vital for prediction, explanation and control respectively, an RBN can be applied to all these tasks. We show in particular how (...)
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  • Leyes, mecanismos y modelos en biología: el caso de la genética mendeliana.Mario Casanueva - 2017 - Scientiae Studia 15 (2):343.
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  • How to Model Mechanistic Hierarchies.Lorenzo Casini - 2016 - Philosophy of Science 83 (5):946-958.
    Mechanisms are usually viewed as inherently hierarchical, with lower levels of a mechanism influencing, and decomposing, its higher-level behaviour. In order to adequately draw quantitative predictions from a model of a mechanism, the model needs to capture this hierarchical aspect. The recursive Bayesian network formalism was put forward as a means to model mechanistic hierarchies by decomposing variables. The proposal was recently criticized by Gebharter and Gebharter and Kaiser, who instead propose to decompose arrows. In this paper, I defend the (...)
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  • Can Interventions Rescue Glennan’s Mechanistic Account of Causality?Lorenzo Casini - 2016 - British Journal for the Philosophy of Science 67 (4):1155-1183.
    Glennan appeals to interventions to solve the ontological and explanatory regresses that threaten his mechanistic account of causality . I argue that Glennan’s manoeuvre fails. The appeal to interventions is not able to address the ontological regress, and it blocks the explanatory regress only at the cost of making the account inapplicable to non-modular mechanisms. I offer a solution to the explanatory regress that makes use of dynamic Bayesian networks. My argument is illustrated by a case study from systems biology, (...)
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  • Alexander Gebharter: Causal Nets, Interventionism, and Mechanisms. Philosophical Foundations and Applications.Lorenzo Casini - 2018 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 49 (3):481-485.
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  • Mechanisms, laws and explanation.Nancy Cartwright, John Pemberton & Sarah Wieten - 2020 - European Journal for Philosophy of Science 10 (3):1-19.
    Mechanisms are now taken widely in philosophy of science to provide one of modern science’s basic explanatory devices. This has raised lively debate concerning the relationship between mechanisms, laws and explanation. This paper focuses on cases where a mechanism gives rise to a ceteris paribus law, addressing two inter-related questions: What kind of explanation is involved? and What is going on in the world when mechanism M affords behavior B described in a ceteris paribus law? We explore various answers offered (...)
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  • On the supposed explanatory heteronomy of functional biology.Gustavo Caponi - 2015 - Scientiae Studia 13 (3):547-575.
    RESUMENSegún un punto de vista muy difundido, y alineado con la concepción nómica de la explicación causal, la biología funcional está sometida a un régimen de heteronomía explicativa en cuyo marco los fenómenos orgánicos deben explicarse causalmente recurriendo a leyes oriundas de la física y la química. En contra de esa perspectiva, la concepción experimental de la causación permite entender la naturaleza de muchas explicaciones biológicas que, sin hacer referencia a leyes causales - físicas, químicas o de cualquier otra naturaleza (...)
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  • Understanding mechanisms in the health sciences.Raffaella Campaner - 2010 - Theoretical Medicine and Bioethics 32 (1):5-17.
    This article focuses on the assessment of mechanistic relations with specific attention to medicine, where mechanistic models are widely employed. I first survey recent contributions in the philosophical literature on mechanistic causation, and then take issue with Federica Russo and Jon Williamson’s thesis that two types of evidence, probabilistic and mechanistic, are at stake in the health sciences. I argue instead that a distinction should be drawn between previously acquired knowledge of mechanisms and yet-to-be-discovered knowledge of mechanisms and that both (...)
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  • Evidence and the Assessment of Causal Relations in the Health Sciences.Raffaella Campaner & Maria Carla Galavotti - 2012 - International Studies in the Philosophy of Science 26 (1):27-45.
    This contribution claims that the two fundamental notions of causation at work in the health sciences are manipulative and mechanistic, and investigates what kinds of evidence matter for the assessment of causal relations. This article is a development of our 2007 article, ‘Plurality of Causality’, where we argue for a pluralistic account of causation with an eye to econometrics and a single medical example. The present contribution has a wider focus, and considers the notion of evidence within a whole range (...)
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  • Why how and why aren’t enough: more problems with Mayr’s proximate-ultimate distinction.Brett Calcott - 2013 - Biology and Philosophy 28 (5):767-780.
    Like Laland et al., I think Mayr’s distinction is problematic, but I identify a further problem with it. I argue that Mayr’s distinction is a false dichotomy, and obscures an important question about evolutionary change. I show how this question, once revealed, sheds light on some debates in evo-devo that Laland et al.’s analysis cannot, and suggest that it provides a different view about how future integration between biological disciplines might proceed.
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  • Mechanisms, Experiments, and Theory-Ladenness: A Realist–Perspectivalist View.Marco Buzzoni - 2016 - Axiomathes 26 (4):411-427.
    The terms “perspectivism” and “perspectivalism” have been the focus of an intense philosophical discussion with important repercussions for the debate about the role of mechanisms in scientific explanations. However, leading exponents of the new mechanistic philosophy have conceded more than was necessary to the radically subjectivistic perspectivalism, and fell into the opposite error, by retaining not negligible residues of objectivistic views about mechanisms. In order to remove this vacillation between the subjective-cultural and the objective-natural sides of mechanisms, we shall raise (...)
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  • Getting over Atomism: Functional Decomposition in Complex Neural Systems.Daniel C. Burnston - 2021 - British Journal for the Philosophy of Science 72 (3):743-772.
    Functional decomposition is an important goal in the life sciences, and is central to mechanistic explanation and explanatory reduction. A growing literature in philosophy of science, however, has challenged decomposition-based notions of explanation. ‘Holists’ posit that complex systems exhibit context-sensitivity, dynamic interaction, and network dependence, and that these properties undermine decomposition. They then infer from the failure of decomposition to the failure of mechanistic explanation and reduction. I argue that complexity, so construed, is only incompatible with one notion of decomposition, (...)
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  • A contextualist approach to functional localization in the brain.Daniel C. Burnston - 2016 - Biology and Philosophy 31 (4):527-550.
    Functional localization has historically been one of the primary goals of neuroscience. There is still debate, however, about whether it is possible, and if so what kind of theories succeed at localization. I argue for a contextualist approach to localization. Most theorists assume that widespread contextual variability in function is fundamentally incompatible with functional decomposition in the brain, because contextualist accounts will fail to be generalizable and projectable. I argue that this assumption is misplaced. A properly articulated contextualism can ground (...)
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  • Explicating Agency: The Case of Visual Attention.Denis Buehler - 2023 - Philosophical Quarterly 73 (2):379-413.
    How do individuals guide their activities towards some goal? Harry Frankfurt once identified the task of explaining guidance as the central problem in action theory. An explanation has proved to be elusive, however. In this paper, I show how we can marshal empirical research to make explanatory progress. I contend that human agents have a primitive capacity to guide visual attention, and that this capacity is actually constituted by a sub-individual psychological control-system: the executive system. I thus illustrate how we (...)
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  • Agential capacities: a capacity to guide.Denis Buehler - 2021 - Philosophical Studies 179 (1):21-47.
    In paradigm exercises of agency, individuals guide their activities toward some goal. A central challenge for action theory is to explain how individuals guide. This challenge is an instance of the more general problem of how to accommodate individuals and their actions in the natural world, as explained by natural science. Two dominant traditions–primitivism and the causal theory–fail to address the challenge in a satisfying way. Causal theorists appeal to causation by an intention, through a feedback mechanism, in explaining guidance. (...)
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  • The role of models in the process of epistemic integration: the case of the Reichardt motion detector.Daniel S. Brooks - 2014 - History and Philosophy of the Life Sciences 36 (1):90-113.
    Recent work on epistemic integration in the life sciences has emphasized the importance of integration in thinking about explanatory practice in science, particularly for articulating a robust alternative to reductionism and anti-reductionism. This paper analyzes the role of models in balancing the relative contributions of lower- and higher-level epistemic resources involved in this process. Integration between multiple disciplines proceeds by constructing a problem agenda (Love 2008), a set of interrelated problems that structures the problem space of a complex phenomenon that (...)
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  • In Defense of Levels: Layer Cakes and Guilt by Association.Daniel S. Brooks - 2017 - Biological Theory 12 (3).
    Despite the ubiquity of “levels of organization” in the scientific literature, a nascent “levels skepticism” now claims that the concept of levels is an inherently flawed, misleading, or otherwise inadequate notion for understanding how life scientists produce knowledge about the natural world. However, levels skeptics rely on the maligned “layer-cake” account of levels stemming from Oppenheim and Putnam’s defense of the unity of science for their critical commentary. Recourse to layer-cake levels is understandable, as it is arguably the default conception (...)
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  • A New Look at ‘Levels of Organization’ in Biology.Daniel S. Brooks - 2021 - Erkenntnis 86.
    Despite its pervasiveness, the concept of ‘levels of organization’ has received relatively little attention in its own right. I propose here an emerging approach that posits ‘levels’ as a fragmentary concept situated within an interest-relative matrix of operational usage within scientific practice. To this end I propose one important component of meaning, namely the epistemic goal motivating the term’s usage, which recovers a remarkably conserved and sufficiently unifying significance attributable to ‘levels’ across different instances of usage. This epistemic goal, to (...)
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  • Should Explanations Omit the Details?Darren Bradley - 2020 - British Journal for the Philosophy of Science 71 (3):827-853.
    There is a widely shared belief that the higher-level sciences can provide better explanations than lower-level sciences. But there is little agreement about exactly why this is so. It is often suggested that higher-level explanations are better because they omit details. I will argue instead that the preference for higher-level explanations is just a special case of our general preference for informative, logically strong, beliefs. I argue that our preference for informative beliefs entirely accounts for why higher-level explanations are sometimes (...)
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  • Complexity and integration. A philosophical analysis of how cancer complexity can be faced in the era of precision medicine.Giovanni Boniolo & Raffaella Campaner - 2019 - European Journal for Philosophy of Science 9 (3):1-25.
    Complexity and integration are longstanding widely debated issues in philosophy of science and recent contributions have largely focused on biology and biomedicine. This paper specifically considers some methodological novelties in cancer research, motivated by various features of tumours as complex diseases, and shows how they encourage some rethinking of philosophical discourses on those topics. In particular, we discuss the integrative-cluster approach, and analyse its potential in the epistemology of cancer. We suggest that, far from being the solution to tame cancer (...)
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  • Complexity and integration. A philosophical analysis of how cancer complexity can be faced in the era of precision medicine.Giovanni Boniolo & Raffaella Campaner - 2019 - European Journal for Philosophy of Science 9 (3):1-25.
    Complexity and integration are longstanding widely debated issues in philosophy of science and recent contributions have largely focused on biology and biomedicine. This paper specifically considers some methodological novelties in cancer research, motivated by various features of tumours as complex diseases, and shows how they encourage some rethinking of philosophical discourses on those topics. In particular, we discuss the integrative-cluster approach, and analyse its potential in the epistemology of cancer. We suggest that, far from being the solution to tame cancer (...)
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  • Fiction As a Vehicle for Truth: Moving Beyond the Ontic Conception.Alisa Bokulich - 2016 - The Monist 99 (3):260-279.
    Despite widespread evidence that fictional models play an explanatory role in science, resistance remains to the idea that fictions can explain. A central source of this resistance is a particular view about what explanations are, namely, the ontic conception of explanation. According to the ontic conception, explanations just are the concrete entities in the world. I argue this conception is ultimately incoherent and that even a weaker version of the ontic conception fails. Fictional models can succeed in offering genuine explanations (...)
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  • Linking Mind to Molecular Pathways: The Role of Experiment Tools.John Bickle - 2019 - Axiomathes 29 (6):577-597.
    Neurobiologists talk of linking mind to molecular dynamics in and between neurons. Such talk is dismissed by cognitive scientists, including many cognitive neuroscientists, due to the number of “levels” that separate behaviors from these molecular events. In this paper I explain what neurobiologists mean by such claims by describing the kinds of experiment tools that have forged these linkages, directly on lab benches. I here focus on one of these tools, gene targeting techniques, brought into behavioral neuroscience from developmental biology (...)
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  • Connection experiments in neurobiology.John Bickle & Aaron Kostko - 2018 - Synthese 195 (12):5271-5295.
    Accounts of causal explanation are standard in philosophy of science. Less common are accounts of experimentation to investigate causal relations: detailed discussions of the specific kinds of experiments scientists design and run. Silva, Landreth, and Bickle’s account of “connection experiments” derives directly from landmark experiments in “molecular and cellular cognition.” We start with its key components, and then using a detailed case study from recent social neuroscience we emphasize and extend three features of SLB’s account: a division of distinct types (...)
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  • Understanding endogenously active mechanisms: A scientific and philosophical challenge. [REVIEW]William Bechtel - 2012 - European Journal for Philosophy of Science 2 (2):233-248.
    Abstract Although noting the importance of organization in mechanisms, the new mechanistic philosophers of science have followed most biologists in focusing primarily on only the simplest mode of organization in which operations are envisaged as occurring sequentially. Increasingly, though, biologists are recognizing that the mechanisms they confront are non-sequential and the operations nonlinear. To understand how such mechanisms function through time, they are turning to computational models and tools of dynamical systems theory. Recent research on circadian rhythms addressing both intracellular (...)
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  • The Importance of Constraints and Control in Biological Mechanisms: Insights from Cancer Research.William Bechtel - 2018 - Philosophy of Science 85 (4):573-593.
    Research on diseases such as cancer reveals that primary mechanisms, which have been the focus of study by the new mechanists in philosophy of science, are often subject to control by other mechanisms. Cancer cells employ the same primary mechanisms as healthy cells but control them differently. I use cancer research to highlight just how widespread control is in individual cells. To provide a framework for understanding control, I reconceptualize mechanisms as imposing constraints on flows of free energy, with control (...)
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  • The Downs and Ups of Mechanistic Research: Circadian Rhythm Research as an Exemplar. [REVIEW]William Bechtel - 2010 - Erkenntnis 73 (3):313 - 328.
    In the context of mechanistic explanation, reductionistic research pursues a decomposition of complex systems into their component parts and operations. Using research on the mechanisms responsible for circadian rhythms, I consider both the gains that have been made by discovering genes and proteins that figure in these intracellular oscillators and also highlight the increasingly recognized need to understand higher-level integration, both between cells in the central oscillator and between the central and peripheral oscillators. This history illustrates a common need to (...)
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  • The Layer Cake Model of the World and Non-Reductive Physicalism.Matthew Baxendale - 2016 - Kriterion - Journal of Philosophy 30 (1):39-60.
    In this paper I argue that non-reductive physicalism (NRP) continues to rely on the ontological aspect of the layer cake model of the world (LCM). NRP is a post-unity account of the relationship between phenomena in the world in the sense that it has been developed in response to the perceived failure of the unity of science thesis. The LCM constitutes a framework for the organisation of phenomena in the world. It articulates the idea that phenomena in the world are (...)
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  • Horizontal Surgicality and Mechanistic Constitution.Michael Baumgartner, Lorenzo Casini & Beate Krickel - 2020 - Erkenntnis 85 (2):417-430.
    While ideal interventions are acknowledged by many as valuable tools for the analysis of causation, recent discussions have shown that, since there are no ideal interventions on upper-level phenomena that non-reductively supervene on their underlying mechanisms, interventions cannot—contrary to a popular opinion—ground an informative analysis of constitution. This has led some to abandon the project of analyzing constitution in interventionist terms. By contrast, this paper defines the notion of a horizontally surgical intervention, and argues that, when combined with some innocuous (...)
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  • Horizontal Surgicality and Mechanistic Constitution.Michael Baumgartner, Lorenzo Casini & Beate Krickel - 2020 - Erkenntnis 85:417-430.
    While ideal interventions are acknowledged by many as valuable tools for the analysis of causation, recent discussions have shown that, since there are no ideal interventions on upper-level phenomena that non-reductively supervene on their underlying mechanisms, interventions cannot—contrary to a popular opinion—ground an informative analysis of constitution. This has led some to abandon the project of analyzing constitution in interventionist terms. By contrast, this paper defines the notion of a horizontally surgical intervention, and argues that, when combined with some innocuous (...)
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  • Constitutive Relevance, Mutual Manipulability, and Fat-Handedness.Michael Baumgartner & Alexander Gebharter - 2016 - British Journal for the Philosophy of Science 67 (3):731-756.
    The first part of this paper argues that if Craver’s ([2007a], [2007b]) popular mutual manipulability account (MM) of mechanistic constitution is embedded within Woodward’s ([2003]) interventionist theory of causation--for which it is explicitly designed--it either undermines the mechanistic research paradigm by entailing that there do not exist relationships of constitutive relevance or it gives rise to the unwanted consequence that constitution is a form of causation. The second part shows how Woodward’s theory can be adapted in such a way that (...)
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  • The Compact Compendium of Experimental Philosophy.Alexander Max Bauer & Stephan Kornmesser (eds.) - 2023 - Berlin and Boston: De Gruyter.
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  • Negative causation in causal and mechanistic explanation.D. Benjamin Barros - 2013 - Synthese 190 (3):449-469.
    Instances of negative causation—preventions, omissions, and the like—have long created philosophical worries. In this paper, I argue that concerns about negative causation can be addressed in the context of causal explanation generally, and mechanistic explanation specifically. The gravest concern about negative causation is that it exacerbates the problem of causal promiscuity—that is, the problem that arises when a particular account of causation identifies too many causes for a particular effect. In the explanatory context, the problem of promiscuity can be solved (...)
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  • Mental machines.David L. Barack - 2019 - Biology and Philosophy 34 (6):63.
    Cognitive neuroscientists are turning to an increasingly rich array of neurodynamical systems to explain mental phenomena. In these explanations, cognitive capacities are decomposed into a set of functions, each of which is described mathematically, and then these descriptions are mapped on to corresponding mathematical descriptions of the dynamics of neural systems. In this paper, I outline a novel explanatory schema based on these explanations. I then argue that these explanations present a novel type of dynamicism for the philosophy of mind (...)
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  • Mental machines.David L. Barack - 2019 - Biology and Philosophy 34 (6):63.
    Cognitive neuroscientists are turning to an increasingly rich array of neurodynamical systems to explain mental phenomena. In these explanations, cognitive capacities are decomposed into a set of functions, each of which is described mathematically, and then these descriptions are mapped on to corresponding mathematical descriptions of the dynamics of neural systems. In this paper, I outline a novel explanatory schema based on these explanations. I then argue that these explanations present a novel type of dynamicism for the philosophy of mind (...)
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  • Mental machines.David L. Barack - 2019 - Biology and Philosophy 34 (6):63.
    Cognitive neuroscientists are turning to an increasingly rich array of neurodynamical systems to explain mental phenomena. In these explanations, cognitive capacities are decomposed into a set of functions, each of which is described mathematically, and then these descriptions are mapped on to corresponding mathematical descriptions of the dynamics of neural systems. In this paper, I outline a novel explanatory schema based on these explanations. I then argue that these explanations present a novel type of dynamicism for the philosophy of mind (...)
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  • Mental kinematics: dynamics and mechanics of neurocognitive systems.David L. Barack - 2020 - Synthese 199 (1-2):1091-1123.
    Dynamical systems play a central role in explanations in cognitive neuroscience. The grounds for these explanations are hotly debated and generally fall under two approaches: non-mechanistic and mechanistic. In this paper, I first outline a neurodynamical explanatory schema that highlights the role of dynamical systems in cognitive phenomena. I next explore the mechanistic status of such neurodynamical explanations. I argue that these explanations satisfy only some of the constraints on mechanistic explanation and should be considered pseudomechanistic explanations. I defend this (...)
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  • Cajal’s Law of Dynamic Polarization: Mechanism and Design.Sergio Daniel Barberis - 2018 - Philosophies 3 (2):11.
    Santiago Ramón y Cajal, the primary architect of the neuron doctrine and the law of dynamic polarization, is considered to be the founder of modern neuroscience. At the same time, many philosophers, historians, and neuroscientists agree that modern neuroscience embodies a mechanistic perspective on the explanation of the nervous system. In this paper, I review the extant mechanistic interpretation of Cajal’s contribution to modern neuroscience. Then, I argue that the extant mechanistic interpretation fails to capture the explanatory import of Cajal’s (...)
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  • The ‘Big Picture’: The Problem of Extrapolation in Basic Research.Tudor M. Baetu - 2016 - British Journal for the Philosophy of Science 67 (4):941-964.
    Both clinical research and basic science rely on the epistemic practice of extrapolation from surrogate models, to the point that explanatory accounts presented in review papers and biology textbooks are in fact composite pictures reconstituted from data gathered in a variety of distinct experimental setups. This raises two new challenges to previously proposed mechanistic-similarity solutions to the problem of extrapolation: one pertaining to the absence of mechanistic knowledge in the early stages of research and the second to the large number (...)
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  • On the Possibility of Crucial Experiments in Biology.Tudor Baetu - 2019 - British Journal for the Philosophy of Science 70 (2):407-429.
    The article analyses in detail the Meselson–Stahl experiment, identifying two novel difficulties for the crucial experiment account, namely, the fragility of the experimental results and the fact that the hypotheses under scrutiny were not mutually exclusive. The crucial experiment account is rejected in favour of an experimental-mechanistic account of the historical significance of the experiment, emphasizing that the experiment generated data about the biochemistry of DNA replication that is independent of the testing of the semi-conservative, conservative, and dispersive hypotheses. _1_ (...)
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  • Teleosemantic modeling of cognitive representations.Marc Artiga - 2016 - Biology and Philosophy 31 (4):483-505.
    Naturalistic theories of representation seek to specify the conditions that must be met for an entity to represent another entity. Although these approaches have been relatively successful in certain areas, such as communication theory or genetics, many doubt that they can be employed to naturalize complex cognitive representations. In this essay I identify some of the difficulties for developing a teleosemantic theory of cognitive representations and provide a strategy for accommodating them: to look into models of signaling in evolutionary game (...)
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  • The case for regularity in mechanistic causal explanation.Holly Andersen - 2012 - Synthese 189 (3):415-432.
    How regular do mechanisms need to be, in order to count as mechanisms? This paper addresses two arguments for dropping the requirement of regularity from the definition of a mechanism, one motivated by examples from the sciences and the other motivated by metaphysical considerations regarding causation. I defend a broadened regularity requirement on mechanisms that takes the form of a taxonomy of kinds of regularity that mechanisms may exhibit. This taxonomy allows precise explication of the degree and location of regular (...)
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