It is undeniable that much scientific work is model-based. Despite this, the justification for this reliance on models is still controversial. A particular difficulty here is the fact that many scientific models are based on assumptions that do not describe the exact details of many or even any empirical situations very well. This raises the question of why it is that, despite their frequent lack of descriptive accuracy, employing models is scientifically useful.One..

It is often claimed that scientists can obtain new knowledge about nature by running computer simulations. How is this possible? I answer this question by arguing that computer simulations are arguments. This view parallels Norton’s argument view about thought experiments. I show that computer simulations can be reconstructed as arguments that fully capture the epistemic power of the simulations. Assuming the extended mind hypothesis, I furthermore argue that running the computer simulation is to execute the reconstructing argument. I discuss some (...) objections and reject the view that computer simulations produce knowledge because they are experiments. I conclude by comparing thought experiments and computer simulations, assuming that both are arguments. (shrink)

Reasons are given to justify the claim that computer simulations and computational science constitute a distinctively new set of scientific methods and that these methods introduce new issues in the philosophy of science. These issues are both epistemological and methodological in kind.

Advancements in machine learning have fuelled the popularity of using AI decision algorithms in procedures such as bail hearings, medical diagnoses and recruitment. Academic articles, policy texts, and popularizing books alike warn that such algorithms tend to be opaque: they do not provide explanations for their outcomes. Building on a causal account of transparency and opacity as well as recent work on the value of causal explanation, I formulate a moral concern for opaque algorithms that is yet to receive a (...) systematic treatment in the literature: when such algorithms are used in life-changing decisions, they can obstruct us from effectively shaping our lives according to our goals and preferences, thus undermining our autonomy. I argue that this concern deserves closer attention as it furnishes the call for transparency in algorithmic decision-making with both new tools and new challenges. (shrink)

Computer simulations have conventionally been understood to be either extensions of formal methods such as mathematical models or as special cases of empirical practices such as experiments. Here, I argue that computer simulations are best understood as instruments. Understanding them as such can better elucidate their actual role as well as their potential epistemic standing in relation to science and other scientific methods, practices and devices.

This paper attempts to describe and address a specific puzzle related to compositionality in artificial networks such as Deep Neural Networks and machine learning in general. The puzzle identified here touches on a larger debate in Artificial Intelligence related to epistemic opacity but specifically focuses on computational applications of human level linguistic abilities or properties and a special difficulty with relation to these. Thus, the resulting issue is both general and unique. A partial solution is suggested.

For computer simulation models to usefully inform climate risk management, uncertainties in model projections must be explored and characterized. Because doing so requires running the model many ti...

Computer simulations and experiments share many important features. One way of explaining the similarities is to say that computer simulations just are experiments. This claim is quite popular in the literature. The aim of this paper is to argue against the claim and to develop an alternative explanation of why computer simulations resemble experiments. To this purpose, experiment is characterized in terms of an intervention on a system and of the observation of the reaction. Thus, if computer simulations are experiments, (...) either the computer hardware or the target system must be intervened on and observed. I argue against the first option using the non-observation argument, among others. The second option is excluded by e.g. the over-control argument, which stresses epistemological differences between experiments and simulations. To account for the similarities between experiments and computer simulations, I propose to say that computer simulations can model possible experiments and do in fact often do so. (shrink)

This paper, which is based on recent empirical research at the University of Leeds, the University of Edinburgh, and the University of Bristol, presents two difficulties which arise when condensed matter physicists interact with molecular biologists: the former use models which appear to be too coarse-grained, approximate and/or idealized to serve a useful scientific purpose to the latter; and the latter have a rather narrower view of what counts as an experiment, particularly when it comes to computer simulations, than the (...) former. It argues that these findings are related; that computer simulations are considered to be undeserving of experimental status, by molecular biologists, precisely because of the idealizations and approximations that they involve. The complexity of biological systems is a key factor. The paper concludes by critically examining whether the new research programme of ‘systems biology’ offers a genuine alternative to the modelling strategies used by physicists. It argues that it does not. (shrink)

There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have (...) a lot to learn by paying closer attention to the practice of simulation. (shrink)

Computer simulations are widely used for surrogative reasoning in scientific research. They also play a crucial role in engineering, more specifically in the design of new robotic systems, yet the nature of this role has been little discussed so far in the philosophy of technology literature. The main claim made in this article is that the notion of surrogative reasoning is central to understanding how computer simulations can serve the purpose of designing new robots. More specifically, it is argued that (...) computer simulations can support two forms of surrogative reasoning, which are called model-oriented and prediction-oriented, whose inferential structure is reconstructed to some extent. And it is argued that, when computer simulations are used to design new robots, they are distinctively used in the model-oriented way. By unravelling the structure of the computer simulation-supported methods adopted in robotic design, this article may contribute to a finer-grained understanding of the epistemic processes involved in technological research. (shrink)

A chronicled approach to the notion of computer simulations shows that there are two predominant interpretations in the specialized literature. According to the first interpretation, computer simulations are techniques for finding the set of solutions to a mathematical model. I call this first interpretation the problem-solving technique viewpoint. In its second interpretation, computer simulations are considered to describe patterns of behavior of a target system. I call this second interpretation the description of patterns of behavior viewpoint of computer simulations. This (...) article explores these two interpretations of computer simulations from three different angles. First, I collect a series of definitions of computer simulation from the historical record. I track back definitions to the early 1960s and show how each viewpoint shares similar interpretations of computer simulations—ultimately clustering into the two viewpoints aforementioned. This reconstruction also includes the most recent literature. Second, I unpack the philosophical assumptions behind each viewpoint, with a special emphasis on their differences. Third, I discuss the philosophical implications of each viewpoint in the context of the recent discussion on the logic of scientific explanation for computer simulations. (shrink)

Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...) computational models. Drawing on epistemological work in the philosophy of medicine, we explain why these two methods, while powerful, are neither truly personalised nor, epistemologically speaking, novel strategies. Both are forms of correlational black box. We then argue that the iPSC models would count as a new kind of black box. They would not rely entirely on mechanistic knowledge, and they would utilise correlational evidence in a different way from other strategies—a way that would enable personalised predictions. In arguing that the iPSC models would present a novel method of gaining evidence for clinical practice, we provide an epistemic analysis that can help to inform the practical, regulatory, and ethical challenges of developing an iPSC system. (shrink)

What does it mean to trust the results of a computer simulation? This paper argues that trust in simulations should be grounded in empirical evidence, good engineering practice, and established theoretical principles. Without these constraints, computer simulation risks becoming little more than speculation. We argue against two prominent positions in the epistemology of computer simulation and defend a conservative view that emphasizes the difference between the norms governing scientific investigation and those governing ordinary epistemic practices.

Modularity is a key concept in building and evaluating complex simulation models. My main claim is that in simulation modeling modularity degenerates for systematic methodological reasons. Consequently, it is hard, if not impossible, to accessing how representational structure and dynamical properties of a model are related. The resulting problem for validating models is one of holism. The argument will proceed by analyzing the techniques of parameterization, tuning, and kludging. They are – to a certain extent – inevitable when building complex (...) simulation models, but corrode modularity. As a result, the common account of validating simulations faces a major problem and testing the dynamical behavior of simulation models becomes all the more important. Finally, I will ask in what circumstances this might be sufficient for model validation. (shrink)

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

In this paper, we argue for the centrality of prediction in the use of computational models in science. We focus on the consequences of the irreversibility of computational models and on the conditional or ceteris paribus, nature of the kinds of their predictions. By irreversibility, we mean the fact that computational models can generally arrive at the same state via many possible sequences of previous states. Thus, while in the natural world, it is generally assumed that physical states have a (...) unique history, representations of those states in a computational model will usually be compatible with more than one possible history in the model. We describe some of the challenges involved in prediction and retrodiction in computational models while arguing that prediction is an essential feature of non-arbitrary decision making. Furthermore, we contend that the non-predictive virtues of computational models are dependent to a significant degree on the predictive success of the models in question. (shrink)

QC 20120521. Review of 'Science in the Age of Computer Simulation' by Eric Winsberg.

A chronicled approach to the notion of computer simulations shows that there are two predominant interpretations in the specialized literature. According to the first interpretation, computer simulations are techniques for finding the set of solutions to a mathematical model. I call this first interpretation the problem-solving technique viewpoint. In its second interpretation, computer simulations are considered to describe patterns of behavior of a target system. I call this second interpretation the description of patterns of behavior viewpoint of computer simulations. This (...) article explores these two interpretations of computer simulations from three different angles. First, I collect a series of definitions of computer simulation from the historical record. I track back definitions to the early 1960s and show how each viewpoint shares similar interpretations of computer simulations—ultimately clustering into the two viewpoints aforementioned. This reconstruction also includes the most recent literature. Second, I unpack the philosophical assumptions behind each viewpoint, with a special emphasis on their differences. Third, I discuss the philosophical implications of each viewpoint in the context of the recent discussion on the logic of scientific explanation for computer simulations. (shrink)

It has been argued that the Duhem problem is renewed with computational models since model assumptions having a representational aim and computational assumptions cannot be tested in isolation. In particular, while the Verification and Validation methodology is supposed to prevent such holism, Winsberg argues that verification and validation cannot be separated in practice. Morrison replies that Winsberg overstates the entanglement between the steps. The paper aims at arbitrating these two positions, by stressing their respective validity in relation to domains of (...) application. It importantly argues for an increasing use of formal methods in verification, that makes disentanglement possible. (shrink)

Several philosophical issues in connection with computer simulations rely on the assumption that results of simulations are trustworthy. Examples of these include the debate on the experimental role of computer simulations :483–496, 2009; Morrison in Philos Stud 143:33–57, 2009), the nature of computer data Computer simulations and the changing face of scientific experimentation, Cambridge Scholars Publishing, Barcelona, 2013; Humphreys, in: Durán, Arnold Computer simulations and the changing face of scientific experimentation, Cambridge Scholars Publishing, Barcelona, 2013), and the explanatory power of (...) computer simulations :277–292, 2008; Durán in Int Stud Philos Sci 31:27–45, 2017). The aim of this article is to show that these authors are right in assuming that results of computer simulations are to be trusted when computer simulations are reliable processes. After a short reconstruction of the problem of epistemic opacity, the article elaborates extensively on computational reliabilism, a specified form of process reliabilism with computer simulations located at the center. The article ends with a discussion of four sources for computational reliabilism, namely, verification and validation, robustness analysis for computer simulations, a history of successful implementations, and the role of expert knowledge in simulations. (shrink)

This paper argues that the difference between contemporary software intensive scientific practice and more traditional non-software intensive varieties results from the characteristically high conditionality of software. We explain why the path complexity of programs with high conditionality imposes limits on standard error correction techniques and why this matters. While it is possible, in general, to characterize the error distribution in inquiry that does not involve high conditionality, we cannot characterize the error distribution in inquiry that depends on software. Software intensive (...) science presents distinctive error and uncertainty modalities that pose new challenges for the epistemology of science. (shrink)

We give an overview of the practice of developing and using complex climate models, as seen from experiences in a major climate modelling center and through participation in the Coupled Model Intercomparison Project. We discuss the construction and calibration of models; their evaluation, especially through use of out-of-sample tests; and their exploitation in multi-model ensembles to identify biases and make predictions. We stress that adequacy or utility of climate models is best assessed via their skill against more naïve predictions. The (...) framework we use for making inferences about reality using simulations is naturally Bayesian, and has many points of contact with more familiar examples of scientific epistemology. While the use of complex simulations in science is a development that changes much in how science is done in practice, we argue that the concepts being applied fit very much into traditional practices of the scientific method, albeit those more often associated with laboratory work. (shrink)

Scientificity is essentially methodology. The use of information technology as methodological instruments in science has been increasing for decades, this raises the question: Does this transform science? This question is the subject of the Special Issue in Minds and Machines “The epistemological significance of methods in computer simulation and machine learning”. We show that there is a technological change in this area that has three methodological and epistemic consequences: methodological opacity, reproducibility issues, and altered forms of justification.

Verification and validation of computer codes and models used in simulations are two aspects of the scientific practice of high importance that recently have been discussed widely by philosophers of science. While verification is predominantly associated with the correctness of the way a model is represented by a computer code or algorithm, validation more often refers to the model’s relation to the real world and its intended use. Because complex simulations are generally opaque to a practitioner, the Duhem problem can (...) arise with verification and validation due to their entanglement; such an entanglement makes it impossible to distinguish whether a coding error or the model’s general inadequacy to its target should be blamed in the case of a failure. I argue that a clear distinction between computer modeling and simulation has to be made to disentangle verification and validation. Drawing on that distinction, I suggest to associate modeling with verification and simulation, which shares common epistemic strategies with experimentation, with validation. To explain the reasons for their entanglement in practice, I propose a Weberian ideal–typical model of modeling and simulation as roles in practice. I examine an approach to mitigate the Duhem problem for verification and validation that is generally applicable in practice and is based on differences in epistemic strategies and scopes. Based on this analysis, I suggest two strategies to increase the reliability of simulation results, namely, avoiding alterations of verified models at the validation stage as well as performing simulations of the same target system using two or more different models. In response to Winsberg’s claim that verification and validation are entangled I argue that deploying the methodology proposed in this work it is possible to mitigate inseparability of V&V in many if not all domains where modeling and simulation are used. (shrink)

The epistemology of computer simulations has become a mainstream topic in the philosophy of technology. Within this large area, significant differences hold between the various types of models and simulation technologies. Agent-based and multi-agent systems simulations introduce a specific constraint on the types of agents and systems modelled. We argue that such difference is crucial and that simulation for the artificial sciences requires the formulation of its own specific epistemological principles. We present a minimally committed epistemology which relies on the (...) methodological principles of the Philosophy of Information and requires weak assumptions on the usability of the simulation and the controllability of the model. We use these principles to provide a new definition of simulation for the context of interest. (shrink)

In many scientific fields, today’s practices of empirical enquiry rely heavily on the production of images that display the investigated phenomena. And while scientific images of phenomena have been important for a long time, what is striking now is that scientists have found ways to visualize such widely different types of phenomena. In the past twenty or thirty years, we have become accustomed to seeing images of galaxies, of cells, of the human brain but also of blood flow or of (...) turbulent fluids. This success in making images relies first on the set of imaging devices that have flourished in the twentieth century, instruments such as radio-telescopes, electronic microscopes, MRI and many more. Without these... (shrink)

The pervasive use of computer simulations in the sciences brings novel epistemological issues discussed in the philosophy of science literature since about a decade. Evolutionary biology strongly relies on such simulations, and in relation to it there exists a research program (Artificial Life) that mainly studies simulations themselves. This paper addresses the specificity of computer simulations in evolutionary biology, in the context (described in Sect. 1) of a set of questions about their scope as explanations, the nature of validation processes (...) and the relation between simulations and true experiments or mathematical models. After making distinctions, especially between a weak use where simulations test hypotheses about the world, and a strong use where they allow one to explore sets of evolutionary dynamics not necessarily extant in our world, I argue in Sect. 2 that (weak) simulations are likely to represent in virtue of the fact that they instantiate specific features of causal processes that may be isomorphic to features of some causal processes in the world, though the latter are always intertwined with a myriad of different processes and hence unlikely to be directly manipulated and studied. I therefore argue that these simulations are merely able to provide candidate explanations for real patterns. Section 3 ends up by placing strong and weak simulations in Levins’ triangle, that conceives of simulations as devices trying to fulfil one or two among three incompatible epistemic values (precision, realism, genericity). (shrink)

ABSTRACT This paper examines consequences of the computer revolution in mathematics. By comparing its repercussions with those of conceptual developments that unfolded in the nineteenth century, I argue that the key epistemological lesson to draw from the two transformative periods is that effective and successful mathematical practices in science result from integrating the computational and conceptual styles of mathematics, and not that one of the two styles of mathematical reasoning is superior. Finally, I show that the methodology deployed by applied (...) mathematicians in modern scientific computing is a paradigmatic instance of this key lesson. (shrink)

Many philosophical accounts of scientific models fail to distinguish between a simulation model and other forms of models. This failure is unfortunate because there are important differences pertaining to their methodology and epistemology that favor their philosophical understanding. The core claim presented here is that simulation models are rich and complex units of analysis in their own right, that they depart from known forms of scientific models in significant ways, and that a proper understanding of the type of model simulations (...) are fundamental for their philosophical assessment. I argue that simulation models can be distinguished from other forms of models by the many algorithmic structures, representation relations, and new semantic connections involved in their architecture. In this article, I reconstruct a general architecture for a simulation model, one that faithfully captures the complexities involved in most scientific research with computer simulations. Furthermore, I submit that a new methodology capable of conforming such architecture into a fully functional, computationally tractable computer simulation must be in place. I discuss this methodology—what I call recasting—and argue for its philosophical novelty. If these efforts are heading towards the right interpretation of simulation models, then one can show that computer simulations shed new light on the philosophy of science. To illustrate the potential of my interpretation of simulation models, I briefly discuss simulation-based explanations as a novel approach to questions about scientific explanation. (shrink)

Deep neural networks have become increasingly successful in applications from biology to cosmology to social science. Trained DNNs, moreover, correspond to models that ideally allow the prediction of new phenomena. Building in part on the literature on ‘eXplainable AI’, I here argue that these models are instrumental in a sense that makes them non-explanatory, and that their automated generation is opaque in a unique way. This combination implies the possibility of an unprecedented gap between discovery and explanation: When unsupervised models (...) are successfully used in exploratory contexts, scientists face a whole new challenge in forming the concepts required for understanding underlying mechanisms. (shrink)

The Epistemology Of Computer Simulation has developed as an epistemological and methodological analysis of simulative sciences using quantitative computational models to represent and predict empirical phenomena of interest. In this paper, Executable Cell Biology and Agent-Based Modelling are examined to show how one may take advantage of qualitative computational models to evaluate reachability properties of reactive systems. In contrast to the thesis, advanced by EOCS, that computational models are not adequate representations of the simulated empirical systems, it is shown how (...) the representational adequacy of qualitative models is essential to evaluate reachability properties. Justification theory, if not playing an essential role in EOCS, is exhibited to be involved in the process of advancing and corroborating model-based hypotheses about empirical systems in ECB and ABM. Finally, the practice of evaluating model-based hypothesis by testing the simulated systems is shown to constitute an argument in favour of the thesis that computer simulations in ECB and ABM can be put on a par with scientific experiments. (shrink)