In this essay, I argue that to create a genomics that offers more gifts than weights, central attention must be paid to questions of justice. This will require expanding bioethical imaginations so that they grasp and can respond to questions of structural inequity. It will necessitate building novel coalitions and collaborations that turn the attention of bioethical governance away from narrow individual questions such as, “Do I consent?” and toward the broader collective question, is this just? What kind of lives (...) and collectivities are made possible? What rights and principles should govern them? The essay ends with one example of this novel coalition building arising from the Science and Justice Research Center at the University of California, Santa Cruz. It draws lessons from this effort to build new alliances that bridge the social sciences and natural sciences, arts and engineering, to create new kinds of training and thinking that create a genomics that more adequately responds to fundamental questions of justice. (shrink)

Scientists employ a variety of procedures to eliminate degrees of freedom from computationally and/or analytically intractable equations. In the process, they often construct new models and discover new concepts, laws and functional relations. I argue these procedures embody a central notion of reduction, namely, the containment of one structure within another. However, their inclusion in the philosophical concept of reduction necessitates a reevaluation of many standard assumptions about the ontological, epistemological and functional features of a reduction. On the basis of (...) the reevaluation, I advocate a continuum of reduction which proceeds from the eliminative to the constructive. The metaphysical aspects of theory use in constructive reductions are sketched. (shrink)

Several philosophers of science have claimed that the correspondence principle can be generalized from quantum physics to all of (particularly physical) science and that in fact it constitutes one of the major heuristical rules for the construction of new theories. In order to evaluate these claims, first the use of the correspondence principle in (the genesis of) quantum mechanics will be examined in detail. It is concluded from this and from other examples in the history of science that the principle (...) should be qualified with respect to its nature and relativized with respect to its scope of application. At the same time this conclusion implies a qualification and a relativization of the heuristic power of the principle. Generally speaking, intertheoretical correspondence is primarily of a formal-mathematical and empirical but not of a conceptual nature. Moreover, it only applies to certain parts of the theories involved. Finally, a number of philosophical justifications of the principle are discussed and some conclusions are drawn concerning the debates on theory reduction and on the discovery-justification distinction. (shrink)

The 1980s, it is often claimed, was the decade when experimentation finally became a philosophical topic. This was the responsibility, the claim continues, of one particular movement within philosophy of science, called “new experimentalism.” The aim of this article is to complicate this historical narrative. We argue that in the 1980s, the study of experimentation was carried out not by one movement with one particular aim but rather in a diverse and open-ended way by people with different aims and backgrounds. (...) We then argue that from the late 1990s onward, this diversity disappeared and made room for disciplinary divisions—questions concerning experimentation became philosophical, others sociological, and so on. The reason for this, we claim, was that science and technology studies, philosophy of technology, and philosophy of science took over aspects of the 1980s study of experimentation. In this way, we argue, these elements became institutionalized, whereas others were forgotten. The importance of this process of institutionalization is illustrated by means of a discussion of other, similar approaches to the philosophy of experimentation that have not been able to ensure continuity because they did not find an institutional home. (shrink)

In recent years a unified strategy in dealing with constructivism has been emerging in the writings of historians and philosophers of science. In my own experience, the strategy is exemplified in the long critiques of all or parts of my book, Constructing Quarks (CQ), set out by Paul Roth, Peter Galison and Allan Franklin. These critiques have two common features. First, the substance of constructivist claims is more or less ignored, in favour a fictional version that simply asserts the opposite (...) of what the critic wants to affirm, which is, second, that the evolution of science should be grasped in terms of some relatively simple and unsituated concept of ‘reason’ (or ‘logic’ or ‘persuasive argument’).1 Allan Franklin’s discussion of the history of parity-violation experiments in atomic and high-energy physics exemplifies both of these features.2 Concerning the first, the position he attributes to CQ is summarised as a pure negative: Pickering, he says, ‘obviously doubts that science is a reasonable enterprise based on valid experimental or observational evidence’ (165).3. (shrink)

The main problems faced by a conception of perception as passive will be introduced through a critical examination of John McDowell's account of 'empirical thinking'. Overcoming these difficulties will lead to a conception of perception as involving an active cognitive participation of the perceiver, and an account of how observational judgment is warranted that is focused on the conditions of experience. In both cases, analogies to inquiry in scientific experimental practice will be explored.

In his 1939 Lectures, the prominent Soviet physicist L. I. Mandelstam proposed an interpretation of quantum mechanics that was understood in different ways. To assess Mandelstam's interpretation, we classify contemporary interpretations of quantum mechanics and compare his interpretation with others developed in the 1930s. We conclude that Mandelstam's interpretation belongs to the family of minimal statistical interpretations and has much in common with interpretations developed by American physicists. Mandelstam's characteristic message was his theory of indirect measurement, which influenced his discussion (...) of the "reduction of the wave packet" and the Einstein, Podolsky, and Rosen argument. This article also reconstructs what lay behind Mandelstam's interpretation of quantum mechanics. This was his operationalism, by virtue of which his interpretation resembled Kemble's, in which the statistical and Copenhagen views had been combined. Like Popper and Margenau, Mandelstam followed R. von Mises's empirical conception of probability. Mandelstam, like the other proponents of the statistical approach to quantum mechanics, was affected by the culture of macroscopic experimentation with its emphasis on statistical measurement. (shrink)

In Social Empiricism, Miriam Solomon proposes a via media between traditional philosophical realism and social construction of scientific knowledge, but ignores a large body of historical literature that has attempted to plough just that path. She also proposes a standard for normatively appropriate consensus that, arguably, no theory in the history of science has ever achieved, including her own ideal type—plate tectonics. And while valorizing dissent, she fails to consider how dissent has been used in recent decades as a political (...) tool to challenge scientific evidence on diverse issues, including the link between tobacco and cancer and the reality of anthropogenic global warming. (shrink)

The topic of the presence, legitimacy and epistemic worth of narrative explanations in different kinds of scientific discourse has already enjoyed several revivals within related discussions in contemporary philosophy of science. In fact, we have recently witnessed a more extensive, more unprejudiced and ambitious attention to narrative modes of making science. I think we need a systematic theoretical framework in order to categorize these different functions of narratives and understand their role in scientific explanatory and justificatory practice. My claim is (...) that some distinctions and analytic tools developed within the field of contemporary Argumentation Theory might be of help. (shrink)

Key words: rationality, communication, maxwellian revolution, Ampere-Weber research programme, synthesis, Kantian epistemology.. Why did Maxwell’s programme supersede the Ampere-Weber one? – To answer the question one has to consider the intertheoretic context of maxwellian electrodynamics genesis and development. It is demonstrated that maxwellian electrodynamics was created as a result of the old pre-maxwellian programmes reconciliation: the electrodynamics of Ampere-Weber, the wave theory of Young-Fresnel and Faraday’s programme. The programmes’ meeting led to construction of the hybrid theory at first with an (...) irregular set of theoretical schemes. However, step by step, on revealing and gradual eliminating the contradictions between the programmes involved, the hybrid set is “put into order”.A hierarchy of theoretical schemes starting from the crossbreeds and up to usual hybrids is set up. And after the displacement current construction the interpenetration of the pre-maxwellian programmes begins that markes the commencement of theoretical schemes of optics and electromagnetism real unification. Maxwell’s programme did supersede the Ampere-Weber one because it did assimilate the ideas of the Ampere-Weber programme, as well as the presuppositions of the programmes of Young-Fresnel and Faraday properly co-ordinating them with each other. But the opposite proposition is not true. Ampere-Weber programme did not assimilate the propositions of the Maxwellian programme. Maxwell’s victory became possible because the core of Maxwell’s unification strategy was formed by Kantian epistemology looked through the prism of William Whewell and such representatives of Scottish Enlightenment as Thomas Reid and William Hamilton. Maxwell did put forward as a basic synthetic principle the idea that radically differed from that of Ampere-Weber approach by its open, flexible and contra-ontological, strictly epistemological, Kantian character. For Maxwell, ether was not the last building block of physical reality, from which all the charges and fields should be constructed. “Action at a distance”, “incompressible fluid”, “molecular vortices” were contrived analogies for Maxwell, capable only to direct the researcher at the “right” mathematical relations. Namely the application of Kantian epistemology enabled Hermann von Helmholtz and his pupil Heinrich Hertz to arrive at such a version of Maxwell’s theory that served a heuristical basis for the radio waves discovery. (shrink)

The last forty years have produced a dramatic reversal in leading accounts of science. Once thought necessary to (explain) scientific progress, a rigid method of science is now widely considered impossible. Study of products yields to study of processes and practices, .unity gives way to diversity, generality to particularity, logic to luck, and final justification to heuristic scaffolding. I sketch the story, from Bacon and Descartes to the present, of the decline and fall of traditional scientific method, conceived as The (...) Central Planning Bureau for Science or as Rationality Czar. I defend a deflationary account of method and of rational judgment,. with emphasis on heuristic appraisal and cognitive economy. (shrink)

The ArgumentStylistic analysis of an admittedly speculative scientific article can suggest what is involved in the social act of speculation. Walter Gilbert's influential paper “Why Genes in Pieces?” serves as an example of the conflicting demands of the need to display politeness and the need to display the urgency and excitement of the issues. Socially significant stylistic features emerge in comparison with another paper Gilbert co-authored, where the speculations occur in the discussion section of an experimental report, and in comparison (...) with another, more typical “News and Views” article by another author. The stylistic features include the use of impersonal subjects, the hedging of verbs, the unusual uses of the present tense, and the reliance on repetition, rather than conjunctions or pronouns, for textual cohesion. Later references to the article assimilate it to various lines of research without suggesting its speculative style. (shrink)

The ArgumentMany find it “notoriously difficult to see how societal context can affect in any essential way how someone solves a mathematical problem or makes a measurement.” That may be because it has been a habit of western scientists to assert their numerical schemes were untainted by any hint of anthropomorphism. Nevertheless, that Platonist penchant has always encountered obstacles in practice, primarily because the stability of any applied numerical scheme requires some alien or external warrant.This paper surveys the history of (...) measurement standards, physical dimensions and dimensionless constants as one instance of the quest to purge all anthropomorphic taint first in the metric system, then in the dimensions provided by the atom, then in physical constants intelligible to extraterrestrials, only then to end up back at overt anthropomorphism in the late 20th century. This suggests that the “naturalness” of natural numbers has always been conceptualized in locally contingent cultural terms. (shrink)

The ArgumentThis paper argues that science and technology studies need to adopt a much wider view of what counts as a laboratory. The factory, it is suggested, is as much a site of invention and intervention as the laboratory. As a site for the government of economic life, the factory is a laboratorypar excellence. One particular factory is studied — the Decatur, Illinois, plant of Caterpillar Inc. — as it is rethought and remade in accordance with ideals of cellular manufacturing, (...) Just-In-Time systems, customer-driven manufacturing, and competitor benchmarking. But it is not just the changes at the factory itself that are studied. The paper analyzes the linkages and relays between the redesign of a particular manufacturing plant and the plethora of calls for a revitalization of North American manufacturing industry and a new form of economic citizenship. The paper examines the remaking of a factory as anassemblage, a historically specific and temporarily stabilized complex of relations among ways of problematizing the factory in a multiplicity of locales. There are four steps to the changes analyzed here: a problematizing of the factory at the level of North American manufacturing as a whole in the 1980s; a problematizing of the notion of competitiveness at Caterpillar Inc, through the calculative practices of competitor benchmarking and related expertises; a diagraming of the ideal factory in systems terms; and the embedding of notions of the product, of competitiveness, and of a new economic citizenship in the “Assembly Highway” at the Decatur plant. Rethinking the factory took place within this assemblage of relations, rether than at any one site. (shrink)

A central point of debate over environmental policies concerns how future costs and benefits should be assessed. The most commonly used method for assessing the value of future costs and benefits is economic discounting. One often-cited justification for discounting is uncertainty. More specifically, it is risk aversion coupled with the expectation that future prospects are more risky. In this paper I argue that there are at least two reasons for disputing the use of risk aversion as a justification for discounting (...) when dealing with longterm decisions, one technical and one ethical. Firstly, I argue that technically, it implies an inconsistency between theory and practice. And secondly, I argue that discounting for uncertainty relies on a form of individualism which, while reasonable in standard microeconomic theory where an agent chooses how to spread her own consumption over her own lifetime, is inappropriate in the context of intergenerational social decisions. (shrink)

Experimental balance is usually understood as the control for the value of the conditions, other than the one under study, which are liable to affect the result of a test. We discuss three different approaches to balance. ‘Millean balance’ requires identifying and equalizing ex ante the value of these conditions in order to conduct solid causal inferences. ‘Fisherian balance’ measures ex post the influence of uncontrolled conditions through the analysis of variance. In ‘efficiency balance’ the value of the antecedent conditions (...) is decided ex ante according to the efficiency they yield in the estimation of the treatment outcome. Against some old arguments by Worrall, we show that in both Fisherian and efficiency balance there are good reasons to randomize the allocation of treatments, in particular when there is no agreement among experimenters as to the antecedent conditions to be controlled for. (shrink)

In this paper, I introduce and examine the notion of “mathematical engineering” and its impact on mathematical change. Mathematical engineering is an important part of contemporary mathematics and it roughly consists of the “construction” and development of various machines, probes and instruments used in numerous mathematical fields. As an example of such constructions, I briefly present the basic steps and properties of homology theory. I then try to show that this aspect of contemporary mathematics has important consequences on our conception (...) of mathematical knowledge, in particular mathematical growth. (shrink)

In this article, I introduce the notion of horizon for scientific practice (HSP), representing limits or boundaries within which scientists ply their trade, to facilitate analysis of scientific discovery and progress. The notion includes not only constraints that delimit scientific practice, e.g. of bringing experimentation to a temporary conclusion, but also possibilities that open up scientific practice to additional scientific discovery and to further scientific progress. Importantly, it represents scientific practice as a dynamic and developmental integration of activities to investigate (...) and analyze the natural world. I use the discovery of the clotting factor, thrombin, and the experiments conducted by the Johns Hopkins physiologist, William Howell, on the enzymatic nature of thrombin to illustrate the notion of HSP. In a concluding section, I compare the notion of HSP to other notions for scientific practice proposed in the history and philosophy of science literature. (shrink)

Sociologists, philosophers and historians of science are gradually recognizing the importance of visual representation. This is part of a more general movement away from a theory-centric view of science and towards an interest in practical aspects of observation and experimentation. Rather than treating science as a matter of demonstrating the logical connection between theoretical and empirical statements, an increasing number of investigations are examining how scientists compose and use diagrams, graphs, photographs, micrographs, maps, charts, and related visual displays. This paper (...) focuses on diagrams in biology, and tries to demonstrate how diagrams are an integral part of the production of scientific knowledge. In order to disclose some of the distinctive practical and analytical uses of diagrams, the paper contrasts the way diagrams and photographs are used in biological texts. Both diagrams and photographs are shown to be “constructions” that separately and together mediate the investigation of scientific phenoman. (shrink)

The ArgumentThere can be no doubt about the moral and epistemological significance of what Shapin calls the “physical place” of the scientific laboratory. The physical place is defined by the locales, barriers, ports of entry, and lines of sight that bound the laboratory and separate it from other urban and architectural environments. Shapin's discussion of the emergence of the scientific laboratory in seventeenth-century England provides a convincing demonstration that credible knowledge is situated at an intersection between physical locales and social (...) distinctions. In this paper I take up Shapin's theme of the “siting of knowledge production,” but I give it a different treatment – one based on ethnomethodological studies of work. Without denying all that can be witnessed in the spectacle of the scientist at the bench and of the architectural habitat of the bench, I argue that the “place” of scientific work is defined by locally organizedtopical contextures. The paper describes two examples of such spatial orders – “opticism” and “digitality” – associated with distinct complexes of equipment and practice. These topical spaces might initially be viewed as “ideal” or “symbolic” spaces, but I argue that they are no less material than the “physical setting” of the laboratory; indeed, they are the physical setting. (shrink)

Does Allan Franklin’s study of atomic parity-violation experiments provide convincing evidence against social constructivism? According to Franklin (1990a, p. 2), “when questions of theory choice, confirmation, or refutation are raised they are answered on the basis of valid experimental evidence… [and] there are good reasons for belief in the validity of that evidence.” Franklin asserts that social constructivists take the opposite position: “They would say that it is not the experimental results, but rather the social and/or cognitive interests of the (...) scientists, that must be used in the explanation.” Having set up the contrasting positions, he then asks the reader, “which of us is telling the more plausible story?” (Franklin 1990b, p. 163). Consistent with his evidence model, he proposes to discriminate between the two opposed positions by consulting historical evidence. He describes the results of two different sets of experiments on atomic parity-violations, and assesses the extent to which the experimental data match predictions based on the Weinberg-Salam unified theory of electroweak interactions. (shrink)

This paper consists of three sections. In the first one, some of the main developments in the philosophy of science through the xx century up to the present will be pointed out, and inserted them in the frame of some more general philosophical transformations, such as the so-called “linguistic turn” and “pragmatic turn”, respectively. In the second one, the established connection will be nuanced, from a revision of the work of a “classical” author such as Carnap. Finally, it will be (...) intended a kind of “balance and future perspectives”. (shrink)

Practice-based philosophy of science has gradually arisen in the sociology of scientific knowledge (SSK) and science and technology studies (STS) during the past decades. It studies science as an ensemble of practices and theorising as one of these practices. A recent study has shown how the practice-based approach can be methodologically justified with reference to Peirce and Dewey. In this article, I will explore one consequence of that notion: science, as practice, is necessarily social. I will disambiguate five different senses (...) in which science is social. First, science presupposes language, which is essentially social. Second, practices, including science, are adaptations of the behaviour of an organism to an environment, of which other organisms are a part. Third, practices, including science, are public and hence shareable. Fourth, scientific knowledge can serve as a vehicle of social and moral reform. Fifth, scientific knowledge can be applied to improve the human condition. This fivefold result bears on the problem of realism. (shrink)

Practice-based philosophy of science has gradually arisen in the sociology of scientific knowledge (SSK) and science and technology studies (STS) during the past decades. It studies science as an ensemble of practices and theorising as one of these practices. A recent study has shown how the practice-based approach can be methodologically justified with reference to Peirce and Dewey. In this article, I will explore one consequence of that notion: science, as practice, is necessarily social. I will disambiguate five different senses (...) in which science is social. First, science presupposes language, which is essentially social. Second, practices, including science, are adaptations of the behaviour of an organism to an environment, of which other organisms are a part. Third, practices, including science, are public and hence shareable. Fourth, scientific knowledge can serve as a vehicle of social and moral reform. Fifth, scientific knowledge can be applied to improve the human condition. This fivefold result bears on the problem of realism. (shrink)

ABSTRACTExperimentation is traditionally considered a privileged means of confirmation. However, why and how experiments form a better confirmatory source relative to other strategies is unclear, and recent discussions have identified experiments with various modeling strategies on the one hand, and with ‘natural’ experiments on the other hand. We argue that experiments aiming to test theories are best understood as controlled investigations of specimens. ‘Control’ involves repeated, fine-grained causal manipulation of focal properties. This capacity generates rich knowledge of the object investigated. (...) ‘Specimenhood’ involves possessing relevant properties given the investigative target and the hypothesis in question. Specimens are thus representative members of a class of systems, to which a hypothesis refers. It is in virtue of both control and specimenhood that experiments provide powerful confirmatory evidence. This explains the distinctive power of experiments: although modelers exert extensive control, they do not exert this control over specimens; although natural experiments utilize specimens, control is diminished. (shrink)

Those with knowledge about scientific instruments come from many different fields. Prominent among them are (1) collectors and dealers, (2) curators, (3) historians, (4) instrument makers, (5) philosophers, and (6) scientists (the order is alphabetical, not value-laden). The annual symposium of the Scientific Instrument Commission often brings members of each of these groups together, and they learn from one another. What follows are brief reflections on the activities of each group when its members consider instruments.

Today, mechanisms and mechanistic explanation are very popular in philosophy of science and are deemed a welcome alternative to laws of nature and deductive‐nomological explanation. Starting from Mitchell's pragmatic notion of laws, I cast doubt on their status as a genuine alternative. I argue that (1) all complex‐systems mechanisms ontologically must rely on stable regularities, while (2) the reverse need not hold. Analogously, (3) models of mechanisms must incorporate pragmatic laws, while (4) such laws themselves need not always refer to (...) underlying mechanisms. Finally, I show that Mitchell's account is more encompassing than the mechanistic account *Received August 2008; revised January 2010. †To contact the author, please write to: Centre for Logic and Philosophy of Science, Ghent University, Blandijnberg 2, B‐9000 Belgium; e‐mail: [email protected]. (shrink)

Experiment, instrumentation, and procedures of measurement, the body of practices and technologies forming the technical culture of science, have received at most a cameo appearance in most histories. For the history of science is almost always written as the history of theory. Of course, the interpretation of science as dominated by theory was the main pillar of the critique, launched by Kuhn, Quine, Hanson, Feyerabend, and others, of the positivist and logical empiricist traditions in the philosophy of science. Against Carnap, (...) Hempel, Nagel, and Popper, who accorded observation reports an independent status either as a source of inductive support or as a basis for the falsification of scientific theories, Hanson and Kuhn emphasized the theory-ladenness of observation. They made this central point – that all observation is shaped by reference to theory – the cornerstone of a full-blown philosophy of science by buttressing it with two additional lines of argument: First, theories are always underdetermined by the data, several theories being compatible with the same set of data. Hence, choice between theories is never a matter of empirical support, but always turns around conceptual issues. Second, statements derived from theory never confront nature alone; they are always clothed in a web of interrelated beliefs. Thus, theories, their associated observation languages, and the entire technical culture they support must be accepted or rejected as wholes. (shrink)

It is usually believed that science goes with things like theoria, ‘knowing that’, ontology and representing, and that techne, know-how, technology and intervening are only instrumental to science or its beneficial but nonetheless accidental side effect. In this context to be instrumental means also to be eliminable, or at least transparent, something that leaves no trace. Following the historical development of experimentation, from simple observation to modern microscopic experiments. I try to show how that view loses its ground. To produce (...) an artefact, scientific or other, is to be engaged in a complex dynamics, both ontological and epistemological in which at least two component processes, that of bringing forth and that of bringing into, are intertwined. The old dictum: ‘Science discovers, technology invents’, should be replaced by: science discovers because it invents. As a consequence scientific theory becomes an instrument of design. (shrink)

Abstract: Particularism is usually understood as a position in moral philosophy. In fact, it is a view about all reasons, not only moral reasons. Here, I show that particularism is a familiar and controversial position in the philosophy of science and mathematics. I then argue for particularism with respect to scientific and mathematical reasoning. This has a bearing on moral particularism, because if particularism about moral reasons is true, then particularism must be true with respect to reasons of any sort, (...) including mathematical and scientific reasons. (shrink)

It is argued in this study that (i) progress in the philosophy of mathematical practice requires a general positive account of informal proof; (ii) the best candidate is to think of informal proofs as arguments that depend on their matter as well as their logical form; (iii) articulating the dependency of informal inferences on their content requires a redefinition of logic as the general study of inferential actions; (iv) it is a decisive advantage of this conception of logic that it (...) accommodates the many mathematical proofs that include actions on objects other than propositions; (v) this conception of logic permits the articulation of project-sized tasks for the philosophy of mathematical practice, thereby supplying a partial characterisation of normal research in the field. (shrink)

This article examines in detail a remarkable but short-lived cosmological theory of 1959. The theory depended crucially on a hypothesis that could be, and was, tested in the laboratory. I use the case to discuss the nature of testing in cosmology and to argue against ideas about astronomy suggested by Ian Hacking. The case of the electrical universe exemplifies how disagreements can be settled by good experiments and also how experiments of wide-ranging theoretical significance need not be biased by either (...) theory or the experimentalists’ predisposed ideas. I argue that the episode supports Allan Franklins “evidence model” and disputes accounts based on the sociology of scientific knowledge. (shrink)

Since the practice turn, the role technologies play in the production of scientific knowledge has become a prominent topic in science studies. Much existing scholarship, however, either limits technology to merely mechanical instrumentation or uses the term for a wide variety of items. This article argues that technologies in scientific practice can be understood as a result of past scientific knowledge becoming sedimented in materials, like model organisms, synthetic reagents or mechanical instruments, through the routine use of these materials in (...) subsequent research practice. The proposed theoretical interpretation of technology is examined through a case where a model organism—Drosophila melanogaster—acted as a technology for investigating a contested biological effect of a mechanical instrument: Hermann J. Muller’s experiments on X-ray mutagenicity in the 1920s. The article reconstructs how Muller employed two synthetic Drosophila stocks as tests for measuring X-rays’ capacity to cause genetic aberration. It argues that past scientific knowledge sedimented in the Drosophila stocks influenced Muller’s perception of X-ray-induced mutation. It further describes how Muller’s concept of X-ray mutagenicity sedimented through the adoption of X-ray machines as a ready-made resource for producing mutants by other geneticists, for instance George Beadle and Edward Tatum in their experiments on Neurospora crassa, despite ongoing disputes surrounding Muller’s conclusions. Technological sedimentation is proposed as a potential explanation why sedimentation and disputation may often coexist in the history of science. (shrink)

Harry Collins' central argument about experimental practice revolves around the thesis that facts can only be generated by good instruments but good instruments can only be recognized as such if they produce facts. This is what Collins calls the experimenters' regress. For Collins, scientific controversies cannot be closed by the ‘facts’ themselves because there are no formal criteria independent of the outcome of the experiment that scientists can apply to decide whether an experimental apparatus works properly or not.No one seems (...) to have noticed that the debate is in fact a rehearsal of the ancient philosophical debate about skepticism. The present article suggests that the way out of radical skepticism offered by the so-called mitigated skeptics is a solution to the problem of consensus formation in science.Keywords: Argumentation; Skepticism; Sociology of science; Philosophy of science; Scientific controversies. (shrink)

There has been a growing trend to include non-causal models in accounts of scientific explanation. A worry addressed in this paper is that without a higher threshold for explanation there are no tools for distinguishing between models that provide genuine explanations and those that provide merely potential explanations. To remedy this, a condition is introduced that extends a veridicality requirement to models that are empirically underdetermined, highly-idealised, or otherwise non-causal. This condition is applied to models of electroweak symmetry breaking beyond (...) the Standard Model. (shrink)