An interpretation of John Dewey’s views about realism, science, and naturalistic philosophy is presented. Dewey should be seen as an unorthodox realist, with respect to both general metaphysical debates about realism and with respect to debates about the aims and achievements of science.

http://dx.doi.org/10.5007/1808-1711.2012v16n2p209 This article explores and attempts to resolve some issues that arise when at stake is the incommensurability between the concepts of reality developed by philosophical hermeneutics, on the one hand, and realist branches of analytical philosophy, on the other. The view of hermeneutic realism is suggested not as a remedy against this incommensurability, but as a vehicle for revising those aspects of both hermeneutics and ontological realism which impede the dialogue between them. It is a view that opposes epistemological (...) foundationalism, Cartesian dualism, essentialism about theoretical objects, and cognitive relativism. The role of reading/textualizing in science’s spaces of representation is specified. (shrink)

Scholars concerned with the foundations of quantum mechanics (QM) usually think that contextuality (hence nonobjectivity of physical properties, which implies numerous problems and paradoxes) is an unavoidable feature of QM which directly follows from the mathematical apparatus of QM. Based on some previous papers on this issue, we criticize this view and supply a new informal presentation of the extended semantic realism (ESR) model which embodies the formalism of QM into a broader mathematical formalism and reinterprets quantum probabilities as conditional (...) on detection rather than absolute. Because of this reinterpretation a hidden variables theory can be constructed which justifies the assumptions introduced in the ESR model and proves its objectivity. When applied to special cases the ESR model settles long-standing conflicts (it reconciles Bell’s inequalities with QM), provides a general framework in which previous results obtained by other authors (as local interpretations of the GHZ experiment) are recovered and explained, and supports an interpretation of quantum logic which avoids the introduction of the problematic notion of quantum truth. (shrink)

Everything you always wanted to know about structural realism but were afraid to ask Content Type Journal Article Pages 227-276 DOI 10.1007/s13194-011-0025-7 Authors Roman Frigg, Department of Philosophy, Logic and Scientific Method, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE UK Ioannis Votsis, Philosophisches Institut, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 23.21/04.86, 40225 Düsseldorf, Germany Journal European Journal for Philosophy of Science Online ISSN 1879-4920 Print ISSN 1879-4912 Journal Volume Volume 1 Journal Issue Volume 1, Number 2.

According to classical molecular chemistry, molecules have a structure, that is, they are sets of atoms with a definite arrangements in space and held together by chemical bonds. The concept of molecular structure is central to modern chemical thought given its impressive predictive power. It is also a very useful concept in chemistry education, due to its role in the rationalization and visualization of microscopic phenomena. However, such a concept seems to find no place in the ontology described by quantum (...) mechanics, since it appeals to classical notions such as the position of the atomic nuclei or the individuality of electrons. Although this problem has attracted the attention of several authors, the discussion is far from settled. Some authors adopt an explicitly reductionist position and advocate to reconstruct the concept of molecular structure within the framework of the quantum theory. Others, although acknowledging the conceptual discontinuity between quantum mechanics and molecular chemistry, keep the hope of future reduction alive. From an explicitly non-reductionist position, on the contrary, others authors conceive molecular structure as an emergent phenomenon. The purpose of this article is to propose a different line of argumentation to address this problem. By contrast to reduction and emergence, the admission of a multiplicity of ontologies, not necessarily linked by hierarchical connections, cancels the need of finding a relation of dependence between the molecular level and the quantum level. This ontologically pluralist position can be applied to the issue of molecular structure, in order to argue that it is possible to admit the existence of structure in the ontology of molecular chemistry, in spite of the fact that it does not exist in the quantum world. (shrink)

This paper asks (a) how new scientific objects of research are onceptualized at a point in time when little is known about them, and (b) how those conceptualizations, in turn, figure in the process of investigating the phenomena in question. Contrasting my approach with existing notions of concepts and situating it in relation to existing discussions about the epistemology of experimentation, I propose to think of concepts as research tools. I elaborate on the conception of a tool that informs my (...) account. Narrowing my focus to phenomena in cognitive neuropsychology, I then illustrate my thesis with the example of the concept of implicit memory. This account is based on an original reconstruction of the nature and function of operationism in psychology. (shrink)

ABSTRACTIan Hacking puts forward a distinction between two kinds of scientific realism. According to scientific realism about theories, scientific theories are accepted as approximately true; according to scientific realism about unobservable entities, the theoretical terms occurring in scientific theories refer to existing, real entities. This article seeks to show that Claude Bernard's philosophy of science is a realist one about scientific theories, but anti-realist about unobservable entities. The term “fictionalism” is used here to stand for this sort of anti-realism about (...) unobservable entities. (shrink)

The ambition of “scientific creationism” is to prove that science actually confirms religion. This is especially true in the case of Muslim creationism, which adopts a reasoning of a syllogistic type: divine revelation is truth; good science confirms truth; divine revelation is henceforth scientifically proven. Harun Yahya is a prominent Muslim “creationist” whose website hosts many texts and documentary films, among which “Evidence of the true faith in historical sources”. This is a small audiovisual production which, starting from some archeological (...) files, seeks to demonstrate that Qur’an truth precedes science but is equally proven by it. In this paper, we examine the organization of the scientific and religious argumentative repertoires and, in particular, what in each of them is taken as evidence and gets access to an authoritative status. It leads us to show how much this type of Muslim creationism constitutes a kind of scientism. (shrink)

The Principle of the Benefit of Doubt dictates that, whenever reasonably possible, we interpret earlier-day scientists as referring to entities posited by current science. Putnam has presented the principle as supplementary to his Causal Theory of Reference in order to make this theory generally applicable to theoretical terms. The present paper argues that the principle is of doubtful standing. In particular, it will be argued that the principle lacks a justification and, indeed, is unjustifiable as it stands.

The writings of Kuhn and Feyerabend on incommensurability challenged the idea that science progresses towards the truth. Davidson famously criticized the notion of incommensurability, arguing that it is incoherent. Davidson's argument was in turn criticized by Kuhn and others. This article argues that, although at least some of the objections raised against Davidson's argument are formally correct, they do it very little harm. What remains of the argument once the objections have been taken account of is still quite damaging to (...) the thesis that formerly endorsed scientific theories are incommensurable with those of today's science. (shrink)

In this paper I analyze the difficult question of the truth of mature scientific theories by tackling the problem of the truth of laws. After introducing the main philosophical positions in the field of scientific realism, I discuss and then counter the two main arguments against realism, namely the pessimistic metainduction and the abstract and idealized character of scientific laws. I conclude by defending the view that well-confirmed physical theories are true only relatively to certain values of the variables that (...) appear in the laws. (shrink)

It is now over 15 years since Hilary Putnam first urged that we take the “narrow path” of internal realism as a way of navigating between “the swamps of metaphysics and the quicksands of cultural relativism and historicism” (1983, p. 226). In the opening lines of the Preface toRealism with a Human Face, a collection of Putnam's recent papers edited by James Conant, Putnam reaffirms his allegiance to this narrow path, unmoved by Realist murmurings from the swamps and laconic Rortian (...) suggestions that only the quicksands are a proper metaphilosophical abode for those willing to confront our lack of epistemological and metaphysical foundations. If there are changes to be discerned in these writings, Putnam avers, they pertain only to the burden allotted to different considerations in the overall economy of his argument: “It might be said that the difference between the present volume and my work prior toThe Many Faces of Realismis a shift in emphasis: a shift from emphasizing model-theoretic arguments against metaphysical realism to emphasizing conceptual relativity” (p. xi). (shrink)

The dominant neuroscientific theory of spatial memory is, like many theories in neuroscience, a multilevel description of a mechanism. The theory links the activities of molecules, cells, brain regions, and whole organisms into an integrated sketch of an explanation for the ability of organisms to navigate novel environments. Here I develop a taxonomy of interlevel experimental strategies for integrating the levels in such multilevel mechanisms. These experimental strategies include activation strategies, interference strategies, and additive strategies. These strategies are mutually reinforcing, (...) providing a kind of interlevel and intratheoretic robustness that has not previously been recognized. (shrink)

In this paper, I argue that, contrary to the constructive empiricist’s position, observability is not an adequate criterion as a guide to ontological commitment in science. My argument has two parts. First, I argue that the constructive empiricist’s choice of observability as a criterion for ontological commitment is based on the assumption that belief in the existence of unobservable entities is unreasonable because belief in the existence of an entity can only be vindicated by its observation. Second, I argue that (...) the kind of ontological commitment that is under consideration when accepting a scientific theory is commitment to what I call theoretical kinds and that observation can vindicate commitment to kinds only in exceptional cases. (shrink)

I seek to provide a systematic and comprehensive framework for the description and analysis of scientific practice—a philosophical grammar of scientific practice, ‘grammar’ as meant by the later Wittgenstein. I begin with the recognition that all scientific work, including pure theorizing, consists of actions, of the physical, mental, and ‘paper-and-pencil’ varieties. When we set out to see what it is that one actually does in scientific work, the following set of questions naturally emerge: who is doing what, why, and how? (...) More specifically, we must arrive at some coherent philosophical accounts of the following elements of scientific practice: the agent—free, embodied, and constantly in second-person interactions with other agents; the purposes and proximate aims of the agent; types of activities that the agent engages in; ontological principles necessarily presumed for the performance of particular activities; instruments and other resources that the agent pulls together for the performance of each activity. After sketching the general framework, I also give some illustrative contrasts between the more traditional descriptions of scientific practice and the kind of descriptions enabled by the proposed framework. (shrink)

In this article, from the characterization of technoscience of the English historian J. Pickstone and the recognition of the importance of models and modelling in research and teaching of chemistry, the term technochemistry is introduced as a way of chemical knowledge. With the above new possibilities, rethinking the chemistry curriculum is opened.

En este trabajo intento articular y desarrollar la defensa que Roberto Torretti hace del realismo pragmático. En el núcleo de la visión de Torretti existe un rechazo a la idea de que la verdad de las teorías científicas consista en su correspondencia con el mundo. Propongo entonces entender la correspondencia como una noción metafórica. Articularé una noción de coherencia pragmática sobre la cual establezco una nueva teoría de la coherencia entre verdad y realidad. En consecuencia, resultará posible afirmar que el (...) realismo pragmático consiste en la búsqueda del verdadero conocimiento de la realidad, de un modo que también concuerda con el pragamatismo defendido por Torretti. (shrink)

Enhanced indispensability arguments claim that Scientific Realists are committed to the existence of mathematical entities due to their reliance on Inference to the best explanation. Our central question concerns this purported parity of reasoning: do people who defend the EIA make an appropriate use of the resources of Scientific Realism to achieve platonism? We argue that just because a variety of different inferential strategies can be employed by Scientific Realists does not mean that ontological conclusions concerning which things we should (...) be Scientific Realists about are arrived at by any inferential route which eschews causes, and nor is there any direct pressure for Scientific Realists to change their inferential methods. We suggest that in order to maintain inferential parity with Scientific Realism, proponents of EIA need to give details about how and in what way the presence of mathematical entities directly contribute to explanations. (shrink)

Can a constructive empiricist make sense of scientific representation? Usually, a scientific model is an abstract entity, and scientific representation is conceptualized as an intentional relation between scientific models and certain aspects of the world. On this conception, since both the models and the representation relation are abstract, a constructive empiricist, who is not committed to the existence of abstract entities, would be unable to invoke these notions to make sense of scientific representation. In this paper, instead of understanding representation (...) as a relation between abstract entities, I focus on the activity of representing, and argue that it provides a way of making sense of representation within the boundaries of empiricism. The activity of representing doesn’t deal with abstract entities, but with concrete ones, such as inscriptions, templates, and blueprints. In the end, by examining the practice of representing, rather than an artificially reified product—the representation—the constructive empiricist has the resources to make sense of scientific representation in empiricist terms. (shrink)

Whereas an inference (deductive as well as inductive) is usually viewed as being valid in virtue of its argument form, the present paper argues that scientific reasoning is material inference, i.e., justified in virtue of its content. A material inference is licensed by the empirical content embodied in the concepts contained in the premises and conclusion. Understanding scientific reasoning as material inference has the advantage of combining different aspects of scientific reasoning, such as confirmation, discovery, and explanation. This approach explains (...) why these different aspects (including discovery) can be rational without conforming to formal schemes, and why scientific reasoning is local, i.e., justified only in certain domains and contingent on particular empirical facts. The notion of material inference also fruitfully interacts with accounts of conceptual change and psychological theories of concepts. (shrink)

Les questions qui ont suscité le présent texte concernent la relation entre la théorie et le réel empirique: comment peut-on identifier le contenu empirique d'une théorie? Dans quelle mesure sa prétention à révéler le réel estelle justifiée? La première tâche que ces interrogations commandent est celle d'exposer les conceptions de la structure des théories scientifiques les plus marquantes de ce siècle. Dans cette période la philosophie des sciences a d'abord été dominée par l'empirisme logique et son approche formelle de la (...) structure des théories scientifiques. L'empirisme logique est certes un mouvement qui a eu une histoire mouvementée et qui a été le théâtre de nombreuses modifications, mais une de ses thèses les plus persistantes peut le caractériser de façon générale: sa représentation de la théorie sous la forme d'un système d'énoncés. Pour désigner cette position, nous utiliserons l'expression «conception assertive» comme traduction de statement view. L'approche sémantique est une conception plus récente de la structure de la théorie qui semble peu à peu vouloir prendre la place de la conception assertive. Nous décrirons donc dans un premier temps ces deux approches afin de déterminer chaque fois la fagon dont le rapport de la théorie au réel est envisagé. (shrink)

Instances of explanatory reduction are often advocated on metaphysical grounds; given that the only real things in the world are subatomic particles and their interaction, we have to try to explain everything in terms of the laws of physics. In this paper, we show that explanatory reduction cannot be defended on metaphysical grounds. Nevertheless, indispensability arguments for reductive explanations can be developed, taking into account actual scientific practice and the role of epistemic interests. Reductive explanations might be indispensable to address (...) some epistemic interest answering a specific explanation-seeking question in the most accurate, adequate and efficient way. Just like explanatory pluralists often advocate the indispensability of higher levels of explanation pointing at the pragmatic value of the explanatory information obtained on these higher levels, we argue that explanatory reduction—traditionally understood as the contender of pluralism—can be defended in a similar way. The pragmatic value reductionist, lower level explanations might have in the biomedical sciences and the social sciences is illustrated by some case studies. (shrink)

This article outlines a philosophy of science in practice that focuses on the engineering sciences. A methodological issue is that these practices seem to be divided by two different styles of scientific reasoning, namely, causal-mechanistic and mathematical reasoning. These styles are philosophically characterized by what Kuhn called ?disciplinary matrices?. Due to distinct metaphysical background pictures and/or distinct ideas of what counts as intelligible, they entail distinct ideas of the character of phenomena and what counts as a scientific explanation. It is (...) argued that the two styles cannot be reduced to each other. At the same time, although they are incompatible, they must not be regarded as competing. Instead, they produce different kinds of epistemic results, which serve different kinds of epistemic functions. Moreover, some scientific breakthroughs essentially result from relating them. This view of complementary styles of scientific reasoning is supported by pluralism about metaphysical background pictures. (shrink)

New sciences born or developed in the 20th century (information, materials, life science) are based on forms of complementarity that differ from the past. The paper discusses cognitive, or disciplinary, institutional, and technical complementarity. It argues that new sciences apply a reductionist explanatory strategy to complex multi-layered systems. In doing so the reductionist promise is falsified, generating the need for multi-level kinds of explanation (e.g. in post-genomic molecular biology), new forms of complementarity between scientific and non-scientific organizations, and new forms (...) of experimental and informational facilities. The paper develops the argument in theoretical terms, comparing it with the STS literature, and offers preliminary evidence based on the experience of Networks of Excellence. (shrink)

Self-fulfillment of theories is argued to be a threat to social science in at least two ways. First, a realist might worry that self-fulfillment constitutes a threat to the idea that social science is a proper science consistent with a realist approach that develops true and successful statements about the world. Second, one might argue that the potential self-fulfilling nature of social science theories potentially undermines the ethical integrity of social scientists. We argue that if one accepts that social science (...) theories are not based on laws akin to those that govern natural reality or acknowledges that if one can predict self-fulfillment via a meta-theory that explains the underlying regularities of the self-fulfilling change, the threat to realism is dismantled. Furthermore, on the basis of these arguments, we show that if one is unable to predict the consequences of a theory, it is difficult to ascribe moral responsibility at the individual level. It is, therefore, not the potential self-fulfillment of theories per se that poses an ethical challenge, in contrast to claims in the literature. (shrink)

The meaning of scientific propositions is not always expressible in terms of observable phenomena. Such propositions involve generalizations, and also terms that are theoretical constructs. I study here how to assess the meaning of scientific propositions, that is, the specific import of theoretical terms. Empiricists have expressed a concern that scientific propositions, and theoretical terms, should always be, to some degree, related to observable consequences. We can see that the former empiricist criterion of meaning only implies for theoretical terms not (...) to be definable in terms of observable, but that their use put a constraint on the observable consequences of a theory. To that effect, Ramsey's method of formal elimination of theoretical terms can be an interesting tool. It has faced important logical objections, which have mostly been addressed with respect to the problem of the ontological commitment of the second-order quantification they imply. I show here that these criticisms can be overcome, and that there can be a successful Ramsey elimination of theoretical terms with first order sentences, making Ramsey's method a relevant tool to assess the empirical meaning of scientific propositions. (shrink)

According to a common belief concerning the Mach-Boltzmann debate on atoms, the new experiments performed in microphysics at the turn of the 19th and 20th centuries confirmed Boltzmann’s atomic hypothesis and disproved Mach’s anti-atomic view. This paper intends to show that this belief is partially unjustified. Mach’s view on atoms consists in fact of different kinds of arguments. While the new experiments in microphysics refute indeed his scientific arguments against the atomic hypothesis, his epistemological arguments are unaffected. In this regard, (...) Mach’s epistemological approach remains relevant for today’s discussion on the status of the notion of atom. (shrink)

Multidisciplinary models aggregating ‘lower-level’ biological and ‘higher-level’ psychological and social determinants of a phenomenon raise a puzzle. How is the interaction between the physical, the psychological and the social conceptualized and explained? Using biopsychosocial models of pain as an illustration, I argue that these models are in fact level-neutral compilations of empirical findings about correlated and causally relevant factors, and as such they neither assume, nor entail a conceptual or ontological stratification into levels of description, explanation or reality. If inter-level (...) causation is deemed problematic or if debates about the superiority of a particular level of description or explanation arise, these issues are fueled by considerations other than empirical findings. (shrink)

The article analyses in detail the Meselson–Stahl experiment, identifying two novel difficulties for the crucial experiment account, namely, the fragility of the experimental results and the fact that the hypotheses under scrutiny were not mutually exclusive. The crucial experiment account is rejected in favour of an experimental-mechanistic account of the historical significance of the experiment, emphasizing that the experiment generated data about the biochemistry of DNA replication that is independent of the testing of the semi-conservative, conservative, and dispersive hypotheses. _1_ (...) Introduction _2_ The Meselson–Stahl Experiment _3_ Some Difficulties for the Crucial Experiment Account _3.1_ Additional experiments were required _3.2_ Simplicity considerations are unconvincing _3.3_ The fragility of the experimental results _3.4_ The problematic interpretation of falsifyng results _3.5_ Not all possible hypotheses considered or tested _3.6_ The tested hypotheses were not mutually exclusive _4_ The Historical and Scientific Significance of the Meselson–Stahl Experiment _4.1_ The challenge for the crucial experiment account _4.2_ A mechanistic perspective on the experiment _4.3_ The experimental design and its independence from theoretical speculations _4.4_ The advantages of a ‘bottom-up’ mechanistic account _5_ Conclusion. (shrink)

This article argues that the limited influence of Ludwik Fleck's ideas on philosophy of science is due not only to their indirect dissemination by way of Thomas Kuhn, but also to an incommensurability between the standard conceptual framework of history and philosophy of science and Fleck's own more integratedly historico-social and praxis-oriented approach to understanding the evolution of scientific discovery. What Kuhn named "paradigm" offers a periphrastic rendering or oblique translation of Fleck's Denkstil/Denkkollektiv , a derivation that may also account (...) for the lability of the term "paradigm". This was due not to Kuhn's unwillingness to credit Fleck but rather to the cold war political circumstances surrounding the writing of The Structure of Scientific Revolutions . Following a discussion of Fleck's anatomical allusions, I include a brief discussion of Aristotle (on menstruation and darkened mirrors) and conclude with a reference to the productivity of error in Mach and Nietzsche. (shrink)

The ramifications are explored of taking physical theories to commit their advocates only to ‘physically real’ entities, where ‘physically real’ means ‘causally efficacious’ (e.g., actual particles moving through space, such as dust motes), the ‘physically significant’ (e.g., centers of mass), and the merely mathematical—despite the fact that, in ordinary physical theory, all three sorts of posits are quantified over. It's argued that when such theories are regimented, existential quantification, even when interpreted ‘objectually’ (that is, in terms of satisfaction via variables, (...) rather than by substitution-instances) need not imply any ontological commitments. (shrink)

This paper takes part in the methodological debate concerning the nature and the justification of hypotheses about computational systems in software engineering by providing an epistemological analysis of Software Testing, the practice of observing the programs’ executions to examine whether they fulfil software requirements. Property specifications articulating such requirements are shown to involve falsifiable hypotheses about software systems that are evaluated by means of tests which are likely to falsify those hypotheses. Software Reliability metrics, used to measure the growth of (...) probability that given failures will occur at specified times as new executions are observed, is shown to involve a Bayesian confirmation of falsifiable hypotheses on programs. Coverage criteria, used to select those input values with which the system under test is to be launched, are understood as theory-laden principles guiding software tests, here compared to scientific experiments. Redundant computations, fault seeding models and formal methods used in software engineering to evaluate test results are taken to be instantiations of some epistemological strategies used in scientific experiments to distinguish between valid and non-valid experimental outcomes. The final part of the paper explores the problem, advanced in the context of the philosophy of technology, of defining the epistemological status of software engineering by conceiving it as a scientifically attested technology. (shrink)

b>. Recent findings in cognitive science suggest that the epistemic subject is more complex and epistemically porous than is generally pictured. Human knowers are open to the world via multiple channels, each operating for particular purposes and according to its own logic. These findings need to be understood and addressed by the philosophical community. The current essay argues that one consequence of the new findings is to invalidate certain arguments for epistemic anti-realism.

The ideas of interdisciplinarity and transdisciplinarity have been widely applied to the relationship between sciences. This article is an attempt to discuss the reasons why scientific interdisciplinarity and transdisciplinarity pose specific problems. First of all, certain questions about terminology are taken into account in order to clarify the meaning of the word ?discipline? and its cognates. Secondly, we argue that the specificity of sciences does not lie in becoming disciplines. Then, we focus on the relationship between sciences, and between sciences (...) and technologies: we argue that multidisciplinarity and interdisciplinarity are a common practice among strict sciences and technologies. Finally, we discuss the different meanings of transdisciplinarity when it is applied to sciences. (shrink)

On the basis of Levin’s claim that truth is not a scientific explanatory factor, Michel Ghins argues that the “no miracle” argument (NMA) is not scientific, therefore scientific realism is not a scientific hypothesis, and naturalism is wrong. I argue that there are genuine senses of ‘scientific’ and ‘explanation’ in which truth can yield scientific explanations. Hence, the NMA can be considered scientific in the sense that it hinges on a scientific explanation, it follows a typically scientific inferential pattern (IBE), (...) and it is based on an empirical fact (the success of science). Scientific realism, in turn, is scientific in the sense that it is supported both by a meta-level scientific argument (the NMA), and by first level scientific arguments through semantic ascent and generalization. However, both the NMA and scientific realism are not purely scientific, since they go beyond properly scientific concerns, and require additional philosophical reasoning. In turn, naturalism is correct in the sense that philosophy is continuous with science, partly based on it, and potentially equally well warranted. Beside denying the scientific nature of the NMA, Ghins raises some objections to its cogency , to which I reply in the final section. (shrink)

It is a widely shared view among philosophers of science that the theory-dependence (or theory-ladenness) of observations is worrying, because it can bias empirical tests in favour of the tested theories. These doubts are taken to be dispelled if an observation is influenced by a theory independent of the tested theory and thus circularity is avoided, while (partially) circular tests are taken to require special attention. Contrary to this consensus, it is argued that the epistemic value of theory-dependent tests has (...) nothing to do with the circularity or non-circularity of the test, but is instead based on the minimal empiricality and reliability of observations. Since theory-dependence does not in general prevent observations fulfilling these requirements, it should not be regarded as a phenomenon that is basically detrimental, but as neutral with respect to successful scientific knowledge gathering. (shrink)

Rational drug design is a method for developing new pharmaceuticals that typically involves the elucidation of fundamental physiological mechanisms. It thus combines the quest for a scientific understanding of natural phenomena with the design of useful technology and hence integrates epistemic and practical aims of research and development. Case studies of the rational design of the cardiovascular drugs propranolol, captopril and losartan provide insights into characteristics and conditions of this integration. Rational drug design became possible in the 1950s when theoretical (...) knowledge of drug-target interaction and experimental drug testing could interlock in cycles of mutual advancement. The integration does not, however, diminish the importance of basic research for pharmaceutical development. Rather, it can be shown that still in the 1990s, linear processes of innovation and the close combination of practical and epistemic work were interdependent. (shrink)

Proven experience can be shared. Given this, we cannot assume that the character of proven experience is always manifest as a physical token in each individual sharing it. But the token might still exist somewhere. Perhaps that is a condition of the proven experience’s existence. Something similar could have been accepted as true of scientific knowledge, especially if those who argued that scientific claims were only shorthand for more complicated claims about observations had been right. But it seems that they (...) were not. Hence there might be an ontological difference explaining why there will always be a netto divergence between science and proven experience. (shrink)

The purpose of the paper is twofold. I first outline a philosophical theory of concepts based on conceptual role semantics. This approach is explicitly intended as a framework for the study and explanation of conceptual change in science. Then I point to the close similarities between this philosophical framework and the theory theory of concepts, suggesting that a convergence between psychological and philosophical approaches to concepts is possible. An underlying theme is to stress that using a non-atomist account of concepts (...) is crucial for the successful study of conceptual development and change. (shrink)

The current view of the relationship between areas of the mind-brain sciences is one where cross-disciplinary collaboration is required to advance claims about the mind-brain that stand on firm epistemic footing. My goal in this dissertation is to analyze what it means for information from different areas of science to fit together to produce strong epistemic claims by addressing how and to what extent claims about the mind-brain are corroborated in scientific practice. Philosophers of science have advanced various concepts of (...) the notion of fitting together information from different areas of science and its relation to scientific progress (e.g., Bickle, 1998, 2003, 2006; Darden and Maull, 1977; Mitchell, 2002, 2003; Mitchell and Dietrich, 2006; Nagel 1949, 1970, 1979; Piccinini and Craver, 2011; and Roskies, 2010). However, each concept of fitting together is vague and subject to multiple clarificatory questions. To get a handle on the notion of fitting together, I introduce the term ‘interdisciplinary corroboration’ as a placeholder for the various accounts of fitting together to facilitate my investigation of how claims about the mind-brain are corroborated in scientific practice. I argue review papers are a good place to begin analyzing interdisciplinary corroboration; accordingly, I conduct a two-part analysis of a review paper by Eichenbaum (2013) entitled ‘Memory on Time’. I use the lessons from my analysis to develop and advance a methodology for philosophers of science interested in knowledge production for evaluating review papers for corroboration in the mind-brain sciences. (shrink)

This article is devoted to the description of the experience associated with listening to a sound. In the first part, we describe the method we used to gather descriptions of auditory experience and to analyse these descriptions. This work of explicitation and analysis has enabled us to identify a threefold generic structure of this experience, depending on whether the attention of the subject is directed towards the event which is at the source of the sound, the sound in itself, considered (...) independently from its source, the felt sound. In the second part of the article, we describe this structure. The third part is devoted to a discussion of these results and the paths they open up in various fields of theoretical and applied research. (shrink)

This dissertation defends the reliability of first-person methods for studying consciousness, and applies first-person experiments to two philosophical problems: the experience of size and of the self. In chapter 1, I discuss the motivations for taking a first-person approach to consciousness, the background assumptions of the dissertation and some methodological preliminaries. In chapter 2, I address the claim that phenomenal judgements are far less reliable than perceptual judgements (Schwitzgebel, 2011). I argue that the main errors and limitations in making phenomenal (...) judgements are due to domain-general factors, which are shared in the formation of perceptual judgements. Phenomenal judgements may still be statistically less reliable than perceptual judgements, though I provide reasons for thinking that Schwitzgebel (2011) overstates the case for statistical unreliability. I also provide criteria for distinguishing between reliable and unreliable phenomenal judgements, hence defending phenomenal judgements against general introspective scepticism. Having identified the main errors in making phenomenal judgements, in chapter 3, I discuss how first-person experiments can be used to control for these errors. I provide examples, and discuss how they overcome attentional and conceptual errors, minimise biases, and exhibit high intersubjective reliability. In chapter 4, I investigate size experience. I use first-person experiments and empirical findings to argue that distant things looking smaller cannot be explained as an awareness of instantiated objective properties (visual angle or retinal image size). I also discuss how an awareness of uninstantiated objective properties cannot adequately account for the phenomenal character of size experience. This provides support for a subjectivist account of variance in size experience. In chapter 5, I investigate the sense of self. I distinguish between a weak sense of self (for-me-ness) and a strong sense of self in which there is a polarity between subject and object. I use first-person experiments from Douglas Harding to demonstrate an explicit strong sense of self, specifically when I point at where others see my face. I also argue that this sense of self is not explained by inference, thoughts, feelings, imagination nor the viewpoint. Rather, it is part of the structure of experience that I seem to be looking from here. Even if there is a sense of self, there may be no self. The question of chapter 6 is whether there can be a direct experience of the self. I argue that to function as a bearer of experience the subject must be single and lack sensory qualities in itself. I use Harding’s first-person experiments to investigate the visual gap where I cannot see my head. I argue that it conforms to the above criteria, and hence is a candidate for being the subject. This finding, in conjunction with the fact that I seem to be looking from the same location, provides prima facie evidence for the reality of the subject. I hold then that contrary to Hume and most philosophers since, that there can be a direct self-experience, if one knows which direction to attend. (shrink)

Part I Introduction The specific problem adressed in this thesis is: what is the rational use of theory and experiment in the process of scientific discovery, in theory and in the practice of drug research for Parkinson’s disease? The thesis aims to answer the following specific questions: what is: 1) the structure of a theory?; 2) the process of scientific reasoning?; 3) the route between theory and experiment? In the first part I further discuss issues about rationality in science as (...) introduction to part II, and I present an overview of my case-study of neuropharmacology, for which I interviewed researchers from the Groningen Pharmacy Department, as an introduction to part III. Part II Discovery In this part I discuss three theoretical models of scientific discovery according to studies in the fields of Logic, Cognition, and Computation. In those fields the structure of a theory is respectively explicated as: a set of sentences; a set of associated memory chunks; and as a computer program that can generate the observed data. Rationality in discovery is characterized by: finding axioms that imply observation sentences; heuristic search for a hypothesis, as part of problem solving, by applying memory chunks and production rules that represent skill; and finding the shortest program that generates the data, respectively. I further argue that reasoning in discovery includes logical fallacies, which are neccesary to introduce new hypotheses. I also argue that, while human subjects often make errors in hypothesis evaluation tasks from a logical perspective, these evaluations are rational given a probabilistic interpretation. Part III Neuropharmacology In this last part I discusses my case-study and a model of discovery in a practice of drug research for Parkinson’s disease. I discuss the dopamine theory of Parkinson’s disease and model its structure as a qualitative differential equation. Then I discuss the use and reasons for particular experiments to both test a drug and explore the function of the brain. I describe different kinds of problems in drug research leading to a discovery. Based on that description I distinguish three kinds of reasoning tasks in discovery, inference to: the best explanation, the best prediction and the best intervention. I further demonstrate how a part of reasoning in neuropharmacology can be computationally modeled as qualitative reasoning, and aided by a computer supported discovery system. (shrink)

Realists regarding scientific knowledge – those who think that our best scientific representations truly describe both observable and unobservable aspects of the natural world – have special need of a notion of approximate truth. Since theories and models are rarely considered true simpliciter, the realist requires some means of making sense of the claim that they may be false and yet close to the truth, and increasingly so over time. In this paper, I suggest that traditional approaches to approximate truth (...) are insensitive to two crucial features of scientific knowledge, and that for each of these, analogies between representational practices in the sciences and in art prove useful to understanding how this situation can be remedied. First, I outline two distinct ways in which representations deviate from the truth, commonly referred to as ‘abstraction’ and ‘idealization’. Second, I argue that these practices exemplify different conventions of representation, and that for each, the conditions of approximation relevant to explicating the concept of approximate truth must be understood differently. The concept is thus heterogeneous; approximate truth is a virtue that is multiply realized, relative to different contexts of representation. This understanding is facilitated, I suggest, by considering the distinction between realistic and non-realistic representation in art. (shrink)