Philip Kitcher has advocated and advanced an influential antireductionist picture of science on which the higher-level sciences pursue their aims largely independently of the lower-level sciences -- a view of the sciences as autonomous. Explanatory autonomy as Kitcher understands it is incompatible with explanatory reductionism, the view that a high-level explanation is inevitably improved by providing a lower-level explanation of its parts. This paper explores an alternative conception of autonomy based on another major theme of Kitcher's philosophy of science: the (...) importance of the division of cognitive labor. That the sciences are in practice autonomous is compatible with reductionism, I argue, if we understand the high-level sciences' systematic explanatory disregard of lower-level details of implementation as practically, rather than intellectually, motivated. (shrink)

Recently some philosophers suggested an exclusion problem for moral non-naturalism, which is similar to the exclusion problem in philosophy of mind. In this article, the author aims to advance the discussion of exclusion in morality by investigating two influential solutions to the exclusion problem: the autonomy solution and the overdetermination solution. The author attempts to show that the moral non-naturalist can solve the exclusion problem in a way that is different from the approach to solving mental-physical exclusion. First, the author (...) argues that while the autonomy solution to mental exclusion may work, a similar autonomy approach to moral exclusion is implausible. Second, the author argues that whereas the overdetermination solution to mental exclusion fails, a similar overdetermination solution to moral exclusion is promising. (shrink)

The influence that philosophy of science has had on scientific practice is as controversial as it is undeniable, especially in the case of biology. The dynamic between philosophy and biology as disciplines has developed along two different lines that can be characterized as 'paternal', on the one hand, and more 'fraternal', on the other. The role Popperian principles of demarcation and falsifiability have played in both the systematics community as well as the ongoing evolution-creation debates illustrate these contrasting forms of (...) interdisciplinary engagement, underscoring the influence philosophy of science in shaping our contemporary understanding of biology in the North American context. However, a strict disciplinary distinction between philosophy and science may itself be a false dichotomy that risks hampering future development of the biological sciences. By actively engaging with philosophical considerations as an integral part of their scientific practice, nineteenth-century biologists offer an interesting counterpoint to current trends of overspecialization and provide a model of scientists who avoided extremes of antagonism with, or subservience to, philosophy. (shrink)

Pluralism is often put forth as a counter-position to reductionism. In this essay, I argue that reductionism and pluralism are in fact consistent. I propose that there are several potential goals for reductions and that the proper form of a reduction should be considered in tandem with the goal that it aims to achieve. This insight provides a basis for clarifying what version of reductionism are currently defended, for explicating the notion of a fundamental level of explanation, and for showing (...) how one can be both a reductionist and a pluralist. (shrink)

My main aim in this paper is to show that influential antireductionist arguments such as Fodor's, Kitcher's, and Dupré's state stronger conclusions than they actually succeed in establishing. By putting to the fore the role of metaphysical presuppositions in these arguments, I argue that they are convincing only as 'temporally qualified argument', and not as 'generally valid ones'. I also challenge the validity of the strategy consisting in drawing metaphysical lessons from the failure of reductionist programmes. What most of these (...) antireductionist standpoints have in common is a pretension to methodological imports. I conclude by explaining why, in order to remain relevant for scientific practice, antireductionist arguments should stay clear of metaphysics, for the latter, I argue, does not mix well with a taste for methodological prescriptions. (shrink)

Reductionism is a metaphysical thesis, a claim about explanations, and a research program. The metaphysical thesis reductionists advance (and antireductionists accept) is that all facts, including all biological facts, are fixed by the physical and chemical facts; there are no non-physical events, states, or processes, and so biological events, states and processes are “nothing but” physical ones. The research program can be framed as a methodological prescription which follows from the claim about explanations. Antireductionism does not dispute reductionism’s metaphysical claim, (...) but rejects the explanatory claim and so the methodological moral. To a first approximation what reductionists and antireductionists disagree about is whether explanations in functional biology can be or need to be explained by or completed or perhaps replaced by explanations in terms of molecular biology.i And this disagreement over the adequacy of explanations in functional biology drives a significant methodological disagreement with consequence for the research program of biology. (shrink)

Robert Deltete and Anastasios Brenner have provided a thorough examination of my translation of Duhem’s Le mixte et la combinaison chimique (1902) and associated essays. I am very grateful for their efforts and gratified that such competent reviewers should be generally positive. They provide an overview of relevant aspects of Duhem’s life and work, which may serve to introduce him to readers of this journal and promote interest in Duhem studies. They also raise and answer some questions about the interpretation (...) and evaluation of Duhem’s work, make some points of criticism of my choice of material and question certain points of translation. The editor has suggested that I make a response, and I shall take up some issues in these three areas. Since Duhem’s views play a central role in the development of the concept of chemical substance which I have worked on in recent years, I will make several references to my own publications. (shrink)

Reductionists in biology claim that all biological events can be explained in terms of genes and macromolecules alone, while antireductionists argue that some biological events must be explained at a higher level. The literature, however, does not distinguish between different kinds of molecular explanation. The goal of this article is to identify and analyze three such kinds. The analysis of molecular explanations herein carries an important philosophical implication; in shunning crude reductionism and extreme versions of holism, we can combine the (...) insights of thoughtful reductionists with sophisticated antireductionism. When this is done, the question of explanatory reductionism becomes less substantial than often supposed. (shrink)

This paper aims to show that there is a lot of philosophy in the philosophy of chemistry—not only in the problems and questions specific to chemistry, which this science brings up in philosophical discussions, but also in the topics of wider interest like reductionism and emergence, for which chemistry proves to be an ideal case study. The fact that chemical entities and properties are amenable to a quantitative understanding, to measurement and experiment to a greater extent than those in psychology (...) or biology, makes chemistry an ideal case study for those interested in reductionism and emergence. (shrink)

Mathematics is often taken to play one of two roles in the empirical sciences: either it represents empirical phenomena or it explains these phenomena by imposing constraints on them. This article identifies a third and distinct role that has not been fully appreciated in the literature on applicability of mathematics and may be pervasive in scientific practice. I call this the “bridging” role of mathematics, according to which mathematics acts as a connecting scheme in our explanatory reasoning about why and (...) how two different descriptions of an empirical phenomenon relate to each other. I discuss two bridging roles appearing in biological and physical explanations. (shrink)

The Tree of Life has traditionally been understood to represent the history of species lineages. However, recently researchers have suggested that it might be better interpreted as representing the history of cellular lineages, sometimes called the Tree of Cells. This paper examines and evaluates reasons offered against this cellular interpretation of the Tree of Life. It argues that some such reasons are bad reasons, based either on a false attribution of essentialism, on a misunderstanding of the problem of lineage identity, (...) or on a limited view of scientific representation. I suggest that debate about the Tree of Cells and other successors to the traditional Tree of Life should be formulated in terms of the purposes these representations may serve. In pursuing this strategy, we see that the Tree of Cells cannot serve one purpose suggested for it: as an explanation for the hierarchical nature of taxonomy. We then explore whether, instead, the tree may play an important role in the dynamic modeling of evolution. As highly-integrated complex systems, cells may influence which lineage components can successfully transfer into them and how they change once integrated. Only if they do in fact have a substantial role to play in this process might the Tree of Cells have some claim to be the Tree of Life. (shrink)

La biología sintética encierra un enorme potencial transformador de los organismos vivos, incluyendo en un futuro quizás no muy lejano la transformación del propio genoma humano. Son claras las conexiones que pueden establecerse entre este enorme potencial transformador y las pretensiones de los partidarios del biomejoramiento humano. La construcción de genomas completamente sintéticos puede cambiar de forma definitiva e irreversible aspectos fundamentales de la vida humana, quizás hasta el punto de dar lugar a un organismo que difiera de nuestra especie (...) como ahora nosotros podemos diferir de los grandes simios. En este artículo se discuten los principales pros y contras que ha suscitado este debate, señalando algunos de los presupuestos más problemáticos de las propuestas recientes sobre el biomejoramiento humano. (shrink)

Reductionism is a central issue in the philosophy of biology. One common objection to reduction is that molecular explanation requires reference to higher-level properties, which I refer to as the context objection. I respond to this objection by arguing that a well-articulated notion of a mechanism and what I term mechanism extension enables one to accommodate the context-dependence of biological processes within a reductive explanation. The existence of emergent features in the context could be raised as an objection to the (...) possibility of reduction via this strategy. I argue that this objection can be overcome by showing that there is no tenable argument for the existence of emergent properties that are not susceptible to a reductive explanation. (shrink)

Philosophers have proposed various kinds of relations between Mendelian genetics and molecular biology: reduction, replacement, explanatory extension. This paper argues that the two fields are best characterized as investigating different, serially integrated, hereditary mechanisms. The mechanisms operate at different times and contain different working entities. The working entities of the mechanisms of Mendelian heredity are chromosomes, whose movements serve to segregate alleles and independently assort genes in different linkage groups. The working entities of numerous mechanisms of molecular biology are larger (...) and smaller segments of DNA plus related molecules. Discovery of molecular DNA mechanisms filled black boxes that were noted, but unilluminated, by Mendelian genetics. (shrink)

I argue that images of the notion of group, in correspondence with their social and political values, shape the debate over the evolution of altruism by group selection. Important aspects of this debate are empirical, and criteria can decide among a variety of selection processes. However, leading researchers undermine or reinterpret such tests, explaining the evolution of altruism on the basis of a single extreme metaphor of ‘group’ and a single inclusive selection process. I shall argue that the extreme images (...) for the notion of group are associated with ideologies that these researchers support or fear. Hence, the history of social and political uses of ‘group’ and ‘group selection’ can explain, at least in part, some of the empirical deficiencies of the debate, and why it has continued without resolution or dissolution. (shrink)

Convincing disputes about explanatory reductionism in the philosophy of biology require a clear and precise understanding of what a reductive explanation in biology is. The central aim of this book is to provide such an account by revealing the features that determine the reductive character of a biological explanation. Chapters I-IV provide the ground, on which I can then, in Chapter V, develop my own account of explanatory reduction in biology: Chapter I reveals the meta-philosophical assumptions that underlie my analysis (...) of reduction, Chapter II introduces the previous debate about reduction in the philosophy of biology by pointing out the most crucial lessons one should learn from this debate, Chapter III critically discusses the two perspectives on explanatory reduction that have been proposed in the philosophy of biology so far, and Chapter IV clarifies in what ways the issue of reduction is entangled with the issue of explanation. In Chapter V I present my own account of explanatory reduction. My main claim is that reductive explanations in the biological sciences possess three main characteristics: they explain the behavior of a biological system S, first, exclusively in terms of factors that are located on a lower level of organization than S, second, by focusing on factors that are internal to S , and third, by describing the genuine parts of S only as “parts in isolation”. This account is ontic because it traces the reductivity of an explanation back to certain relations that exist in the world. (shrink)

n this article the author develops a critique of reductionism in biological sciences from three different points of view. The first is related to the problem of reduction in the context of scientific theories. More specifically, reduction deals with a special form of intertheoretic relationship between molecular biology and the rest of biology. The second meaning of reductionism has to do with the significance of its genetic outfit for the ontogeny of an organism, i.e. its development from zygote to its (...) final or adult structure and function. Third, closely related to this more biological topic are questions about the anthropological consequences of the application of reductionistic methodologies for the explanation and evaluation of human behaviour. (shrink)

The past decade or so has witnessed an increase in the number of philosophical discussions about emergence and reduction in science. However, many of these discussions (though not all) remain too abstract and theoretical, and are wanting with respect to concrete examples taken from the sciences. This dissertation studies the topics of reduction and emergence in the context of a case study. I focus on the case of chemistry and investigate how emergentism can help us secure the autonomy of this (...) discipline in relation to the underlying microphysics. I develop an account of emergence (called functional emergence) that is, I argue, capable of answering the question of why we have chemistry instead of just applied quantum mechanics. I argue that functionally emergent properties in chemistry -- properties that are defined by their behaviour, not by some shared microphysical constituent -- can help us defend the autonomy of chemistry; they allow for the existence of sui generis chemical regularities, which can be used in sui generis chemical explanations. Functional emergence generates difficulties for some accounts of inter-theoretic reduction, but unlike other theories of emergence it is compatible with weaker forms of reductionism. (shrink)

This paper sketches a causal account of scientific explanation designed to sustain the judgment that high-level, detail-sparse explanations—particularly those offered in biology—can be at least as explanatorily valuable as lower-level counterparts. The motivating idea is that complete explanations maximize causal economy: they cite those aspects of an event’s causal run-up that offer the biggest-bang-for-your-buck, by costing less (in virtue of being abstract) and delivering more (in virtue making the event stable or robust).