A decade after the completion of the Human Genome Project, the widespread appeal of personalized genomic medicine's vision and potential virtues for health care remains compelling. Advocates argue that our current medical regime “is in crisis as it is expensive, reactive, inefficient, and focused largely on one size fits all treatments for events of late stage disease.” What is revolutionary about this kind of medicine, its advocates maintain, is that it promises to resolve that crisis by simultaneously increasing the ability (...) to be “personalized,” “predictive,” “preventive,” and “participatory.” Some call personalized genomic medicine “P4 Medicine,” inscribing these cardinal virtues into the movement's name. All of these putative virtues have interesting implications for the future of health care. In this essay, we are especially interested in the claims that personalized medicine will lead to a more “participatory” or “patient‐centered” approach to health care, in which patients are “empowered” to take more personal control over their care. The rhetoric of patient empowerment is nothing new in health care, but personalized medicine is an interesting case study because it portrays empowerment as one of its key virtues and as a mechanism for fixing the health care “crisis.”. (shrink)

Group selection may be defined either broadly or narrowly. Narrowly defined group selection may involve either selection for altruism or group selection between alternative evolutionarily stable states. The last variety of group selection is likely to have been particularly important in human evolution.

I carved a massive cake of beeswax into bits and rolled them in my hands until they softened … Going forward I carried wax along the line, and laid it thick on their ears. They tied me up, then, plumb amidships, back to the mast, lashed to the mast, and took themselves again to rowing. Soon, as we came smartly within hailing distance, the two Sirens, noting our fast ship off their point, made ready, and they sang … The lovely (...) voices in ardor appealing over the water made me crave to listen, and I tried to say ‘Untie me!’ to the crew, jerking my brows; but they bent steady to the oars. (shrink)

This paper is an exercise in intellectual history, an attempt to understand how a specific term—”informal logic”— came to be interpreted in so many different ways. I trace the emergence and development of “informal logic” to help explain the many different meanings, how they emerged and how they are related. This paper is also, to some degree, an account of a movement that developed outside the mainstream of philosophy, whose origins lie in a desire to make logic useful (echoing Dewey).

The ArgumentMichael Polanyi is placed in the ongoing Enlightenment-reform tradition as one of the first twentieth-century scientists to propose a program to correct the gravest internal conflict of the modern Enlightenment project of radical criticism: scientific detachment and moral nihilism in conflict with humanist values. He held that radical criticism leads not to truth but to destructive doubt. Only the inclusion of the “personal element,” the judicial attitude of reasonable doubt and the acknowledgment of belief in the regulative principle of (...) truth can overcome this end. Freedom — to reason, to criticize the method of doubt, and freedom of scientific thinking — is a precondition to reach truth. His epistemology of nonsubjective personal knowledge has redefined scientific knowing and objectivity as grounded in tacit knowing. Debate is continuing on objectivity and freedom versus the social duty of science. Polanyi's Hungarian correspondence highlights his commitment to truth and the contemporary cultural-political situation of Jewish intellectuals. (shrink)

The concept of moral identity based on virtue ethics has become an issue of considerable import in explaining moral behavior. This attempt to offer adequate explanations of the full range of morally relevant human behavior inevitably provokes boundary issues between ethics and moral psychology. In terms of the relationship between the two disciplines, some argue for ?naturalized (or psychologized) morality,? whereas, on the other hand, others insist on ?moralized psychology.? This article investigates the relationship between virtue ethics and moral identity (...) based on previous research on the relationship between ethics and moral psychology. This article especially attempts to show that meaningful links between the two concepts possible by using theoretical frameworks constructed by the most influential philosophers of science such as Kuhn and Lakatos. (shrink)

Every scientific or intellectual movement is founded upon basic assumptions and hypotheses that shape its specifically formulated philosophy. This study seeks to explore and explicate the basic philosophical underpinnings of grey systems theory, as well as the paradigm governing its postulates. The study, more specifically, scrutinizes the underlying principles of GST from the perspective of postmodern philosophy. To accomplish this, the epistemology, ontology, human nature, and methodology of GST are substantially investigated in the light of postmodern philosophy. The study draws (...) on Burrell and Morgan’s framework to reveal the paradigm underlying the philosophy of GST. Results demonstrate that GST is an anti-realistic, anti-positivistic, and non-deterministic theory which is inherently pluralistic and ideographic. Based on the principles of GST, change is an indispensable dimension of human speculation about the world and systems, and knowledge is ceaselessly reproduced as new information is collected. As a result, knowledge, narratives, theories and scientific laws are dynamically changed. GST, then, is remarkably compatible with the foundations of postmodern thought and it could be regarded as a postmodern theory governed by a humanistic paradigm. (shrink)

The relationship of humans to other primates – both in terms of abilities and evolution - has been an age-old topic of dispute in science. In this paper the claim is made that the different views of authors are based not so much on differences in empirical evidence, but on the ontological stances of the authors and the underlying ground narratives that they use. For comparing and reconciling the views presented by the representatives of, inter alia, cognitive ethology, comparative psychology, (...) and zoosemiotics, an overarching approach of multi-constructivism is introduced. The paper proposes an analytic model that distinguishes four logical possibilities in representing anthropological difference: Gradualism, Transformativism, Unitarism, and Pluralism. Using this typology, the views of C. Darwin, F. de Waal, M. Tomasello, and T. A. Sebeok regarding the similarities and differences between human and animal capacities for cognition, culture and communication are analyzed. The results indicate systematic differences in the selected narratives by these authors that can be related to the types of underlying ontologies. (shrink)

Scripture, the creeds, and tradition have provided the raw material that theology has attempted to refine. The contribution of much recent theology comes from new insight into these materials by women, blacks, and the Third World, often as examined by analytic tools derived from post‐Christian ideologies. The theology of Rosemary Ruether stands out because of her choice of sources, among which she includes documents excoriated as heretical by what she calls the patriarchal orthodoxy of the early Christian church. Because of (...) this it is useful to examine this type of theology in relation to other theological inquiries of recent years. The thesis of this paper is that, in her ability to incorporate source material hitherto regarded as heretical, Ruether has demonstrated the scientific character of this kind of theology. (shrink)

Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of nucleoprotein complexes, (...) epigenetic modifications, and natural genetic engineering activities, the genome can serve as a read-write storage system. An interactive informatic conceptualization of the genome allows us to understand the functional importance of DNA that does not code for protein or RNA structure, clarifies the essential multidirectional and systemic nature of genomic information transfer, and emphasizes the need to investigate how cellular computation operates in reproduction and evolution. (shrink)

Popper, Polanyi and Duncker represent the widely held position that theoretical and experimental scientific research are motivated by problems to which discoveries are solutions. According to the argument here, their views are unsupported and - in light of counter-instances, anomalous chance discoveries, and the force of curiosity - over-generalized.

Most ?theories of consciousness? are based on vague speculations about the properties of conscious experience. We aim to provide a more solid basis for a science of consciousness. We argue that a theory of consciousness should provide an account of the very processes that allow us to acquire and use information about our own mental states ? the processes underlying introspection. This can be achieved through the construction of information processing models that can account for ?Type-C? processes. Type-C processes can (...) be specified experimentally by identifying paradigms in which awareness of the stimulus is necessary for an intentional action. The Shallice (1988b) framework is put forward as providing an initial account of Type-C processes, which can relate perceptual consciousness to consciously performed actions. Further, we suggest that this framework may be refined through the investigation of the functions of prefrontal cortex. The formulation of our approach requires us to consider fundamental conceptual and methodological issues associated with consciousness. The most significant of these issues concerns the scientific use of introspective evidence. We outline and justify a conservative methodological approach to the use of introspective evidence, with attention to the difficulties historically associated with its use in psychology. (shrink)

To explore the mechanism of sensation correlations between EP component amplitude and signal detection indices were studied. The time of sensation coincided with the peak latency of those EP components that showed a correlation with both indices. The components presumably reflected information synthesis in projection cortical neurons. A mechanism providing the synthesis process is proposed.

Scientists often use aesthetic values in the evaluation and choice of theories. Aesthetic values are not only regarded as leading to practically more useful theories but are often taken to stand in a special epistemic relation to the truth of a theory such that the aesthetic merit of a theory is evidence of its truth. This paper explores what aesthetic considerations influence scientists' reasoning, how such aesthetic values relate to the utility of a scientific theory, and how one can justify (...) the epistemic role for such values. The paper examines ways in which the link between beauty and truth can be defended, the challenges facing such accounts, and explores alternative epistemic roles for aesthetic values in scientific practice. (shrink)

The importance of unconscious cognition is seeping into popular consciousness. A number of recent books bridging the academic world and the reading public stress that at least a portion of decision-making depends not on conscious reasoning, but instead on cognition that occurs below awareness. However, these books provide a limited perspective on how the unconscious mind works and the potential power of intuition. This essay is an effort to expand the picture. It is structured around the book that has garnered (...) the most attention, Malcolm Gladwell’s Blink , but it also considers Gut Feelings by Gerd Gigerenzer and How Doctors Think by Jerome Groopman . These books help deepen the . (shrink)

Gray takes an information-processing paradigm as his departure point, invoking a comparator as part of the system. He concludes that consciousness is to be found “in” the comparator but is unable to point to how the comparison takes place. Thus, the comparator turns out not to be an entity arising out of brain research per se, but out of the logic of the paradigm. In this way, Gray both reinvents dualism and remains trapped in the language game of his own (...) model – ending up dealing with the unknowable. (shrink)

ABSTRACTDeliberative and decisional groups play crucial roles in most aspects of social life. But it is not obvious how to organize these groups and various socio-cognitive mechanisms can spoil debates and decisions. In this paper we focus on one such important mechanism: the misrepresentation of views, i.e. when agents express views that are aligned with those already expressed, and which differ from their private opinions. We introduce a model to analyze the extent to which this behavioral pattern can warp deliberations (...) and distort the decisions that are finally taken. We identify types of situations in which misrepresentation can have major effects and investigate how to reduce these effects by adopting appropriate deliberative procedures. We discuss the beneficial effects of holding a sufficient number of rounds of expression of views; choosing an appropriate order of speech, typically a random one; rendering the deliberation dissenter-friendly; having agents express fined-grained views. These applicable procedures help improve deliberations because they dampen conformist behavior, give epistemic minorities more opportunities to be heard, and reduce the number of cases in which an inadequate consensus or majority develops. (shrink)

Fundamentismus und Skeptizismus-Anarchismus sind zwei entgegengesetzte Positionen in der traditionellen Erkenntnistheorie und in der modernen Wissenschaftstheorie. Zwischen ihnen gibt es einen dritten Standpunkt, den Evolutionismus. Beispiele sind zwei neuere Arbeiten von Putnam und Stegmüller . Im Gegensatz zum logisch-statischen Fundamentismus berücksichtigt der Evolutionismus auch dynamische und naturalistische Ansätze. Stegmüller folgend entlehnen wir in der vorliegenden Untersuchung aus der Sprachphilosophie pragmatische Gesichtspunkte, um die logische Syntax und Semantik, die Werkzeuge des Fundamentismus, zu ersetzen. Wir zeigen die Kraft der Pragmatik bei der (...) Behandlung von Problemen wie Erkenntniswachstum, Begriffswechsel, Theorien- und Bedeutungsdynamik, wissenschaftliche Entdeckung und besonders beim Problem der Inkommensurabilität. Unser nicht-fundamentistischer Vorschlag ist ein heuristisches Modell, das auf der modernen genetischen Theorie basiert. (shrink)

I consider the problem of political pluralism for political liberalism: that not everybody agrees on fundamental political principles. I critically examine three defenses of liberal principles in situations of political pluralism—the realist defense, the pragmatic defense, and Gerald Gaus’ “justificatory liberalism”—all of which I find wanting. Instead, I propose a dialectical approach to justifying political liberalism. A dialectical approach is based on engaging contradictory positions through conceptual investigation of key concepts claimed by both sides. Through such dialectical engagement, I seek (...) a way to deal with contradictions between liberal and non-liberal philosophies as conceptual issues, rather than as antagonisms beyond reason. The ambition is to contribute to a more robust liberalism capable of defending itself in contexts of political pluralism. As an example, I apply this dialectical approach to the disagreement between political Islam and political liberalism on t... (shrink)

Summary In the first part of this contribution, the three probably most influential conceptions of evolutionary epistemology are surveyed, as they were put forward by Konrad Lorenz, Gerhard Vollmer, and Rupert Riedl, respectively. It is demonstrated that, as far as the essentials are concerned, these conceptions largely correspond with each other as well as with a further conception advanced by Karl Popper from the point of view of Critical Rationalism. It can be clearly shown, moreover, that fundamentals of the latter (...) conception can be traced back to Popper's earliest publications (e. g., to hisLogik der Forschung [The Logic of Scientific Discovery]). By means of an examination of the language used by these authors, it is tried to elucidate the fact that, for the reasons of lacking consideration of the lingual/non-lingual distinction and of faults and inadequacies in consequence of this lack alone, the proposed conceptions can be rejected as being at least highly defective. (shrink)

Perspective and reflection have each been considered in some way basic to phenomenal consciousness. Each has possible evolutionary value, though neither seems sufficient for consciousness. Consider an account of consciousness in terms of the combination of perspective and reflection, its relationship to the problem of other minds, and its capacity to inherit evolutionary explanation from its components.

The chiasm is usually considered the key notion for Merleau-Ponty’s later philosophy. I argue against a common conclusion, namely that ‘the chiasm’ is equivalent to ‘reversibility’. Even when the two terms are not taken as interchangeable, the precise nature of their relation has not been adequately established. Focusing exclusively on ‘reversibility’ has implications for a range of philosophical issues, including relations between self and other. The danger of substituting one term for the other is that existential relations are construed as (...) inversions, rather than as genuine exchanges. I examine two trajectories that can be discovered in ‘The Intertwining—The Chiasm’. The first is the inclusion of difference within a peculiar, extended sense of ‘reversibility’. The second is the development of a plurality of expressions, among which ‘reversibility’ is necessary but not sufficient. I go on to argue that Merleau-Ponty secures difference within the chiasm by supplementing the notion of reversibility with ‘imminence’, the idea that something has not yet occurred. I also propose that the figure of a threshold illuminates how the chiasm operates as a transition where both joining and differentiation occur. (shrink)

Numerous approaches to a quantum theory of gravity posit fundamental ontologies that exclude spacetime, either partially or wholly. This situation raises deep questions about how such theories could relate to the empirical realm, since arguably only entities localized in spacetime can ever be observed. Are such entities even possible in a theory without fundamental spacetime? How might they be derived, formally speaking? Moreover, since by assumption the fundamental entities cannot be smaller than the derived and so cannot ‘compose’ them in (...) any ordinary sense, would a formal derivation actually show the physical reality of localized entities? We address these questions via a survey of a range of theories of quantum gravity, and generally sketch how they may be answered positively. (shrink)

The paper discusses some aspects of the relationship between Feyerabend and Kuhn. First, some biographical remarks concerning their connections are made. Second, four characteristics of Feyerabend and Kuhn's concept of incommensurability are discussed. Third, Feyerabend's general criticism of Kuhn's Structure of Scientific Revolutions is reconstructed. Forth and more specifically, Feyerabend's criticism of Kuhn's evaluation of normal science is critically investigated. Finally, Feyerabend's re-evaluation of Kuhn's philosophy towards the end of his life is presented.

Abstract:Alasdair Maclntyre (1984) asserts that the ethical systems of the Enlightenment (formalism and utilitarianism) have failed to provide a meaningful definition of “good.” Lacking such a definition, business managers have no internal standards by which they can morally evaluate their roles or acts. Maclntyre goes on to claim that managers have substituted external measures of “winning” or “effectiveness” for any internal concept of good. He supports a return to the Aristotelian notion of virtue or “excellence.” Such a system of virtue (...) ethics depends on an interrelationship of the community, one’s roles in that community, and the virtues one needs to perform that role well. This article develops Maclntyre’s concept of virtue ethics and shows how this paradigm fits well with existing theories about organizational behavior. (shrink)

In recent times it has become fashionable to emphasize the role of conceptual change in the history of science. To judge from recent writers, every significant theoretical change in science is first and foremost a revolution in scientific concepts—a conceptual revolution. According to this view, every level of experience is affected by each fundamental theoretical change: physical theory, experimental practice and even perceptual experience. The Aristotelian patrician who watched the sun sink beneath the horizon not only had different beliefs about (...) the phenomenon but actually saw something different from the Newtonian gentleman who saw the horizon rise above his eye-sun line, and the Einsteinian professional who saw the sun's varying geometrical relations to the world light-geodesics on which successive temporal stages of his eye world-line lay. Moreover, such is the completeness of the conceptual-experiential shifts undergone in a fundamental scientific change that it is impossible to meaningfully discuss the one theory within the confines of the other or, indeed, to provide any systematic, cumulative comparison of successive theories. (shrink)

The relationship between Legal Realism and Legal Positivism has been a recurrent source of debate. The question has been further complicated by the related difficulty of assessing the internal relationship between the two main original strands of Legal Realism: American and Scandinavian. This paper suggests considering American and Scandinavian Realism as instantiations of forward-looking and backward-looking rule skepticism respectively. This distinction brings into sharp relief not only the fundamentally different relationship between each of these two Realist schools and Legal Positivism (...) but also their equally different potentials as starting points for naturalizing jurisprudence. (shrink)

Börje Holmberg; A Paradigm for Research in Education, Journal of Philosophy of Education, Volume 16, Issue 1, 30 May 2006, Pages 19–33, https://doi.org/10.1111/.

The concept of major scientific advances occurring as a short-term ‘revolutionary’ change in thinking interspersed by long periods of so-called ‘normal’ science seems to be losing ground to more ecological models, which are more inimical of the twists and turns of life. From this idea it is a short step to charting science’s progress against stages used in fictional storytelling, which after all is life-based. This paper explores the development of the periodic table in terms of the achievement of a (...) fictional ‘quest’, and finds the stages of such a story are well represented. While Mendeleev or perhaps Meyer might be considered by some to be the hero of the quest, its first stage—the call—is represented by the Karlsruhe conference in 1860, with an international cast of ‘companions’ and ‘helpers’ who contributed to the Table’s early development. The ‘journey’ may have been frustrated by lack of appropriate data and understanding of concepts, but the ‘arrival’ phase is clearly marked by the award of the Davy medal jointly to Mendeleev and Meyer in 1882, Throughout these stages there are lesser, although still significant contributions made by “little people” of science to the overall progress of the Table. The end of the journey is not the end of the quest: the discovery of new elements—“new ordeals”—and their incorporation into an increasing range of types and styles of periodic table, which—akin to the “life-renewing goal” of the fictional quest—continue. (shrink)