I argue that scientific realism, insofar as it is only committed to those scientific posits of which we have causal knowledge, is immune to Kyle Stanford’s argument from unconceived alternatives. This causal strategy is shown not to repeat the shortcomings of previous realist responses to Stanford’s argument. Furthermore, I show that the notion of causal knowledge underlying it can be made sufficiently precise by means of conceptual tools recently introduced into the debate on scientific realism. Finally, I apply this strategy (...) to the case of Jean Perrin’s experimental work on the atomic hypothesis, disputing Stanford’s claim that the problem of unconceived alternatives invalidates a realist interpretation of this historical episode. 1 Stanford’s Argument from Unconceived Alternatives2 Previous Attempts to Undermine the Problem of Unconceived Alternatives2.1 The plausibility of unconceived alternatives2.2 The distinctness of unconceived alternatives2.3 The induction from past to present3 Causal Knowledge as a Criterion for the Realist3.1 How Chakravartty’s proposal differs from earlier causal strategies3.2 Causal realism and the detection/auxiliary distinction4 Causal Realism, Unconceived Alternatives, and the Atomic Hypothesis4.1 Perrin and the philosophers: some initial observations4.2 Roush and Stanford on Perrin4.3 From Brownian motion to the reality of atoms4.4 What we know about atoms5 Conclusion. (shrink)

Scientific and statistical inferences build heavily on explicit, parametric models, and often with good reasons. However, the limited scope of parametric models and the increasing complexity of the studied systems in modern science raise the risk of model misspecification. Therefore, I examine alternative, data-based inference techniques, such as bootstrap resampling. I argue that their neglect in the philosophical literature is unjustified: they suit some contexts of inquiry much better and use a more direct approach to scientific inference. Moreover, they make (...) more parsimonious assumptions and often replace theoretical understanding and knowledge about mechanisms by careful experimental design. Thus, it is worthwhile to study in detail how nonparametric models serve as inferential engines in science. (shrink)

The likelihood principle (LP) is a core issue in disagreements between Bayesian and frequentist statistical theories. Yet statements of the LP are often ambiguous, while arguments for why a Bayesian must accept it rely upon unexamined implicit premises. I distinguish two propositions associated with the LP, which I label LP1 and LP2. I maintain that there is a compelling Bayesian argument for LP1, based upon strict conditionalization, standard Bayesian decision theory, and a proposition I call the practical relevance principle. In (...) contrast, I argue that there is no similarly compelling argument for or against LP2. I suggest that these conclusions lead to a restrictedly pluralistic view of Bayesian confirmation measures. (shrink)

The function and legitimacy of values in decision making is a critically important issue in the contemporary analysis of science. It is particularly relevant for some of the more application-oriented areas of science, specifically decision-oriented science in the field of regulation of technological risks. Our main objective in this paper is to assess the diversity of roles that non-cognitive values related to decision making can adopt in the kinds of scientific activity that underlie risk regulation. We start out, first, by (...) analyzing the issue of values with the help of a framework taken from the wider philosophical debate on science and values. Second, we study the principal conceptualizations used by scholars who have applied them to numerous case studies. Third, we appraise the links between those conceptualizations and learning processes in decision-oriented science. In this, we recur to the concept of methodological learning, i.e., learning about the best methodologies for generating knowledge that is useful for science-based regulatory decisions. The main result of our analysis is that non-cognitive values can contribute to methodological improvements in science in three principal ways: as basis for critical analysis, for contextualizing methodologies, and for establishing the burden of proof. (shrink)

Between the fourth and the recent fifth IPCC report, science as well as policy making have made great advances in dealing with uncertainties in global climate models. However, the uncertainties public decision making has to deal with go well beyond what is currently addressed by policy makers and climatologists alike. It is shown in this paper that within an anthropocentric framework, a whole hierarchy of models from various scientific disciplines is needed for political decisions as regards climate change. Via what (...) is sometimes referred to as ‘uncertainty cascade’ in the technical literature, the uncertainties of various models accumulate in the input to political decision making. This paper aims to chart the uncertainties in the multi-disciplinary enterprise of current climate modeling in broad strokes. It is shown that the uncertainty cascade makes it impossible to quantify uncertainties in the form of probability estimates. Moreover the paper highlights how global climate models fail to provide probability estimates. A better treatment of the uncertainties of climate predictions on the political level would require an overhaul of the current IPCC practice that separates the various scientific fields in various working groups. (shrink)

This chapter contains sections titled: Highlights of Past Literature Current Work Future Work.

I develop the idea of what I call an interpretive praxis as a generalized procedure for analyzing how experimenters can formulate observable predictions, discern real effects from experimental artifacts, and compare predictions with data. An interpretive praxis requires theories – theories not only about instruments and the interpretation of phenomena, but also theories that connect the use of instruments and interpretation of phenomena to high‐level theory. I will call all such theories that enable experimentation to work intermediate theories. I offer (...) an account of theory‐networks that embrace these intermediate theories and explain their functions. (shrink)

This chapter provides an introduction to the study of the philosophical notions of mechanisms and causality in biology and economics. This chapter sets the stage for this volume, Mechanism and Causality in Biology and Economics, in three ways. First, it gives a broad review of the recent changes and current state of the study of mechanisms and causality in the philosophy of science. Second, consistent with a recent trend in the philosophy of science to focus on scientific practices, it in (...) turn implies the importance of studying the scientific methods employed by researchers. Finally, by way of providing an overview of each chapter in the volume, this chapter demonstrates that biology and economics are two fertile fields for the philosophy of science and shows how biological and economic mechanisms and causality can be synthesized. (shrink)

: Evidence claims depend on fallible assumptions. Three strategies for making true evidence claims in spite of this fallibility are strengthening the support for those assumptions, weakening conclusions, and using multiple independent tests to produce robust evidence. Reliability itself, understood in frequentist terms, does not explain the usefulness of all three strategies; robustness, in particular, sometimes functions in a way that is not well-characterized in terms of reliability. I argue that, in addition to reliability, the security of evidence claims is (...) of epistemic value, where an evidence claim is secure relative to an epistemic situation if it remains true in all scenarios that are epistemically possible relative to that epistemic situation. (shrink)

Although theoretical results for several algorithms in many application domains were presented during the last decades, not all algorithms can be analyzed fully theoretically. Experimentation is necessary. The analysis of algorithms should follow the same principles and standards of other empirical sciences. This article focuses on stochastic search algorithms, such as evolutionary algorithms or particle swarm optimization. Stochastic search algorithms tackle hard real-world optimization problems, e.g., problems from chemical engineering, airfoil optimization, or bio-informatics, where classical methods from mathematical optimization fail. (...) Nowadays statistical tools that are able to cope with problems like small sample sizes, non-normal distributions, noisy results, etc. are developed for the analysis of algorithms. Although there are adequate tools to discuss the statistical significance of experimental data, statistical significance is not scientifically meaningful per se. It is necessary to bridge the gap between the statistical significance of an experimental result and its scientific meaning. We will propose some ideas on how to accomplish this task based on Mayo’s learning model (NPT*). (shrink)

The quantitative problem of old evidence is the problem of how to measure the degree to which e confirms h for agent A at time t when A regards e as justified at t. Existing attempts to solve this problem have applied the e-difference approach, which compares A's probability for h at t with what probability A would assign h if A did not regard e as justified at t. The quantitative problem has been widely regarded as unsolvable primarily on (...) the grounds that the e-difference approach suffers from intractable problems. Various philosophers have proposed that 'Bayesianism' should be rejected as a research strategy in confirmation theory in part because of the unsolvability of this problem. I develop a version of the e-difference approach which overcomes these problems and possesses various advantages (but also certain limitations). I develop an alternative 'theistic' approach which handles many cases that my development of the e-difference approach does not handle. I conclude with an assessment of the significance of the quantitative problem for Bayesianism and argue that this problem is misunderstood in so far as it is regarded as unsolvable, and in so far as it is regarded as a problem only for Bayesians. (shrink)

The paper proposes a practical answer to Duhem's problem within the framework of experimental psychology. First, this problem is briefly discussed; second, two studies in psychology are presented illustrating how theories are tested. Thirdly, based on the foregoing, an approach called the “Empirical Reasoning” is developed and justified. It is shown that the ER approach can successfully cope with Duhem's problem. Finally, the ER approach and the Error Statistics approach of Mayo are critically compared with regard to Duhem's problem.

Introduces a series of articles which deals with the relationship between history of science and philosophy of science.; Introduces a series of articles which deals with the relationship between history of science and philosophy of science.

Many decades ago Patrick Suppes argued rather convincingly that theoretical hypotheses are not confronted with the direct, raw results of an experiment, rather, they are typically compared with models of data. What exactly is a data model however? And how do the interactions of particles at the subatomic scale give rise to the huge volumes of data that are then moulded into a polished data model? The aim of this paper is to answer these questions by presenting a detailed case (...) study of the construction of data models at the LHCb for testing Lepton Flavour Universality in rare decays of B-mesons. The close examination of the scientific practice at the LHCb leads to the following four main conclusions: raw data in their pure form are practically useless for the comparison of experimental results with theory, and processed data are in some cases epistemically more reliable, real and simulated data are involved in the co-production of the final data model and cannot be easily distinguished, theory-ladenness emerges at three different levels depending on the scope and the purpose for which background theory guides the overall experimental process and the overall process of acquiring and analysing data in high energy physics is too complicated to be fully captured by a generic methodological description of the experimental practice. (shrink)

Accuracy-based arguments for conditionalization and probabilism appear to have a significant advantage over their Dutch Book rivals. They rely only on the plausible epistemic norm that one should try to decrease the inaccuracy of one’s beliefs. Furthermore, conditionalization and probabilism apparently follow from a wide range of measures of inaccuracy. However, we argue that there is an under-appreciated diachronic constraint on measures of inaccuracy which limits the measures from which one can prove conditionalization, and none of the remaining measures allow (...) one to prove probabilism. That is, among the measures in the literature, there are some from which one can prove conditionalization, others from which one can prove probabilism, but none from which one can prove both. Hence at present, the accuracy-based approach cannot underwrite both conditionalization and probabilism. (shrink)

In this paper I explore an underdiscussed factor contributing to the replication crisis: Scientists, and following them policy makers, often neglect sources of errors in the production and interpretation of data and thus overestimate what can be learnt from them. This neglect leads scientists to conduct experiments that are insufficiently informative and science consumers, including other scientists, to put too much weight on experimental results. The former leads to fragile empirical literatures, the latter to surprise and disappointment when the fragility (...) of the empirical basis of some disciplines is revealed. (shrink)

Biased research occurs frequently in the sciences. In this paper, I will focus on one particular kind of biased research: research that is subject to sponsorship bias. I will address the following epistemological question: what precisely is epistemically wrong with biased research of this kind? I will defend the evidential account of epistemic wrongness: that is, research affected by sponsorship bias is epistemically wrong if and only if the researchers in question make false claims about the evidential support of some (...) hypothesis H by data E. I will argue that the evidential account captures the epistemic wrongness of three paradigmatic types of sponsorship bias. (shrink)

Amedeo Giorgi has published a review article devoted to Phenomenology as Qualitative Research: A Critical Analysis of Meaning Attribution. However, anyone reading this article, but unfamiliar with the book, will get a distorted view of what it is about, whom it is addressed to, what it seeks to achieve and how it goes about presenting its arguments. Not mildly distorted, in need of the odd correction here and there, but systematically misrepresented. The article is a study in misreading. Giorgi misreads (...) the book's mise en scène; he misreads its narrative arc; he misreads individual arguments; he misreads short, simple passages; he misreads the philosophy of the science literature; he misreads his own data; he misreads the title; he misreads the blurb; he misreads the acknowledgements. In addition, there are serious failures of scholarship (ironically, he demonstrates how unacquainted he is with the relevant literature at the very moment he is accusing me of being ill‐informed). In this reply, I provide several examples of these errors, but my primary aim is to understand why Giorgi's misreading is as ubiquitous as it is. To this end, I explain his mistakes by reference to the hermetic epistemology within which he is confined. (shrink)

In this paper we consider the problem of how to measure the strength of statistical evidence from the perspective of evidence amalgamation operations. We begin with a fundamental measurement amalgamation principle : for any measurement, the inputs and outputs of an amalgamation procedure must be on the same scale, and this scale must have a meaningful interpretation vis a vis the object of measurement. Using the p value as a candidate evidence measure, we examine various commonly used approaches to amalgamation (...) of evidence across similar studies, including standard forms of meta-analysis. We show that none of these methods satisfies MAP. Thus an underlying measurement problem remains. We argue that a successful approach to evidence amalgamation necessitates a solution to the problem of evidence measurement, and we suggest some lines of reasoning that might guide further work towards this end. (shrink)

Neuroimaging technology is the most widely used tool to study human cognition. While originally a promising tool for mapping the content of cognitive theories onto the structures of the brain, recently developed tools for the analysis, handling and sharing of data have changed the theoretical landscape of cognitive neuroscience. Even with these advancements philosophical analyses of evidence in neuroimaging remain skeptical of the promise of neuroimaging technology. These views often treat the analysis techniques used to make sense of data produced (...) in a neuroimaging experiment as one, attributing the inferential limitations of analysis pipelines to the technology as a whole. Situated against the neuroscientists own critical assessment of their methods and the limitations of those methods, this skepticism appears based on a misunderstanding of the role data analysis techniques play in neuroimaging research. My project picks up here, examining how data analysis techniques, such as pattern classification analysis, are used to assess the evidential value of neuroimaging data. The project takes the form of three papers. In the first I identify the use of multiple data analysis techniques as an important aspect of the data interpretation process that is overlooked by critics. In the second I develop an account of inferences in neuroimaging research that is sensitive to this use of data analysis techniques, arguing that interpreting neuroimaging data is a process of isolating and explaining a variety of data patterns. In the third I argue that the development and uptake of new techniques for analyzing data must be accompanied by changes in research practices and standards of evidence if they are to promote knowledge generation. My approach to this work is both traditionally philosophical, insofar as it involves reading and analyzing the work of philosophers and neuroscientists, and embedded insofar as most of the research was conducted while engaged in attending lab meetings and participating in the work of those scientists whose work is the object of my research. (shrink)

After describing the disorder of psychopathy, I examine the theories and the evidence concerning the psychopaths’ deficient moral capacities. I first examine whether or not psychopaths can pass tests of moral knowledge. Most of the evidence suggests that they can. If there is a lack of moral understanding, then it has to be due to an incapacity that affects not their declarative knowledge of moral norms, but their deeper understanding of them. I then examine two suggestions: it is their deficient (...) practical reason or their stunted emotions that are at fault. The evidence supports both explanations. I conclude with an overview of the debate concerning whether they are morally or legally responsible for their actions. (shrink)

Statistical reasoning is an integral part of modern scientific practice. In The Seven Pillars of Statistical Wisdom Stephen Stigler presents seven core ideas, or pillars, of statistical thinking and the historical developments of each of these pillars, many of which were concurrent with developments in biology. Here we focus on Stigler’s fifth pillar, regression, and his discussion of how regression to the mean came to be thought of as a solution to a challenge for the theory of natural selection. Stigler (...) argues that the purely mathematical phenomenon of regression to the mean provides a resolution to a problem for Darwin’s evolutionary theory. Thus, he argues that the resolution to the problem for Darwin’s theory is purely mathematical, rather than causal. We show why this argument is problematic. (shrink)

It is argued that the high degree of trust in the Higgs particle before its discovery raises the question of a Bayesian perspective on data analysis in high energy physics in an interesting way that differs from other suggestions regarding the deployment of Bayesian strategies in the field.

This paper looks at an appeal to the authority of biomedical research that has recently been used by empirical economists to motivate and justify their methods. I argue that those who make this appeal mistake the nature of biomedical research. Randomised trials, which are said to have revolutionised biomedical research, are a central methodology, but according to only one paradigm. There is another paradigm at work in biomedical research, the inferentialist paradigm, in which randomised trials play no special role. I (...) outline the inferentialist alternative in broad strokes, apply it to a recent controversy in econometrics and draw some general conclusions concerning econometric methodology. (shrink)

Phenomenology as rhetoric The literature on ‘nursing phenomenology’ is driven by a range of ontological and epistemological considerations, intended to distance it from conventionally scientific approaches. However, this paper examines a series of discrepancies between phenomenological rhetoric and phenomenological practice. The rhetoric celebrates perceptions and experience; but the concluding moment of a research report almost always makes implicit claims about reality. The rhetoric insists on uniquely personal meanings; but the practice offers blank, anonymous abstractions. The rhetoric invites us to believe (...) that knowing is subjective and involved, but at the same time it recommends a technique (bracketing) which can only represent a crude, and entirely misconceived, gesture towards objectivity. Finally, the rhetoric claims that generalisation is beside the point; but the majority of researchers generalise anyway. In quietly ignoring their own rhetoric, ‘phenomenologists’ appropriate scientific prerogatives illegitimately. For their methods do not entitle them to lay claim to anything resembling ‘objectivity’, or generalisability, or ‘reality’, or theoretical abstraction. Like other researchers, they want to talk in generalisable terms about reality; they want to be objective, they want to do theory. But they are saddled with a philosophy that is disabling, because it says they can only talk about perceptions, and meanings, and uniqueness. (shrink)

This paper synthesizes confirmation by instances and confirmation by successful predictions, and thereby the Hempelian and the hypothetico-deductive traditions in confirmation theory. The merger of these two approaches is subsequently extended to the piecemeal confirmation of entire theories. It is then argued that this synthetic account makes a useful contribution from both a historical and a systematic perspective.

The interpretation of tests of a point null hypothesis against an unspecified alternative is a classical and yet unresolved issue in statistical methodology. This paper approaches the problem from the perspective of Lindley's Paradox: the divergence of Bayesian and frequentist inference in hypothesis tests with large sample size. I contend that the standard approaches in both frameworks fail to resolve the paradox. As an alternative, I suggest the Bayesian Reference Criterion: it targets the predictive performance of the null hypothesis in (...) future experiments; it provides a proper decision-theoretic model for testing a point null hypothesis and it convincingly accounts for Lindley's Paradox. (shrink)

Additionally, the text shows how to develop computationally feasible methods to mesh with this framework.

The orthodox view in statistics has it that frequentism and Bayesianism are diametrically opposed—two totally incompatible takes on the problem of statistical inference. This paper argues to the contrary that the two approaches are complementary and need to mesh if probabilistic reasoning is to be carried out correctly.

This paper investigates some metaphysical and epistemological assumptions behind Bogen and Woodward’s data-to-phenomena inferences. I raise a series of points and suggest an alternative possible Kantian stance about data-to-phenomena inferences. I clarify the nature of the suggested Kantian stance by contrasting it with McAllister’s view about phenomena as patterns in data sets.

The Lottery Paradox and the Preface Paradox both involve the thesis that high probability is sufficient for rational acceptability. The standard solution to these paradoxes denies that rational acceptability is deductively closed. This solution has a number of untoward consequences. The present paper suggests that a better solution to the paradoxes is to replace the thesis that high probability suffices for rational acceptability with a somewhat stricter thesis. This avoids the untoward consequences of the standard solution. The new solution will (...) be defended against a seemingly obvious objection. 1 The paradoxes of rational acceptability 2 The standard solution 3 A new solution to the paradoxes 4 Basic assumptions 5 The new solution defended 6 Conclusion 7 Appendix. (shrink)

US testing of nuclear weapons has resulted in about 800,000 premature fatal cancers throughout the globe, and the nuclear tests of China, France, India, Russia, and the UK have added to this total. Surprisingly, however, these avoidable deaths have not received much attention, as compared, for example, to the smaller number of US fatalities on 9-11-01. This essay (1) surveys the methods and models used to assess effects of low-dose ionizing radiation from above-ground nuclear weapons tests and (2) explains some (...) of the epistemological and logical problems (with these methods and models) that have caused scientists to decide against health screening of the most likely test victims. It also (3) argues that, once the faulty presuppositions and question-begging frames about testing and screening are recognized, there are compelling arguments in favor of nuclear-test nations'' screening fallout victims, at least among their citizens. Finally, it (4) suggests that logically and epistemically flawed fallout studies/recommendations against screening are more like to occur when scientists adopt a Laudan-style comparativist rationality, rather than when they adopt a metascience more like that of Kuhn and others. (shrink)

: Peter Galison has recently claimed that twentieth-century microphysics has been pursued by two distinct experimental traditions--the image tradition and the logic tradition--that have only recently merged into a hybrid tradition. According to Galison, the two traditions employ fundamentally different forms of experimental argument, with the logic tradition using statistical arguments, while the image tradition strives for non-statistical demonstrations based on compelling ("golden") single events. I show that discoveries in both traditions have employed the same statistical form of argument, even (...) when basing discovery claims on single, golden events. Where Galison sees an epistemic divide between two communities that can only be bridged by a creole- or pidgin-like "interlanguage," there is in fact a shared commitment to a statistical form of experimental argument. (shrink)

: Where there are cases of underdetermination in scientific controversies, such as the case of the molecular clock, scientists may direct the course and terms of dispute by playing off the multidimensional framework of theory evaluation. This is because assessment strategies themselves are underdetermined. Within the framework of assessment, there are a variety of trade-offs between different strategies as well as shifting emphases as specific strategies are given more or less weight in assessment situations. When a strategy is underdetermined, scientists (...) can change the dynamics of a controversy by making assessments using different combinations of evaluation strategies and/or weighting whatever strategies are in play in different ways. Following an underdetermination strategy does not end or resolve a scientific dispute. Consequently, manipulating underdetermination is a feature of controversy dynamics and not controversy closure. (shrink)

The enduring replication crisis in many scientific disciplines casts doubt on the ability of science to estimate effect sizes accurately, and in a wider sense, to self-correct its findings and to produce reliable knowledge. We investigate the merits of a particular countermeasure—replacing null hypothesis significance testing with Bayesian inference—in the context of the meta-analytic aggregation of effect sizes. In particular, we elaborate on the advantages of this Bayesian reform proposal under conditions of publication bias and other methodological imperfections that are (...) typical of experimental research in the behavioral sciences. Moving to Bayesian statistics would not solve the replication crisis single-handedly. However, the move would eliminate important sources of effect size overestimation for the conditions we study. (shrink)

The article analyses in detail the Meselson–Stahl experiment, identifying two novel difficulties for the crucial experiment account, namely, the fragility of the experimental results and the fact that the hypotheses under scrutiny were not mutually exclusive. The crucial experiment account is rejected in favour of an experimental-mechanistic account of the historical significance of the experiment, emphasizing that the experiment generated data about the biochemistry of DNA replication that is independent of the testing of the semi-conservative, conservative, and dispersive hypotheses. _1_ (...) Introduction _2_ The Meselson–Stahl Experiment _3_ Some Difficulties for the Crucial Experiment Account _3.1_ Additional experiments were required _3.2_ Simplicity considerations are unconvincing _3.3_ The fragility of the experimental results _3.4_ The problematic interpretation of falsifyng results _3.5_ Not all possible hypotheses considered or tested _3.6_ The tested hypotheses were not mutually exclusive _4_ The Historical and Scientific Significance of the Meselson–Stahl Experiment _4.1_ The challenge for the crucial experiment account _4.2_ A mechanistic perspective on the experiment _4.3_ The experimental design and its independence from theoretical speculations _4.4_ The advantages of a ‘bottom-up’ mechanistic account _5_ Conclusion. (shrink)

The paper examines the claim that significance testing violates the Principle of Total Evidence. I argue that p-values violate PTE for two-sided tests but satisfy PTE for one-sided tests invoking a sufficient test statistic independent of the preferred theory of evidence. While the focus of the paper is to evaluate a particular claim about the relationship of significance testing and PTE, I clarify the reading of this methodological principle along the way.

The aim of this article is to contribute to the discussion about the so-called “empirical claim” and “empirical basis” of theory testing. First, the proposals of reconceptualization of the standard notions of partial potential model, intended application and empirical claim of a theory made by Balzer (1982, 1988, 1997a, 1997b, 2006, Balzer, Lauth & Zoubek 1993) and Gähde (1996, 2002, 2008) will be first discussed. Then, the distinction between “global” and “local empirical basis” will be introduced, linking it with that (...) of “global” and “local or particular empirical claim”. After that, following Balzer (1997a), along the lines of Suppes (1962), I will present a way in which what count as ‘data’ for a theory can be modeltheoretically represented and conceptualized. Finally, the proposed analysis will be exemplified with the case of classical genetics (reconstructed in Balzer & Lorenzano 2000, Lorenzano, 1995, 2000, 2002). (shrink)

This paper surveys and critically assesses existing theories of evidence with respect to four desiderata. A good theory of evidence should be both a theory of evidential support (i.e., be informative about what kinds of facts speak in favour of a hypothesis), and of warrant (i.e., be informative about how strongly a given set of facts speaks in favour of the hypothesis), it should apply to the non-ideal cases in which scientists typically find themselves, and it should be ‘descriptively adequate’, (...) i.e., able to adequately represent typical episodes of evidentiary reasoning. The theories surveyed here—Bayesianism, hypotheticodeductivism,satisfaction theories, error statistics as well as Achinstein’s and Cartwright’s theories—are all found wanting in important respects. I finally argue that a deficiency all these theories have in common is a neglect or underplaying of the epistemic context in which the episode of evidentiary reasoning takes place.Este artículo describe y valora críticamente diversas teorías de la evidencia en relación a cuatro desiderata. Una buena teoría de la evidencia debería ser tanto una teoría sobre el apoyo evidencial [evidential support] (ser informativa sobre qué tipos de hechos hablan a favor de la hipótesis) como sobre la justificación [warrant]; debería aplicarse en las situaciones no ideales en las que normalmente se encuentran los científicos; y debería ser ‘descriptivamente adecuada’, esto es, capaz de representar correctamente episodios típicos de razonamiento evidencial. Las teorías aquí revisadas—bayesianismo, hipotético-deductivismo, teorías de la satisfacibilidad, la estadística del error, así como las propuestas de Achinstein y Cartwright—se consideran deficientes en aspectos básicos. Argumentaré que un defecto común en todas ellas es que olvidan, o minusvaloran, el contexto epistémico en el que el episodio de razonamiento evidencial tiene lugar. (shrink)

The potential for financial conflicts of interest (COIs) to damage the credibility of scientific research has become a significant social concern, especially in the wake of high-profile incidents involving the pharmaceutical, tobacco, fossil-fuel, and chemical industries. Scientists and policy makers have debated whether the presence of financial COIs should count as a reason for treating research with suspicion or whether research should instead be evaluated solely based on its scientific quality. This paper examines a recent proposal to develop criteria for (...) evaluating the credibility of research without considering its source of funding. It concludes that proposals of this sort are likely to be either ineffective or impractical in many cases. Nevertheless, this does not imply that all research funded by those with an interest in the outcome must be placed under a cloud of suspicion; there are conditions under which research is at much more serious risk of being corrupted than in other cases, and attention to these conditions can guide productive responses to financial COIs. (shrink)

The present work constitutes an attempt to make explicit those pragmatic norms successfully operating in empirical science. I will first comment on the initial presuppositions of the discussion, in particular, on those concerning the instrumental character of scientific practice and the nature of scientific goals. Then I will depict the moderately naturalistic frame in which, from this approach, the pragmatic norms make sense. Third, I will focus on the specificity of the pragmatic norms, making special emphasis on what I regard (...) as a key idea underlying them, namely, the view, vigorously advocated by classical pragmatists like C. S. Peirce and G. Vailati, that the best test for objectivity is the test of action. Finally, I am going to put forward a tentative list of pragmatic norms that can be abstracted from a careful observation and analysis of scientific practice as provided by current philosophers of experimentation (A. Franklin and F. Steinle among others). The norms will be divided into four classes corresponding to four aspects of science in which they rule, that is, self-correction, prediction, explanation and both experimentation and computation. In the following account, the formulation of those pragmatic norms successfully governing science will be understood as a contribution that scientifically-oriented pragmatism can make to the normative naturalistic project in epistemology. (shrink)

There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have (...) a lot to learn by paying closer attention to the practice of simulation. (shrink)

Allan Franklin has identified a number of strategies that scientists use to build confidence in experimental results. This paper shows that Franklin's strategies have direct analogues in the context of computer simulation and then suggests that one of his strategies—the so-called 'Sherlock Holmes' strategy—deserves a privileged place within the epistemologies of experiment and simulation. In particular, it is argued that while the successful application of even several of Franklin's other strategies (or their analogues in simulation) may not be sufficient for (...) justified belief in results, the successful application of a slightly elaborated version of the Sherlock Holmes strategy is sufficient. (shrink)

Error is protean, ubiquitous and crucial in scientific process. In this paper it is argued that understanding scientific process requires what is currently absent: an adaptable, context-sensitive functional role for error in science that naturally harnesses error identification and avoidance to positive, success-driven, science. This paper develops a new account of scientific process of this sort, error and success driving Self-Directed Anticipative Learning (SDAL) cycling, using a recent re-analysis of ape-language research as test example. The example shows the limitations of (...) other accounts of error, in particular Mayo’s (Error and the growth of experimental knowledge, 1996) error-statistical approach, and SDAL cycling shows how they can be fruitfully contextualised. (shrink)

Incommensurability of scientific theories, as conceived by Thomas Kuhnand Paul Feyerabend, is thought to be a major or even insurmountable obstacletothe empirical comparison of these theories. I examine this problem in light ofaconcrete case from the history of experimental biology, namely the oxidativephosphorylation controversy in biochemistry (ca. 1961-1977). After a briefhistorical exposition, I show that the two main competing theories which werethe subject of the ox-phos controversy instantiate some of the characteristicfeatures of incommensurable theories, namely translation failure,non-corresponding predictions, and different (...) claims about what kinds ofentitiesexist in the world. By examining how the controversy was eventually resolved, Ithen show that at least this pair of incommensurable theories couldneverthelessbe empirically compared. (shrink)

Why do people get sick? I argue that a disease explanation is best thought of as causal network instantiation, where a causal network describes the interrelations among multiple factors, and instantiation consists of observational or hypothetical assignment of factors to the patient whose disease is being explained. This paper first discusses inference from correlation to causation, integrating recent psychological discussions of causal reasoning with epidemiological approaches to understanding disease causation, particularly concerning ulcers and lung cancer. It then shows how causal (...) mechanisms represented by causal networks can contribute to reasoning involving correlation and causation. The understanding of causation and causal mechanisms provides the basis for a presentation of the causal network instantiation model of medical explanation. (shrink)

Philosophical discussions of biological classification have failed to recognise the central role of homology in the classification of biological parts and processes. One reason for this is a misunderstanding of the relationship between judgments of homology and the core explanatory theories of biology. The textbook characterisation of homology as identity by descent is commonly regarded as a definition. I suggest instead that it is one of several attempts to explain the phenomena of homology. Twenty years ago the ‘new experimentalist’ movement (...) in philosophy of science drew attention to the fact that many experimental phenomena have a ‘life of their own’: the conviction that they are real is not dependent on the theories used to characterise and explain them. I suggest that something similar can be true of descriptive phenomena, and that many homologies are phenomena of this kind. As a result the descriptive biology of form and function has a life of its own—a degree of epistemological independence from the theories that explain form and function. I also suggest that the two major ‘homology concepts’ in contemporary biology, usually seen as two competing definitions, are in reality complementary elements of the biological explanation of homology. (shrink)

I propose a framework that explicates and distinguishes the epistemic roles of data and models within empirical inquiry through consideration of their use in scientific practice. After arguing that Suppes’ characterization of data models falls short in this respect, I discuss a case of data processing within exploratory research in plant phenotyping and use it to highlight the difference between practices aimed to make data usable as evidence and practices aimed to use data to represent a specific phenomenon. I then (...) argue that whether a set of objects functions as data or models does not depend on intrinsic differences in their physical properties, level of abstraction or the degree of human intervention involved in generating them, but rather on their distinctive roles towards identifying and characterizing the targets of investigation. The paper thus proposes a characterization of data models that builds on Suppes’ attention to data practices, without however needing to posit a fixed hierarchy of data and models or a highly exclusionary definition of data models as statistical constructs. (shrink)