El artículo presenta las bondades y deficiencias de los tres enfoques predominantes en las teorías ontológicas de los artefactos técnicos, que son los enfoques: (1) funcional, (2) intencional y (3) dual. Mostraré que no es conveniente enfocarnos únicamente en las «funciones» o «intenciones» para formular una teoría general sobre los artefactos, sino en un enfoque «dual» que no deje por fuera los elementos materiales y estructurales, pero que tenga coherencia con los elementos simbólicos y contextuales en los que estamos sumergidos (...) los seres humanos. (shrink)

The term functional domain is often used to describe the region containing the cis acting sequences that regulate a gene locus. “Strong” domain models propose that the domain is a spatially isolated entity consisting of a region of extended accessible chromatin bordered by insulators that have evolved to act as functional boundaries. However, the observation that independently regulated loci can overlap partially or completely raises questions about functional requirements for physically isolated domain structures. An alternative model, the “weak” domain model, (...) proposes that domain structure is determined by the distribution of binding sites for positively acting factors, without a requirement for functional boundaries. The domain would effectively be the region that contains these factor-binding sites. Specificity of promoter-enhancer interactions would play a major role in maintaining the functional autonomy of adjacent genes. Sequences that interfere with these interactions (frequently characterised as insulators) would be selected against if they occurred within the domain but not at the edges, or in the interdomain regions. As a result, insulators would often be found near the borders of domains without necessarily being selected to act as boundaries. BioEssays 22:657–665, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Emergent antireductionism in biological sciences states that even though all living cells and organisms are composed of molecules, molecular wholes are characterized by emergent properties that can only be understood from the perspective of cellular and organismal levels of composition. Thus, an emergence claim (molecular wholes are characterized by emergent properties) is thought to support a form of antireductionism (properties of higher-level molecular wholes can only be understood by taking into account concepts, theories and explanations dealing with higher-level entities). I (...) argue that this argument is flawed: even if molecular wholes are characterized by emergent properties and even if many successful explanations in biology are not molecular, there is no entailment between the two claims. (shrink)

There is a social or collective sense of ‘knowledge’, as used, for example, in the phrase ‘the growth of scientific knowledge’. In this paper I show that social knowledge does not supervene on facts about what individuals know, nor even what they believe or intend, or any combination of these or other mental states. Instead I develop the idea that social knowing is an analogue to individual knowing, where the analogy focuses on the functional role of social and individual knowing.

The language of evolutionary biology and psychology is built on concepts applicable in the first instance to individual strategic rationality but extended to the level of genetic explanation. Current discussions of mental disorders as evolutionary adaptations would apply that extended language back to the individual level, with potentially problematic moral/political implications as well as possibilities of confusion. This paper focuses on one particularly problematic area: the explanation of women's greater tendency to depression. The suggestion that there are "good evolutionary reasons" (...) for depression makes sense, and might be helpful to note in therapy, as implying that the tendency is not a defect. However, evolutionary adaptiveness should not be confused with individual or psychological adaptiveness. Besides making reference to an earlier environment, it presupposes a strategic standpoint that may not accord with the legitimate interests of the individual, as this example makes vivid. (shrink)

I distinguish three evolutionary explanations of mental illness: first, breakdowns in evolved computational systems; second, evolved systems performing their evolutionary function in a novel environment; third, evolved personality structures. I concentrate on the second and third explanations, as these are distinctive of an evolutionary psychopathology, with progressively less credulity in the light of the empirical evidence. General morals are drawn for evolutionary psychiatry.

Mechanism realists assert the existence of mechanisms as objective structures in the world, but their exact metaphysical commitments are unclear. We introduce Local Hierarchy Realism (LHR) as a substantive and plausible form of mechanism realism. The limits of LHR reveal a deep tension between two aspects of mechanists’ explanatory strategy. Functional decomposition identifies locally relevant entities and activities, while these same entities and activities are also embedded in a nested hierarchy of levels. In principle, a functional decomposition may identify entities (...) engaging in causal interactions that crosscut the hierarchical structure of composition relations, violating the mechanist’s injunction against interlevel causation. We argue that this possibility is realized in the example of ephaptic coupling, a subsidiary process of neural computation that crosscuts the hierarchy derived from synaptic transmission. These considerations undermine the plausibility of LHR as a general view, yet LHR has the advantages that (i) its metaphysical implications are precisely stateable; (ii) the structure it identifies is not reducible to mere aggregate causation; and (iii) it clearly satisfies intuitive and informal definitions of mechanism. We conclude by assessing the prospects for a form of mechanism realism weaker than LHR that nevertheless satisfies all three of these requirements. (shrink)

In his _Between Logic and the World_, in the course of presenting his theory of generics, Nickel (Between logic and the world, Oxford University Press, 2016) argues for a theory of characteristicness, or “genericity”, which states that a property is characteristic for a kind if and only if its presence among the members of that kind is explicable by some explanatory domain that recognizes the existence of that kind in the course of engaging the explanatory strategies made available by that (...) explanatory domain. I argue that this notion of genericity is too narrow, excluding properties characteristic for kinds that go unrecognized in such explanatory domains. In particular, Nickel’s theory excludes some characteristic properties of anthropic kinds, such as lilies and cedars, members of which have properties that may be similarly exploited in various human practices despite having divergent geneses. I argue for a generalization of Nickel’s view of genericity where explicability of presence is only one sort of genericity, with others, such as practicability, being possible too. (shrink)

I give a biological account of epistemic normativity. My account explains the sense in which it is true that belief is subject to a standard of correctness, and reduces epistemic norms to there being doxastic strategies which guide how best to meet that standard. Additionally, I give an explanation of the mistakes we make in our epistemic discourse, understood as either taking epistemic properties and norms to be sui generis and irreducible, and/or as failing to recognize the reductive base of (...) epistemic normativity. This explanation will appeal to the claim that the beliefs which constitute our epistemic discourse are false but adaptive, and are the outcome of a non-truth tracking process. The opponents of my position are philosophers who take epistemic normativity not to be reducible in this way, and to involve sui generis properties and norms governing belief. The aim of the paper is to show that epistemic normativity can be explained by appeal to the biological functions of our mechanisms of belief-production. (shrink)

Design thinking in general, and optimality modeling in particular, have traditionally been associated with adaptationism—a research agenda that gives pride of place to natural selection in shaping biological characters. Our goal is to evaluate the role of design thinking in non-evolutionary analyses. Specifically, we focus on research into abstract design principles that underpin the functional organization of extant organisms. Drawing on case studies from engineering-inspired approaches in biology we show how optimality analysis, and other design-related methods, play a specific methodological (...) role that is tangential to the study of adaptation. To account for the role of these reasoning strategies in contemporary biology, we therefore suggest a reevaluation of the connection between design thinking and adaptationism. (shrink)

Arguably, the most widely endorsed account of normative functions in philosophy of biology is an etiological theory that holds that the function of current traits is fixed by the past selection history of other traits of that type. The earlier formulations of this “selected-effects” theory had trouble accommodating vestigial traits. In order to remedy these difficulties, the influential recent selection or modern history selected-effects theory was introduced. This paper expands upon and strengthens the argument that this theory has trouble stemming (...) from recent “no variation” cases. In addition, several influential arguments for the necessity of including a selection requirement in a theory of normative biological functions are contested. It is suggested that accounting for biological functions in certain areas of biology does not require adverting to selection. (shrink)

We sketch a novel and improved version of Boorse’s biostatistical theory of functions. Roughly, our theory maintains that (i) functions are non-negligible contributions to survival or inclusive fitness (when a trait contributes to survival or inclusive fitness); (ii) situations appropriate for the performance of a function are typical situations in which a trait contributes to survival or inclusive fitness; (iii) appropriate rates of functioning are rates that make adequate contributions to survival or inclusive fitness (in situations appropriate for the performance (...) of that function); and (iv) dysfunction is the inability to perform a function at an appropriate rate in appropriate situations. Based on our theory, we sketch solutions to three problems that have afflicted Boorse’s theory of function, namely, Kingma’s ([2010]) problem of the situation-specificity of functions, the problem of multi-functional traits, and the problem of how to distinguish between appropriate and inappropriate rates of functioning. (shrink)

Normic laws have the form "if A, then normally B." They are omnipresent in everyday life and non-physical 'life' sciences such as biology, psychology, social sciences, and humanities. They differ significantly from ceteris-paribus laws in physics. While several authors have doubted that normic laws are genuine laws at all, others have argued that normic laws express a certain kind of prototypical normality which is independent of statistical majority. This paper presents a foundation for normic laws which is based on generalized (...) evolution theory and explains their omnipresence, lawlikeness, and reliability. It is argued that the fact that normic laws are a product of evolution must establish a systematic connection between prototypical and statistical normality. (shrink)

I examine the way in which Daniel Dennett (1987, 1995) uses his 'intentional' and 'design' stances to make the claim that intentionality is derived from design. I suggest that Dennett is best understood as attempting to supply an objective, nonintentional, naturalistic rationale for our use of intentional concepts. However, I demonstrate that his overall picture presupposes prior application of the intentional stance in a preconditional, ineliminable,'sense-giving' role. Construed as such, Dennett's account is almost identical to the account of biological teleology (...) offered by Kant in The Critique of Judgement, with the consequence that Dennett's naturalism is untenable. My conclusions lead to doubts concerning the legitimacy of any account attempting to naturalise intentionality by extracting normativity from biology and also point to a novel account of biological function. (shrink)

The 1990’s, we’ve been told, were the decade of the brain. But without anyone announcing or declaring, much less deciding that it should be so, the 90’s were also a breakthrough decade for the study of consciousness. (Of course we think the two are related, but that is another matter altogether.) William G. Lycan leads the charge with his 1987 book Consciousness (MIT Press), and he has weighed-in again with Consciousness and Experience (1996, MIT Press). Together these two books put (...) forth Lycan’s formidable view of consciousness, extending the theory of mind that he calls ‘homuncular functionalism.’ Roughly, Lycan’s view is that conscious beings are hierarchically composed intentional systems, whose representational powers are to be understood in terms of their biological function. In this review we will call the view ‘teleological functionalism’ or ‘teleofunctionalism’ – the homuncular part, for which Lycan and Daniel Dennett argued convincingly, is now so widely accepted that it fails to distinguish Lycan’s view from other versions of functionalism. This, by itself, is a testament to the importance of Lycan’s work. (shrink)

Justin Garson has recently argued that proper functions are proximal activities of traits selected by phylogenetic or ontogenetic selection processes, and that traits are dysfunctional only if they cannot perform their proper functions for constitutional reasons. We partially agree with Garson, but reject the view that functions are proximal activities, as well as his account of dysfunctions. Instead, we propose our own theory that biological functions are selected dispositions and that a trait is dysfunctional in virtue of not having the (...) dispositions for which it was selected. This account can explain both defects (or dysfunctions in Garson’s sense) and dysfunctions due to environmental factors. Moreover, it offers a neat way to explain the graduality of dysfunction. (shrink)

Functional localization is a central aim of cognitive neuroscience. But the nature and extent of functional localization in the human brain have been subjects of fierce theoretical debate since the 19th Century. In this essay, I first examine how concepts of functional localization have changed over time. I then analyze contemporary challenges to functional localization drawing from research on neural reuse, neural degeneracy, and the context-dependence of neural functions. I explore the consequences of these challenges for topics in philosophy of (...) science and philosophy of mind including localizationist versus anti-localizationist approaches to cognitive neuroscience, multiple realizability, reverse inference in functional neuroimaging, and the modularity of mind. (shrink)

While developments of a shared intellectual tradition, the enactivist approach and the organizational account proffer importantly different accounts of organismic normativity. Where enactivists tend to follow Hans Jonas, Andres Weber, and Francisco Varela in grounding intrinsic affordance norms in existential concern, organizational theorists such as Alvaro Moreno, Matteo Mossio, and Leonardo Bich seek a more deflationary account of these normative phenomena. Critiques directed at both of these accounts of organismic normativity motivate the introduction of the precedential account of organismic normativity, (...) which I nevertheless locate within the enactivist approach, broadly construed. After detailing empirical evidence that would seem to vindicate the precedential account, I explore some of its implications. (shrink)

Individuals come into the world with talents that differ greatly in their marketability. These talents command a wide variety of rents; from millions of dollars per film for a movie star, to just a few thousands of dollars per annum for a fast-food joint worker. How should we distribute income fairly given these disparities? That is the topic of Kristi Olson’s excellent new book, The Solidarity Solution: Principles for a Fair Income Distribution. 1 1 The question is not new, but (...) Olson’s treatment is among the most comprehensive and well-argued one can find. The manuscript is well researched, scholarly, thorough, packed full of arguments and low on fluff. It is well worth the time of anyone interested in fairness in the sphere of work and income. (shrink)

Mechanism realists assert the existence of mechanisms as objective structures in the world, but their exact metaphysical commitments are unclear. We introduce Local Hierarchy Realism (LHR) as a substantive and plausible form of mechanism realism. The limits of LHR reveal a deep tension between two aspects of mechanists’ explanatory strategy. Functional decomposition identifies locally relevant entities and activities, while these same entities and activities are also embedded in a nested hierarchy of levels. In principle, a functional decomposition may identify entities (...) engaging in causal interactions that crosscut the hierarchical structure of composition relations, violating the mechanist’s injunction against interlevel causation. We argue that this possibility is realized in the example of ephaptic coupling, a subsidiary process of neural computation that crosscuts the hierarchy derived from synaptic transmission. These considerations undermine the plausibility of LHR as a general view, yet LHR has the advantages that (i) its metaphysical implications are precisely stateable; (ii) the structure it identifies is not reducible to mere aggregate causation; and (iii) it clearly satisfies intuitive and informal definitions of mechanism. We conclude by assessing the prospects for a form of mechanism realism weaker than LHR that nevertheless satisfies all three of these requirements. (shrink)

El representacionismo defiende que el carácter fenoménico de la experiencia queda completamente determinado por su contenido intencional. El representacionismo es una teoría muy atractiva dentro del proyecto de naturalizar la consciencia según la hipótesis de que la relación de representación puede a su vez ser naturalizada. Para este propósito, los representacionistas con inquietudes naturalistas acuden normalmente a teorías teleosemánticas del contenido mental. No se ha prestado, sin embargo, demasiada atención a la interacción entre el representacionismo y las teorías teleosemánticas del (...) contenido mental. Este artículo da razones para pensar que tal interacción no es venturosa. En particular, argumentaré que aquellos que abrazan la conjunción de ambas teorías están comprometidos con la existencia de experiencias imposibles. (shrink)

There is a conceptual crisis in the biomedical sciences that is particularly salient in psychopathology research. Underlying the crisis is a controversy that pertains to the current medical model of disease that largely draws from causal-mechanistic explanations. The bedrock of this model is the analysis of biological part-dysfunctions that aims at unequivocally defining a pathological condition and demarcating it from its neighboring entities. This endeavor has led to a quest for physiological, biochemical, and genetic signatures. Yet, so far there is (...) little evidence for reliable biomarkers for any mental disorder. The contemporary biomedical paradigm largely ignores historical, dynamic, and system-level aspects—a view that has contributed much to the conceptual disjunction of the patient as a person from his/her disease. Notwithstanding the impressive progress in the biomedical sciences, increasingly more critics question whether the constituting framework is sufficient to convey a comprehensive understanding of illnesses, especially mental illnesses. Thus, the medical model urgently requires an update. But rather than revamping it by methodological advancements, it will be necessary to critically review its philosophical roots. The most problematic issues that require reworking are: the preponderance of the biostatistical theory; the undue decoupling of physiological from evolutionary explanations of function; the clinging to the Modern Synthesis ; and the neglect of dynamic and system-level properties. The proposed overhaul requires the heeding of historical explanations that draw from the Extended Evolutionary Synthesis as well as systems biology approaches for tackling multilevel and dynamic phenomena of complex systems. (shrink)

Theories in cognitive science, and especially cognitive neuroscience, often claim that parts of cognitive systems are reused for different cognitive functions. Philosophical analysis of this concept, however, is rare. Here, I first provide a set of criteria for an analysis of reuse, and then I analyse reuse in terms of the functions of subsystems. I also discuss how cognitive systems execute cognitive functions, the relation between learning and reuse, and how to differentiate reuse from related concepts like multi-use, redundancy, and (...) duplication of parts. Finally, I illustrate how my account captures the reuse of dynamical subsystems as unveiled by recent research in cognitive neurobiology. This recent research suggests two different evolutionary justifications for reuse claims. (shrink)

If reason is a real causal force,operative in some, but not all ofour cognition and conation, then itought to be possible to tell anaturalistic story that distinguishes themind which is moved byreason from the mind which is movedby forces other than reason.This essay proposes some steps towardthat end. I proceed by showingthat it is possible to reconcile certainemerging psychological ideasabout the causal powers of themind/brain with a venerablephilosophical vision of reason as the facultyof norms. My accountof reason is psychologistic, social, (...) and consistent with anevolutionary approach to mind. The account preserves thenormativity by deflating it. But I argue that onlysuch deflated normativity has any chance of beingmade naturalistically respectable. (shrink)

In the biological realm, a complete explanation of a trait seems to include an explanation in terms of function. It is natural to ask of some trait, "What is its function?" or "What purpose in the organism does the particular trait serve?" or "What is the goal of its activity?" There are several views concerning the appropriate definition of function for biological matters. Two popular views of function with respect to living things are Cummins' organizational account and the Griffiths/Godfrey-Smith modern (...) history account. Whereas Cummins argues that a trait functions so as to contribute to the general organization of some organism's present structure, Griffiths, and Godfrey-Smith argue that a trait functions because of its fitness with respect to the organism's recent evolutionary history. In this paper, I show how these accounts can be made compatible and compliment one another. Given that structure, organization, operational flexibility, function, and evolutionary history are all factors to be considered in an organism's makeup, we should expect that the traits of an organism function the way they do because such traits presently contribute to the overall organization of the organism (Cummins) as well as were selected for in the organism's species' recent ancestry (Griffiths/Godfrey-Smith). (shrink)

A meaningful distinction can be made between functions and mere effects in biological systems without resorting to teleological arguments: (i) biological systems must cope with a multitude of problems or they will cease to exist; (ii) the solutions to these problems invariably depend on circular causal chains (“feedback loops”); and (iii) biological functions are attributes of elements in biological systems that have an effect which, by contributing to the correcting behavior of a feedback control system, assists in solving a biological (...) problem. The analysis is applied to several biological systems. The proposed solution is discussed primarily in its relation to two popular approaches to the concept of biological function, i.e., the “causal role accounts” and the “selected effect accounts”. (shrink)

I defend and revise the systematic account of normative functions (teleofunctions), as recently developed by Gerhard Schlosser and by W. D. Christensen and M. H. Bickhard. This account proposes that teleofunctions are had by structures that play certain kinds of roles in complex systems. This theory is an alternative to the historical etiological account of teleofunctions, developed by Ruth Millikan and others. The historical etiological account is susceptible to a general ontological problem that has been under-appreciated, and that offers important (...) reasons to adopt the systematic account. However, the systematic account must be revised to allow for two distinct kinds of teleofunctions in order to avoid another ontological problem. (shrink)

Realism, defined as a justified belief in the existence of the external world, is jeopardized by ‘meaning rationalism,’ the classic theory of meaning that sees the extension of words as a function of the intensions of individual speakers, with no way to ensure that these intensions actually correspond to anything in the external world. To defend realism, Ruth Millikan ( 1984 , 1989a , b , 1993 , 2004 , 2005 ) offers a biological theory of meaning called ‘teleosemantics’ in (...) which words, without requiring any contribution from the speaker’s intensions, are supposedly matched directly with their extensions by external norms. But even if one granted as a theoretical possibility that word meaning might possibly be stabilized through an external process, nonetheless, realists who wish to appeal to teleosemantics for a semantic proof of the external world must be capable of identifying these external norms, something that Millikan describes as highly fallible. Furthermore, because they can be aware of these norms only as these are internally represented, it would also be necessary for realists to verify that these internal representations accurately reflect the norms as they occur in the external world. But given that this is virtually the same stumbling block to realism found in meaning rationalism, it is concluded that teleosemantics is not likely to restore faith in this worldview. (shrink)

What is knowledge of one's own current, consciously entertained intentional states a form of inner awareness? If so, what form? In this paper I explore the prospects for a quasi-observational account of a certain class of cases where subjects appear to have self-knowledge, namely, the so-called cogito-like cases. In section one I provide a rationale for the claim that we need an epistemology of self-knowledge, and specifically, an epistemology of the cogito-like cases. In section two I argue that contentful properties (...) in such cases have two features in common with observational properties of objects. In section three, I develop a quasi-observational account of self-knowledge for the cogito-like cases by considering various accounts of the nature of observational properties (specifically, secondary qualities) and by applying them to these cases. I conclude by addressing some important objections to the account. (shrink)

A number of areas of biology raise questions about what is of value in the natural environment and how we ought to behave towards it: conservation biology, environmental science, and ecology, to name a few. Based on my experience teaching students from these and similar majors, I argue that the field of environmental ethics has much to teach these students. They come to me with pent-up questions and a feeling that more is needed to fully engage in their subjects, and (...) I believe some exposure to environmental ethics can help focus their interests and goals. I identify three primary areas in which environmental ethics can con- tribute to their education. The first is an examination of who (or what) should be considered to be part of our moral community (i.e., the community to whom we owe direct duties). Is it humans only? Or does it include all sentient life? Or all life? Or ecosystems considered holistically? Often, readings implicitly assume one or more of these answers; the goal is to make the student more sensitive to these implicit claims and to get them to think about the different reasons that support them. The second area, related to the first, is the application of the different answers concerning the extent of the ethical community to real environmental issues and problems. Students need to be aware of how the different answers concerning the moral community can imply conflicting answers for how we should act in certain cases and to think about ways to move toward conflict resolution. The third area in which environmental ethics can contribute is a more conceptual one, focusing on central concepts such as biodiversity, sustainability, species, and ecosystems. Exploring and evaluating various meanings of these terms will make students more reflective and thoughtful citizens and biologists, sensitive to the implications that different conceptual choices make. (shrink)

Teleosemantic theories of representation are often criticized as being “too liberal”, i.e. as categorizing states as representations which are not representational at all. Recently, a powerful version of this objection has been put forth by Tyler Burge. Focusing on perception, Burge defends the claim that all teleosemantic theories apply too broadly, thereby missing what is distinctive about representation. Contra Burge, I will argue in this paper that there is a teleosemantic account of perceptual states that does not fall prey to (...) this problem, and that we can arrive at this account by combining some of Burge’s insights with a producer-oriented version of teleosemantics. The resulting theory turns out to be attractive and perfectly coherent. By contrast, the coherence of Burge’s own anti-teleosemantic approach becomes quite doubtful under closer examination—or so I will argue. (shrink)

In this paper, I discuss the aetiological account of biological interests, developed by Varner, in the context of artefactual organisms envisioned by current research in synthetic biology. In “Sections 2–5”, I present Varner's theory and criticise it for being incapable of ascribing non-derivative interests to artefactual organisms due to their lack of a history of natural selection. In “Sections 6–7”, I develop a new alternative to Varner's account, building on the organisational theory of biological teleology and function. I argue that (...) the organisational account of biological interest is superior to Varner's aetiological account because it can accommodate both artefactual and naturally evolved organisms, provides a non-arbitrary and practical way of determining biological interests, supports the claim that organisms have interests in a sense in which artefacts do not, and avoids the possibility of there being a conflict between what an organismic part is supposed to do and what is in the interest of the organism. (shrink)

Our aim in the present paper is to approach the nature of life from the perspective of autonomy, showing that this perspective can be helpful for overcoming the traditional Cartesian gap between the physical and cognitive domains. We first argue that, although the phenomenon of life manifests itself as highly complex and multidimensional, requiring various levels of description, individual organisms constitute the core of this multifarious phenomenology. Thereafter, our discussion focuses on the nature of the organization of individual living entities, (...) proposing autonomy as the main concept to grasp it. In the second part of the article we show how autonomy is also fundamental to explaining major evolutionary transitions, in an attempt to rethink evolution from the point of view of the organizational structure of the entities/organisms involved. This gives further support to the idea of autonomy not only as a key to understanding life in general but also the complex expressions of it that we observe on our planet. Finally, we suggest a possible general principle that underlies those evolutionary transitions, which allow for the open-ended redefinition of autonomous systems: namely, the relative dynamic decoupling that must be articulated among distinct parts, modules or modes of operation in these systems. (shrink)

In this paper we present a functional analysis of biotechnology and identify the particular status that genetic engineering has relative to other biotechnological techniques such as domestication. The analysis builds on work by Dan Sperber and characterises biotechnology in primarily technical and biological functional terms as symbiotic interactions in which humans modify other organisms. We identify three main routes by which these interactions are established in biotechnology. We argue that two of these routes have in-built mechanisms for preventing an uncontrolled (...) dissemination of the modified organisms, and that one has an in-built mechanism for promoting such dissemination. The three routes are available to traditional forms of biotechnology as to state-of-the-art genetic engineering. Drawing now on work by Alfred Nordmann on the uncanniness of modern technologies, we show that genetic engineering is set apart by the epistemic consequences of the microscopic size of its progeny: genetically modified organisms, when disseminating, do so beyond our perceptual and conceptual control. Existing strategies against unwanted dissemination of organisms modified in traditional biotechnology are therefore typically not adequate against possible unwanted dissemination of genetically modified organisms, giving this dissemination a status similar to that of untraceable natural disasters. (shrink)

In Molecular Models: Philosophical Papers on Molecular Biology, Sahotra Sarkar presents a historical and philosophical analysis of four important themes in philosophy of science that have been influenced by discoveries in molecular biology. These are: reduction, function, information and directed mutation. I argue that there is an important difference between the cases of function and information and the more complex case of scientific reduction. In the former cases it makes sense to taxonomise important variations in scientific and philosophical usage of (...) the terms function and information . However, the variety of usage of reduction across scientific disciplines (and across philosophy of science) makes such taxonomy inappropriate. Sarkar presents reduction as a set of facts about the world that science has discovered, but the facts in question are remarkably disparate; variously semantic, epistemic and ontological. I argue that the more natural conclusion of Sarkar’s analysis is eliminativism about reduction as a scientific concept. (shrink)

In order to vindicate rational-choice theory as a mode of explaining social patterns in general - social patterns beyond the narrow range of economic behaviour - we have to recognize the legitimacy of explaining the resilience of certain patterns of behaviour: that is, explaining, not necessarily why they emerged or have been sustained, but why they are robust and reliable. And once we allow the legitimacy of explaining resilience, then we can see how functionalist theory may also serve us well (...) in social science; we lose the basis - the empty black box argumenton which the rational-choice critique of the theory has mostly been grounded. (shrink)

Foot , Hursthouse , and Thompson , along with other philosophers, have argued for a metaethical position, the natural goodness approach, that claims moral judgments are, or are on a par with, teleological claims made in the biological sciences. Specifically, an organism’s flourishing is characterized by how well they function as specified by the species to which they belong. In this essay, I first sketch the Neo-Aristotelian natural goodness approach. Second, I argue that critics who claim that this sort of (...) approach is inconsistent with evolutionary biology due to its species essentialism are incorrect. Third, I contend that combining the natural goodness account of natural-historical judgments with our best account of natural normativity, the selected effects theory of function, leads to implausible moral judgments. This is so if selected effects function are understood in terms of evolution by natural selection, but also if they are characterized in terms of cultural evolution. Thus, I conclude that proponents of the natural goodness approach must either embrace non-naturalistic vitalism or troubling moral revisionism. (shrink)

The aim of this paper is to evaluate etiological accounts of functions for the domain of technical artefacts. Etiological theories ascribe functions to items on the basis of the causal histories of those items; they apply relatively straightforwardly to the biological domain, in which neo‐Darwinian evolutionary theory provides a well‐developed and generally accepted background for describing the causal histories of biological items. Yet there is no well‐developed and generally accepted theory for describing the causal history of artefacts, so the application (...) of etiological theories to the technical domain is hardly straightforward. In this paper we consider the transposition of etiological theories in general from the biological to the technical domain. We argue that a number of etiological theories that appear defensible for biology become untenable for technology. We illustrate our argument by showing that the standard etiological accounts of Neander and Millikan, and some recent attempts to improve on them, provide examples of such untenable theories.1Introduction2Desiderata for theories of functions3Etiological theories in general3.1Common core and divergent aims3.2Reproduction versus non‐reproduction etiological theories3.3Intentionalist versus non‐intentionalist etiological theories4Problems for etiological theories in the technical domain5The failure of existing reproduction theories6The failure of existing non‐reproduction theories7Improving reproduction by hybridisation8Conclusions. (shrink)

Karen Neander’s (1991a, b) Selected Effects (SE) theory of biological proper functions argues that the function of a trait is the action for which it was “caused” to be selected by natural selection. Her life’s work has already left a lasting impact, however SE theory has yet to be more properly formalized as a conceptual analysis of biological functions. Although other SE theories have sought to build upon Neander’s work (e.g., Garson, 2017), there remains an ambiguity in the theory’s use (...) of causal descriptors. For the success of her successors, delineating the function of causality for SE theory is of utmost importance. Here, I systematize Neander’s theory according to the different senses of causation inherent to it. I argue that structuring SE theory in terms of causal transitivity and intransitivity reveals that Neander’s analysis not only supersedes her detractors but likely exposes areas of vulnerability in others’ SE theory derivatives. (shrink)

The notion of biological function is fraught with difficulties—intrinsically and irremediably so, we argue. The physiological practice of functional ascription originates from a time when organisms were thought to be designed and remained largely unchanged since. In a secularized worldview, this creates a paradox which accounts of functions as selected effect attempt to resolve. This attempt, we argue, misses its target in physiology and it brings problems of its own. Instead, we propose that a better solution to the conundrum of (...) biological functions is to abandon the notion altogether, a prospect not only less daunting than it appears, but arguably the natural continuation of the naturalisation of biology. (shrink)

This thesis is about the notions of health and pathology in medical theory. I develop a theory, which defines ‘health’ and ‘pathology’ in a way that solves several problems with earlier suggestions of how to define these terms. I call the theory ‘the disposition profile efficiency theory’, abbreviated ‘the DPE-theory’. According to the DPE-theory, a trait token is healthy, roughly, if and only if all of its dispositions for performing physiological functions are efficient enough. A trait token is pathological, roughly, (...) if and only if at least one of its dispositions for performing a physiological function is not efficient enough. The notion of efficiency, I suggest, is reference class-relative: the efficiency of a trait token’s disposition for performing a physiological function expresses a relation between the trait token and a health standard for the trait token’s bearer’s reference class. The thesis also examines the most discussed theory of health and pathology, “the biostatistical theory” proposed by Boorse. Both the DPE-theory and the biostatistical theory are evaluated against a number of desiderata: the theory should be theoretically sound; only use empirical, statistical, and logical terms; not involve values; be clear; both account for health and pathology as reference class-relative properties, and account for the importance of integration of different physiological functions for health; and have reasonable implications. It is argued that the DPE-theory satisfies the desiderata, and that it does so better than the biostatistical theory. The main contributions of the thesis are the DPE-theory’s models of dispositions, its approach to defining reference classes, its efficiency measure, and its way of drawing the line between high enough efficiencies and too low efficiencies. Other important contributions concern the desideratum about reasonable implications. It is shown how the DPE-theory contributes to solving two much discussed objections directed towards the biostatistical theory, “the problem of common diseases” and “Kingma’s dilemma”. Further, the DPE-theory is used to illuminate discussions about certain types of conditions for which it is contested whether they should count as healthy or pathological. (shrink)

I analyze a tension at the core of the mechanistic view of computation generated by its joint commitment to the medium independence of computational vehicles and to computational systems possessing teleological functions to compute. While computation is individuated in medium-independent terms, teleology is sensitive to the constitutive physical properties of vehicles. This tension spells trouble for the mechanistic view, suggesting that there can be no teleological functions to compute. I argue that, once considerations about the relevant function-bestowing factors for computational (...) systems are brought to bear, the tension dissolves: physical systems can have the teleological function to compute. (shrink)

Philosophers of science have by and large neglected technology. In this book, I have tried to do something about this lacuna by analyzing a few aspects of technical artifacts from a philosophical angle. The project was part of the research program "The Dual Nature of Technical Artifacts" based at Delft University of Technology in the Netherlands. Technical artifacts are both plain physical objects and objects that have been purposefully made for a purpose; which is to say they have a physical (...) structure and a technical function. As a result, they belong equally in a purely physical conceptualisation of the world "in which human intentions and goals seem to have no place" and in an intentional conceptualisation, which is used to describe and understand people and their mental lives. My main goal was to find out how these two philosophically very different aspects of artifacts are related to one another. To achieve this goal, I looked at two contexts in which these aspects are regularly brought together in a systematic fashion. First, the context of design; design can be characterized as a transition from a desired function or goal to a physical structure. In particular, I have studied and analyzed the role of functional decomposition in design processes. The second context is the explanation of how artifacts are able to fulfill their technical function in virtue of their specific physical structure. The result of this part of the project is a general account of such explanations. (shrink)

This research aims to propose a new theory to account for the functions of biological objects. For this, I will show that the most accepted theories of biological functions fail, and then I will propose a new alternative that overcomes the given counterexamples. The research is divided into the following questions: i) appealing to various counterexamples, noting that there is no robust theory capable of accounting for the phenomenon; finally ii) I will give a minimal provisional / operational theory, which (...) allows us to continue incorporating the functional dimension of the features. (shrink)