This paper seeks to reinterpret the life and work of J. B. S. Haldane by focusing on an illuminating but largely ignored essay he published in 1927, "The Last Judgment" -- the sequel to his better known work, "Daedalus" (1924). This astonishing essay expresses a vision of the human future over the next 40,000,000 years, one that revises and updates Wellsian futurism with the long range implications of the "new biology" for human destiny. That vision served as a kind of (...) lifelong credo, one that infused and informed his diverse scientific work, political activities, and popular writing, and that gave unity and coherence to his remarkable career. (shrink)

In 1967, American biologist Adrian Wenner (1928-) launched an extensive challenge to Karl von Frisch's (1886-1982) theory that bees communicate to each other the direction and distance of food sources by a symbolic dance language. Wenner and various collaborators argued that bees locate foods solely by odors. Although the dispute had largely run its course by 1973 -- von Frisch was awarded a Nobel Prize, while Wenner withdrew from active bee research -- it offers us a rare window into mid-twentieth (...) century discussions about animals, language, and cognition. Historians, sociologists, and scientists have commented on the debate and its outcome, but none has seriously questioned why von Frisch and Wenner pursued such different explanations of the bees' dances. In this paper, I explore von Frisch and Wenner's differing visions of animals and their behaviors and show how these contributed to their respective positions. Von Frisch's early-twentieth-century training in experimental physiology disposed him to focus on individual animals, their abilities, and their behaviors' evolutionary significance. Wenner, by contrast, was trained in mathematics and statistics and the Schneirla school of behavior. He viewed the bees' behaviors probabilistically with an eye toward the entire hive and its surroundings and ultimately explained them in terms of simple stimulus--response conditioning. Finally, while the debate was resolved in von Frisch's favor, he neither waged nor won the battle by himself. Instead, I show that practitioners, whose agendas ranged from the nascent fields of sociobiology to cognitive ethology, took up the cause of the communicating bees. (shrink)

The aim of regenerative medicine is to reconstruct tissue that has been lost or pathologically altered. Therapeutic cloning seems to offer a method of achieving this aim; however, the ethical debate surrounding human therapeutic cloning is highly controversial. Artificial parthenogenesis—obtaining embryos from unfertilised eggs—seems to offer a way to sidestep these ethical pitfalls. Jacques Loeb , the founding father of artificial parthogenesis, faced negative public opinion when he published his research in 1899. His research, the public’s response to his findings, (...) and his ethical foundations serve as an historical argument both for the communication of science and compromise in biological research. (shrink)

The emergent new science of synthetic biology is challenging entrenched distinctions between, amongst others, life and non-life, the natural and the artificial, the evolved and the designed, and even the material and the informational. Whenever such culturally sanctioned boundaries are breached, researchers are inevitably accused of playing God or treading in Frankenstein’s footsteps. Bioethicists, theologians and editors of scientific journals feel obliged to provide an authoritative answer to the ambiguous question of the ‘meaning’ of life, both as a scientific definition (...) and as an explication with wider existential connotations. This article analyses the arguments mooted in the emerging societal debates on synthetic biology and the way its practitioners respond to criticism, mostly by assuming a defiant posture or professing humility. It explores the relationship between the ‘playing God’ theme and the Frankenstein motif and examines the doctrinal status of the ‘playing God’ argument. One particularly interesting finding is that liberal theologians generally deny the religious character of the ‘playing God’ argument—a response which fits in with the curious fact that this argument is used mainly by secular organizations. Synthetic biology, it is therefore maintained, does not offend so much the God of the Bible as a deified Nature. While syntheses of artificial life forms cause some vague uneasiness that life may lose its special meaning, most concerns turn out to be narrowly anthropocentric. As long as synthetic biology creates only new microbial life and does not directly affect human life, it will in all likelihood be considered acceptable. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des massenmedialen Diskurses seit (...) den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)

Although the term integration is central to the definition of brain death, there is little agreement on what it means. Through a genealogical analysis, this essay argues that there have been two primary ways of understanding integration in regard to organismal wholeness. One stems from neuroscience, focusing on the role of the brain in responding to external stimuli, which was taken up in phenomenological accounts of life. A second, arising out of cybernetics, focuses on the brain’s role in homeostasis. Recent (...) debates over brain death are largely over this cybernetic understanding of integration. However, the phenomenological understanding of organismal wholeness can be seen in arguments by the President’s Council on Bioethics in favor of brain death. This essay argues that the cybernetic understanding of life is problematic and should be discarded. A phenomenological understanding of life can provide a better basis for arguments over definitions of life and death. (shrink)

Around the turn of the twentieth century, microbiologists in Western Europe and North America began to organize centralized collections of microbial cultures. Collectors published lists of the strains they cultured, offering to send duplicates to colleagues near and far. This essay explores the history of microbial culture collections through two cases: Johanna Westerdijk’s collection of phytopathogenic fungi in the Netherlands and Ernst Georg Pringsheim’s collection of single-celled algae at the German University in Prague. Historians of science have tended to look (...) at twentieth-century biological specimen collections as either repositories of communal research materials or storehouses of economically important biological variation. An examination of Westerdijk’s and Pringsheim’s collections illustrates how collectors, researchers, and patrons ascribed different kinds of value to collections featuring distinctive microbial life forms. This essay argues that characteristics of cultivated microorganisms, such as a fungus’s propensity to infect crops or an alga’s amenability to experimentation, shaped the trajectories of Westerdijk’s and Pringsheim’s collections as these collectors developed relationships with colleagues and patrons. Letters between Westerdijk and Pringsheim open a window onto divergences in their approaches to collecting cultures, while also shedding light on the aspirational internationality of the collections that resulted. (shrink)

When the Human Genome Project (HGP) was launched, our genome was presented as our ‘blueprint’, a metaphor reflecting a genetic deterministic epistemology. Eventually, however, the HGP undermined rather than strengthened the understanding of genomes as blueprints and of genes as ultimate causal units. A symbolical turning point was the discovery that the human genome only contains 22,500 genes. Initially, this was seen as a narcissistic offence. Gradually, however, it strengthened the shift from traditional genetics and biotechnology (i.e., gene-oriented approaches) to (...) genomics, i.e. genome-oriented or systems approaches, emphasizing complexity. The 20th century can be regarded as the century of biotechnology and of the gene. Its history demonstrated that the will to know (notably: to know ourselves) has never been a disinterested affair: it is driven by a will to improve (notably: to improve ourselves). In this article it is claimed that, as genomics takes us beyond a genetic deterministic understanding of life, this must have consequences for societal research and debate as well. Policies for self-improvement will increasingly rely on the use of complex interpretation. Therefore, the emphasis must shift from issues such as genetic manipulation and human enhancement to issues involved in governance of novel forms of information. (shrink)

Synthetic cells spark intriguing questions about the nature of life. Projects such as BaSyC (‘Building a Synthetic Cell’) aim to build an entity that mimics how living cells work from basic components. But what kind of entity would a synthetic cell really be? I assess this question from a philosophical perspective, and show how early fictional narratives of artificial life – such as the laboratory scene in Goethe’s Faust – can help us to understand the challenges faced by synthetic biology (...) researchers. (shrink)

This volume aims to develop a philosophical diagnostic of the present, focussing on contemporary technoscience. psychoanalysis submits contemporary technoscientific discourse to a symptomatic reading, analysing it with evenly-poised attention and from an oblique perspective. Psychoanalysis is not primarily interested in protons, genes or galaxies, but rather in the ways in which they are disclosed and discussed, focussing on the symptomatic terms, the metaphors and paradoxes at work in technoscientific discourse. This monograph presents a psychoanalytical assessment of technoscience. The first four (...) chapters provide a short introduction into the psychoanalysis of technoscience, its basic concepts and methods, as developed Sigmund Freud, Carl Gustav Jung, Gaston Bachelard and Jacques Lacan. In subsequent chapters, this approach is fleshed out with the help of case histories (palaeoanthropology, classical conditioning and virology). Psychoanalysis reveals that, rather than by disinterested curiosity, technoscience is driven by desire, resistance and the will to control. Moreover, the focus is on primal scenes, such as Dubois’ quixotic quest for the missing link and Pavlov’s discovery of the conditioned reflex. In addition, psychoanalysis opts for triangulation: understanding technoscientific research by comparing it to “different scenes”: to genres of the imagination, notably novels, so that, in this volume, the discovery of a Homo erectus skull by Dubois is compared to missing link novels by Jules Verne and Jack London (dating from the same period), Pavlov’s discovery of the conditioned reflex is compared with B.F. Skinner’s novel Walden Two and virology as a research field is considered through the lens of viral fiction. (shrink)

This paper examines processes of translation through which molecular genetic technologies and practices are incorporated into environmental health research and regulation. Specifically, it considers how scientists, risk assessors, and regulators have used genetically modified mouse models to translate across scientific disciplines, articulate emergent molecular forms, standards, and practices with the extant? gold standard,? and establish roles for molecular knowledge in risk assessment and regulation. Noting variation both within and between regulatory agencies in responses to data from these models, the article (...) describes also the role of public-private networks and their effects on professional and institutional imperatives which shape regulators? responses to the potential applications of these models. The conclusions address the importance of translation for understanding the wider implications of the molecularization of environmental health science. (shrink)

Gene editing tools are ‘revolutionizing’ microbiological research. Much of the public debate focuses on the possibility of human germ line applications. The use of genome editing to alter non-human animals, however, will have more immediate impacts on our daily lives. Genome edited animals are used for basic biological and biomedical research and could soon play a role in the livestock industry and ecosystem management. Genome editing thus provides an occasion to rethink societal narratives about the relationships between humans and other (...) animals. Even though the technique can be easily incorporated as an example into a conventional storyline about the development of the modern life sciences as striving for control over nature, it can also help to highlight the anthropocentric biases expressed in these narratives and demonstrate the continuities between humans and other animals. (shrink)

In the late 19th century, physiologists such as David Ferrier, Eduard Hitzig, and Hermann Munk argued that cerebral brain functions are localized in discrete structures. By the early 20th century, this became the dominant position. However, another prominent physiologist, Friedrich Goltz, rejected theories of cerebral localization and argued against these physiologists until his death in 1902. I argue in this paper that previous historical accounts have failed to comprehend why Goltz rejected cerebral localization. I show that Goltz adhered to a (...) falsificationist methodology, and I reconstruct how he designed his experiments and weighted different kinds of evidence. I then draw on the exploratory experimentation literature from recent philosophy of science to trace one root of the debate to differences in how the German localizers designed their experiments and reasoned about evidence. While Goltz designed his experiments to test hypotheses about the functions of predetermined cerebral structures, the localizers explored new functions and structures in the process of constructing new theories. I argue that the localizers relied on untested background conjectures to justify their inferences about functional organization. These background conjectures collapsed a distinction between phenomena they produced direct evidence for (localized symptoms) and what they reached conclusions about (localized functions). (shrink)

While behaviourist psychology had proven its worth to the US military during the Second World War, the 1950s saw behaviourism increasingly associated with a Cold War discourse of ‘totalitarianism’. This article considers the argument made in Hannah Arendt’s The Origins of Totalitarianism on totalitarianism as a form of behaviourist control. By connecting Arendt’s Cold War anti-behaviourism both to its discursive antecedents in a Progressive-era critique of industrial labour, and to contemporaneous attacks on behaviourism, this paper aims to answer two interlocking (...) questions: Why was behaviourism overtaken by cognitivism as the dominant theoretical orientation of psychologists in the 1960s, and what role did the concept of language play in this shift? (shrink)

In the most inclusive sense, psychological mechanisms offer a type of causal explanation of mental states and behavior, often with reference to underlying processes, systems, activities, or entities. By postulating and investigating such mechanisms, researchers have sought explanations of a wide range of psychological phenomena. However, the concept has been deployed in dramatically different ways, with very different meanings, depending upon the particular school or tradition of psychology (and specific research program therein). In fact, usage has been so diverse as (...) to defy easy categorization or definition. But a historical perspective, even if rather selective, can trace the broad outlines of the significance of psychological mechanisms for the study of the mind. Perhaps most notable is the role they have played in the psychoanalytic tradition; research efforts within behaviorism and cognitive science have also made liberal use of versions of the concept in their explanatory frameworks (for discussion of evolutionary psychology, see the entry “evolved psychological mechanisms”). Cutting across all of these traditions are several key themes relating to psychological mechanisms, including questions concerning the scope of the relevant causal claims, debates about causal determinism and regularity, and the unresolved relation between mind and body. (shrink)

The history of twentieth-century life sciences is not exactly a new topic. However, in view of the increasingly rapid development of the life sciences themselves over the past decades, some of the well-established narratives are worth revisiting. Taking stock of where we stand on these issues was the aim of a conference in 2015, entitled “Perspectives for the History of Life Sciences”. The papers in this topical collection are based on work presented and discussed at and around this meeting. Just (...) as the conference, the collection aims at exploring fields in the history of life sciences that appear understudied, sources that have been overlooked, and novel ways of engaging with this material. The papers convened in this collection may not be representative of the field as a whole; but we feel that they do indicate some elements that have received emphasis in recent years, and may become more central in the years to come, such as the history of previously neglected contexts and domains of the life sciences, the question of continuity and change on the level of practices, the history of complexity and diversity in twentieth-century life sciences and the reconsideration of the relationship between history and philosophy of life sciences. (shrink)

Sociologists have challenged the discipline to account for and incorporate biological factors in their analyses. Heeding this call, this article asks how chimeras, a particularly puzzling biological organism, are being officially classified in the interrelated sites of endangered species preservation and the zoo. Based on a qualitative study of endeavors to clone endangered animals, I contend that biology alone cannot determine the classification of these interspecies organisms. Rather, categorizing chimeras requires metaphoric, schematic references to more familiar entities. Here culture and (...) biology are tools for classification, which has consequences for preservation practices and the materiality of endangered wildlife. Drawing on the sociology of culture, I show that positions on classification represent an intermediary space for interpreting the relationship between meaning and action in discourse elaboration. Building on the sociology of science and technology, I show the epistemological limitations of understanding the biological as an a priori factor. (shrink)

From 1900 onwards, scientists and novelists have explored the contours of a future society based on the use of “anthropotechnologies” (techniques applicable to human beings for the purpose of performance enhancement ranging from training and education to genome-based biotechnologies). Gradually but steadily, the technologies involved migrated from (science) fiction into scholarly publications, and from “utopia” (or “dystopia”) into science. Building on seminal ideas borrowed from Nietzsche, Peter Sloterdijk has outlined the challenges inherent in this development. Since time immemorial, and at (...) least since the days of Plato’s Academy, human beings have been interested in possibilities for (physical or mental) performance enhancement. We are constantly trying to improve ourselves, both collectively and individually, for better or for worse. At present, however, new genomics-based technologies are opening up new avenues for self-amelioration. Developments in research facilities using animal models may to a certain extent be seen as expeditions into our own future. Are we able to address the bioethical and biopolitical issues awaiting us? After analyzing and assessing Sloterdijk’s views, attention will shift to a concrete domain of application, namely sport genomics. For various reasons, top athletes are likely to play the role of genomics pioneers by using personalized genomics information to adjust diet, life-style, training schedules and doping intake to the strengths and weaknesses of their personalized genome information. Thus, sport genomics may be regarded as a test bed where the contours of genomics-based self-management are tried out. (shrink)

T. H. Morgan, A. H. Sturtevant, H. J. Muller and C. B. Bridges published their comprehensive treatise "The Mechanism of Mendelian Heredity" in 1915. By 1920 Morgan 's "Chromosome Theory of Heredity" was generally accepted by geneticists in the United States, and by British geneticists by 1925. By 1930 it had been incorporated into most general biology, botany, and zoology textbooks as established knowledge. In this paper, I examine the reasons why it was accepted as part of a series of (...) comparative studies of theory-acceptance in the sciences. In this context it is of interest to look at the persuasiveness of confirmed novel predictions, a factor often regarded by philosophers of science as the most important way to justify a theory. Here it turns out to play a role in the decision of some geneticists to accept the theory, but is generally less important than the CTH's ability to explain Mendelian inheritance, sex-linked inheritance, non-disjunction, and the connection between linkage groups and the number of chromosome pairs; in other words, to establish a firm connection between genetics and cytology. It is remarkable that geneticists were willing to accept the CTH as applicable to all organisms at a time when it had been confirmed only for Drosophila. The construction of maps showing the location on the chromosomes of genes for specific characters was especially convincing for non-geneticists. (shrink)

In Unifying Biology, Smocovitis offers a series of claimsregarding the relationship between key actors in the synthesisperiod of evolutionary studies and positivism, especially claimsentailing Joseph Henry Woodger and the Unity of Science Movement.This commentary examines Woodger''s possible relevance to key synthesis actors and challenges Smocovitis'' arguments for theexplanatory relevance of logical positivism, and positivism moregenerally, to synthesis history. Under scrutiny, these arguments areshort on evidence and subject to substantial conceptual confusion.Though plausible, Smocovitis'' minimal interpretation – that somegeneralised form of Comtean (...) positivism had a role in synthesishistory – requires more of an evidential basis and must engageexisting scholarship on epistemic reforms in the biological sciencesprior to the synthesis period. Smocovitis is right to investigateepistemology in the synthesis period of evolutionary studies and tolook for links to wider changes in science and philosophy. However,in its present form, Unifying Biology fails to support herbasic interpretation. (shrink)

Medicalization is frequently defined as a process by which some non-medical aspects of human life become to be considered as medical problems. Overdiagnosis, on the other hand, is most often defined as diagnosing a biomedical condition that in the absence of testing would not cause symptoms or death in the person’s lifetime. Medicalization and overdiagnosis are related concepts as both expand the extension of the concept of disease. They are both often used normatively to critique unwarranted or contested expansion of (...) medicine and to address health services that are considered to be unnecessary, futile, or even harmful. However, there are important differences between the concepts, as not all cases of overdiagnosis are medicalizations and not all cases of medicalizations are overdiagnosis. The objective of this article is to clarify the differences between medicalization and overdiagnosis. It will demonstrate how the subject matter of medicalization traditionally has been non-medical (social or cultural everyday life) phenomena, while the subject matter of overdiagnosis has been biological or biomolecular conditions or processes acknowledged being potentially harmful. They also refer to different types of uncertainty: medicalization is concerned with indeterminacy, while overdiagnosis is concerned with lack of prognostic knowledge. Medicalization is dealing with sickness (sick role) while overdiagnosis with disease. Despite these differences, medicalization and overdiagnosis are becoming more alike. Medicalization is expanding, encompassing the more “technical” aspects of overdiagnosis, while overdiagnosis is becoming more ideologized. Moreover, with new trends in modern medicine, such as P4 (preventive, predictive, personal, and participatory) medicine, medicalization will become all-encompassing, while overdiagnosis more or less may dissolve. In the end they may converge in some total “iatrogenization.” In doing so, the concepts may lose their precision and critical sting. (shrink)

The technique of nuclear transplantation – popularly known as cloning – has been integrated into several different histories of twentieth century biology. Historians and science scholars have situated nuclear transplantation within narratives of scientific practice, biotechnology, bioethics, biomedicine, and changing views of life. However, nuclear transplantation has never been the focus of analysis. In this article, I examine the development of nuclear transplantation techniques, focusing on the people, motivations, and institutions associated with the first successful nuclear transfer in metazoans in (...) 1952. The conflict between embryologists and geneticists over the mechanisms of differentiation motivated Robert Briggs to pursue nuclear transplantation experiments as a way to resolve the debate. Briggs worked at the Lankenau Hospital Research Institute, a research facility devoted to the study of cancer. The goal of understanding cancer would play a role in the development of the technique, and the story of nuclear transplantation sheds light on the role that biomedical contexts play in biological research in the second half of the twentieth century. (shrink)

Investigators of animal behavior since the eighteenth century have sought to make their work integral to the enterprises of natural history and/or the life sciences. In their efforts to do so, they have frequently based their claims of authority on the advantages offered by the special places where they have conducted their research. The zoo, the laboratory, and the field have been major settings for animal behavior studies. The issue of the relative advantages of these different sites has been a (...) persistent one in the history of animal behavior studies up to and including the work of the ethologists of the twentieth century. (shrink)

Argument Herbert Mehrtens‘ work and the implications of the historical ideas he advanced went beyond the history of any single discipline. The article therefore addresses three broad issues: (1) Mehrtens‘ reconceptualization of mathematical modernism, in his field-changing book Moderne—Sprache—Mathematik (1990) and other works, as an epistemic and cultural phenomenon in a way that could potentially reach across and also beyond the sciences and also link scientific and cultural modernisms; (2) the extension of his work to the history of modernity itself (...) via the concept of “technocratic modernism”; (3) his seminal contributions to the historiography of the sciences and technology during the National Socialist period, focusing on his critique of claims that mathematics, the natural sciences and technology were morally or politically “neutral” during or after the Nazi era, and on his counter-claim that mathematicians and other scientists had in fact mobilized themselves and their knowledge in support of Nazism’s central political projects. Taken as a guide for understanding science-politics relations in general, Mehrtens‘ work was and remains a counterweight to the political abstinence adopted by many who have followed the “cultural turn” in history of science and technology. In the broadest sense, the article is a plea for the culturally relevant and politically engaged historiography of the sciences and humanities that Mehrtens himself pursued. (shrink)

This paper aims to propose an inferential and dynamic approach to understanding with models in biology. Understanding plays a central role in the practice of modeling. From its links with the other two central elements of scientific research, experimentation, and explanation, we show its epistemic relevance to the case of explanation in biology. Furthermore, by including the notion of understanding, we propose a non-referentialist perspective on scientific models, which is determined by their use.

The emerging concept of systems medicine (or ‘P4 medicine’—predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards ‘precision medicine’. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary new biomedical approach that is holistic rather than reductionist. This article analyzes its concept of holism, both with regard to methods and conceptualization of health and disease. Rather than representing a medical (...) holism associated with basic humanistic ideas, we find a technoscientific holism resulting from altered technological and theoretical circumstances in biology. We argue that this holism, which is aimed at disease prevention and health optimization, points towards an expanded form of medicalization, which we call ‘holistic medicalization’: Each person’s whole life process is defined in biomedical, technoscientific terms as quantifiable and controllable and underlain a regime of medical control that is holistic in that it is all-encompassing. It is directed at all levels of functioning, from the molecular to the social, continual throughout life and aimed at managing the whole continuum from cure of disease to optimization of health. We argue that this medicalization is a very concrete materialization of a broader trend in medicine and society, which we call ‘the medicalization of health and life itself’. We explicate this holistic medicalization, discuss potential harms and conclude by calling for preventive measures aimed at avoiding eventual harmful effects of overmedicalization in systems medicine (quaternary prevention). (shrink)

In modern discourse about the history of science, it seems to be widely accepted that at the end of the nineteenth century, Germany was one of the leading countries in the production of science. In the past, historians of science tried to trace back a specific ‘German style’ of science that—in combination with other factors—determined this German dominance around 1900, especially in the life sciences. Considering the theoretical concept of ‘national styles’, it has to be kept in mind that around (...) 1900, contemporaries already proclaimed ‘national styles’ of science as representations of national identity. Thus, the question arises as to how far existing historiographical conceptions of national styles may include earlier claims and prejudices. Careful reconstructions of contemporary discourses on national styles and inquiries into the ‘stylisation’ of a dominant, successful ‘German style’ are necessary. One of the contemporary critics of a ‘German style’ of science was the physiologist Jacques Loeb (1859–1924), who emigrated to the USA in 1891. Loeb corresponded regularly with the physicist and philosopher Ernst Mach (1838–1916). Ernst Mach can be considered Loeb's intellectual father with whom he corresponded about strategic, philosophical, and epistemological questions. Using the Loeb–Mach correspondence, the aim of the paper is to reconstruct Loeb's conception of a ‘German style’ of science and its differences to an ‘American style’. Changes in his views are discussed as well as the roots of his views and some of their consequences. Finally, Loeb's ideas on national styles and his working profiles before and after his emigration are compared to historiographical analyses of ‘American’ or ‘German’ styles of science around 1900. (shrink)

Review of: Sophia Roosth, Synthetic: How Life Got Made (University of Chicago Press, 2017); and Andrew S. Balmer, Katie Bulpin, and Susan Molyneux-Hodgson, Synthetic Biology: A Sociology of Changing Practices (Palgrave Macmillan, 2016).

The ArgumentThe paper is divided into the two parts. In the first, I examine the relations among molecular biology, gene technology, and medicine as some aspect of the consequences of these relations with respect to the human genome project of the consequences of these relations with respect to the human genome project. I argue that the prevailing momentum of early molecular biology resided in argue that the prevailing momentum of relay molecular biology resided in crating the technical means for an (...) extracellular representation of intracellular configurations. Assuch, its medical impact was rather limited. With the advent of recombinant DNA technology is based on the prospects of an intracellular representation of extracellular projects—the “rewriting” of life. Its medical impact is potentially unlimited. In the second part, I question the very opposition between nature and culture that implicitly underlies the notion of medicine as a “cultural system.” I argue that both on a macroscopic level and on a microscopic level, the “natural” and the “social” are no longer to be seen as ontologically different.In its uncanny oscillation between retrospection and foresight, between description and proclamation, and between assertion and hesitation, this essay translates an uneasiness that I have not been able to overcome while writing it. The essay conveys the tangled views of a hybrid author who himself cannot but oscillate between the perspectives of an actor in the field of molecular biology, a participant in the field of science studies, and a citizen. (shrink)

This paper takes an integrated history and philosophy of science approach to the topic of "simplicity out of complexity". The reflex theory was a framework within early twentieth century psychology and neuroscience which aimed to decompose complex behaviours and neural responses into simple reflexes. It was controversial in its time, and did not live up to its own theoretical and empirical ambitions. Examination of this episode poses important questions about the limitations of simplifying strategies, and the relationship between simplification and (...) the engineering approach to biology. (shrink)

ArgumentThe article retraces the shifting conceptualizations of psychological trauma in experimental psychopathological research in the middle decades of the twentieth century in the United States. Among researchers studying so-called experimental neuroses in animal laboratories, trauma was an often-invoked category used to denote the clash of conflicting forces believed to lead to neurotic suffering. Experimental psychologists, however, soon grew skeptical of the traumatogenic model and ultimately came to reject neurosis as a disease entity. Both theoretical differences and practical circumstances, such as (...) the technical challenge of stabilizing neurotic symptoms in rats, led to this demise. Yet, despite their reservations, experimental psychologists continued to employ traumatic stimuli to produce psychopathological syndromes. In the 1960s, a new understanding of trauma evolved, which emphasized the loss of control experienced by traumatized animal subjects. These shifting ideas about trauma, I argue, reflect both varying experimental cultures, epistemic norms as well as changing societal concerns. (shrink)

This paper argues that the 1953 double-helix solution to the problem of DNA structure was understood, at the time, as a blow within a fiercely fought dispute over the material nature of life. The paper examines the debates, between those for whom life was a purely material phenomenon and religious people for whom it had a spiritual significance, that were waged from the aftermath of the First World War to the 1960s. It looks at the developing arguments of early promoters (...) of molecular biology, including J.D. Bernal, his pupil Max Perutz and his pupil Francis Crick, on the one side, and of the so-called ‘Inkling’ cluster of writers including C.S. Lewis and J.R.R. Tolkien, on the other. This debate was conducted through polemical works, journalism, and science fiction and through the Festival of Britain and can be followed through the commentary of Jacob Bronowski. The paper concludes with the model of the double helix now at the Science Museum, which can be considered an archaeological relic of a battle in a war which is still being fought. (shrink)

Iceland has not been known as a contributor to the history of science. This small nation in the North-Atlantic has only in recent decades made its mark on international science. But the Icelandic naturalist Thorvaldur Thoroddsen (1855-1921) is an exception to this generalisation, for he was well known at the turn of the 20th century in Europe and America for his research on the geography and geology of Iceland. Though Thoroddsen's contribution to these sciences is of great interest there is (...) another very interesting side to his career. This is his transformation from "mechanist" to "vitalist," which is the main focus of this paper. Thoroddsen, who began his career as a follower of Darwinism and Haeckelian monism, started to express his worries about materialism in society in 1902 culminating in a full-fledged denial of materialism in politics and science in 1910. Thoroddsen's transformation is in its nature a very complex process, but overall it can be traced to his view that materialism was destroying the Danish and Icelandic societies. In the years before 1902 Thoroddsen was a monistic atheist, relatively liberal in his politics, a firm believer in the power of the natural sciences, and considered the laws of physics the key to human progress. His views were strikingly similar to the ones Haeckel expounded in "The Riddle of the Universe" (1899), whose reception in Germany is explored in this paper in order to contextualise Thoroddsen's transformation. Between 1902 and 1910, however, Thoroddsen rejected this worldview in favour of conservative politics and ontological dualism, becoming a staunch believer in a higher, godly, authority. The theories of Darwin and Haeckel were now obsolete and needed to be replaced by the idea of purpose, direction and the final goal of life (Teleology). In order to understand Thoroddsen's transformation, I focus on the interaction of scientific knowledge, politics and other cultural issues in his writings. This is done by looking at Thoroddsen's views on biology, on the natural sciences in general, and on politics as published in Icelandic articles, manuscripts and letters in the period 1872 to 1910. I show that the transformation was due to influences from the German holistic movement, Thoroddsen's engagement with the Royal elite in Denmark and its political concerns, new developments in physics, and from personal traumas and professional disappointments. I also show that Thoroddsen's transformation seems to be a good example of the social shaping of scientific knowledge. (shrink)

The Darwinian economic theory that Thorstein Veblen proposed and refined while he served as a professor of Political Economy at the University of Chicago from 1891 to 1906 should be assessed in the context of the community of Darwinian scientists and social scientists with whom Veblen worked and lived at Chicago. It is important to identify Veblen as a member of this broad community of Darwinian-inclined philosophers, physiologists, geologists, astronomers, and biologists at Chicago because Veblen’s involvement with this circle suggests (...) that the possible sources of his engagement with Darwinism extend beyond the pragmatists and Continental socialists to whom scholars have typically ascribed Veblen’s Darwinian roots. Additionally, that an extensive community continued to use Darwinian evolutionary theory to construct new models of scientific and social scientific analysis at the turn of the twentieth century, a period during which Darwinism was purportedly in decline, suggests that the “eclipse of Darwinism” narrative has been overstated in literature about Darwinism’s intellectual arc. (shrink)

Among the many groups of scholars whose work now illuminates science, technology and medicine (STM), historians, it seems to me, have a key responsibility not just to elucidate change but to establish and explain variety. One of the big pictures we need is a model of the varieties of STM over time; one which does not presume the timeless existence of disciplines, or the distinctions between science, technology and medicine; a model which is both synchronic and diachronic, and both cognitive (...) and social. To that end, this brief paper presents a historical typology of STM from about 1700 to the present by focusing on four ‘ideal’ socio-cognitive types – four knowledge structures which correspond to four sets of social relations. To some extent these are period specific, but they do not have to be – hence, one may hope, the flexibility and usefulness of the model. (shrink)

In the first decades of the twentieth century, the process of photosynthesis was still a mystery: Plant scientists were able to measure what entered and left a plant, but little was known about the intermediate biochemical and biophysical processes that took place. This state of affairs started to change between the two world wars, when a number of young scientists in Europe and the United States, all of whom identified with the methods and goals of physicochemical biology, selected photosynthesis as (...) a topic of research. The protagonists had much in common: They had studied physics and chemistry (although not necessarily plant physiology) to a high level; they used physicochemical methods to study the basic processes of life; they believed these processes were the same, or very similar, in all life forms; and they were affiliated with institutions that fostered this kind of study. This set of cognitive, methodological, and material resources enabled these protagonists to transfer their knowledge of the concepts and techniques from microbiology and human biochemistry, for example, to the study of plant metabolism. These transfers of knowledge had a great influence on the way in which the biochemistry and biophysics of photosynthesis would be studied over the following decades. Through the use of four historical cases, this paper analyzes these knowledge transfers, as well as the investigative pathways that made them possible. (shrink)

Synthetic biology is the engineering view on biotechnology that ultimately aims at fulfilling the quest of building an artificial cell. From the very first attempts of synthesizing life, this subject has made an impact on the media through, very often, misleading headlines and news. We review here the historical journalistic approach on synthetic biology and related disciplines, from the early twentieth century to the lastest achievements on designing protocells or genome reduction. However, it would be very naive to consider the (...) research community and the media to be unidirectionally linked, with the latter being mere displayers of the research “reality”. On the contrary, the research community has also received a strong influence from the media, as evidenced by statements from researchers, common metaphors and, even, a trend to unconsciously develop shared techno-social paradigms. We conclude that, beyond overstatements from researchers and journalists’ misunderstandings, both communities provide strong feedback to each other and, together, contribute to define the dream that synthetic biologists are aiming for. (shrink)

This article examines the study of mind and behavior at the University of Chicago through the career of Charles Judson Herrick, neuroanatomist and psychobiologist. Herrick’s views on human nature, education, and social control are discussed in the context of the progressive evolutionism pervading the university in the early twentieth century. The religious background of Herrick’s work is important to understanding the service ethos that permeated his science, which was also the basis of his interest in pragmatism and of his opposition (...) to certain tenets of behaviorism. Herrick was dedicated to interdisciplinary collaboration, which he thought crucial to the development of psychobiology. His relationship with Karl S. Lashley in the 1920s is analyzed. Their disagreements about the relationship between science and humanism, as revealed in their views on behaviorism, did not prevent them from working together to articulate a holistic theory of brain function and learning. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des massenmedialen Diskurses seit (...) den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)

This article examines to what extent a particular case of cross-disciplinary research in the 1930s was structured by mechanistic reasoning. For this purpose, it identifies the interfield theories that allowed biologists and chemists to use each other’s techniques and findings, and that provided the basis for the experiments performed to identify plant growth hormones and to learn more about their role in the mechanism of plant growth. In 1930, chemists and biologists in Utrecht and Pasadena began to cooperatively study plant (...) growth. I will argue that these researchers decided to join forces because they believed to rely on each other’s findings and methods to solve their research problems adequately. In the course of the cooperation, organic chemists arrived at isolating plant growth hormones by using a test method developed in plant physiology. This achievement, in turn, facilitated biologists’ investigation of the mechanism of plant growth. Researchers eventually believed to have the means to study the relation between a substance’s molecular structure and its physiological activity. The way they conceptualized the problem of identifying hormones and unraveling the mechanism of plant growth, as well as their actual research actions are compatible with the new mechanists’ account of mechanism research. The study illustrates that focusing on researchers’ mechanistic reasoning can contribute considerably to explaining the structure of cross-disciplinary research projects. (shrink)

Das Ideal einer vorhersagenden Medizin in Kombination mit wirkungsvollen, kausalen Strategien der Prävention auf molekularer Ebene ist noch immer weit davon entfernt, klinische Realität zu werden. Es ist jedoch schon heute festzustellen, dass zwischen Medizin und Gesellschaft verhandelte Konzepte von Gesundheit in immer stärkerem Maße auf zukünftige Gesundheit ausgerichtet sind, mithin einen immer präventiveren Charakter aufweisen. Der vorliegende Beitrag untersucht die Frage, ob neue Konzepte einer prädiktiv-präventiven Medizin – insbesondere Public Health Genetics bzw. Public Health Genomics – das Kriterium der (...) Verbesserung der sozialen Erreichbarkeit von Gesundheit erfüllen. Diese Analyse wird vor dem Hintergrund der Rolle sozialer Grundwerte, insbesondere dem der Gerechtigkeit, für Funktionen der Medizin in unserer Gesellschaft einerseits sowie der Bedeutung des Wandels der medizinischen Schlüsselkonzepte „Gesundheit“ und „Krankheit“ andererseits vorgenommen. (shrink)

New emerging biotechnologies, such as gene editing, vastly extend our ability to alter the human being. This comes together with strong aspirations to improve humans not only physically, but also mentally, morally, and socially. These conjoined ambitions aggregate to what can be labelled “the gene editing of super-ego.” This article investigates a general way used to argue for new biotechnologies, such as gene-editing: if it is safe and efficacious to implement technology X for the purpose of a common good Y, (...) why should we not do so? This is a rhetorical question with a conditional, and may be dismissed as such. Moreover, investigating the question transformed into a formal argument reveals that the argument does not hold either. Nonetheless, the compelling force of the question calls for closer scrutiny, revealing that this way of arguing for biotechnology is based on five assumptions. Analysis of these assumptions shows their significant axiological, empirical, and philosophical challenges. This makes it reasonable to claim that these kinds of question based promotions of specific biotechnologies fail. Hence, the aspirations to make a super-man with a super-ego appear fundamentally flawed. As these types of moral bioenhancement arguments become more prevalent, a revealing hype test is suggested: What is special with this technology, compared to existing methods, that makes it successful in improving human social characteristics in order to make the world a better place for all? Valid answers to this question will provide good reasons to pursue such technologies. Hence, the aim is not to bar the development of modern biotechnology, but rather to ensure good developments and applications of highly potent technologies. So far, we still have a long way to go to make persons with goodness gene. (shrink)

Historians and philosophers of twentieth-century life sciences have demonstrated that the choice of experimental organism can profoundly influence research fields, in ways that sometimes undermined the scientists’ original intentions. The present paper aims to enrich and broaden the scope of this literature by analysing the career of unicellular green algae of the genus Chlorella. They were introduced for the study of photosynthesis in 1919 by the German cell physiologist Otto H. Warburg, and they became the favourite research objects in this (...) field up to the 1960s. The paper argues that dealing with Chlorella’s high metabolic flexibility was crucial for the emergence of a new conception of photosynthesis, as a plastic, integrated system of pathways. At the same time, it led to new collaborations between physiologists and phycologists, both of whom started to re-orient their studies in ecologically informed directions. Following Chlorella’s trail, hence, not only elucidates how experimental organisms forced scientists to change their conceptual approaches and techniques, but also provides insight into the interaction of different lines of research of mid-twentieth century plant sciences. (shrink)

The ways in which the various activities of synthetic biology connect to those of conventional biology display both a multiplicity and variety that reflect the multiplicity and variety of meanings for which the term synthetic biology has been invoked, today as in the past. Central to this variety, as well as to the connection itself, is the complex relationship between knowing and making that has prevailed in the life sciences. That relationship is the focus of this article. More specifically, my (...) aim is to explore the different assumptions about how knowing is related to making that have prevailed, implicitly or explicitly in the various activities—now or in the past—subsumed under the name synthetic biology. (shrink)

Despite the controversial nature of studies of reproductive phenomena, a major center of reproductive biology emerged and coalesced in the Department of Zoology at the University of Chicago circa 1892–1940. Led by Frank R. Lillie, several small groups of researchers pioneered the study of sex determination and sex hormones, pursuing these via a Chicago approach to framing biological practice at both cellular and organismic levels. They worked in an interdisciplinary manner, however much in tandem, and drew strongly on local resources—from (...) the stockyards to local philanthropy. Most remarkably, Lillie redirected the mission of the major National Research Council Committee for Research Problems of Sex to address the biology of sex and then garnered about a fifth of its funds for Chicago. He thus guided Chicago biology into the fully modern era of external support for on-campus research and elaborate national scientific networks via promising biological solutions to social problems. (shrink)