We critique the organizational account of biological functions by showing how its basis in the closure of constraints fails to be objective. While the account treats constraints as objective features of physical systems, the number and relationship of potential constraints are subject to potentially arbitrary redescription by investigators. For example, we show that self-maintaining systems such as candle flames can realize closure on a more thorough analysis of the case, contradicting the claim that these “simple” systems lack functional organization. This (...) also raises problems for Moreno and Mossio’s associated theory of biological autonomy, which asserts that living beings are distinguished by their possession of a closed system of constraints that channel and regulate their metabolic processes. (shrink)

This paper considers whether there can be any such thing as a naturalized metaphysics of color—any distillation of the commitments of perceptual science with regard to color ontology. I first make some observations about the kinds of philosophical commitments that sometimes bubble to the surface in the psychology and neuroscience of color. Unsurprisingly, because of the range of opinions expressed, an ontology of color cannot simply be read off from scientists’ definitions and theoretical statements. I next consider two alternative routes. (...) First, conceptual pluralism inspired by Mark Wilson's analysis of scientific representation. I argue that these findings leave the prospects for a naturalized color ontology rather dim. Second, I outline a naturalized epistemology of perception. I ask how the correctness and informativeness of perceptual states is understood by contemporary perceptual science. I argue that the detectionist ideal of correspondence should be replaced by the pragmatic ideal of usefulness. I argue that this result has significant implications for the metaphysics of color. (shrink)

Huw Price has sketched a program for a globalized expressivism in support of which he has repeatedly invoked Rudolf Carnap. This paper argues that this is entirely appropriate, as Carnap had something quite similar in mind. However, it also argues that Price’s recent attempts to integrate Robert Brandom’s inferentialism to this program are less successful, and that a more empirically-oriented descriptive pragmatics along Carnapian lines would be a better fit with his original program than Brandom’s explicitly hermeneutical agenda.

ABSTRACT I propose a division of the literature on natural kinds into metaphysical worries, semantic worries, and methodological worries. I argue that the latter set of worries, which concern how classification influences scientific practices, should occupy centre stage in philosophy of science discussions about natural kinds. I apply this methodological framework to the problems of classifying chemical species and nanomaterials. I show that classification in nanoscience differs from classification in chemistry because the latter relies heavily on compositional identity, whereas the (...) former must consider additional properties, namely, size, shape, and surface chemistry. I use this difference to argue for a scale-dependent theory of scientific classification. _1_ Introduction _2_ The Methodological Problem of Kinds _3_ Chemical Kindhood: Reactivity, Microstructure, and the Structure–Property Paradigm _4_ Scale-Dependence and Nanoscale Kinds _5_ Conclusion. (shrink)

There has always been interest in inconsistency in science, not least within science itself as scientists strive to devise a consistent picture of the universe. Some important early landmarks in this history are Copernicus’s criticism of the Ptolemaic picture of the heavens, Galileo’s claim that Aristotle’s theory of motion was inconsistent, and Berkeley’s claim that the early calculus was inconsistent. More recent landmarks include the classical theory of the electron, Bohr’s theory of the atom, and the on-going difficulty of reconciling (...) Einstein’s general relativity and quantum theory. But over the past few decades philosophers have taken a particular and increasing interest in inconsistency in science. In 2002 this culminated in the first collection of articles specifically dedicated to the topic: Inconsistency in Science, edited by Joke Meheus, published by Kluwer, and featuring twelve articles on a range of topics in the philosophy of science and mathematics.Since then philosophic. (shrink)

In this paper, I present the case of the discovery of complex numbers by Girolamo Cardano. Cardano acquires the concepts of (specific) complex numbers, complex addition, and complex multiplication. His understanding of these concepts is incomplete. I show that his acquisition of these concepts cannot be explained on the basis of Christopher Peacocke’s Conceptual Role Theory of concept possession. I argue that Strong Conceptual Role Theories that are committed to specifying a set of transitions that is both necessary and sufficient (...) for possession of mathematical concepts will always face counterexamples of the kind illustrated by Cardano. I close by suggesting that we should rely more heavily on resources of Anti-Individualism as a framework for understanding the acquisition and possession of concepts of abstract subject matters. (shrink)

This paper surveys some of the grounding literature searching for points of contact between theories of ground and science. I find that there are some places where a would-be naturalistic grounding theorist can draw inspiration. I synthesize a list of recommendations for how science may be put to use in theories of ground. I conclude that the prospects for naturalizing the metaphysics of ground are bright.

Here we challenge the orthodoxy according to which abduction is an a posteriori mode of inference. We start by providing a case study illustrating how abduction can justify a philosophical claim not justifiable by empirical evidence alone. While many grant abduction's epistemic value, nearly all assume that abductive justification is a posteriori, on grounds that our belief in abduction's epistemic value depends on empirical evidence about how the world contingently is. Contra this assumption, we argue, first, that our belief in (...) abduction’s epistemic value is not and could not be justified a posteriori, and second, that attention to the roles experience plays in abductive justification supports taking abduction to be an a priori mode of inference. We close by highlighting how our strategy for establishing the a priority of abduction positively contrasts with strategies in Bonjour (1998), Swinburne (2001), and Peacocke (2004) aiming to establish the a priority of certain ampliative modes of inference or abductive principles. (shrink)

This paper aims to draw attention to an explanatory problem posed by the existence of multiply realized or universal behavior exhibited by certain physical systems. The problem is to explain how it is possible that systems radically distinct at lower-scales can nevertheless exhibit identical or nearly identical behavior at upper-scales. Theoretically this is reflected by the fact that continuum theories such as fluid mechanics are spectacularly successful at predicting, describing, and explaining fluid behaviors despite the fact that they do not (...) recognize the discrete nature of fluids. A standard attempt to reduce one theory to another, is shown to fail to answer the appropriate question about autonomy. (shrink)

The present century has seen renewed interest in characterizing cognition, the object of inquiry of the cognitive sciences. In this paper, I describe the problem of cognition—the absence of a positive characterization of cognition despite a felt need for one. It is widely recognized that the problem is motivated by decades of controversy among cognitive scientists over foundational questions, such as whether non-neural parts of the body or environment can realize cognitive processes, or whether plants and microbes have cognitive processes. (...) The dominant strategy for addressing the problem of cognition is to seek a dichotomous criterion that vindicates some set of controversial claims. However, I argue that the problem of cognition is also motivated by ongoing conceptual development in cognitive science, and I describe four benefits that a characterization of cognition could confer. Given these benefits, I recommend an alternative criterion of success, ecumenical extensional adequacy, on which the aim is to describe the variation in expert judgments rather than to correct this variation by taking sides in sectarian disputes. I argue that if we had an ecumenical solution to the problem of cognition, we would have achieved much of what we should want from a “mark of the cognitive”. (shrink)

The authors survey some debates about the nature and structure of physical theories and about the connections between our physical theories and naturalized metaphysics. The discussion is organized around an “ideal view” of physical theories and criticisms that can be raised against it. This view includes controversial commitments regarding the best analysis of physical modalities and intertheory relations. The authors consider the case in favor of taking laws as the primary modal notion, discussing objections related to alleged violations of the (...) laws, the apparent need to appeal to causality, and the status of probability. The “ideal view” includes a commitment that fundamental physical theories are explanatorily sufficient. The authors discuss several challenges to recovering the manifest image from fundamental physics, along with a distinct challenge to reductionism based on acknowledging the contributions of less fundamental theories in physical explanations. (shrink)

This paper examines the relevance of philosophical work on consciousness to its scientific study. Of particular concern is the debate over whether consciousness can be naturalized, which is typically taken to have consequences for the prospects for its scientific investigation. It is not at all clear that philosophers of consciousness have properly identified and evaluated the assumptions about scientific activity made by both naturalization and anti- naturalization projects. I argue that there is good reason to think that some of the (...) assumptions about physicalism and explanation made by the parties to the debate are open to serious doubt. Thus this paper is an invitation for those inquiring into whether consciousness can be naturalized to more carefully consider the expected payoff of such efforts. (shrink)

This paper focuses on two questions: Is understanding intimately bound up with accurately representing the world? Is understanding intimately bound up with downstream abilities? We will argue that the answer to both these questions is “yes”, and for the same reason-both accuracy and ability are important elements of orthogonal evaluative criteria along which understanding can be assessed. More precisely, we will argue that representational-accuracy and intelligibility are good-making features of a state of understanding. Interestingly, both evaluative claims have been defended (...) by philosophers in the literature on understanding as the criterion of evaluation. We argue that proponents of both approaches have important insights and that, drawing on both their own observations and a few novel arguments, we can construct a more complete picture of understanding evaluation. We thus posit the theory of there being Multiple Understanding Dimensions. The main thing to note about our dualism regarding the evaluative criteria of understanding is that it accounts for the intuitions about cases underlying both previously held positions. (shrink)

Quantum mechanics, and classical mechanics, are framework theories that incorporate many different concrete theories which in general cannot be arranged in a neat hierarchy, but discussion of ‘the ontology of quantum mechanics’ tends to proceed as if quantum mechanics were a single concrete theory, specifically the physics of nonrelativistically moving point particles interacting by long-range forces. I survey the problems this causes and make some suggestions for how a more physically realistic perspective ought to influence the metaphysics of quantum mechanics.

This paper argues first that, contrary to what one would expect, metaphorical interpretations of utterances pass two of Cappelan and Lepore's Minimalist tests for semantic context-sensitivity. I then propose how, in light of that result, one might analyze metaphors on the model of indexicals and demonstratives, expressions that (even) Minimalists agree are semantically context-dependent. This analysis builds on David Kaplan's semantics for demonstratives and refines an earlier proposal in (Stern, Metaphor in context, MIT Press, Cambridge, 2000). In the course of (...) this argument, I also discuss some new examples of linguistic phenomena that motivate a semantic structure underlying metaphorical interpretation, phenomena I argue that neither Minimalists nor Contextualists can explain. (shrink)

In this paper I investigate two notions of concepts that have played a dominant role in 20th century philosophy of mathematics. According to the first, concepts are definite and fixed; in contrast, according to the second notion concepts are open and subject to modifications. The motivations behind these two incompatible notions and how they can be used to account for conceptual change are presented and discussed. On the basis of historical developments in mathematics I argue that both notions of concepts (...) capture important aspects of mathematical and scientific reasoning, and, consequently, that a pluralistic approach that allows for representing both of these aspects is most useful for an adequate account of investigative practices. (shrink)

This paper engages critically with anti-representationalist arguments pressed by prominent enactivists and their allies. The arguments in question are meant to show that the “as-such” and “job-description” problems constitute insurmountable challenges to causal-informational theories of mental content. In response to these challenges, a positive account of what makes a physical or computational structure a mental representation is proposed; the positive account is inspired partly by Dretske’s views about content and partly by the role of mental representations in contemporary cognitive scientific (...) modeling. (shrink)

My aim in this paper is to articulate an account of scientific modeling that reconciles pluralism about modeling with a modest form of scientific realism. The central claim of this approach is that the models of a given physical phenomenon can present different aspects of the phenomenon. This allows us, in certain special circumstances, to be confident that we are capturing genuine features of the world, even when our modeling occurs independently of a wholly theoretical motivation. This framework is illustrated (...) using a recent debate from meteorology. (shrink)

Approaches to the interpretation of physical theories provide accounts of how physical meaning accrues to the mathematical structure of a theory. According to many standard approaches to interpretation, meaning relations are captured by maps from the mathematical structure of the theory to statements expressing its empirical content. In this article I argue that while such accounts adequately address meaning relations when exact models are available or perturbation theory converges, they do not fare as well for models that give rise to (...) divergent perturbative expansions. Since truncations of divergent perturbative expansions often play a critical role in establishing the empirical adequacy of a theory, this is a serious deficiency. I show how to augment state-space semantics, a view developed by Beth and van Fraassen, to capture perturbatively evaluated observables even in cases where perturbation theory is divergent. This new semantics establishes a sense in which the calculations that underwrite the empirical adequacy of a theory are both meaningful and true, but requires departure from the assumption that physical meaning is captured entirely by the exact models of a theory. (shrink)

In “Demonstratives”, David Kaplan introduced a simple and remarkably robust semantics for indexicals. Unfortunately, Kaplan’s semantics is open to a number of apparent counterexamples, many of which involve recording devices. The classic case is the sentence “I am not here now” as recorded and played back on an answering machine. In this essay, I argue that the best way to accommodate these data is to conceive of recording technologies as introducing special, non-basic sorts of contexts, accompanied by non-basic conventions governing (...) the use of indexicals in those contexts. The idea is that recording devices allow us to use indexicals in new and innovative ways to coordinate on objects. And, given sufficient regularity in the use of indexicals on such devices, linguistic conventions will, over time, come to reflect this innovation. I consider several alternatives to this ‘character-shifting’ theory, but none is able to account for the data as well as the present proposal. Many face additional theoretical difficulties as well. I conclude by explaining how the character-shifting theory not only retains many of the virtues of Kaplan’s original semantics, but also coheres with a plausible view on the nature of semantic theorizing more generally. (shrink)

While the Enlightenment promoted thinking for oneself independent of religious authority, the ‘Endarkenment’ (Millgram 2015) concerns deference to a new authority: the specialist, a hyperspecializer. Non-specialists need to defer to such authorities as they are unable to understand their reasoning. Millgram describes how humans are capable of being serial hyperspecializers, able to move from one specialism to another. We support the basic thrust of Millgram’s position, and seek to articulate how the core idea is deployed in very different ways in (...) relation to extremely different philosophical areas. We attend to the issue of the degree of isolation of different specialists and we urge greater emphasis on parallel hyperspecialization, which describes how different specialisms can be embodied in one person at one time. (shrink)

Using the context of controversies surrounding evolutionary developmental biology (EvoDevo) and the possibility of an Extended Evolutionary Synthesis, I provide an account of theory structure as idealized theory presentations that are always incomplete (partial) and shaped by their conceptual content (material rather than formal organization). These two characteristics are salient because the goals that organize and regulate scientific practice, including the activity of using a theory, are heterogeneous. This means that the same theory can be structured differently, in part because (...) theory presentations (as idealizations) intentionally depart from different features known to be present in a theory. Since there are diverse and potentially incompatible theory structures derived from heterogeneous goals found in scientific practices, a question arises about the absence of a unifying theory structure in the background. The notion of a “theory façade” offers a fruitful perspective on this potentially unsettling result. (shrink)

In this article, I argue that the use of scientific models that attribute intentional content to complex systems bears a striking similarity to the way in which statistical descriptions are used. To demonstrate this, I compare and contrast an intentional model with a statistical model, and argue that key similarities between the two give us compelling reasons to consider both as a type of phenomenological model. I then demonstrate how intentional descriptions play an important role in scientific methodology as a (...) type of phenomenal model, and argue that this makes them as essential as any other model of this type. (shrink)

A common view in the philosophy of mind and philosophy of psychology is that there is an ideally correct way of categorizing the structures and operations of the mind, and that the goal of neuroscience and psychology is to find this correct categorizational scheme. Categories which cannot find a place within this correct framework ought to be eliminated from scientific practice. In this paper, I argue that this general idea runs counter to productive scientific practices. Such a view ignores the (...) plurality of aims and goals that neuroscientists and psychologists have in studying mental phenomena, and the necessity of employing distinct classificatory frameworks to achieve them. (shrink)

The concept of the cortical column refers to vertical cell bands with similar response properties, which were initially observed by Vernon Mountcastle’s mapping of single cell recordings in the cat somatic cortex. It has subsequently guided over 50 years of neuroscientific research, in which fundamental questions about the modularity of the cortex and basic principles of sensory information processing were empirically investigated. Nevertheless, the status of the column remains controversial today, as skeptical commentators proclaim that the vertical cell bands are (...) a functionally insignificant by-product of ontogenetic development. This paper inquires how the column came to be viewed as an elementary unit of the cortex from Mountcastle’s discovery in 1955 until David Hubel and Torsten Wiesel’s reception of the Nobel Prize in 1981. I first argue that Mountcastle’s vertical electrode recordings served as criteria for applying the column concept to electrophysiological data. In contrast to previous authors, I claim that this move from electrophysiological data to the phenomenon of columnar responses was concept-laden, but not theory-laden. In the second part of the paper, I argue that Mountcastle’s criteria provided Hubel Wiesel with a conceptual outlook, i.e. it allowed them to anticipate columnar patterns in the cat and macaque visual cortex. I argue that in the late 1970s, this outlook only briefly took a form that one could call a ‘theory’ of the cerebral cortex, before new experimental techniques started to diversify column research. I end by showing how this account of early column research fits into a larger project that follows the conceptual development of the column into the present. (shrink)

In this paper, I argue that looking at the concept of neural function through the lens of cognition alone risks cognitive myopia: it leads neuroscientists to focus only on mechanisms with cognitive functions that process behaviorally relevant information when conceptualizing “neural function”. Cognitive myopia tempts researchers to neglect neural mechanisms with noncognitive functions which do not process behaviorally relevant information but maintain and repair neural and other systems of the body. Cognitive myopia similarly affects philosophy of neuroscience because scholars overlook (...) noncognitive functions when analyzing issues surrounding e.g., functional decomposition or the multifunctionality of neural structures. I argue that we can overcome cognitive myopia by adopting a patchwork approach that articulates cognitive and noncognitive “patches” of the concept of neural function. Cognitive patches describe mechanisms with causally specific effects on cognition and behavior which are likely operative in transforming sensory or other inputs into motor outputs. Noncognitive patches describe mechanisms that lack such specific effects; these mechanisms are enabling conditions for cognitive functions to occur. I use these distinctions to characterize two noncognitive functions at the mesoscale of neural circuits: subsistence functions like breathing are implemented by central pattern generators and are necessary to maintain the life of the organism. Infrastructural functions like gain control are implemented by canonical microcircuits and prevent neural system damage while cognitive processing occurs. By adding conceptual patches that describe these functions, a patchwork approach can overcome cognitive myopia and help us explain how the brain’s capacities as an information processing device are constrained by its ability to maintain and repair itself as a physiological apparatus. (shrink)

This paper explores how the Bayesian program benefits from allowing for objective chance as well as subjective degree of belief. It applies David Lewis’s Principal Principle and David Christensen’s principle of informed preference to defend Howard Raiffa’s appeal to preferences between reference lotteries and scaling lotteries to represent degrees of belief. It goes on to outline the role of objective lotteries in an application of rationality axioms equivalent to the existence of a utility assignment to represent preferences in Savage’s famous (...) omelet example of a rational choice problem. An example motivating causal decision theory illustrates the need for representing subjunctive dependencies to do justice to intuitive examples where epistemic and causal independence come apart. We argue to extend Lewis’s account of chance as a guide to epistemic probability to include De Finetti’s convergence results. We explore Diachronic Dutch book arguments as illustrating commitments for treating transitions as learning experiences. Finally, we explore implications for Martingale convergence results for motivating commitment to objective chances. (shrink)

Constructive field theory aims to rigorously construct concrete, nontrivial solutions to Lagrangians used in particle physics. I examine the relationship of solutions in constructive field theory to both axiomatic and Lagrangian quantum field theory. I argue that Lagrangian QFT provides conditions for what counts as a successful constructive solution and other information that guides constructive field theorists to solutions. Solutions matter because they describe the behavior of QFT systems and thus what QFT says the world is like. Constructive field theory (...) clarifies existing disputes about which parts of QFT are philosophically relevant and how rigor relates to these disputes. (shrink)

In Hard Truths Elijah Millgram argues that ‘partial truth’ is pervasive and for that reason bivalence 1 may rarely be assumed. As classical logic assumes bivalence, and inferences from partial truths to partial truths are central to our thinking, classical logic rarely has application, the argument continues. And so we must develop an account of inference from partial truths to partial truths; as well, our metaphysics must be revised. While the novel positions of Hard Truths 2 raise many interesting challenges, (...) my focus is limited to offering an alternative to Millgram’s account of predication and to exploring some issues raised by his appeal to ‘fit’ in his definitions of truth and partial truth. 1. Introduction to partial truth Millgram defines truth and partial truth in terms of fit, as follows: Advancing a claim as fully true demands complete fit; assessing a claim as partially true allows for slack … but only so much of it. Claims are said to completely fit, slackly fit or not fit, the world, in §6.3. But, the word ‘fit’ is first introduced in §1.2, and it is experience or proto-experience, that fits into moulds provided by claims, thoughts, sentences and predicates. I won’t dwell on which fits what, 3 but on the notion of a ‘complete fit’ and the contrast with a ‘slack fit’; this discussion leads me to ponder the clarity and implications of appealing to these notions in definitions like the above. Millgram’s explanation of fit comes in the context of his account of predication, according to which, most predicates do not quite apply. It’s this that is primarily responsible for his promotion of partial truth. I sketch an alternative account of language whereby predicates do apply because language has come to life as a constituent of the things we do: …. (shrink)

This paper provides a survey of several philosophical issues arising in classical electrodynamics arguing that there is a philosophically rich set of problems in theories of classical physics that have not yet received the attention by philosophers that they deserve. One issue, which is connected to the philosophy of causation, concerns the temporal asymmetry exhibited by radiation fields in the presence of wave sources. Physicists and philosophers disagree on whether this asymmetry reflects a fundamental causal asymmetry or is due to (...) statistical or thermodynamic considerations. I suggest that an explanation appealing to the asymmetry of causation is more promising. Another issue concerns the conceptual structure of the theory. Despite its empirical success, classical electrodynamics faces serious foundational problems. Models of charged particles involve what by the theory's own lights are idealizations, I maintain, and this is a feature that is not readily captured by traditional philosophical accounts of scientific theories. Other issues I discuss concern (i) the relation between Lorentz's theory of the electron and Einstein's Theory of Special Relativity; (ii) the notion of the domain of a theory, the question of theory reduction, and the relation between classical and more fundamental quantum theories; and (iii) the role of locality constraints, their relation to the concept of causation; and the status of locality conditions in the semi-classical theory of the Aharanov-Bohm effect. (shrink)

We argue that two powerful error-theoretic concepts provide a general framework that satisfactorily accounts for key aspects of the explanation of physical patterns. This method gives an objective criterion to determine which mathematical models in a class of neighboring models are just as good as the exact one. The method also emphasizes that abstraction is essential for explanation and provides a precise conceptual framework that determines whether a given abstraction is explanatorily relevant and justified. Hence, it increases our epistemological understanding (...) of how one should go about reconstructing scientific practices by making clear that, at a fundamental level, a key aspect of mathematical modeling consists in exactly solving nearby problems. (shrink)

This thesis offers a naturalist revision of Alain Badiou’s philosophy. This goal is pursued through an encounter of Badiou’s mathematical ontology and theory of truth with contemporary trends in philosophy of mathematics and philosophy of science. I take issue with Badiou’s inability to elucidate the link between the empirical and the ontological, and his residual reliance on a Heideggerian project of fundamental ontology, which undermines his own immanentist principles. I will argue for both a bottom-up naturalisation of Badiou’s philosophical approach (...) to mathematics and a top-down naturalisation. Articulating my particular understanding of what realism and naturalism should commit us to, I propose a creative fusion of Badiou’s attention to metamathematical results with a structural-informational metaphysics, proposing a ‘matherialism’ uniting the more daring speculative insights of the former with the naturalist and empiricist commitments motivating the latter. (shrink)

It is commonly thought that before the introduction of quantum mechanics, determinism was a straightforward consequence of the laws of mechanics. However, around the nineteenth century, many physicists, for various reasons, did not regard determinism as a provable feature of physics. This is not to say that physicists in this period were not committed to determinism; there were some physicists who argued for fundamental indeterminism, but most were committed to determinism in some sense. However, for them, determinism was often not (...) a provable feature of physical theory, but rather an a priori principle or a methodological presupposition. Determinism was strongly connected with principles of causality and continuity and the principle of sufficient reason; this thesis examines the relevance of these principles in the history of physics. Moreover, the history of determinism in this period shows that there were essential changes in the relation between mathematics and physics: whereas in the eighteenth century, there were metaphysical arguments which lent support to differential calculus, by the early twentieth century the development of rigorous foundations of differential calculus led to concerns about its applicability in physics. The thesis consists of six papers. In the first paper, "On the origins and foundations of Laplacian determinism", I argue that Laplace, who is usually pointed out as the first major proponent of scientific determinism, did not derive his statement of determinism directly from the laws of mechanics; rather, his determinism has a background in eighteenth century Leibnizian metaphysics, and is ultimately based on the law of continuity and the principle of sufficient reason. These principles also provided a basis for the idea that one can find laws of nature in the form of differential equations which uniquely determine natural processes. In "The Norton dome and the nineteenth century foundations of determinism", I argue that an example of indeterminism in classical physics which has attracted attention in philosophy of physics in recent years, namely the Norton come, was already discussed during the nineteenth century. However, the significance which this type of indeterminism had back then is very different from the significance which the Norton dome currently has in philosophy of physics. This is explained by the fact that determinism was conceived of in an essentially different way: in particular, the nineteenth century authors who wrote about this type of indeterminism regarded determinism as an a priori principle rather than as a property of the equations of physics. In "Vital instability: life and free will in physics and physiology, 1860-1880", I show how Maxwell, Cournot, Stewart and Boussinesq used the possibility of unstable or indeterministic mechanical systems to argue that the will or a vital principle can intervene in organic processes without violating the laws of physics, so that a strictly dualist account of life and the mind is possible. Moreover, I show that their ideas can be understood as a reaction to the law of conservation of energy and to the way it was used in physiology to exclude vital and mental causes. In "The nineteenth century conflict between mechanism and irreversibility", I show that in the late nineteenth century, there was a widespread conflict between the aim of reducing physical processes to mechanics and the recognition that certain processes are irreversible. Whereas the so-called reversibility objection is known as an objection that was made to the kinetic theory of gases, it in fact appeared in a wide range of arguments, and was susceptible to very different interpretations. It was only when the project of reducing all of physics to mechanics lost favor, in the late nineteenth century, that the reversibility objection came to be used as an argument against mechanism and against the kinetic theory of gases. In "Continuity in nature and in mathematics: Boltzmann and Poincaré", I show that the development of rigorous foundations of differential calculus in the nineteenth century led to concerns about its applicability in physics: through this development, differential calculus was made independent of empirical and intuitive notions of continuity and was instead based on mathematical continuity conditions, and for Boltzmann and Poincaré, the applicability of differential calculus in physics depended on whether these continuity conditions could be given a foundation in intuition or experience. In the final paper, "Determinism around 1900", I briefly discuss the implications of the developments described in the previous two papers for the history of determinism in physics, through a discussion of determinism in Mach, Poincaré and Boltzmann. I show that neither of them regards determinism as a property of the laws of mechanics; rather, for them, determinism is a precondition for science, which can be verified to the extent that science is successful. (shrink)

In Meaning and Necessity (1947/1950), Carnap advances an intensional semantic framework on which modal claims are true in virtue of semantical rules alone, and so are a priori. In 'Empiricism, Semantics, and Ontology' (1950), Carnap advances an epistemic-ontological framework on which metaphysical claims are either trivial or meaningless, since lacking any means of substantive confirmation. Carnap carried out these projects two decades before Kripke influentially argued, in Naming and Necessity (1972/1980), that some modal claims are true a posteriori. How should (...) a neo-Carnapian respond to Kripke's results? Some (notably, Chalmers and Jackson, in their 2001) have suggested that an extension of intensional semantics along lines of "epistemic two-dimensionalism" can accommodate Kripke's results while largely preserving commitment to the semantics-based a priority of modal claims. Here we consider how best to implement this suggestion, and how the resulting semantics fits with Carnap's second project. We find that the most promising (and most Carnapian!) post-Kripke version of Carnap’s semantics---abductive two-dimensionalism---presupposes an epistemology which undermines Carnap's metaphysical anti-realism. (shrink)

In the first half of this dissertation, I develop a heuristic methodology for analyzing scientific solutions to the problem of underdetermination. Heuristics are rough-and-ready procedures used by scientists to construct models, design experiments, interpret evidence, etc. But as powerful as they are, heuristics are also error-prone. Therefore, I argue that they key to prudently using a heuristic is the articulation of meta-heuristics---guidelines to the kinds of problems for which a heuristic is well- or ill-suited. Given that heuristics will introduce certain (...) errors into our scientific investigations, I emphasize the importance of a particular category of meta-heuristics involving the search for robust evidence. Robustness is understood to be the epistemic virtue bestowed by agreement amongst multiple modes of determination. The more modes we have at our disposal, and the more these confirm the same result, the more confident can we be that a result is not a mere artifact of some heuristic simplification. Through an analysis of case-studies in the philosophy of biology and clinical trials, I develop a principled method for modeling and evaluating heuristics and robustness claims in a qualitative problem space. The second half of the dissertation deploys the heuristic methodology to address ethical and epistemological issues in the science of clinical trials. To that end, I develop a network model for the problem space of clinical research, capable of representing the various kinds of experiments, epistemic relationships, and ethical justifications intrinsic to the domain. I then apply this model to ongoing research with the antibacterial agent, moxifloxacin, for the treatment of tuberculosis, tracking its development from initially successful and promising in vitro and animal studies to its disappointing and discordant performance across five human efficacy trials. Given this failure to find a robust result with moxifloxacin across animal and human studies, what should researchers now do? While my final analysis of this case does not definitively answer that question, I demonstrate how my methodology, unlike a statistical meta-analysis, helps to clarify the directions for further research. (shrink)