TGF-beta signaling proteins and the Protein Ontology

BMC Bioinformatics 10 (Suppl 5):S3 (2009)
Download Edit this record How to cite View on PhilPapers
Abstract
The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses.
Categories
PhilPapers/Archive ID
ARITSP-2
Upload history
Archival date: 2017-11-11
View other versions
Added to PP index
2017-04-28

Total views
151 ( #31,282 of 56,907 )

Recent downloads (6 months)
22 ( #33,151 of 56,907 )

How can I increase my downloads?

Downloads since first upload
This graph includes both downloads from PhilArchive and clicks on external links on PhilPapers.